Aliases for CD24 Gene
External Ids for CD24 Gene
Previous GeneCards Identifiers for CD24 Gene
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for CD24 Gene
CD24 (CD24 Molecule) is a Protein Coding gene. Diseases associated with CD24 include Bile Duct Cancer and Mental Retardation, Autosomal Dominant 20. Among its related pathways are Developmental Biology and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include protein kinase binding and carbohydrate binding.
UniProtKB/Swiss-Prot Summary for CD24 Gene
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).