The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR ... See more...

Aliases for CD276 Gene

Aliases for CD276 Gene

  • CD276 Molecule 2 3 5
  • CD276 Antigen 2 3 4
  • B7-H3 2 3 4
  • B7H3 2 3 4
  • Costimulatory Molecule 3 4
  • B7 Homolog 3 3 4
  • 4Ig-B7-H3 3 4
  • B7RP-2 2 3
  • CD276 5

External Ids for CD276 Gene

Previous GeneCards Identifiers for CD276 Gene

  • GC15P071764
  • GC15P073976
  • GC15P050807

Summaries for CD276 Gene

Entrez Gene Summary for CD276 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for CD276 Gene

CD276 (CD276 Molecule) is a Protein Coding gene. Diseases associated with CD276 include Mycoplasma Pneumoniae Pneumonia and Brain Glioma. Among its related pathways are Cell adhesion molecules (CAMs) and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is BTN1A1.

UniProtKB/Swiss-Prot Summary for CD276 Gene

  • May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Gene Wiki entry for CD276 Gene

Additional gene information for CD276 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD276 Gene

Genomics for CD276 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD276 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J073711 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 607.7 +27.5 27487 2.1 CTCF ESR1 CTBP1 PKNOX1 GATA3 NFIB FOXA1 NCOA3 MAZ NFXL1 CD276 HCN4 NONHSAG017383.2 lnc-C15orf59-3 INSYN1
GH15J073705 Promoter 0.6 EPDnew 600.4 +20.2 20248 0.1 ESRRA NR2F1 CTCF CD276 NPTN HCN4 NONHSAG017383.2 NONHSAG017382.2 INSYN1
GH15J072781 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 -899.5 -899517 6.1 BRCA1 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 SIX5 ADPGK lnc-HIGD2B-2 ENSG00000261187 MYO9A HEXA PARP6 ENSG00000261460 ARIH1 BBS4 CELF6
GH15J073921 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +242.7 242700 10.9 CTCF ZBTB33 TEAD4 PRDM10 ZNF629 KDM1A ZNF692 ZNF174 PRDM1 RFX1 LOXL1-AS1 LOXL1 JA662185 EDC3 FAM219B CD276 ENSG00000260624 ISLR STOML1
GH15J074539 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.1 +857.8 857766 4.5 ZNF221 SP1 CREB1 CTCF PRDM10 ZNF629 SIX5 LEF1 ZNF692 POLR2A ARID3B MN297314 SIN3A MAN2C1 ISLR EDC3 COMMD4 UBL7 ENSG00000260274 UBL7-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD276 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD276

Top Transcription factor binding sites by QIAGEN in the CD276 gene promoter:
  • AML1a
  • C/EBPbeta
  • FOXI1
  • HFH-3
  • HSF1 (long)
  • HSF1short
  • Ik-1
  • NF-E2
  • NF-E2 p45

Genomic Locations for CD276 Gene

Genomic Locations for CD276 Gene
chr15:73,683,966-73,714,518
(GRCh38/hg38)
Size:
30,553 bases
Orientation:
Plus strand
chr15:73,976,307-74,006,859
(GRCh37/hg19)
Size:
30,553 bases
Orientation:
Plus strand

Genomic View for CD276 Gene

Genes around CD276 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD276 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD276 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD276 Gene

Proteins for CD276 Gene

  • Protein details for CD276 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5ZPR3-CD276_HUMAN
    Recommended name:
    CD276 antigen
    Protein Accession:
    Q5ZPR3
    Secondary Accessions:
    • Q6P5Y4
    • Q6UXI2
    • Q8NBI8
    • Q8NC34
    • Q8NCB6
    • Q9BXR1

    Protein attributes for CD276 Gene

    Size:
    534 amino acids
    Molecular mass:
    57235 Da
    Quaternary structure:
    • Interacts with TREML2 and this interaction enhances T-cell activation.
    SequenceCaution:
    • Sequence=BAC11344.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species.
    • [Isoform 1]: Contains tandemly repeated immunoglobulin-like V and C domains.
    • [Isoform 2]: Minor transcript. Contains one single set of immunoglobulin-like V and C domains.
    • [Isoform 3]: Contains tandemly repeated immunoglobulin-like V and C domains.
    • [Isoform 4]: Contains tandemly repeated immunoglobulin-like V and C domains.

    Alternative splice isoforms for CD276 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD276 Gene

Post-translational modifications for CD276 Gene

  • Glycosylation at Asn91, Asn104, Asn189, Asn407, Asn215, Asn433, and Asn322
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CD276_HUMAN (1087)

Antibody Products

  • Abcam antibodies for CD276

No data available for DME Specific Peptides for CD276 Gene

Domains & Families for CD276 Gene

Gene Families for CD276 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD276 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin subtype
  • Immunoglobulin C-type
ProtoNet:

Suggested Antigen Peptide Sequences for CD276 Gene

GenScript: Design optimal peptide antigens:
  • Costimulatory molecule (CD276_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5ZPR3

UniProtKB/Swiss-Prot:

CD276_HUMAN :
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with CD276: view

Function for CD276 Gene

Molecular function for CD276 Gene

UniProtKB/Swiss-Prot Function:
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
UniProtKB/Swiss-Prot Induction:
By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants.

