This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this i... See more...

Aliases for CD200R1 Gene

Aliases for CD200R1 Gene

  • CD200 Receptor 1 2 3 5
  • CD200R 2 3 4
  • OX2R 2 3 4
  • Cell Surface Glycoprotein CD200 Receptor 1 3 4
  • CD200 Cell Surface Glycoprotein Receptor 3 4
  • Cell Surface Glycoprotein OX2 Receptor 1 3 4
  • MOX2 Receptor 2 3
  • HCRTR2 2 3
  • MOX2R 3 4
  • Cell Surface Glycoprotein Receptor CD200 3
  • CD200R1 5
  • CRTR2 4

External Ids for CD200R1 Gene

Previous HGNC Symbols for CD200R1 Gene

  • MOX2R

Previous GeneCards Identifiers for CD200R1 Gene

  • GC03M114122
  • GC03M112640
  • GC03M110025

Summaries for CD200R1 Gene

Entrez Gene Summary for CD200R1 Gene

  • This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD200R1 Gene

CD200R1 (CD200 Receptor 1) is a Protein Coding gene. Diseases associated with CD200R1 include Human Herpesvirus 8 and Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD200R1L.

UniProtKB/Swiss-Prot Summary for CD200R1 Gene

  • Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Gene Wiki entry for CD200R1 Gene

Additional gene information for CD200R1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD200R1 Gene

Genomics for CD200R1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD200R1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J112990 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 605.3 -15.6 -15598 5 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST ZNF692 POLR2A NFRKB BACH1 GTPBP8 CD200R1 ENSG00000272844 NEPRO SPICE1 CFAP44 USF3
GH03J112972 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 606.5 +0.4 395 4.6 RAD21 TCF12 IKZF2 RCOR1 TRIM22 YY1 DPF2 CTCF RELB CEBPB CD200R1 CD200R1L-AS1 NEPRO GTPBP8 ENSG00000240057 lnc-NEPRO-4 CD200R1L
GH03J112980 Promoter 0.7 EPDnew 600.7 -4.1 -4124 0.1 CTCF TRIM22 RAD21 FOXA2 CUX1 ZNF664 ARID3A CD200R1 CD200R1L-AS1 GTPBP8
GH03J112773 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 21.3 +197.2 197202 11 CREB1 ZNF24 REST IKZF2 TRIM22 ZNF341 TOE1 CEBPB ARID3A SP1 CD200R1 CD200R1L-AS1 CD200R1L ATG3 piR-56186-042 piR-42799-015 CCDC80
GH03J112634 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +335.5 335509 10.2 CTCF ZNF512 IKZF1 ZNF692 POLR2A JUND MTA2 ZNF143 RELA ZSCAN4 CCDC80 CD200R1 CD200R1L-AS1 C3orf52 MIR567 SLC35A5 lnc-CCDC80-1 lnc-CCDC80-5 ATG3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD200R1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD200R1

Top Transcription factor binding sites by QIAGEN in the CD200R1 gene promoter:
  • AhR
  • aMEF-2
  • AREB6
  • Cdc5
  • FOXD3
  • Gfi-1
  • ISGF-3
  • LHX3b
  • MEF-2A
  • Sp1

Genomic Locations for CD200R1 Gene

Genomic Locations for CD200R1 Gene
chr3:112,921,205-112,975,103
(GRCh38/hg38)
Size:
53,899 bases
Orientation:
Minus strand
chr3:112,640,056-112,693,969
(GRCh37/hg19)
Size:
53,914 bases
Orientation:
Minus strand

Genomic View for CD200R1 Gene

Genes around CD200R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD200R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD200R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD200R1 Gene

Proteins for CD200R1 Gene

  • Protein details for CD200R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD46-MO2R1_HUMAN
    Recommended name:
    Cell surface glycoprotein CD200 receptor 1
    Protein Accession:
    Q8TD46
    Secondary Accessions:
    • B3KWZ9
    • E9PCM9
    • Q52LJ7
    • Q6IS95
    • Q6UW94
    • Q6WHB8
    • Q8TD44
    • Q8TD45
    • Q8TD52

    Protein attributes for CD200R1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36620 Da
    Quaternary structure:
    • CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.
    • (Microbial infection) Interacts with human herpesvirus 8/HHV-8 protein vOX2/K14.

    Alternative splice isoforms for CD200R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD200R1 Gene

Post-translational modifications for CD200R1 Gene

  • The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.
  • Glycosylation at Asn37, Asn46, Asn93, Asn99, Asn162, Asn195, Asn210, and Asn224
  • Modification sites at PhosphoSitePlus

Other Protein References for CD200R1 Gene

Antibody Products

  • Abcam antibodies for CD200R1

Assay Products

  • Signalway ELISA kits for CD200R1

No data available for DME Specific Peptides for CD200R1 Gene

Domains & Families for CD200R1 Gene

Gene Families for CD200R1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD200R1 Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for CD200R1 Gene

GenScript: Design optimal peptide antigens:
  • CD200R1 protein (B7ZKV2_HUMAN)
  • Cell surface glycoprotein OX2 receptor 1 (MO2R1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TD46

UniProtKB/Swiss-Prot:

MO2R1_HUMAN :
  • Belongs to the CD200R family.
Family:
  • Belongs to the CD200R family.
genes like me logo Genes that share domains with CD200R1: view

