Aliases for CD22 Gene

Aliases for CD22 Gene

  • CD22 Molecule 2 3 5
  • CD22 Antigen 2 3 4
  • Sialic Acid-Binding Ig-Like Lectin 2 3 4
  • B-Lymphocyte Cell Adhesion Molecule 3 4
  • T-Cell Surface Antigen Leu-14 3 4
  • B-Cell Receptor CD22 3 4
  • SIGLEC2 3 4
  • BL-CAM 3 4
  • Sialic Acid Binding Ig-Like Lectin 2 2
  • SIGLEC-2 3
  • Siglec-2 4

External Ids for CD22 Gene

Previous GeneCards Identifiers for CD22 Gene

  • GC19U990008
  • GC19P036269
  • GC19P040498
  • GC19P040511
  • GC19P035820
  • GC19P032328
  • GC19P035826
  • GC19P035957

Summaries for CD22 Gene

GeneCards Summary for CD22 Gene

CD22 (CD22 Molecule) is a Protein Coding gene. Diseases associated with CD22 include Refractory Hematologic Cancer and Hairy Cell Leukemia. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Hematopoietic cell lineage. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC1.

UniProtKB/Swiss-Prot Summary for CD22 Gene

  • Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Gene Wiki entry for CD22 Gene

Additional gene information for CD22 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD22 Gene

Genomics for CD22 Gene

GeneHancer (GH) Regulatory Elements for CD22 Gene

Promoters and enhancers for CD22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD22 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD22

Top Transcription factor binding sites by QIAGEN in the CD22 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • AP-4
  • AREB6
  • Egr-1
  • LCR-F1
  • Sp1

Genomic Locations for CD22 Gene

Genomic Locations for CD22 Gene
chr19:35,319,261-35,347,361
(GRCh38/hg38)
Size:
28,101 bases
Orientation:
Plus strand
chr19:35,810,164-35,838,264
(GRCh37/hg19)
Size:
28,101 bases
Orientation:
Plus strand

Genomic View for CD22 Gene

Genes around CD22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD22 Gene

Proteins for CD22 Gene

  • Protein details for CD22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20273-CD22_HUMAN
    Recommended name:
    B-cell receptor CD22
    Protein Accession:
    P20273
    Secondary Accessions:
    • F5GYU4
    • F5H7U3
    • O95699
    • O95701
    • O95702
    • O95703
    • Q01665
    • Q32M46
    • Q92872
    • Q92873
    • Q9UQA6
    • Q9UQA7
    • Q9UQA8
    • Q9UQA9
    • Q9UQB0
    • Q9Y2A6

    Protein attributes for CD22 Gene

    Size:
    847 amino acids
    Molecular mass:
    95348 Da
    Quaternary structure:
    • Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.
    SequenceCaution:
    • Sequence=CAA36988.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD22 Gene

    Alternative splice isoforms for CD22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD22 Gene

Post-translational modifications for CD22 Gene

  • Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
  • Phosphorylated on tyrosine residues by LYN.
  • Glycosylation at Asn231, Asn67, Asn101, Asn112, Asn135, Asn164, Asn363, Asn445, Asn479, Asn574, and Asn634
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CD22

No data available for DME Specific Peptides for CD22 Gene

Domains & Families for CD22 Gene

Gene Families for CD22 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD22 Gene

Blocks:
  • Immunoglobulin C-2 type
  • CD80-like C2-set immunoglobulin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD22 Gene

GenScript: Design optimal peptide antigens:
  • T-cell surface antigen Leu-14 (CD22_HUMAN)
  • CD22 protein (O60926_HUMAN)
  • CD22 protein (O95700_HUMAN)
  • CD22 molecule (Q0EAF5_HUMAN)
  • CD22 protein (Q32M46_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20273

UniProtKB/Swiss-Prot:

CD22_HUMAN :
  • Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with CD22: view

Function for CD22 Gene

Molecular function for CD22 Gene

UniProtKB/Swiss-Prot Function:
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
GENATLAS Biochemistry:
cell differentiation antigen CD22,glycoprotein,identified by monoclonal antibodies HD39,S-HCL1,TO15,specifically expressed in B cells,involved in the regulation of B cell activation sialoadhesin,Ig superfamily,potential susceptibility gene for autoimmune diseases

Phenotypes From GWAS Catalog for CD22 Gene

Gene Ontology (GO) - Molecular Function for CD22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001791 IgM binding TAS 15240561
GO:0005102 signaling receptor binding TAS 15240561
GO:0005515 protein binding IPI 8627166
GO:0019903 protein phosphatase binding TAS 15095367
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD22: view
genes like me logo Genes that share phenotypes with CD22: view

Animal Models for CD22 Gene

MGI Knock Outs for CD22:

miRNA for CD22 Gene

miRTarBase miRNAs that target CD22

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD22 Gene

Localization for CD22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD22 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD22 gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 3
nucleus 3
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 15240561
GO:0005769 early endosome IDA 17562860
GO:0005886 plasma membrane IEA,TAS 15240561
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD22 Gene

Pathways & Interactions for CD22 Gene

genes like me logo Genes that share pathways with CD22: view

Gene Ontology (GO) - Biological Process for CD22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS,IEA --
GO:0030100 regulation of endocytosis IDA 17562860
GO:0030888 regulation of B cell proliferation ISS --
GO:0042113 B cell activation IDA 26017478
GO:0050776 regulation of immune response ISS --
genes like me logo Genes that share ontologies with CD22: view

