This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternativ... See more...

Aliases for CD226 Gene

Aliases for CD226 Gene

  • CD226 Molecule 2 3 5
  • CD226 Antigen 2 3 4
  • DNAM-1 3 4
  • DNAM1 3 4
  • T Lineage-Specific Activation Antigen 1 Antigen 3
  • Platelet And T Cell Activation Antigen 1 3
  • DNAX Accessory Molecule-1 3
  • DNAX Accessory Molecule 1 4
  • Adhesion Glycoprotein 3
  • TLiSA1 3
  • PTA1 3

External Ids for CD226 Gene

Previous GeneCards Identifiers for CD226 Gene

  • GC18M067315
  • GC18M065679
  • GC18M065681
  • GC18M067528
  • GC18M064248

Summaries for CD226 Gene

Entrez Gene Summary for CD226 Gene

  • This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for CD226 Gene

CD226 (CD226 Molecule) is a Protein Coding gene. Diseases associated with CD226 include Refractory Celiac Disease and Polyendocrinopathy. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include protein kinase binding and cell adhesion molecule binding. An important paralog of this gene is NECTIN3.

UniProtKB/Swiss-Prot Summary for CD226 Gene

  • Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).

Gene Wiki entry for CD226 Gene

Additional gene information for CD226 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD226 Gene

Genomics for CD226 Gene

GeneHancer (GH) Regulatory Elements for CD226 Gene

Promoters and enhancers for CD226 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J069934 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 511 +21.0 21002 18 SP1 EP300 TCF7 RELA MEF2C TSC22D4 TRIM22 POLR2A TEAD1 BCL11A CD226 RTTN lnc-RTTN-6
GH18J069954 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 503.7 +4.7 4664 5.9 RELA MEF2C POLR2A TCF12 ZNF316 MAFF CTCF MYNN SMC3 SRF CD226 SOCS6 lnc-RTTN-6
GH18J069961 Promoter/Enhancer 1 EPDnew dbSUPER 500.7 +0.0 10 0.1 CTBP1 NCOR1 NFIC TRIM24 TAL1 STAT5A HDAC2 FOXM1 BHLHE40 TCF12 CD226 lnc-RTTN-6
GH18J069885 Enhancer 1.2 FANTOM5 Ensembl ENCODE 17.4 +75.9 75902 1.4 EP300 MEF2C TRIM22 RELA POLR2A SRF ARNT MEF2B NBN SMARCA5 CD226 RTTN piR-52079-091 lnc-RTTN-6
GH18J069894 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.4 +65.0 65041 4.3 HNRNPK EP300 RELA MEF2C TRIM22 BCL11A TCF12 ZNF316 CBFB MAFF CD226 DOK6 lnc-RTTN-6 piR-52079-091
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD226 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD226

Top Transcription factor binding sites by QIAGEN in the CD226 gene promoter:
  • AP-1
  • Arnt
  • ATF-2
  • c-Jun
  • CUTL1
  • Lhx3a
  • LHX3b
  • Nkx2-5
  • STAT5B

Genomic Locations for CD226 Gene

Genomic Locations for CD226 Gene
chr18:69,831,158-69,961,803
(GRCh38/hg38)
Size:
130,646 bases
Orientation:
Minus strand
chr18:67,498,394-67,629,039
(GRCh37/hg19)
Size:
130,646 bases
Orientation:
Minus strand

Genomic View for CD226 Gene

Genes around CD226 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD226 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD226 Gene

Proteins for CD226 Gene

  • Protein details for CD226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15762-CD226_HUMAN
    Recommended name:
    CD226 antigen
    Protein Accession:
    Q15762
    Secondary Accessions:
    • B2R818

    Protein attributes for CD226 Gene

    Size:
    336 amino acids
    Molecular mass:
    38614 Da
    Quaternary structure:
    • Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.

    Three dimensional structures from OCA and Proteopedia for CD226 Gene

neXtProt entry for CD226 Gene

Post-translational modifications for CD226 Gene

  • Glycosylation at Asn32, Asn83, Asn90, Asn97, Asn147, Asn186, Asn198, and Asn231
  • Ubiquitination at Lys295
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CD226

No data available for DME Specific Peptides for CD226 Gene

Domains & Families for CD226 Gene

Gene Families for CD226 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD226 Gene

Blocks:
  • Immunoglobulin C-2 type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD226 Gene

GenScript: Design optimal peptide antigens:
  • DNAX accessory molecule 1 (CD226_HUMAN)
genes like me logo Genes that share domains with CD226: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD226 Gene

Function for CD226 Gene

Molecular function for CD226 Gene

UniProtKB/Swiss-Prot Function:
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).

