Aliases for CD2 Gene
External Ids for CD2 Gene
Previous HGNC Symbols for CD2 Gene
Previous GeneCards Identifiers for CD2 Gene
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]
GeneCards Summary for CD2 Gene
CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Supine Hypotensive Syndrome and Penis Squamous Cell Carcinoma. Among its related pathways are TGF-Beta Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SLAMF7.
UniProtKB/Swiss-Prot Summary for CD2 Gene
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.