The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016] See more...

Aliases for CD2 Gene

Aliases for CD2 Gene

  • CD2 Molecule 2 3 5
  • CD2 Antigen (P50), Sheep Red Blood Cell Receptor 2 3
  • T-Cell Surface Antigen T11/Leu-5 3 4
  • T-Cell Surface Antigen CD2 3 4
  • Erythrocyte Receptor 3 4
  • Rosette Receptor 3 4
  • LFA-3 Receptor 3 4
  • LFA-2 3 4
  • SRBC 3 4
  • Lymphocyte-Function Antigen-2 3
  • CD2 Antigen 4
  • T11 3

External Ids for CD2 Gene

Previous HGNC Symbols for CD2 Gene

  • SRBC

Previous GeneCards Identifiers for CD2 Gene

  • GC01P117800
  • GC01P116179
  • GC01P116444
  • GC01P116643
  • GC01P117009
  • GC01P117098
  • GC01P117297
  • GC01P115156

Summaries for CD2 Gene

Entrez Gene Summary for CD2 Gene

  • The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]

GeneCards Summary for CD2 Gene

CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Mastocytosis, Cutaneous and Mastocytosis. Among its related pathways are Hematopoietic cell lineage and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CD84.

UniProtKB/Swiss-Prot Summary for CD2 Gene

  • CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Gene Wiki entry for CD2 Gene

Additional gene information for CD2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD2 Gene

Genomics for CD2 Gene

GeneHancer (GH) Regulatory Elements for CD2 Gene

Promoters and enhancers for CD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J116752 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 507.9 +8.4 8385 20.4 CTCF PHB2 EP300 ZBTB11 AFF1 REST KLF4 RELA HES1 MYC CD2 ATP1A1 TTF2 FTH1P22 lnc-IGSF3-4
GH01J116908 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 +156.1 156137 4 HNRNPK ZBTB40 ZNF217 NRF1 ZFX ZIC2 POLR2A ZBTB10 ZNF263 ZBTB11 ENSG00000272715 PTGFRN MAN1A2 CD2 piR-57133-032
GH01J116803 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 14.7 +52.7 52727 7.5 NRF1 PHB2 CTBP1 LEF1 NCOR1 ZNF316 NFIC ARNT TRIM28 FOS lnc-IGSF3-1 CD2 CD101 piR-35031-003
GH01J116823 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +71.8 71768 4.9 CTCF SP1 GTF2E2 JUND PHB2 ZBTB5 EP300 ZIC2 ZBTB11 ZNF423 MAN1A2 IGSF3 CD2 PTGFRN MIR320B1 ATP1A1-AS1 lnc-IGSF3-1 piR-35031-003
GH01J116555 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.1 -196.2 -196244 6.2 ZBTB40 NRF1 SP1 ZNF639 EP300 POLR2A DNMT1 RELA MYC TRIM22 MIR548AC lnc-ATP1A1-1 CD58 ATP1A1 CD2 CD101
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD2

Top Transcription factor binding sites by QIAGEN in the CD2 gene promoter:
  • AML1a
  • c-Myc
  • CREB
  • deltaCREB
  • E47
  • IRF-1
  • Max1
  • Pax-5
  • STAT5A

Genomic Locations for CD2 Gene

Genomic Locations for CD2 Gene
chr1:116,754,430-116,769,229
(GRCh38/hg38)
Size:
14,800 bases
Orientation:
Plus strand
chr1:117,297,007-117,311,851
(GRCh37/hg19)
Size:
14,845 bases
Orientation:
Plus strand

Genomic View for CD2 Gene

Genes around CD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD2 Gene

Proteins for CD2 Gene

  • Protein details for CD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06729-CD2_HUMAN
    Recommended name:
    T-cell surface antigen CD2
    Protein Accession:
    P06729
    Secondary Accessions:
    • Q96TE5

    Protein attributes for CD2 Gene

    Size:
    351 amino acids
    Molecular mass:
    39448 Da
    Quaternary structure:
    • Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (PubMed:10380930). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (PubMed:9857189).

    Three dimensional structures from OCA and Proteopedia for CD2 Gene

neXtProt entry for CD2 Gene

Post-translational modifications for CD2 Gene

  • Glycosylation at Asn89, Asn141, and Asn150
  • Ubiquitination at Lys264 and Lys310
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CD2_HUMAN (586)

Other Protein References for CD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CD2

No data available for DME Specific Peptides for CD2 Gene

Domains & Families for CD2 Gene

Gene Families for CD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD2 Gene

Blocks:
  • T-cell surface antigen CD2
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD2 Gene

GenScript: Design optimal peptide antigens:
  • T-cell surface antigen T11/Leu-5 (CD2_HUMAN)
  • cDNA, FLJ94184, highly similar to Homo sapiens CD2 antigen (p50), sheep red blood cell receptor (CD2), mRNA (Q53F96_HUMAN)
genes like me logo Genes that share domains with CD2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD2 Gene