No data available for SIGNOR curated interactions for CD22 Gene

Drugs & Compounds for CD22 Gene

(20) Drugs for CD22 Gene - From: DrugBank, ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
inotuzumab ozogamicin Approved, Investigational Pharma Target, antibody 39
Moxetumomab Pasudotox Approved, Investigational Pharma Target, binder, antibody 0
Fludarabine Approved Pharma DNA synthsis inhibitor 1470,1470
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3570
Epratuzumab Investigational Pharma Target, antibody 44

(3) Additional Compounds for CD22 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD22: view

Transcripts for CD22 Gene

mRNA/cDNA for CD22 Gene

6 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
34 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
SP1: -
SP2: - - -
SP3: - - - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - - - - - - - -
SP16: - - - - - -
SP17: - - - - - - -
SP18: - - - -
SP19: - - - - - - -
SP20: - - - - - - - - - - - - - - - - - - - - - - -
SP21: - - - -
SP22: - - - - - - - - -
SP23: - - - - - - - - - - - -
SP24: - - - - - - - - - - - - - - - - - - -
SP25: - - - - - -
SP26: - - - - - -
SP27:
SP28:

ExUns: 12b · 12c ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3: - -
SP4: -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11: - -
SP12:
SP13: - -
SP14:
SP15: - -
SP16:
SP17:
SP18:
SP19:
SP20: - -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:

Relevant External Links for CD22 Gene

GeneLoc Exon Structure for
CD22

Expression for CD22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD22 Gene

This gene is overexpressed in Spleen (x8.4) and Ovary (x6.8).

Protein differential expression in normal tissues from HIPED for CD22 Gene

This gene is overexpressed in Blymphocyte (42.9) and Lymph node (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD22 Gene



Protein tissue co-expression partners for CD22 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD22

SOURCE GeneReport for Unigene cluster for CD22 Gene:

Hs.579691

mRNA Expression by UniProt/SwissProt for CD22 Gene:

P20273-CD22_HUMAN
Tissue specificity: B-lymphocytes.

Evidence on tissue expression from TISSUES for CD22 Gene

  • Spleen(4.9)
  • Blood(3.7)
  • Lymph node(3.3)
  • Bone marrow(3)
  • Intestine(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with CD22: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD22 Gene

Orthologs for CD22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD22 31 30
  • 98.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD22 31 30
  • 75.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CD22 31 30
  • 72 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cd22 17 31 30
  • 70.37 (n)
rat
(Rattus norvegicus)
Mammalia Cd22 30
  • 69.65 (n)
oppossum
(Monodelphis domestica)
Mammalia CD22 31
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD22 31
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 25 (a)
OneToMany
-- 31
  • 25 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cd22 30
  • 44.59 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-27j5.10 31
  • 30 (a)
ManyToMany
CABZ01058865.1 31
  • 30 (a)
ManyToMany
si:ch211-1f22.14 31
  • 25 (a)
ManyToMany
Species where no ortholog for CD22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD22 Gene

ENSEMBL:
Gene Tree for CD22 (if available)
TreeFam:
Gene Tree for CD22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD22: view image

Paralogs for CD22 Gene

(3) SIMAP similar genes for CD22 Gene using alignment to 19 proteins:

  • CD22_HUMAN
  • E7ERG6_HUMAN
  • M0QY05_HUMAN
  • M0QY14_HUMAN
  • M0QYP4_HUMAN
  • M0QZ01_HUMAN
  • M0QZP5_HUMAN
  • M0QZR7_HUMAN
  • M0R0R6_HUMAN
  • M0R1M2_HUMAN
  • M0R2M0_HUMAN
  • M0R2R8_HUMAN
  • M0R3H1_HUMAN
  • O60926_HUMAN
  • O95700_HUMAN
  • Q0EAF5_HUMAN
  • Q32M46_HUMAN
  • Q9UQB1_HUMAN
  • Q9UQB2_HUMAN
genes like me logo Genes that share paralogs with CD22: view

Variants for CD22 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD22 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
719268 Benign: not provided 35,344,836(+) G/A SYNONYMOUS_VARIANT
723866 Likely Benign: not provided 35,345,594(+) C/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
735786 Likely Benign: not provided 35,345,097(+) G/A MISSENSE_VARIANT
782645 Benign: not provided 35,338,353(+) G/A MISSENSE_VARIANT,INTRON_VARIANT
789907 Benign: not provided 35,337,831(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CD22 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD22 Gene

Variant ID Type Subtype PubMed ID
esv2758758 CNV loss 17122850
nsv1067129 CNV loss 25217958
nsv173 CNV deletion 15895083
nsv2471 CNV deletion 18451855
nsv510765 CNV deletion 20534489
nsv833810 CNV gain 17160897

Variation tolerance for CD22 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD22 Gene

Human Gene Mutation Database (HGMD)
CD22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD22

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD22 Gene

Disorders for CD22 Gene

MalaCards: The human disease database

(37) MalaCards diseases for CD22 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
refractory hematologic cancer
  • refractory hematologic malignancy
hairy cell leukemia
  • hcl-v
early yaws
  • bone and joint lesions due to yaws
refractory hairy cell leukemia
lymphosarcoma
  • lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search CD22 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD22 Gene

Publications for CD22 Gene

  1. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. (PMID: 1691828) Stamenkovic I … Seed B (Nature 1990) 2 3 4 23 54
  2. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 23 41 54
  3. Identification of the gene variations in human CD22. (PMID: 10079291) Hatta Y … Tokunaga K (Immunogenetics 1999) 3 4 41 54
  4. CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. (PMID: 8627166) Law CL … Clark EA (The Journal of experimental medicine 1996) 3 4 23 54
  5. Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. (PMID: 8647200) Tuscano JM … Kehrl JH (European journal of immunology 1996) 3 4 23 54

Products for CD22 Gene