CD274 Gene (Protein Coding)

CD274 Molecule

GC09P005450
GIFtS:
44
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine productio... See more...

Aliases for CD274 Gene

Aliases for CD274 Gene

  • CD274 Molecule 2 3 5
  • Programmed Cell Death 1 Ligand 1 2 3 4
  • CD274 Antigen 2 3 4
  • B7 Homolog 1 2 3 4
  • PD-L1 2 3 4
  • B7H1 2 3 4
  • PDL1 2 3 4
  • PDCD1 Ligand 1 3 4
  • PDCD1LG1 3 4
  • PDCD1L1 3 4
  • HPD-L1 3 4
  • B7-H1 2 4
  • B7-H 2 3
  • Programmed Death Ligand 1 4
  • CD274 5

External Ids for CD274 Gene

Previous HGNC Symbols for CD274 Gene

  • PDCD1LG1

Previous GeneCards Identifiers for CD274 Gene

  • GC09P005444

Summaries for CD274 Gene

Entrez Gene Summary for CD274 Gene

  • This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CIViC Summary for CD274 Gene

  • CD274, also commonly referred to as PDL1, is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. PD1 expression has been observed in a variety of cancers including melanoma and non-small cell lung cancer. The interaction of PD1/PDL1 is hypothesized to be a possible mechanism for the tumor to escape immune response. A number of checkpoint blockade inhibitors including pembrolizumab and nivolumab have been developed that target the PD1/PDL1 interaction in order to allow T-cells to recognize tumor cells without being deactivated by the tumor.

GeneCards Summary for CD274 Gene

CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include Testicular Lymphoma and Smoldering Myeloma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is PDCD1LG2.

UniProtKB/Swiss-Prot Summary for CD274 Gene

  • Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
  • The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity).

Gene Wiki entry for CD274 Gene

Additional gene information for CD274 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD274 Gene

Genomics for CD274 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CD274 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD274 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD274

Top Transcription factor binding sites by QIAGEN in the CD274 gene promoter:
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for CD274 Gene

Genomic Locations for CD274 Gene
chr9:5,450,503-5,470,567
(GRCh38/hg38)
Size:
20,065 bases
Orientation:
Plus strand
chr9:5,450,503-5,470,567
(GRCh37/hg19)
Size:
20,065 bases
Orientation:
Plus strand

Genomic View for CD274 Gene

Genes around CD274 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD274 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD274 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD274 Gene

Proteins for CD274 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CD274 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZQ7-PD1L1_HUMAN
    Recommended name:
    Programmed cell death 1 ligand 1
    Protein Accession:
    Q9NZQ7
    Secondary Accessions:
    • B2RBA2
    • B4DU27
    • Q14CJ2
    • Q2V8D5
    • Q66RK1
    • Q6WEX4
    • Q9NUZ5

    Protein attributes for CD274 Gene

    Size:
    290 amino acids
    Molecular mass:
    33275 Da
    Quaternary structure:
    • Interacts with PDCD1 (PubMed:11015443, PubMed:18287011, PubMed:26602187). Interacts (via transmembrane domain) with CMTM4 and CMTM6 (PubMed:28813417, PubMed:28813410).
    SequenceCaution:
    • Sequence=BAA91966.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for CD274 Gene

    Alternative splice isoforms for CD274 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD274 Gene

Protein Expression for CD274 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD274 Gene

  • Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
  • Glycosylation at Asn35, Asn192, Asn200, and Asn219
  • Modification sites at PhosphoSitePlus

Other Protein References for CD274 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CD274

Protein Products

  • Abcam proteins for CD274

No data available for DME Specific Peptides for CD274 Gene

Domains & Families for CD274 Gene

Gene Families for CD274 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for CD274 Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
ProtoNet:

Suggested Antigen Peptide Sequences for CD274 Gene

GenScript: Design optimal peptide antigens:
  • B7 homolog 1 (PD1L1_HUMAN)
  • CD274 antigen variant (Q2V8D5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZQ7

UniProtKB/Swiss-Prot:

PD1L1_HUMAN :
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with CD274: view

Function for CD274 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CD274 Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
UniProtKB/Swiss-Prot Function:
The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.

Phenotypes From GWAS Catalog for CD274 Gene

Gene Ontology (GO) - Molecular Function for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18585785
genes like me logo Genes that share ontologies with CD274: view
genes like me logo Genes that share phenotypes with CD274: view

Animal Models for CD274 Gene

MGI Knock Outs for CD274:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD274

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD274

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD274 Gene

Localization for CD274 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD274 Gene

Cell membrane. Single-pass type I membrane protein. Early endosome membrane. Single-pass type I membrane protein. Recycling endosome membrane. Single-pass type I membrane protein. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation. {ECO:0000269 PubMed:28813417}.
[Isoform 1]: Cell membrane. Single-pass type I membrane protein.
[Isoform 2]: Endomembrane system. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD274 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0009986 cell surface IBA 21873635
GO:0012505 endomembrane system IEA --
genes like me logo Genes that share ontologies with CD274: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD274 Gene

Pathways & Interactions for CD274 Gene

genes like me logo Genes that share pathways with CD274: view

Pathways by source for CD274 Gene

1 Cell Signaling Technology pathway for CD274 Gene

SIGNOR curated interactions for CD274 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002845 positive regulation of tolerance induction to tumor cell IMP 28813410
GO:0006955 immune response IBA,IDA 10581077
GO:0007165 signal transduction IBA,IDA 10581077
genes like me logo Genes that share ontologies with CD274: view