Phenotypes From GWAS Catalog for CD276 Gene

Gene Ontology (GO) - Molecular Function for CD276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding NAS 11224528
GO:0005515 protein binding IPI 18650384
genes like me logo Genes that share ontologies with CD276: view
genes like me logo Genes that share phenotypes with CD276: view

Animal Models for CD276 Gene

MGI Knock Outs for CD276:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD276

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD276

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD276 Gene

Localization for CD276 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD276 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD276 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane NAS 15188059
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 15188059
genes like me logo Genes that share ontologies with CD276: view

Pathways & Interactions for CD276 Gene

PathCards logo

SuperPathways for CD276 Gene

genes like me logo Genes that share pathways with CD276: view

Pathways by source for CD276 Gene

1 KEGG pathway for CD276 Gene
1 Cell Signaling Technology pathway for CD276 Gene

Gene Ontology (GO) - Biological Process for CD276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA 21873635
GO:0042102 positive regulation of T cell proliferation IDA 11224528
GO:0042110 T cell activation IDA 18650384
GO:0045078 positive regulation of interferon-gamma biosynthetic process IDA 11224528
GO:0050776 regulation of immune response NAS 11224528
genes like me logo Genes that share ontologies with CD276: view

No data available for SIGNOR curated interactions for CD276 Gene

Drugs & Compounds for CD276 Gene

(1) Drugs for CD276 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MGA271 Pharma antigen, inhibitor immunological response against cancer antigen 0
genes like me logo Genes that share compounds with CD276: view

Transcripts for CD276 Gene

mRNA/cDNA for CD276 Gene

4 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD276

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD276 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CD276 Gene

GeneLoc Exon Structure for
CD276

Expression for CD276 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD276 Gene

Protein differential expression in normal tissues from HIPED for CD276 Gene

This gene is overexpressed in Nasal epithelium (25.1), Amniocyte (17.3), and Cerebral cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD276 Gene



Protein tissue co-expression partners for CD276 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD276

SOURCE GeneReport for Unigene cluster for CD276 Gene:

Hs.744915

mRNA Expression by UniProt/SwissProt for CD276 Gene:

Q5ZPR3-CD276_HUMAN
Tissue specificity: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.

Evidence on tissue expression from TISSUES for CD276 Gene

  • Lung(4.7)
  • Liver(4.6)
  • Nervous system(4.4)
  • Spleen(3.7)
  • Lymph node(3.6)
  • Blood(3.4)
  • Skin(3)
  • Heart(3)
  • Bone marrow(3)
  • Intestine(3)
  • Kidney(2.9)
  • Muscle(2.7)
  • Pancreas(2.7)
  • Thyroid gland(2.3)
  • Stomach(2.3)
  • Adrenal gland(2.3)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with CD276: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD276 Gene

Orthologs for CD276 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD276 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD276 30 31
  • 99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD276 30 31
  • 90.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CD276 30 31
  • 89.65 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd276 30
  • 89.35 (n)
Mouse
(Mus musculus)
Mammalia Cd276 30 17 31
  • 88.89 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CD276 31
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CD276 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CD276 30 31
  • 73.36 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CD276 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cd276 30
  • 57.73 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15387 30
Zebrafish
(Danio rerio)
Actinopterygii cd276 30 31
  • 61.65 (n)
OneToOne
Species where no ortholog for CD276 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CD276 Gene

ENSEMBL:
Gene Tree for CD276 (if available)
TreeFam:
Gene Tree for CD276 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD276: view image

Paralogs for CD276 Gene

(6) SIMAP similar genes for CD276 Gene using alignment to 10 proteins:

  • CD276_HUMAN
  • H0YK40_HUMAN
  • H0YK59_HUMAN
  • H0YKQ9_HUMAN
  • H0YL10_HUMAN
  • H0YLT3_HUMAN
  • H0YLT8_HUMAN
  • H0YN29_HUMAN
  • H0YN85_HUMAN
  • H3BM68_HUMAN
genes like me logo Genes that share paralogs with CD276: view

Variants for CD276 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD276 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
722881 Benign: not provided 73,703,652(+) C/T INTRON_VARIANT
750335 Likely Benign: not provided 73,703,649(+) C/T INTRON_VARIANT
779896 Benign: not provided 73,704,360(+) G/A SYNONYMOUS_VARIANT
rs11574479 -. - p.Thr160Metp.Thr378Met
rs7173476 -. - p.Arg111Serp.Arg329Ser

Additional dbSNP identifiers (rs#s) for CD276 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD276 Gene

Variant ID Type Subtype PubMed ID
nsv1121512 CNV deletion 24896259
nsv471252 CNV loss 18288195
nsv819417 CNV gain 19587683

Variation tolerance for CD276 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.61; 98.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD276 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD276

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD276 Gene

Disorders for CD276 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CD276 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mycoplasma pneumoniae pneumonia
  • cold agglutinin positive pneumonia
brain glioma
  • lower grade glioma
autoimmune peripheral neuropathy
neuroblastoma
  • nb
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
- elite association - COSMIC cancer census association via MalaCards
Search CD276 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD276

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CD276: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD276 Gene

Publications for CD276 Gene

  1. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. (PMID: 11224528) Chapoval AI … Chen L (Nature immunology 2001) 2 3 4 23
  2. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. (PMID: 14764704) Steinberger P … Knapp W (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 23
  3. Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. (PMID: 12906861) Ling V … Collins M (Genomics 2003) 3 4 23
  4. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers JC … Kooner JS (Nature genetics 2011) 3 41
  5. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. (PMID: 21738484) Smith EN … Kelsoe JR (PLoS genetics 2011) 3 41

Products for CD276 Gene

Sources for CD276 Gene