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Aliases for CD2BP2 Gene

Aliases for CD2BP2 Gene

  • CD2 Cytoplasmic Tail Binding Protein 2 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 59 2 3
  • CD2 Cytoplasmic Domain-Binding Protein 2 3 4
  • U5 SnRNP 52K Protein 3 4
  • U5-52K 3 4
  • CD2 Antigen (Cytoplasmic Tail)-Binding Protein 2 2
  • CD2 Antigen Cytoplasmic Tail-Binding Protein 2 3
  • CD2 (Cytoplasmic Tail) Binding Protein 2 2
  • CD2 Tail-Binding Protein 2 4
  • KIAA1178 4
  • PPP1R59 3
  • FWP010 3
  • Snu40 3
  • LIN1 3

External Ids for CD2BP2 Gene

Previous GeneCards Identifiers for CD2BP2 Gene

  • GC16P029473
  • GC16M030756
  • GC16M030359
  • GC16M030400
  • GC16M030272
  • GC16M030273
  • GC16M027924

Summaries for CD2BP2 Gene

Entrez Gene Summary for CD2BP2 Gene

  • This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for CD2BP2 Gene

CD2BP2 (CD2 Cytoplasmic Tail Binding Protein 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot for CD2BP2 Gene

  • Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.

Gene Wiki entry for CD2BP2 Gene

Additional gene information for CD2BP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD2BP2 Gene

Genomics for CD2BP2 Gene

GeneHancer (GH) Regulatory Elements for CD2BP2 Gene

Promoters and enhancers for CD2BP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J030353 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.1 -118 4.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 CD2BP2 LOC101928707 PIR45213 SETD1A NPIPB12 SRCAP FUS NPIPB13 INO80E ZNF747
GH16J030525 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.7 -172.0 -171989 3.8 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ZNF768 ENSG00000278922 SETD1A SRCAP RNF40 INO80E ENSG00000260267 ZNF764 ZNF785 ZNF747
GH16J031071 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.6 -718.3 -718279 5 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF646 ZNF668 PIR37153 PIR38332 SETD1A SRCAP ZNF785 KAT8 RNF40 FBRS
GH16J030063 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.6 +289.7 289742 4.9 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 ENSG00000274904 PIR61223 ALDOA RNF40 INO80E SMG1P2 SMG1P5 PRR14 SETD1A SRCAP
GH16J030956 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.6 -602.5 -602530 3.4 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 SETD1A ENSG00000275263 SRCAP INO80E ZNF764 ENSG00000260267 RNF40 ZNF747 SMG1P5 KAT8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD2BP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD2BP2 gene promoter:
  • HFH-1
  • C/EBPalpha
  • p53
  • FOXJ2
  • FOXJ2 (long isoform)

Genomic Locations for CD2BP2 Gene

Genomic Locations for CD2BP2 Gene
chr16:30,350,766-30,355,361
(GRCh38/hg38)
Size:
4,596 bases
Orientation:
Minus strand
chr16:30,362,087-30,366,682
(GRCh37/hg19)
Size:
4,596 bases
Orientation:
Minus strand

Genomic View for CD2BP2 Gene

Genes around CD2BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD2BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD2BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD2BP2 Gene

Proteins for CD2BP2 Gene

  • Protein details for CD2BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95400-CD2B2_HUMAN
    Recommended name:
    CD2 antigen cytoplasmic tail-binding protein 2
    Protein Accession:
    O95400
    Secondary Accessions:
    • B2RDX2
    • Q9ULP2

    Protein attributes for CD2BP2 Gene

    Size:
    341 amino acids
    Molecular mass:
    37646 Da
    Quaternary structure:
    • Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1.

    Three dimensional structures from OCA and Proteopedia for CD2BP2 Gene

neXtProt entry for CD2BP2 Gene

Post-translational modifications for CD2BP2 Gene

  • Ubiquitination at posLast=127127
  • Modification sites at PhosphoSitePlus

Other Protein References for CD2BP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD2BP2 Gene

Domains & Families for CD2BP2 Gene

Protein Domains for CD2BP2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD2BP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD2BP2: view

No data available for UniProtKB/Swiss-Prot for CD2BP2 Gene

Function for CD2BP2 Gene

Molecular function for CD2BP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.