Drugs & Compounds for CD274 Gene

Products:

  1. Drug

(11) Drugs for CD274 Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atezolizumab Approved, Investigational Pharma Target, antibody 439
avelumab Approved, Investigational Pharma Target, antagonist 0
Durvalumab Approved, Investigational Pharma Target, inhibitor, antibody 469
nivolumab Approved Pharma Therapeutic Antibodies, Immunotherapies 1165
Pembrolizumab Approved Pharma 1266
genes like me logo Genes that share compounds with CD274: view

Transcripts for CD274 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CD274 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD274

Alternative Splicing Database (ASD) splice patterns (SP) for CD274 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1:
SP2: - -
SP3: -
SP4: - -

Relevant External Links for CD274 Gene

GeneLoc Exon Structure for
CD274

Expression for CD274 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD274 Gene

mRNA expression in normal human tissues for CD274 Gene
mRNA expression by GTEx for CD274 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD274 Gene

This gene is overexpressed in Breast (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD274 Gene



Protein tissue co-expression partners for CD274 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD274

SOURCE GeneReport for Unigene cluster for CD274 Gene:

Hs.521989

mRNA Expression by UniProt/SwissProt for CD274 Gene:

Q9NZQ7-PD1L1_HUMAN
Tissue specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Evidence on tissue expression from TISSUES for CD274 Gene

  • Lung(4.7)
  • Liver(4.6)
  • Blood(3.9)
  • Spleen(3.9)
  • Lymph node(3.7)
  • Heart(3.3)
  • Intestine(3.3)
  • Bone marrow(3)
  • Nervous system(3)
  • Skin(2.9)
  • Kidney(2.8)
  • Pancreas(2.7)
  • Muscle(2.7)
  • Thyroid gland(2.5)
  • Stomach(2.4)
  • Adrenal gland(2.4)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with CD274: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD274 Gene

Orthologs for CD274 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD274 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CD274 30 31
  • 99.54 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CD274 30 31
  • 83.97 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CD274 30
  • 83.1 (n)
PD-L1 31
  • 73 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cd274 30
  • 76.59 (n)
Mouse
(Mus musculus)
 Mammalia Cd274 30 17 31
  • 76.36 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CD274 31
  • 53 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CD274 31
  • 51 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CD274 30 31
  • 55.9 (n)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia cd274 30
  • 49.49 (n)
Zebrafish
(Danio rerio)
 Actinopterygii si:ch211-241b2.5 30
  • 46.77 (n)
CD274 31
  • 15 (a)
 OneToMany
Species where no ortholog for CD274 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CD274 Gene

ENSEMBL:
Gene Tree for CD274 (if available)
TreeFam:
Gene Tree for CD274 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD274: view image

Paralogs for CD274 Gene

Paralogs for CD274 Gene

(3) SIMAP similar genes for CD274 Gene using alignment to 2 proteins:

  • PD1L1_HUMAN
  • Q2V8D5_HUMAN
genes like me logo Genes that share paralogs with CD274: view

Variants for CD274 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD274 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
738348 Benign: not provided 5,457,389(+) C/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
792122 Benign: not provided 5,457,224(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CD274 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD274 Gene

Variant ID Type Subtype PubMed ID
esv2759660 CNV loss 17122850
nsv466108 CNV gain 19166990
nsv509292 CNV insertion 20534489
nsv519771 CNV loss 19592680
nsv613196 CNV gain 21841781

Variation tolerance for CD274 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD274 Gene

Human Gene Mutation Database (HGMD)
CD274
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD274

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD274 Gene

Disorders for CD274 Gene

MalaCards: The human disease database

(113) MalaCards diseases for CD274 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
testicular lymphoma
  • lymphoma of the testis
smoldering myeloma
lymphoepithelioma-like carcinoma
  • lymphoepithelial carcinoma
pleomorphic carcinoma
penile cancer
  • ca penis
- elite association - COSMIC cancer census association via MalaCards
Search CD274 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PD1L1_HUMAN
  • Note=Truncation of the 3'-untranslated (3'-UTR) region of CD274 transcripts leads to elevated expression of CD274 in multiple cancers including T-cell leukemia, diffuse large B-cell lymphoma and stomach adenocarcinoma (PubMed:27281199). Disruption of 3'-UTR region is caused by structural variants that stabilize CD274 transcripts, leading to overexpression (PubMed:27281199). Increased expression in tumors promotes immune evasion and tumor cell growth by allowing malignant cells to escape destruction by the immune system (PubMed:27281199). {ECO:0000269 PubMed:27281199}.

Additional Disease Information for CD274

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CD274: view

No data available for Genatlas for CD274 Gene

Publications for CD274 Gene

  1. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. (PMID: 11015443) Freeman GJ … Honjo T (The Journal of experimental medicine 2000) 2 3 4 23
  2. Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility. (PMID: 19850680) Mitchell AL … Pearce SH (The Journal of clinical endocrinology and metabolism 2009) 3 23 41
  3. Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients. (PMID: 18322304) Hayashi M … Komiya I (European journal of endocrinology 2008) 3 23 41
  4. PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children. (PMID: 17203303) Ni R … Hara T (Human genetics 2007) 3 23 41
  5. Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. (PMID: 15780196) He XH … Liu Y (Acta pharmacologica Sinica 2005) 3 4 23

ExternalLinks

View latest publications for CD274 gene in Mastermind

Products for CD274 Gene

  • Addgene plasmids for CD274

Sources for CD274 Gene