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Aliases for CD2-LCR Gene

Aliases for CD2-LCR Gene

  • CD2 Locus Control Region 3
  • CD2 Lymphoctye-Specific Enhancer 3
  • CD2 T-Cell-Specific Enhancer 3
  • CD2 Dominant Control Region 3
  • CD2-DCR 3

External Ids for CD2-LCR Gene

Summaries for CD2-LCR Gene

Entrez Gene Summary for CD2-LCR Gene

  • This element represents a locus control region (LCR) that can confer T cell-specific, copy number-dependent, position-independent expression on the CD2 gene in transgenic mice. It is located immediately downstream of the 3' terminal exon of the CD2 gene, and is characterized by three DNase I hypersensitive sites and a core enhancer region. This LCR and the enhancer sub-region have been used to drive T cell-specific expression of several heterologous genes in various vector systems, including retroviral and lentiviral vectors. A truncated version of the LCR has been shown to be heterochromatin-sensitive, and has thus been useful for studying chromatin-related processes, such as triplet-repeat-associated position effect variegation. [provided by RefSeq, Jan 2016]

GeneCards Summary for CD2-LCR Gene

CD2-LCR (CD2 Locus Control Region) is an Uncategorized gene.

Additional gene information for CD2-LCR Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD2-LCR Gene

Genomics for CD2-LCR Gene

Genomic Locations for CD2-LCR Gene

Genomic Locations for CD2-LCR Gene
Unknown strand

Genomic View for CD2-LCR Gene

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CD2-LCR Gene

No data available for GeneHancer (GH) Regulatory Elements for CD2-LCR Gene

Function for CD2-LCR Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD2-LCR Gene

Localization for CD2-LCR Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CD2-LCR Gene

Pathways & Interactions for CD2-LCR Gene

SuperPathways for CD2-LCR Gene

No Data Available

Interacting Proteins for CD2-LCR Gene

Gene Ontology (GO) - Biological Process for CD2-LCR Gene


No data available for Pathways by source and SIGNOR curated interactions for CD2-LCR Gene

Drugs & Compounds for CD2-LCR Gene

No Compound Related Data Available

Transcripts for CD2-LCR Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CD2-LCR Gene

No ASD Table

No data available for mRNA/cDNA for CD2-LCR Gene

Expression for CD2-LCR Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD2-LCR Gene

Orthologs for CD2-LCR Gene

No data available for Orthologs and Evolution for CD2-LCR Gene

Paralogs for CD2-LCR Gene

No data available for Paralogs for CD2-LCR Gene

Variants for CD2-LCR Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for CD2-LCR Gene

Disorders for CD2-LCR Gene

No disorders were found for CD2-LCR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for CD2-LCR Gene

Publications for CD2-LCR Gene

  1. Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. (PMID: 24586197) Huser CA … Neil JC (PLoS genetics 2014) 3 58
  2. LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. (PMID: 24465765) Smith S … Davé UP (PloS one 2014) 3 58
  3. Neoplastic transformation of T lymphocytes through transgenic expression of a virus host modification protein. (PMID: 22558084) Almeida SC … Parkhouse RM (PloS one 2012) 3 58
  4. Modulation of the murine CD8 gene complex following the targeted integration of human CD2-locus control region sequences. (PMID: 21880987) Menzel U … Kioussis D (Journal of immunology (Baltimore, Md. : 1950) 2011) 3 58
  5. Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages. (PMID: 20837519) Menzel U … Kioussis D (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 58

Products for CD2-LCR Gene

Sources for CD2-LCR Gene

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