Aliases for CD22 Gene
Aliases for CD22 Gene
External Ids for CD22 Gene
- HGNC: 1643
- Entrez Gene: 933
- Ensembl: ENSG00000012124
- OMIM: 107266
- UniProtKB: P20273
Previous GeneCards Identifiers for CD22 Gene
- GC19U990008
- GC19P036269
- GC19P040498
- GC19P040511
- GC19P035820
- GC19P032328
- GC19P035826
- GC19P035957
Summaries for CD22 Gene
GeneCards Summary for CD22 Gene
CD22 (CD22 Molecule) is a Protein Coding gene. Diseases associated with CD22 include Refractory Hematologic Cancer and Hairy Cell Leukemia. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC1.
UniProtKB/Swiss-Prot for CD22 Gene
-
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD22 Gene
Genomics for CD22 Gene
GeneHancer (GH) Regulatory Elements for CD22 Gene
Promoters and enhancers for CD22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD22 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CD22 gene promoter:
-
- AP-2alphaA
- AP-2alpha isoform 4
- AP-2alpha isoform 3
- AP-2alpha isoform 2
- AP-2alpha
- Sp1
- AREB6
- AP-4
- Egr-1
- LCR-F1
Regulatory Element Products
Genomic Locations for CD22 Gene
Genomic Locations for CD22 Gene
- chr19:35,319,261-35,347,361
- (GRCh38/hg38)
- Size:
- 28,101 bases
- Orientation:
- Plus strand
- chr19:35,810,164-35,838,264
- (GRCh37/hg19)
- Size:
- 28,101 bases
- Orientation:
- Plus strand
Genomic View for CD22 Gene
Genes around CD22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.12 by Entrez Gene
- 19q13.12 by HGNC
- 19q13.12 by Ensembl
CD22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD22 Gene
Proteins for CD22 Gene
-
Protein details for CD22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20273-CD22_HUMAN
- Recommended name:
- B-cell receptor CD22
- Protein Accession:
- P20273
- F5GYU4
- F5H7U3
- O95699
- O95701
- O95702
- O95703
- Q01665
- Q32M46
- Q92872
- Q92873
- Q9UQA6
- Q9UQA7
- Q9UQA8
- Q9UQA9
- Q9UQB0
- Q9Y2A6
Protein attributes for CD22 Gene
- Size:
- 847 amino acids
- Molecular mass:
- 95348 Da
- Quaternary structure:
-
- Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.
- SequenceCaution:
-
- Sequence=CAA36988.1; Type=Frameshift; Positions=806; Evidence={ECO:0000305};
Protein Expression for CD22 Gene
Post-translational modifications for CD22 Gene
- Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
- Phosphorylated on tyrosine residues by LYN.
- Glycosylation at Asn634, posLast=574574, posLast=479479, posLast=445445, Asn363, Asn231, Asn164, Asn135, posLast=112112, posLast=101101, and Asn67
- Modification sites at PhosphoSitePlus
Other Protein References for CD22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD22 (Siglec-2/CD22)
-
Custom Antibody ServicesOriGene Antibodies for CD22
- AM00647RP-N
- AM01320PU-N
- AM03204AC-N
- AM03204AF-N
- AM03204FC-N
- AM03204RP-N
- AM05182RP-N
- AM08033AC-N
- AM08033BT-N
- AM08033FC-N
- AM08033LE-N
- AM08033PU-N
- AM08033RP-N
- AM33030PU-N
- AM39016FC-N
- AM39016PU-N
- AM39016RP-N
- AP00119PU-N
- AP01136BT-N
- AP01136BT-S
- AP01136PU-N
- AP01136PU-S
- AP23282PU-N
- AP55784PU-N
- AP55784PU-S
- SM1787BT
- SM1787FT
- SM1854P
- SM1854PE
- SM1854PT
- SM1929F
- SM1929FT
- SM1929P
- SM1929PE
- SM1929PT
- SM1929RT
- SM3085F
- SM3085P
- SM3085PX
- SM3085R
- TA313576
- TA313577
- TA324091
- TA328277
- TA328278
- TA332916
- TA349769
- TA353033
- TA353034
- TA353035
- TA353036
- TA353674
- TA353675
- TA506404
- CF506404
- TA506405
- CF506405
- TA506407
- CF506407
- TA506412
- CF506412
- TA590727
- TA807825
- CF807825
- TA807826
- CF807826
- TA807831
- CF807831
- TA807844
- CF807844
- TA807845
- CF807845
- TA506412S
- Novus Biologicals Antibodies for CD22
-
Abcam antibodies for CD22
- Invitrogen Antibodies for CD22
- GeneTex CD22 Antibody for CD22
-
Boster Bio Antibodies for CD22
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD22
- Sino Biological Antibodies for CD22
Protein Products
- R&D Systems Proteins and Enzymes for CD22 (Siglec-2/CD22)
-
OriGene Purified Proteins for CD22
- Search Origene for MassSpec and Protein Over-expression Lysates for CD22
- Origene Custom Protein Services for CD22
- Novus Biologicals proteins for CD22
- Sino Biological Recombinant Proteins for CD22
- Sino Biological Cell Lysates for CD22
- GeneTex Proteins for CD22
-
ProSci Proteins for CD22
-
Abcam proteins for CD22
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CD22
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for CD22 (Siglec-2/CD22)
- antibodies-online: Search results for 26 available CD22 Elisa Kits ranked by validation data
- Compare Top CD22 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CD22
-
Abcam assays for CD22
No data available for DME Specific Peptides for CD22 Gene
