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The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]
CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Mastocytosis, Cutaneous and Mastocytosis. Among its related pathways are ERK Signaling and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is LY9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IPI | 17344209 |
GO:0005515 | protein binding | IPI | 1970422 |
GO:0019901 | protein kinase binding | IEA | -- |
GO:0030971 | receptor tyrosine kinase binding | IEA | -- |
GO:0038023 | signaling receptor activity | NAS | 7544493 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0005887 | integral component of plasma membrane | NAS | 7544493 |
GO:0005911 | cell-cell junction | IEA | -- |
GO:0009897 | external side of plasma membrane | IEA,IDA | 21460847 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
|
3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
5 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
PAK Pathway
.56
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001766 | membrane raft polarization | TAS | 11376005 |
GO:0006915 | apoptotic process | TAS | 9270771 |
GO:0007155 | cell adhesion | IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | TAS | 10575274 |
GO:0030101 | natural killer cell activation | NAS | 12714509 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cd2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CD2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD2 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100487379 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35591188 | Benign: not provided | 116,768,672(+) |
G/A NM_001767.5(CD2):c.945G>A (p.Pro315=) |
SYNONYMOUS | |
rs864622018 | Uncertain Significance: Malignant tumor of prostate | 116,768,701(+) |
G/C NM_001767.5(CD2):c.974G>C (p.Gly325Ala) |
MISSENSE | |
VAR_035504 | A breast cancer sample |
p.Cys217Tyr |
|||
rs35880225 | - |
p.His339Asn |
|||
rs699738 | - |
p.His266Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2716618 | CNV | deletion | 23290073 |
esv3587305 | CNV | loss | 21293372 |
nsv2555 | CNV | insertion | 18451855 |
nsv831148 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mastocytosis, cutaneous |
|
|
mastocytosis |
|
|
benign mastocytoma |
|
|
extracutaneous mastocytoma |
|
|
systemic epstein-barr virus-positive t-cell lymphoma of childhood |
|
|