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Aliases for CD200R1 Gene

Aliases for CD200R1 Gene

  • CD200 Receptor 1 2 3 5
  • Cell Surface Glycoprotein OX2 Receptor 1 3 4
  • CD200 Cell Surface Glycoprotein Receptor 3 4
  • MOX2 Receptor 2 3
  • CD200R 3 4
  • MOX2R 3 4
  • OX2R 3 4
  • Cell Surface Glycoprotein CD200 Receptor 1 3
  • Cell Surface Glycoprotein Receptor CD200 3
  • HCRTR2 3
  • CRTR2 4

External Ids for CD200R1 Gene

Previous HGNC Symbols for CD200R1 Gene

  • MOX2R

Previous GeneCards Identifiers for CD200R1 Gene

  • GC03M114122
  • GC03M112640
  • GC03M110025

Summaries for CD200R1 Gene

Entrez Gene Summary for CD200R1 Gene

  • This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD200R1 Gene

CD200R1 (CD200 Receptor 1) is a Protein Coding gene. Diseases associated with CD200R1 include Primary Hypertrophic Osteoarthropathy. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD200R1L.

UniProtKB/Swiss-Prot for CD200R1 Gene

  • Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Gene Wiki entry for CD200R1 Gene

Additional gene information for CD200R1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD200R1 Gene

Genomics for CD200R1 Gene

GeneHancer (GH) Regulatory Elements for CD200R1 Gene

Promoters and enhancers for CD200R1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I112972 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 556.6 +0.3 314 4.4 MEIS2 EBF1 BMI1 BATF IRF4 ZFHX2 NFATC1 ATF7 ETV6 NFE2 CD200R1 ENSG00000242770 NEPRO GTPBP8 LOC102723430 CD200R1L
GH03I112773 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 21.3 +198.1 198087 7.3 NFIB SIN3A RFX5 FOS IKZF2 RUNX3 SMARCC1 USF2 CEBPB REST CD200R1 ENSG00000242770 CD200R1L ATG3 LINC02042
GH03I112634 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +335.5 335528 10.2 PKNOX1 ZNF133 SIN3A ZNF2 POLR2B ARID2 ZNF143 FOS RUNX3 DEK CCDC80 CD200R1 ENSG00000242770 SPICE1 C3orf52 MIR567 SLC35A5 LINC01279
GH03I112812 Enhancer 0.9 Ensembl ENCODE 16.6 +161.3 161338 1.8 HDAC1 CTCF TEAD4 MAX EBF1 RAD21 ZBTB40 RELA CTBP1 ZNF766 CD200R1 CD200R1L GTPBP8 ENSG00000242770
GH03I112817 Enhancer 0.9 FANTOM5 Ensembl ENCODE 15.1 +156.8 156775 1.7 ZNF316 MAFG CEBPB NFE2 CEBPG FOS CD200R1 CD200R1L ATG3 SLC35A5 ENSG00000242770
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD200R1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD200R1 gene promoter:

Genomic Locations for CD200R1 Gene

Genomic Locations for CD200R1 Gene
chr3:112,921,057-112,975,122
(GRCh38/hg38)
Size:
54,066 bases
Orientation:
Minus strand
chr3:112,640,056-112,693,969
(GRCh37/hg19)

Genomic View for CD200R1 Gene

Genes around CD200R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD200R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD200R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD200R1 Gene

Proteins for CD200R1 Gene

  • Protein details for CD200R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD46-MO2R1_HUMAN
    Recommended name:
    Cell surface glycoprotein CD200 receptor 1
    Protein Accession:
    Q8TD46
    Secondary Accessions:
    • B3KWZ9
    • E9PCM9
    • Q52LJ7
    • Q6IS95
    • Q6UW94
    • Q6WHB8
    • Q8TD44
    • Q8TD45
    • Q8TD52

    Protein attributes for CD200R1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36620 Da
    Quaternary structure:
    • CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.

    Alternative splice isoforms for CD200R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD200R1 Gene

Post-translational modifications for CD200R1 Gene

  • The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.
  • Glycosylation at posLast=3737, posLast=4646, posLast=9393, posLast=9999, Asn162, posLast=195195, Asn210, and Asn224
  • Modification sites at PhosphoSitePlus

Other Protein References for CD200R1 Gene

Antibody Products

  • Abcam antibodies for CD200R1

No data available for DME Specific Peptides for CD200R1 Gene

Domains & Families for CD200R1 Gene

Gene Families for CD200R1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD200R1 Gene

Suggested Antigen Peptide Sequences for CD200R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TD46

UniProtKB/Swiss-Prot:

MO2R1_HUMAN :
  • Belongs to the CD200R family.
Family:
  • Belongs to the CD200R family.
genes like me logo Genes that share domains with CD200R1: view