Domains & Families for CD22 Gene
Gene Families for CD22 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CD22 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD22 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P20273UniProtKB/Swiss-Prot:
CD22_HUMAN :- Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Domain:
-
- Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Family:
-
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Function for CD22 Gene
Molecular function for CD22 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
- GENATLAS Biochemistry:
- cell differentiation antigen CD22,glycoprotein,identified by monoclonal antibodies HD39,S-HCL1,TO15,specifically expressed in B cells,involved in the regulation of B cell activation sialoadhesin,Ig superfamily,potential susceptibility gene for autoimmune diseases
Phenotypes From GWAS Catalog for CD22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 8627166 |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for CD22 Gene
- MGI mutant phenotypes for CD22:
- inferred from 16 alleles
- GenomeRNAi human phenotypes for CD22:
Animal Models for CD22 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD22
-
CRISPR Products
-
OriGene CRISPR knockouts for CD22
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD22
- genomics-online: gRNA clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
- Applied Biological Materials CRISPR for CD22
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD22
- GenScript: Design CRISPR guide RNA sequences for CD22
miRNA for CD22 Gene
- miRTarBase miRNAs that target CD22
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD22
- Browse OriGene Inhibitory RNA Products For CD22
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD22
- genomics-online: shRNA clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
Clone Products
-
OriGene ORF clones in human for CD22
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD22
- VectorBuilder custom plasmid, inducible vectors for CD22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD22
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD22
- Applied Biological Materials Clones for CD22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD22 (Siglec-2/CD22)
Cell Line Products
-
Horizon Cell Lines for CD22
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD22 Gene
Localization for CD22 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD22 Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 20458337 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD22 Gene
Pathways & Interactions for CD22 Gene
Pathways by source for CD22 Gene
1 Sino Biological pathway for CD22 Gene
2 BioSystems pathways for CD22 Gene
3 KEGG pathways for CD22 Gene
1 GeneGo (Thomson Reuters) pathway for CD22 Gene
Interacting Proteins for CD22 Gene
Selected Interacting proteins:
ENSP00000085219
P20273-CD22_HUMAN
for CD22 Gene via
STRING
IID
MINT
UniProtKB
GPS-Prot Interaction Network for CD22
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA,NAS | -- |
No data available for SIGNOR curated interactions for CD22 Gene
Drugs & Compounds for CD22 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| inotuzumab ozogamicin | Approved, Investigational | Pharma | Target, antibody | 0 | ||
| Epratuzumab | Investigational | Pharma | antibody, Target | 0 | ||
| Moxetumomab Pasudotox | Investigational | Pharma | antibody | 0 | ||
| Analgesics | Pharma | 12601 | ||||
| Analgesics, Non-Narcotic | Pharma | 6911 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for CD22 Gene
mRNA/cDNA for CD22 Gene
- (6) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (286) Selected AceView cDNA sequences:
- (34) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000598537 554 bps (uc060xbg.1)
- ENST00000601414 563 bps (uc060xbh.1)
- ENST00000595419 623 bps (uc060xbi.1)
- ENST00000599717 567 bps (uc060xbj.1)
- ENST00000600131 603 bps (uc060xbk.1)
CRISPR Products
-
OriGene CRISPR knockouts for CD22
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD22
- genomics-online: gRNA clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
- Applied Biological Materials CRISPR for CD22
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD22
- GenScript: Design CRISPR guide RNA sequences for CD22
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD22
- Browse OriGene Inhibitory RNA Products For CD22
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD22
- genomics-online: shRNA clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
Clone Products
-
OriGene ORF clones in human for CD22
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD22
