This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Al... See more...

Aliases for CD200 Gene

Aliases for CD200 Gene

  • CD200 Molecule 2 3 5
  • CD200 Antigen 2 3 4
  • Antigen Identified By Monoclonal Antibody MRC OX-2 2 3
  • OX-2 Membrane Glycoprotein 3 4
  • MOX1 3 4
  • MOX2 3 4
  • OX-2 2 3
  • MRC 2 3
  • CD200 5

External Ids for CD200 Gene

Previous HGNC Symbols for CD200 Gene

  • MOX1
  • MOX2

Previous GeneCards Identifiers for CD200 Gene

  • GC03M109425
  • GC03P113534
  • GC03P112051
  • GC03P109436

Summaries for CD200 Gene

Entrez Gene Summary for CD200 Gene

  • This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for CD200 Gene

CD200 (CD200 Molecule) is a Protein Coding gene. Diseases associated with CD200 include Hairy Cell Leukemia and Bile Duct Cystadenoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is NECTIN2.

UniProtKB/Swiss-Prot Summary for CD200 Gene

  • Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Gene Wiki entry for CD200 Gene

Additional gene information for CD200 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD200 Gene

Genomics for CD200 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD200 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD200 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD200

Top Transcription factor binding sites by QIAGEN in the CD200 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • p53

Genomic Locations for CD200 Gene

Genomic Locations for CD200 Gene
chr3:112,332,347-112,362,812
(GRCh38/hg38)
Size:
30,466 bases
Orientation:
Plus strand
chr3:112,051,194-112,081,659
(GRCh37/hg19)
Size:
30,466 bases
Orientation:
Plus strand

Genomic View for CD200 Gene

Genes around CD200 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD200 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD200 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD200 Gene

Proteins for CD200 Gene

  • Protein details for CD200 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41217-OX2G_HUMAN
    Recommended name:
    OX-2 membrane glycoprotein
    Protein Accession:
    P41217
    Secondary Accessions:
    • B3KQI1
    • B4DLW9
    • D3DN65
    • Q6J2Q6
    • Q6PIQ4
    • Q8TB85
    • Q9H3J3

    Protein attributes for CD200 Gene

    Size:
    278 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    • CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

    Alternative splice isoforms for CD200 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD200 Gene

Post-translational modifications for CD200 Gene

  • Glycosylation at Asn95, Asn103, Asn110, Asn157, Asn181, and Asn190
  • Modification sites at PhosphoSitePlus

Antibody Products

Protein Products

No data available for DME Specific Peptides for CD200 Gene

Domains & Families for CD200 Gene

Gene Families for CD200 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD200 Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
  • Immunoglobulin V-type
ProtoNet:

Suggested Antigen Peptide Sequences for CD200 Gene

GenScript: Design optimal peptide antigens:
  • OX-2 membrane glycoprotein (OX2G_HUMAN)
genes like me logo Genes that share domains with CD200: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD200 Gene

Function for CD200 Gene

Molecular function for CD200 Gene

UniProtKB/Swiss-Prot Function:
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Phenotypes From GWAS Catalog for CD200 Gene

Gene Ontology (GO) - Molecular Function for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
GO:0086080 protein binding involved in heterotypic cell-cell adhesion ISS --
GO:0140081 glycosylated region protein binding TAS 10981966
genes like me logo Genes that share ontologies with CD200: view
genes like me logo Genes that share phenotypes with CD200: view

Animal Models for CD200 Gene

MGI Knock Outs for CD200:
  • Cd200 Cd200<tm1Jods>
  • Cd200 Cd200<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD200

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD200 Gene

Localization for CD200 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD200 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD200 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3032785
GO:0009986 cell surface TAS 9295026
GO:0016020 membrane IEA,NAS 12072366
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD200: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD200 Gene

Pathways & Interactions for CD200 Gene

genes like me logo Genes that share pathways with CD200: view

Pathways by source for CD200 Gene

Gene Ontology (GO) - Biological Process for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002695 negative regulation of leukocyte activation TAS 12072366
GO:0008285 negative regulation of cell proliferation ISS --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 26670206
GO:0032793 positive regulation of CREB transcription factor activity IDA 26670206
GO:0034113 heterotypic cell-cell adhesion ISS --
genes like me logo Genes that share ontologies with CD200: view

No data available for SIGNOR curated interactions for CD200 Gene

Drugs & Compounds for CD200 Gene

(3) Drugs for CD200 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 7499
Antibodies, Monoclonal Pharma 3764
Immunoglobulins Pharma 7499
genes like me logo Genes that share compounds with CD200: view

Transcripts for CD200 Gene

mRNA/cDNA for CD200 Gene

11 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD200

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD200 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - -
SP13:
SP14:
SP15: - - -
SP16: - - - - - - -
SP17:

ExUns: 11a · 11b · 11c ^ 12a · 12b · 12c · 12d
SP1: - -
SP2:
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14: -
SP15:
SP16:
SP17:

Relevant External Links for CD200 Gene

GeneLoc Exon Structure for
CD200

Expression for CD200 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD200 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD200 Gene

This gene is overexpressed in Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for CD200 Gene

This gene is overexpressed in Placenta (31.5), Frontal cortex (12.6), and Fetal Brain (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD200 Gene



Protein tissue co-expression partners for CD200 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD200

SOURCE GeneReport for Unigene cluster for CD200 Gene:

Hs.79015

Evidence on tissue expression from TISSUES for CD200 Gene

  • Nervous system(5)
  • Blood(4.6)
  • Lymph node(3)
  • Spleen(2.7)
  • Skin(2.7)
  • Heart(2.6)
  • Kidney(2.6)
  • Intestine(2.6)
  • Lung(2.5)
  • Muscle(2.4)
  • Eye(2.4)
  • Bone marrow(2.3)
  • Liver(2.3)
  • Pancreas(2.3)
  • Thyroid gland(2.2)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with CD200: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD200 Gene

Orthologs for CD200 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD200 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD200 30 31
  • 99.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CD200 30 31
  • 84.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD200 30 31
  • 82.83 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cd200 30 17 31
  • 81.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd200 30
  • 80.61 (n)
Oppossum
(Monodelphis domestica)
Mammalia CD200 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CD200 30 31
  • 53.68 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CD200 31
  • 33 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CD200 (1 of 3) 31
  • 17 (a)
OneToMany
CD200 (2 of 3) 31
  • 15 (a)
OneToMany
CD200 (3 of 3) 31
  • 15 (a)
OneToMany
Species where no ortholog for CD200 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CD200 Gene

ENSEMBL:
Gene Tree for CD200 (if available)
TreeFam:
Gene Tree for CD200 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD200: view image

Paralogs for CD200 Gene

genes like me logo Genes that share paralogs with CD200: view

Variants for CD200 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD200 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs1131199 - p.Ser11Cys
rs2272022 - p.Pro46Thr
rs35465733 - p.Val76Gly

Additional dbSNP identifiers (rs#s) for CD200 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD200 Gene

Variant ID Type Subtype PubMed ID
nsv10307 CNV gain 18304495
nsv591293 CNV loss 21841781

Variation tolerance for CD200 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD200 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD200

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD200 Gene

Disorders for CD200 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CD200 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
bile duct cystadenoma
  • cystadenoma of the bile duct
angioimmunoblastic t-cell lymphoma
  • aitl
mantle cell lymphoma
  • mcl
monofixation syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CD200 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD200

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CD200: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD200 Gene

Publications for CD200 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. CD200: a putative therapeutic target in cancer. (PMID: 18060862) Moreaux J … Klein B (Biochemical and biophysical research communications 2008) 3 23
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  4. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. (PMID: 16177086) Shiratori I … Arase H (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 23
  5. Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. (PMID: 15699757) Chen DX … Gorczynski RM (Transplantation 2005) 3 23

Products for CD200 Gene

Sources for CD200 Gene