Function for CD200R1 Gene

Molecular function for CD200R1 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Phenotypes From GWAS Catalog for CD200R1 Gene

Gene Ontology (GO) - Molecular Function for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD200R1: view
genes like me logo Genes that share phenotypes with CD200R1: view

Animal Models for CD200R1 Gene

MGI Knock Outs for CD200R1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD200R1 Gene

Localization for CD200R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD200R1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD200R1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD200R1: view

Pathways & Interactions for CD200R1 Gene

genes like me logo Genes that share pathways with CD200R1: view

Pathways by source for CD200R1 Gene

Gene Ontology (GO) - Biological Process for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD200R1: view

No data available for SIGNOR curated interactions for CD200R1 Gene

Drugs & Compounds for CD200R1 Gene

No Compound Related Data Available

Transcripts for CD200R1 Gene

Unigene Clusters for CD200R1 Gene

CD200 receptor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD200R1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for CD200R1 Gene

GeneLoc Exon Structure for
CD200R1
ECgene alternative splicing isoforms for
CD200R1

Expression for CD200R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD200R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD200R1 Gene

This gene is overexpressed in Spleen (x5.5).

Protein differential expression in normal tissues from HIPED for CD200R1 Gene

This gene is overexpressed in Liver, secretome (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD200R1 Gene



Protein tissue co-expression partners for CD200R1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD200R1 Gene:

CD200R1

SOURCE GeneReport for Unigene cluster for CD200R1 Gene:

Hs.309158

mRNA Expression by UniProt/SwissProt for CD200R1 Gene:

Q8TD46-MO2R1_HUMAN
Tissue specificity: Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.

Evidence on tissue expression from TISSUES for CD200R1 Gene

  • Liver(4)
  • Spleen(2.1)
  • Blood(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CD200R1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD200R1 Gene

Orthologs for CD200R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD200R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD200R1 33 34
  • 98.75 (n)
cow
(Bos Taurus)
Mammalia CD200R1L 33
  • 75.54 (n)
-- 34
  • 53 (a)
ManyToMany
CD200R1 34
  • 53 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CD200R1 33
  • 72.54 (n)
-- 34
  • 50 (a)
ManyToMany
-- 34
  • 49 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd200r1 33
  • 71.25 (n)
mouse
(Mus musculus)
Mammalia Cd200r1 33 16 34
  • 70.85 (n)
Cd200r2 34
  • 54 (a)
ManyToMany
Cd200r4 34
  • 50 (a)
ManyToMany
Cd200r3 34
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves CD200R1L 33 34
  • 56.69 (n)
CD200R1A 34
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731855 33
  • 51.19 (n)
Species where no ortholog for CD200R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD200R1 Gene

ENSEMBL:
Gene Tree for CD200R1 (if available)
TreeFam:
Gene Tree for CD200R1 (if available)

Paralogs for CD200R1 Gene

Paralogs for CD200R1 Gene

(1) SIMAP similar genes for CD200R1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD200R1 Gene

genes like me logo Genes that share paralogs with CD200R1: view

Variants for CD200R1 Gene

Sequence variations from dbSNP and Humsavar for CD200R1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000055881 -- 112,974,220(-) G/A intron_variant
rs1000070854 -- 112,966,139(-) G/T intron_variant
rs1000080573 -- 112,925,451(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000137894 -- 112,959,492(-) G/A intron_variant
rs1000298278 -- 112,944,708(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD200R1 Gene

Variant ID Type Subtype PubMed ID
esv3597428 CNV loss 21293372
nsv591293 CNV loss 21841781
nsv965199 CNV duplication 23825009

Variation tolerance for CD200R1 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD200R1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD200R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD200R1 Gene

Disorders for CD200R1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD200R1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary hypertrophic osteoarthropathy
  • pachydermoperiostosis of nail
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CD200R1

genes like me logo Genes that share disorders with CD200R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD200R1 Gene

Publications for CD200R1 Gene

  1. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PMID: 12960329) Wright GJ … Barclay AN (Journal of immunology (Baltimore, Md. : 1950) 2003) 3 4 22 58
  2. Distribution of OX2 antigen and OX2 receptor within retina. (PMID: 11133863) Dick AD … Wright GJ (Investigative ophthalmology & visual science 2001) 2 3 22 58
  3. The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions. (PMID: 24388216) Vaine CA … Soberman RJ (Advances in immunology 2014) 3 4 58
  4. Altered regulation of CD200 receptor in monocyte-derived macrophages from individuals with Parkinson's disease. (PMID: 19924532) Luo XG … Ding JQ (Neurochemical research 2010) 3 22 58
  5. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. (PMID: 19151626) Koning N … Huitinga I (Journal of neuropathology and experimental neurology 2009) 3 22 58

Products for CD200R1 Gene

Sources for CD200R1 Gene

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