- VectorBuilder custom plasmid, inducible vectors for CD22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD22
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD22
- Applied Biological Materials Clones for CD22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD22 (Siglec-2/CD22)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP21: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP25: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP26: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP27: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP28: |
| ExUns: | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||
| SP11: | - | - | |||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | - | - | |||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: | - | - | |||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||
| SP20: | - | - | |||||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||||
| SP23: | |||||||||||||||||||||||||||||
| SP24: | |||||||||||||||||||||||||||||
| SP25: | |||||||||||||||||||||||||||||
| SP26: | |||||||||||||||||||||||||||||
| SP27: | |||||||||||||||||||||||||||||
| SP28: |
Expression for CD22 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Basophils Peripheral Blood
- Common Dendritic Cell Precursors Hematopoietic Bone Marrow
- Mature B-Cells Peripheral Blood
- Conventional Dendritic Cells II Spleen
- Spleen (Hematopoietic System)
- Adipose (Muscoskeletal System)
-
Lung (Respiratory System)
-
Tonsil (Hematopoietic System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for CD22 Gene
This gene is overexpressed in Spleen (x8.4) and Ovary (x6.8).
This gene is overexpressed in Blymphocyte (42.9) and Lymph node (19.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD22 Gene
NURSA nuclear receptor signaling pathways regulating expression of CD22 Gene:
CD22SOURCE GeneReport for Unigene cluster for CD22 Gene:
Hs.579691mRNA Expression by UniProt/SwissProt for CD22 Gene:
P20273-CD22_HUMAN
Tissue specificity:
B-lymphocytes.
Evidence on tissue expression from TISSUES for CD22 Gene
- Spleen(4.9)
- Blood(3.7)
- Lymph node(3.3)
- Bone marrow(3)
- Intestine(2.2)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for CD22
- genomics-online: primer clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD22 Gene
Orthologs for CD22 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD22 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CD22 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CD22 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cd22 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd22 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD22 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CD22 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cd22 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-27j5.10 34 |
|
ManyToMany | |
| CABZ01058865.1 34 |
|
ManyToMany | |||
| si:ch211-1f22.14 34 |
|
ManyToMany |
- Species where no ortholog for CD22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CD22 Gene
- ENSEMBL:
- Gene Tree for CD22 (if available)
- TreeFam:
- Gene Tree for CD22 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD22: view image
Paralogs for CD22 Gene
(3) SIMAP similar genes for CD22 Gene using alignment to 19 proteins:
- CD22_HUMAN
- E7ERG6_HUMAN
- M0QY05_HUMAN
- M0QY14_HUMAN
- M0QYP4_HUMAN
- M0QZ01_HUMAN
- M0QZP5_HUMAN
- M0QZR7_HUMAN
- M0R0R6_HUMAN
- M0R1M2_HUMAN
- M0R2M0_HUMAN
- M0R2R8_HUMAN
- M0R3H1_HUMAN
- O60926_HUMAN
- O95700_HUMAN
- Q0EAF5_HUMAN
- Q32M46_HUMAN
- Q9UQB1_HUMAN
- Q9UQB2_HUMAN
Variants for CD22 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009513 | -- | 35,330,986(+) | A/G | intron_variant | |
| rs1000022293 | -- | 35,330,043(+) | A/G | intron_variant | |
| rs1000087744 | -- | 35,336,082(+) | G/A | coding_sequence_variant, intron_variant, synonymous_variant | |
| rs1000151437 | -- | 35,339,279(+) | G/A | intron_variant | |
| rs1000176298 | -- | 35,345,822(+) | C/G/T | intron_variant |
Residual Variation Intolerance Score:
37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.73;
66.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD22 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD22 Gene
Disorders for CD22 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| refractory hematologic cancer |
|
|
| hairy cell leukemia |
|
|
| refractory hairy cell leukemia |
|
|
| early yaws |
|
|
| colon lymphoma |
|
|
Search CD22 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD22
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CD22 Gene
Publications for CD22 Gene
- The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. (PMID: 1691828) Stamenkovic I … Seed B (Nature 1990) 2 3 4 22 58
- Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 22 44 58
- Identification of the gene variations in human CD22. (PMID: 10079291) Hatta Y … Tokunaga K (Immunogenetics 1999) 3 4 44 58
- CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. (PMID: 8627166) Law CL … Clark EA (The Journal of experimental medicine 1996) 3 4 22 58
- Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. (PMID: 8647200) Tuscano JM … Kehrl JH (European journal of immunology 1996) 3 4 22 58
Products for CD22 Gene
- R&D Systems Antibodies for CD22 (Siglec-2/CD22)
- R&D Systems Proteins and Enzymes for CD22 (Siglec-2/CD22)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for CD22 (Siglec-2/CD22)
- R&D Systems cDNA Clones for CD22 (Siglec-2/CD22)
- Browse Human Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for CD22
- AM00647RP-N
- AM01320PU-N
- AM03204AC-N
- AM03204AF-N
- AM03204FC-N
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- AM05182RP-N
- AM08033AC-N
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- AP01136BT-S
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- AP23282PU-N
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- SM1787BT
- SM1787FT
- SM1854P
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- SM1929F
- SM1929FT
- SM1929P
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- SM1929RT
- SM3085F
- SM3085P
- SM3085PX
- SM3085R
- TA313576
- TA313577
- TA324091
- TA328277
- TA328278
- TA332916
- TA349769
- TA353033
- TA353034
- TA353035
- TA353036
- TA353674
- TA353675
- TA506404
- CF506404
- TA506405
- CF506405
- TA506407
- CF506407
- TA506412
- CF506412
- TA590727
- TA807825
- CF807825
- TA807826
- CF807826
- TA807831
- CF807831
- TA807844
- CF807844
- TA807845
- CF807845
- TA506412S
- Custom Assay ServicesOriGene ELISA Kits for CD22
- OriGene Purified Proteins for CD22
- Search Origene for MassSpec and Protein Over-expression Lysates for CD22
- Origene Custom Protein Services for CD22
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD22
- Browse OriGene Inhibitory RNA Products For CD22
- OriGene qPCR primer pairs for CD22
- OriGene CRISPR knockouts for CD22
- OriGene ORF clones in human for CD22
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD22
- GenScript: Next-day shipping of latest version cDNA ORF clones for CD22 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CD22
- GenScript Custom Assay Services for CD22
- GenScript Custom overexpressing Cell Line Services for CD22
- GenScript: Design CRISPR guide RNA sequences for CD22
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD22
- Sino Biological Human cDNA Clone for CD22
- Sino Biological Recombinant Proteins for CD22
- Sino Biological Cell Lysates for CD22
- Sino Biological Antibodies for CD22
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CD22
- Novus Biologicals proteins for CD22
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for CD22
- Abcam proteins for CD22
- Abcam assays for CD22
- Find your target
- Browse Primary Antibodies
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- VectorBuilder custom plasmid, inducible vectors for CD22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD22
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 701 available CD22 Antibodies ranked by validation data
- Compare Top CD22 Antibodies
- antibodies-online: Search results for 26 available CD22 Elisa Kits ranked by validation data
- Compare Top CD22 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 33 available CD22 Proteins ranked by validation data
- Compare Top CD22 Proteins
- GeneTex CD22 Antibody for CD22
- GeneTex Proteins for CD22
- Santa Cruz Biotechnology (SCBT) Antibodies for CD22
- Search Santa Cruz Biotechnology (SCBT) for CD22 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD22
- Horizon Cell Lines for CD22
- genomics-online: cdna clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
- orf clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
- genomics-online: gRNA clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
- genomics-online: primer clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
- genomics-online: shRNA clones - Search results for 116 available CD22 gene related products
- Overview of 116 available CD22 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD22
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD22
- GeneCopoeia miRNA 3'UTR Target clone products for CD22
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD22
- Boster Bio Antibodies for CD22
- Boster Bio ELISA Kits for CD22
Sources for CD22 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt