Aliases for CD274 Gene
Aliases for CD274 Gene
External Ids for CD274 Gene
- HGNC: 17635
- Entrez Gene: 29126
- Ensembl: ENSG00000120217
- OMIM: 605402
- UniProtKB: Q9NZQ7
Previous HGNC Symbols for CD274 Gene
- PDCD1LG1
Previous GeneCards Identifiers for CD274 Gene
- GC09P005444
Summaries for CD274 Gene
-
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
-
CD274, also commonly referred to as PDL1, is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. PD1 expression has been observed in a variety of cancers including melanoma and non-small cell lung cancer. The interaction of PD1/PDL1 is hypothesized to be a possible mechanism for the tumor to escape immune response. A number of checkpoint blockade inhibitors including pembrolizumab and nivolumab have been developed that target the PD1/PDL1 interaction in order to allow T-cells to recognize tumor cells without being deactivated by the tumor.
GeneCards Summary for CD274 Gene
CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include Lymphoepithelioma-Like Carcinoma and Ovarian Carcinosarcoma. Among its related pathways are Innate Immune System and NF-kappaB Signaling. An important paralog of this gene is PDCD1LG2.
UniProtKB/Swiss-Prot for CD274 Gene
-
Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
Additional gene information for CD274 Gene
- Monarch Initiative
- Search for CD274 at DataMed
- Search for CD274 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD274 Gene
Genomics for CD274 Gene
GeneHancer (GH) Regulatory Elements for CD274 Gene
Promoters and enhancers for CD274 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD274 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CD274 gene promoter:
-
- STAT1
- STAT1beta
- STAT1alpha
Regulatory Element Products
Genomic Locations for CD274 Gene
Genomic Locations for CD274 Gene
- chr9:5,450,381-5,470,567
- (GRCh38/hg38)
- Size:
- 20,187 bases
- Orientation:
- Plus strand
- chr9:5,450,503-5,470,567
- (GRCh37/hg19)
- Size:
- 20,065 bases
- Orientation:
- Plus strand
Genomic View for CD274 Gene
Genes around CD274 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p24.1 by Entrez Gene
- 9p24.1 by HGNC
- 9p24.1 by Ensembl
CD274 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD274 Gene
Proteins for CD274 Gene
-
Protein details for CD274 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NZQ7-PD1L1_HUMAN
- Recommended name:
- Programmed cell death 1 ligand 1
- Protein Accession:
- Q9NZQ7
- B2RBA2
- B4DU27
- Q14CJ2
- Q2V8D5
- Q66RK1
- Q6WEX4
- Q9NUZ5
Protein attributes for CD274 Gene
- Size:
- 290 amino acids
- Molecular mass:
- 33275 Da
- Quaternary structure:
-
- Interacts with PDCD1 (PubMed:11015443, PubMed:18287011). Interacts (via transmembrane domain) with CMTM4 and CMTM6 (PubMed:28813417, PubMed:28813410).
- SequenceCaution:
-
- Sequence=BAA91966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for CD274 Gene
Protein Expression for CD274 Gene
Post-translational modifications for CD274 Gene
- Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
- Glycosylation at Asn219, posLast=200200, Asn192, and posLast=3535
- Modification sites at PhosphoSitePlus
Other Protein References for CD274 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD274 (PD-L1/B7-H1)
-
Custom Antibody ServicesOriGene Antibodies for CD274
- AM05612FC-N
- AM05612LE-N
- AM05612PU-L
- AM05612PU-N
- AM05613FC-N
- AM05613PU-L
- AM05613PU-N
- CF507086
- CF507087
- CF507099
- CF507105
- CF507122
- CF808771
- CF809809
- TA810744
- CF810744
- TA810750
- CF810750
- TA810872
- CF810872
- TA810925
- CF810925
- TA302988
- TA306401
- TA320254
- TA320255
- TA327120
- TA507086
- TA507087
- TA507099
- TA507105
- TA507122
- TA808771
- TA809809
- Novus Biologicals Antibodies for CD274
-
Abcam antibodies for CD274
- Invitrogen Antibodies for CD274
- GeneTex CD274 Antibody for CD274
-
CrownBio Antibodies for CD274
-
Custom Antibody ServicesProSci Antibodies for CD274
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD274
- Sino Biological Antibodies for CD274
Protein Products
- R&D Systems Proteins and Enzymes for CD274 (PD-L1/B7-H1)
- Search Origene for MassSpec and Protein Over-expression Lysates for CD274
- Origene Custom Protein Services for CD274
- Sino Biological Recombinant Proteins for CD274
- Sino Biological Cell Lysates for CD274
- ProSpec Recombinant Proteins for CD274