Phenotypes From GWAS Catalog for CD2BP2 Gene

Gene Ontology (GO) - Molecular Function for CD2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9741631
GO:0043021 ribonucleoprotein complex binding IDA 15840814
genes like me logo Genes that share ontologies with CD2BP2: view
genes like me logo Genes that share phenotypes with CD2BP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD2BP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD2BP2 Gene

Localization for CD2BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD2BP2 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD2BP2 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA 15840814
GO:0005654 nucleoplasm TAS,IDA --
GO:0005682 U5 snRNP IDA 15840814
GO:0005737 cytoplasm TAS 9843987
genes like me logo Genes that share ontologies with CD2BP2: view

Pathways & Interactions for CD2BP2 Gene

genes like me logo Genes that share pathways with CD2BP2: view

Pathways by source for CD2BP2 Gene

Gene Ontology (GO) - Biological Process for CD2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly NAS 15840814
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with CD2BP2: view

No data available for SIGNOR curated interactions for CD2BP2 Gene

Drugs & Compounds for CD2BP2 Gene

No Compound Related Data Available

Transcripts for CD2BP2 Gene

mRNA/cDNA for CD2BP2 Gene

Unigene Clusters for CD2BP2 Gene

CD2 (cytoplasmic tail) binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD2BP2

Alternative Splicing Database (ASD) splice patterns (SP) for CD2BP2 Gene

No ASD Table

Relevant External Links for CD2BP2 Gene

GeneLoc Exon Structure for
CD2BP2
ECgene alternative splicing isoforms for
CD2BP2

Expression for CD2BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD2BP2 Gene

Protein differential expression in normal tissues from HIPED for CD2BP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD2BP2 Gene



Protein tissue co-expression partners for CD2BP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD2BP2 Gene:

CD2BP2

SOURCE GeneReport for Unigene cluster for CD2BP2 Gene:

Hs.202677

Evidence on tissue expression from TISSUES for CD2BP2 Gene

  • Nervous system(4.8)
  • Lung(4.6)
  • Blood(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with CD2BP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD2BP2 Gene

Orthologs for CD2BP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD2BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD2BP2 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD2BP2 34 33
  • 89.31 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD2BP2 34 33
  • 87.75 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cd2bp2 16 34 33
  • 86.18 (n)
rat
(Rattus norvegicus)
Mammalia Cd2bp2 33
  • 86.04 (n)
oppossum
(Monodelphis domestica)
Mammalia CD2BP2 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD2BP2 34
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD2BP2 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clip4 33
  • 64.51 (n)
MGC76157 33
African clawed frog
(Xenopus laevis)
Amphibia cd2bp2-prov 33
zebrafish
(Danio rerio)
Actinopterygii cd2bp2 34 33
  • 55.99 (n)
OneToOne
zgc56165 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011494 33
  • 50.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta holn1 34 33
  • 47.82 (n)
OneToOne
CG5198 35
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea teg-1 34 33
  • 44.49 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4310 34
  • 34 (a)
OneToOne
Species where no ortholog for CD2BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD2BP2 Gene

ENSEMBL:
Gene Tree for CD2BP2 (if available)
TreeFam:
Gene Tree for CD2BP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD2BP2: view image

Paralogs for CD2BP2 Gene

Pseudogenes.org Pseudogenes for CD2BP2 Gene

genes like me logo Genes that share paralogs with CD2BP2: view

No data available for Paralogs for CD2BP2 Gene

Variants for CD2BP2 Gene

Sequence variations from dbSNP and Humsavar for CD2BP2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000267867 -- 30,352,463(-) A/G/T 3_prime_UTR_variant
rs1000671819 -- 30,356,398(-) T/C upstream_transcript_variant
rs1000848578 -- 30,351,491(-) A/C 3_prime_UTR_variant
rs1001652822 -- 30,353,151(-) C/G intron_variant
rs1001890416 -- 30,356,707(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CD2BP2 Gene

Variant ID Type Subtype PubMed ID
esv2758642 CNV gain 17122850

Variation tolerance for CD2BP2 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD2BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD2BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD2BP2 Gene

Disorders for CD2BP2 Gene

Additional Disease Information for CD2BP2

No disorders were found for CD2BP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD2BP2 Gene

Publications for CD2BP2 Gene

  1. Investigating the functional role of CD2BP2 in T cells. (PMID: 17906334) Heinze M … Freund C (International immunology 2007) 3 4 22 58
  2. The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. (PMID: 15840814) Laggerbauer B … Lührmann R (RNA (New York, N.Y.) 2005) 3 4 22 58
  3. Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. (PMID: 9843987) Nishizawa K … Reinherz EL (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
  4. Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2). (PMID: 17467737) Nielsen TK … Ficner R (Journal of molecular biology 2007) 3 4 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for CD2BP2 Gene

Sources for CD2BP2 Gene

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