Phenotypes From GWAS Catalog for CD226 Gene

Gene Ontology (GO) - Molecular Function for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 16831868
GO:0005515 protein binding IPI 21982860
GO:0019901 protein kinase binding IPI 16831868
GO:0050839 cell adhesion molecule binding IPI 12913096
genes like me logo Genes that share ontologies with CD226: view
genes like me logo Genes that share phenotypes with CD226: view

Animal Models for CD226 Gene

MGI Knock Outs for CD226:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD226

CRISPR Products

miRNA for CD226 Gene

miRTarBase miRNAs that target CD226

Clone Products

  • Addgene plasmids for CD226

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD226 Gene

Localization for CD226 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD226 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD226 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
mitochondrion 1
endosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8673704
GO:0009897 external side of plasma membrane IBA 21873635
GO:0009986 cell surface IDA 16831868
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD226: view

Pathways & Interactions for CD226 Gene

genes like me logo Genes that share pathways with CD226: view

Gene Ontology (GO) - Biological Process for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IBA 21873635
GO:0002729 positive regulation of natural killer cell cytokine production IBA 21873635
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA,IMP 12913096
GO:0002891 positive regulation of immunoglobulin mediated immune response IDA,IBA 16831868
GO:0007155 cell adhesion TAS,IEA --
genes like me logo Genes that share ontologies with CD226: view

No data available for SIGNOR curated interactions for CD226 Gene

Drugs & Compounds for CD226 Gene

(4) Drugs for CD226 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pembrolizumab Approved Pharma 1134
Antineoplastic Agents, Immunological Pharma 9196

(1) Additional Compounds for CD226 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD226: view

Transcripts for CD226 Gene

mRNA/cDNA for CD226 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CD226

Alternative Splicing Database (ASD) splice patterns (SP) for CD226 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP2:
SP3: -
SP4: -

Relevant External Links for CD226 Gene

GeneLoc Exon Structure for
CD226

Expression for CD226 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD226 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD226 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.4), Platelet (25.2), and Monocytes (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD226 Gene



Protein tissue co-expression partners for CD226 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD226

SOURCE GeneReport for Unigene cluster for CD226 Gene:

Hs.660130

mRNA Expression by UniProt/SwissProt for CD226 Gene:

Q15762-CD226_HUMAN
Tissue specificity: Expressed by peripheral blood T-lymphocytes.

Evidence on tissue expression from TISSUES for CD226 Gene

  • Blood(4.6)
  • Nervous system(4.1)
  • Spleen(2.4)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with CD226: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD226 Gene

Orthologs for CD226 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD226 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD226 31 30
  • 99.31 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD226 31 30
  • 77.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CD226 31 30
  • 72.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cd226 17 31 30
  • 68.89 (n)
rat
(Rattus norvegicus)
Mammalia Cd226 30
  • 68.09 (n)
oppossum
(Monodelphis domestica)
Mammalia CD226 31
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD226 31
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD226 31 30
  • 50.99 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD226 31
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd226 31 30
  • 43.7 (n)
OneToOne
Species where no ortholog for CD226 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD226 Gene

ENSEMBL:
Gene Tree for CD226 (if available)
TreeFam:
Gene Tree for CD226 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD226: view image

Paralogs for CD226 Gene

(1) SIMAP similar genes for CD226 Gene using alignment to 6 proteins:

  • CD226_HUMAN
  • J3QKM7_HUMAN
  • J3QL19_HUMAN
  • J3QQW1_HUMAN
  • J3QR77_HUMAN
  • J3QRQ4_HUMAN
genes like me logo Genes that share paralogs with CD226: view

Variants for CD226 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD226 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs763361 - p.Ser307Gly

Additional dbSNP identifiers (rs#s) for CD226 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD226 Gene

Variant ID Type Subtype PubMed ID
dgv1922e59 CNV duplication 20981092
dgv632e214 CNV loss 21293372
esv2717304 CNV deletion 23290073
esv32736 CNV gain+loss 17666407
esv3893135 CNV loss 25118596
esv3893136 CNV loss 25118596
nsv2347 CNV insertion 18451855

Variation tolerance for CD226 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD226 Gene

Human Gene Mutation Database (HGMD)
CD226
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD226

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD226 Gene

Disorders for CD226 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CD226 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
refractory celiac disease
  • refractory cd
polyendocrinopathy
subclavian steal syndrome
  • subclavian artery stenosis
myeloma, multiple
  • multiple myeloma, susceptibility to
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search CD226 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD226

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD226: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD226 Gene

Publications for CD226 Gene

  1. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). (PMID: 15039383) Tahara-Hanaoka S … Shibuya A (International immunology 2004) 3 4 23 54
  2. DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. (PMID: 8673704) Shibuya A … Phillips JH (Immunity 1996) 2 3 4 54
  3. Identification of CD112R as a novel checkpoint for human T cells. (PMID: 26755705) Zhu Y … Edil BH (The Journal of experimental medicine 2016) 3 4 54
  4. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V … Todd JA (PLoS genetics 2011) 3 41 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for CD226 Gene

  • Addgene plasmids for CD226

Sources for CD226 Gene