- GeneTex Proteins for CD274
-
ProSci Proteins for CD274
- CD274 molecule [96-596]
- CD274 molecule [96-598]
- CD274 molecule [96-599]
- CD274 molecule [96-606]
- CD274 antigen [96-608]
- CD274 antigen [96-610]
- programmed cell death 1 ligand 1 isoform a precursor [96-937]
- Programmed cell death 1 ligand 1 [97-020]
- CD274 molecule [RF16030-01]
- CD274 molecule [90-429]
- programmed cell death 1 ligand 1 isoform a precursor [90-430]
- CD274 antigen [90-431]
- CD274 antigen [90-432]
- CD274 molecule [91-293]
- CD274 antigen [92-486]
- CD274 antigen [92-487]
- CD274 molecule [92-599]
- CD274 molecule [92-625]
- CD274 molecule [92-670]
-
Abcam proteins for CD274
Assay Products
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for CD274 (PD-L1/B7-H1)
-
Abcam assays for CD274
No data available for DME Specific Peptides for CD274 Gene
Domains & Families for CD274 Gene
Gene Families for CD274 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- FDA approved drug targets
- Predicted membrane proteins
Protein Domains for CD274 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD274 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NZQ7- Family:
-
- Belongs to the immunoglobulin superfamily. BTN/MOG family.
Function for CD274 Gene
Molecular function for CD274 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.
Phenotypes From GWAS Catalog for CD274 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 18585785 |
Phenotypes for CD274 Gene
- MGI mutant phenotypes for CD274:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for CD274:
Animal Models for CD274 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CD274
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD274
-
CRISPR Products
-
OriGene CRISPR knockouts for CD274
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD274
- genomics-online: gRNA clones - Search results for 147 available PD-L1 gene related products
- Overview of 147 available PD-L1 gene related products
- Applied Biological Materials CRISPR for CD274
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD274
- GenScript: Design CRISPR guide RNA sequences for CD274
miRNA for CD274 Gene
- miRTarBase miRNAs that target CD274
-
- hsa-mir-513a-5p (MIRT003923)
- hsa-mir-103a-3p (MIRT027156)
- hsa-mir-16-5p (MIRT031920)
- hsa-mir-570-3p (MIRT053484)
- hsa-mir-651-3p (MIRT379487)
- hsa-mir-3978 (MIRT393962)
- hsa-mir-593-3p (MIRT438395)
- hsa-mir-885-3p (MIRT438396)
- hsa-mir-380-5p (MIRT438397)
- hsa-mir-124-3p (MIRT438398)
- hsa-mir-601 (MIRT438399)
- hsa-mir-708-5p (MIRT438400)
- hsa-mir-34b-5p (MIRT438401)
- hsa-mir-665 (MIRT438402)
- hsa-mir-940 (MIRT438403)
- hsa-mir-326 (MIRT438404)
- hsa-mir-363-5p (MIRT438405)
- hsa-mir-214-3p (MIRT438406)
- hsa-mir-29c-3p (MIRT438407)
- hsa-mir-3977 (MIRT445286)
- hsa-mir-5706 (MIRT445287)
- hsa-mir-4782-5p (MIRT445288)
- hsa-mir-516b-5p (MIRT445289)
- hsa-mir-1299 (MIRT445290)
- hsa-mir-103a-2-5p (MIRT445291)
- hsa-mir-4790-3p (MIRT445292)
- hsa-mir-6128 (MIRT445293)
- hsa-mir-875-3p (MIRT445294)
- hsa-mir-4496 (MIRT445295)
- hsa-mir-138-5p (MIRT732233)
- hsa-mir-324-5p (MIRT732862)
- hsa-mir-338-5p (MIRT732863)
- hsa-mir-34a-3p (MIRT733651)
- hsa-mir-152-5p (MIRT733737)
- hsa-mir-200b-3p (MIRT733739)
- hsa-mir-152-3p (MIRT734227)
- hsa-mir-1273a (MIRT761789)
- hsa-mir-1273c (MIRT761807)
- hsa-mir-15a-5p (MIRT762924)
- hsa-mir-15b-5p (MIRT762933)
- hsa-mir-194-5p (MIRT763466)
- hsa-mir-195-5p (MIRT763476)
- hsa-mir-424-5p (MIRT767955)
- hsa-mir-4503 (MIRT769815)
- hsa-mir-497-5p (MIRT772806)
- hsa-mir-6792-5p (MIRT779316)
- hsa-mir-6838-5p (MIRT780090)
miRNA Products
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for CD274
- Browse OriGene Inhibitory RNA Products For CD274
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD274
- genomics-online: shRNA clones - Search results for 147 available PD-L1 gene related products
- Overview of 147 available PD-L1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD274
- VectorBuilder custom plasmid, inducible vectors for CD274
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD274
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD274
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD274
- Applied Biological Materials Clones for CD274
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD274 (PD-L1/B7-H1)
Cell Line Products
- GenScript CD274 - overexpressing Cell Line for Assay