Function for CD200R1 Gene

Molecular function for CD200R1 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Phenotypes From GWAS Catalog for CD200R1 Gene

Gene Ontology (GO) - Molecular Function for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
GO:0019763 immunoglobulin receptor activity TAS 10981966
GO:0038023 signaling receptor activity IBA 21873635
GO:0140081 glycosylated region protein binding TAS 10981966
genes like me logo Genes that share ontologies with CD200R1: view
genes like me logo Genes that share phenotypes with CD200R1: view

Animal Models for CD200R1 Gene

MGI Knock Outs for CD200R1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD200R1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD200R1 Gene

Localization for CD200R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD200R1 Gene

[Isoform 1]: Cell membrane. Single-pass type I membrane protein.
[Isoform 4]: Cell membrane. Single-pass type I membrane protein.
[Isoform 2]: Secreted.
[Isoform 3]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD200R1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
cytoskeleton 1
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD200R1: view

Pathways & Interactions for CD200R1 Gene

genes like me logo Genes that share pathways with CD200R1: view

Pathways by source for CD200R1 Gene

Gene Ontology (GO) - Biological Process for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10981966
GO:0016032 viral process IEA --
GO:0034113 heterotypic cell-cell adhesion ISS 11260322
GO:0035556 intracellular signal transduction TAS 12072366
GO:0038093 Fc receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CD200R1: view

No data available for SIGNOR curated interactions for CD200R1 Gene

Drugs & Compounds for CD200R1 Gene

No Compound Related Data Available

Transcripts for CD200R1 Gene

mRNA/cDNA for CD200R1 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD200R1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD200R1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for CD200R1 Gene

GeneLoc Exon Structure for
CD200R1

Expression for CD200R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD200R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD200R1 Gene

This gene is overexpressed in Spleen (x5.5).

Protein differential expression in normal tissues from HIPED for CD200R1 Gene

This gene is overexpressed in Liver, secretome (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD200R1 Gene



Protein tissue co-expression partners for CD200R1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD200R1

SOURCE GeneReport for Unigene cluster for CD200R1 Gene:

Hs.309158

mRNA Expression by UniProt/SwissProt for CD200R1 Gene:

Q8TD46-MO2R1_HUMAN
Tissue specificity: Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.

Evidence on tissue expression from TISSUES for CD200R1 Gene

  • Liver(4.3)
  • Spleen(2.7)
  • Lymph node(2.5)
  • Blood(2.5)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with CD200R1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD200R1 Gene

Orthologs for CD200R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD200R1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD200R1 30 31
  • 98.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CD200R1L 30
  • 75.54 (n)
-- 31
  • 53 (a)
ManyToMany
CD200R1 31
  • 53 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia CD200R1 30
  • 72.54 (n)
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Cd200r1 30
  • 71.25 (n)
Mouse
(Mus musculus)
Mammalia Cd200r1 30 17 31
  • 70.85 (n)
ManyToMany
Cd200r2 31
  • 54 (a)
ManyToMany
Cd200r4 31
  • 50 (a)
ManyToMany
Cd200r3 31
  • 33 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 40 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CD200R1L 30 31
  • 56.69 (n)
ManyToMany
CD200R1A 31
  • 30 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 27 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101731855 30
  • 51.19 (n)
Species where no ortholog for CD200R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD200R1 Gene

ENSEMBL:
Gene Tree for CD200R1 (if available)
TreeFam:
Gene Tree for CD200R1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD200R1: view image

Paralogs for CD200R1 Gene

Paralogs for CD200R1 Gene

(1) SIMAP similar genes for CD200R1 Gene using alignment to 3 proteins:

  • MO2R1_HUMAN
  • B7ZKV2_HUMAN
  • H9KV32_HUMAN

Pseudogenes.org Pseudogenes for CD200R1 Gene

genes like me logo Genes that share paralogs with CD200R1: view

Variants for CD200R1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD200R1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs2171509 - p.Arg89Lys
rs4596117 - p.Pro121Thr
rs9826308 - p.Gln177His
rs9865242 - p.Glu312Gln

Additional dbSNP identifiers (rs#s) for CD200R1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD200R1 Gene

Variant ID Type Subtype PubMed ID
esv3597428 CNV loss 21293372
nsv591293 CNV loss 21841781
nsv965199 CNV duplication 23825009

Variation tolerance for CD200R1 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD200R1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD200R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD200R1 Gene

Disorders for CD200R1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CD200R1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CD200R1

genes like me logo Genes that share disorders with CD200R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD200R1 Gene

Publications for CD200R1 Gene

  1. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PMID: 12960329) Wright GJ … Barclay AN (Journal of immunology (Baltimore, Md. : 1950) 2003) 3 4 23
  2. Distribution of OX2 antigen and OX2 receptor within retina. (PMID: 11133863) Dick AD … Wright GJ (Investigative ophthalmology & visual science 2001) 2 3 23
  3. The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions. (PMID: 24388216) Vaine CA … Soberman RJ (Advances in immunology 2014) 3 4
  4. Altered regulation of CD200 receptor in monocyte-derived macrophages from individuals with Parkinson's disease. (PMID: 19924532) Luo XG … Ding JQ (Neurochemical research 2010) 3 23
  5. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. (PMID: 19151626) Koning N … Huitinga I (Journal of neuropathology and experimental neurology 2009) 3 23

Products for CD200R1 Gene

Sources for CD200R1 Gene