- GenScript CD274 - overexpressing Cell Line for Assay
- GenScript Custom overexpressing Cell Line Services for CD274
-
Horizon Cell Lines for CD274
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD274 Gene
Localization for CD274 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD274 Gene
- Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation. {ECO:0000269 PubMed:28813417}.
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Endomembrane system; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IEA,IBA | -- |
| GO:0012505 | endomembrane system | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for CD274 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell adhesion molecules (CAMs) | ||
| 2 | NF-kappaB Signaling | ||
| 3 | T Cell Co-Signaling Pathway: Ligand-Receptor Interactions | ||
| 4 | Class I MHC mediated antigen processing and presentation | ||
| 5 | CD28 co-stimulation | ||
Pathways by source for CD274 Gene
4 Reactome pathways for CD274 Gene
1 KEGG pathway for CD274 Gene
1 R&D Systems pathway for CD274 Gene
1 Cell Signaling Technology pathway for CD274 Gene
Interacting Proteins for CD274 Gene
Selected Interacting proteins:
Q9NZQ7-PD1L1_HUMAN
ENSP00000370989
for CD274 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CD274
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | IDA | 10581077 |
| GO:0007165 | signal transduction | IDA | 10581077 |
| GO:0007166 | cell surface receptor signaling pathway | IDA | 10581077 |
| GO:0030335 | positive regulation of cell migration | IEA | -- |
| GO:0031295 | T cell costimulation | TAS,IDA | -- |
Drugs & Compounds for CD274 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| atezolizumab | Approved, Investigational | Pharma | Target, antibody | 0 | ||
| avelumab | Approved, Investigational | Pharma | Target, antagonist | 0 | ||
| durvalumab | Approved, Investigational | Pharma | Target, binder | 0 | ||
| nivolumab | Approved | Pharma | Therapeutic Antibodies, Immunotherapies | 604 | ||
| Pembrolizumab | Approved | Pharma | 709 |
Drug Products
Transcripts for CD274 Gene
mRNA/cDNA for CD274 Gene
- (3) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (92) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000381577 3644 bps (uc003zje.4)
- ENST00000498261 704 bps (uc064rzq.1)
- ENST00000474218 442 bps (uc064rzr.1)
- ENST00000492923 601 bps (uc064rzs.1)
- ENST00000381573 3343 bps (uc003zjf.5)
CRISPR Products
-
OriGene CRISPR knockouts for CD274
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD274
- genomics-online: gRNA clones - Search results for 147 available PD-L1 gene related products
- Overview of 147 available PD-L1 gene related products
- Applied Biological Materials CRISPR for CD274
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD274
- GenScript: Design CRISPR guide RNA sequences for CD274
miRNA Products
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for CD274
- Browse OriGene Inhibitory RNA Products For CD274
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD274
- genomics-online: shRNA clones - Search results for 147 available PD-L1 gene related products
- Overview of 147 available PD-L1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD274
- VectorBuilder custom plasmid, inducible vectors for CD274
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD274
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD274
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD274
- Applied Biological Materials Clones for CD274
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD274 (PD-L1/B7-H1)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: | - | - |
Expression for CD274 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Placenta (Extraembryonic Tissues)
-
Lung (Respiratory System)
This gene is overexpressed in Breast (62.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD274 Gene
NURSA nuclear receptor signaling pathways regulating expression of CD274 Gene:
CD274SOURCE GeneReport for Unigene cluster for CD274 Gene:
Hs.521989mRNA Expression by UniProt/SwissProt for CD274 Gene:
Q9NZQ7-PD1L1_HUMAN
Tissue specificity:
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Evidence on tissue expression from TISSUES for CD274 Gene
- Lung(4.6)
- Liver(4.4)
- Blood(3.5)
- Spleen(3.4)
- Lymph node(3.2)
- Heart(2.3)
- Intestine(2.3)
- Bone marrow(2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CD274
-
OriGene qPCR primer pairs for CD274
- genomics-online: primer clones - Search results for 147 available PD-L1 gene related products
- Overview of 147 available PD-L1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD274 Gene
Orthologs for CD274 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD274 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CD274 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CD274 33 |
|
||
| PD-L1 34 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Cd274 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd274 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD274 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CD274 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CD274 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cd274 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-241b2.5 33 |
|
||
| CD274 34 |
|
OneToMany |
- Species where no ortholog for CD274 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CD274 Gene
- ENSEMBL:
- Gene Tree for CD274 (if available)
- TreeFam:
- Gene Tree for CD274 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD274: view image
Paralogs for CD274 Gene
Variants for CD274 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000236972 | -- | 5,469,948(+) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1000430255 | -- | 5,451,976(+) | G/A | intron_variant | |
| rs1000608610 | -- | 5,448,692(+) | A/G | upstream_transcript_variant | |
| rs1000659170 | -- | 5,449,701(+) | A/G | upstream_transcript_variant | |
| rs1000736188 | -- | 5,454,955(+) | G/C | intron_variant |
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.21;
24.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD274 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD274 Gene
Disorders for CD274 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoepithelioma-like carcinoma |
|
|
| ovarian carcinosarcoma |
|
|
| primary mediastinal large b-cell lymphoma |
|
|
| epstein-barr virus-associated gastric carcinoma |
|
|
| gray zone lymphoma |
|
|
Search CD274 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD274
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CD274 Gene
Publications for CD274 Gene
- Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. (PMID: 11015443) Freeman GJ … Honjo T (The Journal of experimental medicine 2000) 2 3 4 22 58
- Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility. (PMID: 19850680) Mitchell AL … Pearce SH (The Journal of clinical endocrinology and metabolism 2009) 3 22 44 58
- Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients. (PMID: 18322304) Hayashi M … Komiya I (European journal of endocrinology 2008) 3 22 44 58
- Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. (PMID: 15780196) He XH … Liu Y (Acta pharmacologica Sinica 2005) 3 4 22 58
- B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. (PMID: 10581077) Dong H … Chen L (Nature medicine 1999) 2 3 4 58
Products for CD274 Gene
- R&D Systems Antibodies for CD274 (PD-L1/B7-H1)
- R&D Systems Proteins and Enzymes for CD274 (PD-L1/B7-H1)
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for CD274 (PD-L1/B7-H1)
- R&D Systems cDNA Clones for CD274 (PD-L1/B7-H1)
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- Custom Antibody ServicesOriGene Antibodies for CD274
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- GeneTex CD274 Antibody for CD274
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- CD274 molecule [96-596]
- CD274 molecule [96-598]
- CD274 molecule [96-599]
- CD274 molecule [96-606]
- CD274 antigen [96-608]
- CD274 antigen [96-610]
- programmed cell death 1 ligand 1 isoform a precursor [96-937]
- Programmed cell death 1 ligand 1 [97-020]
- CD274 molecule [RF16030-01]
- CD274 molecule [90-429]
- programmed cell death 1 ligand 1 isoform a precursor [90-430]
- CD274 antigen [90-431]
- CD274 antigen [90-432]
- CD274 molecule [91-293]
- CD274 antigen [92-486]
- CD274 antigen [92-487]
- CD274 molecule [92-599]
- CD274 molecule [92-625]
- CD274 molecule [92-670]
- Horizon Cell Lines for CD274
- genomics-online: cdna clones - Search results for 147 available PD-L1 gene related products
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Sources for CD274 Gene
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