Function for CD2 Gene

Molecular function for CD2 Gene

UniProtKB/Swiss-Prot Function:
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
GENATLAS Biochemistry:
cell differentiation antigen CD2 (p50),50kDa,membrane glycoprotein,SRBC receptor,LFA3 receptor,identified by monoclonal antibodies 9.6,T11,35.1,M-T910,expressed on all T cells,thymocytes and NK cells,involved in antigen recognition via its role in adhesion and signal transduction,interacting with CD58 prior antigen recognition by TCR,interacting with an adaptor protein (CDC2BP) to trigger cell adhesion,including a 3' locus control region LCR-CD2

Phenotypes From GWAS Catalog for CD2 Gene

Gene Ontology (GO) - Molecular Function for CD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 17344209
GO:0005515 protein binding IPI 1970422
GO:0019901 protein kinase binding IEA --
GO:0030971 receptor tyrosine kinase binding IEA --
GO:0038023 signaling receptor activity NAS 7544493
genes like me logo Genes that share ontologies with CD2: view
genes like me logo Genes that share phenotypes with CD2: view

Animal Models for CD2 Gene

MGI Knock Outs for CD2:
  • Cd2 Cd2<tm1Litt>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CD2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD2 Gene

Localization for CD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 4
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 7544493
GO:0005911 cell-cell junction IEA --
GO:0009897 external side of plasma membrane IEA,IDA 21460847
genes like me logo Genes that share ontologies with CD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD2 Gene

Pathways & Interactions for CD2 Gene

PathCards logo

SuperPathways for CD2 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 PAK Pathway
.56
.56
genes like me logo Genes that share pathways with CD2: view

Pathways by source for CD2 Gene

25 Qiagen pathways for CD2 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling
1 Cell Signaling Technology pathway for CD2 Gene

Gene Ontology (GO) - Biological Process for CD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001766 membrane raft polarization TAS 11376005
GO:0006915 apoptotic process TAS 9270771
GO:0007155 cell adhesion IEA --
GO:0007166 cell surface receptor signaling pathway TAS 10575274
GO:0030101 natural killer cell activation NAS 12714509
genes like me logo Genes that share ontologies with CD2: view

No data available for SIGNOR curated interactions for CD2 Gene

Drugs & Compounds for CD2 Gene

(9) Drugs for CD2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alefacept Approved, Investigational, Withdrawn Pharma Target, inhibitor 40
Siplizumab Investigational Pharma Target, antibody 0

(8) Additional Compounds for CD2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD2: view

Transcripts for CD2 Gene

mRNA/cDNA for CD2 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CD2

Alternative Splicing Database (ASD) splice patterns (SP) for CD2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for CD2 Gene

GeneLoc Exon Structure for
CD2

Expression for CD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD2 Gene

This gene is overexpressed in Whole Blood (x21.9), Spleen (x7.1), and Small Intestine - Terminal Ileum (x5.6).

Protein differential expression in normal tissues from HIPED for CD2 Gene

This gene is overexpressed in Bone marrow stromal cell (15.2), Peripheral blood mononuclear cells (13.9), CD8 Tcells (11.6), Lymph node (9.7), NK cells (8.5), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD2 Gene



Protein tissue co-expression partners for CD2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD2

SOURCE GeneReport for Unigene cluster for CD2 Gene:

Hs.523500

Evidence on tissue expression from TISSUES for CD2 Gene

  • Spleen(4.8)
  • Pancreas(4.1)
  • Blood(3.8)
  • Kidney(3.7)
  • Lymph node(3.3)
  • Bone marrow(2.9)
  • Intestine(2.6)
  • Lung(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with CD2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD2 Gene

Orthologs for CD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD2 31 30
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD2 31 30
  • 73.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CD2 31 30
  • 71.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd2 30
  • 69.35 (n)
mouse
(Mus musculus)
Mammalia Cd2 17 31 30
  • 67.25 (n)
oppossum
(Monodelphis domestica)
Mammalia CD2 31
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD2 31 30
  • 50.23 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487379 30
  • 44.9 (n)
Species where no ortholog for CD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD2 Gene

ENSEMBL:
Gene Tree for CD2 (if available)
TreeFam:
Gene Tree for CD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD2: view image

Paralogs for CD2 Gene

Paralogs for CD2 Gene

genes like me logo Genes that share paralogs with CD2: view

Variants for CD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
791111 Benign: not provided 116,768,672(+) G/A SYNONYMOUS_VARIANT
rs864622018 Uncertain Significance: Malignant tumor of prostate 116,768,701(+) G/C MISSENSE_VARIANT
VAR_035504 A breast cancer sample p.Cys217Tyr
rs35880225 - p.His339Asn
rs699738 - p.His266Gln

Additional dbSNP identifiers (rs#s) for CD2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD2 Gene

Variant ID Type Subtype PubMed ID
esv2716618 CNV deletion 23290073
esv3587305 CNV loss 21293372
nsv2555 CNV insertion 18451855
nsv831148 CNV gain 17160897

Variation tolerance for CD2 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD2 Gene

Human Gene Mutation Database (HGMD)
CD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD2 Gene

Disorders for CD2 Gene

MalaCards: The human disease database

(48) MalaCards diseases for CD2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mastocytosis, cutaneous
  • mastc
mastocytosis
  • mast cell hyperplasia
extracutaneous mastocytoma
  • mast cell neoplasm
lepromatous leprosy
  • type l leprosy
systemic mastocytosis
  • corneal dystrophy, subepithelial mucinous
- elite association - COSMIC cancer census association via MalaCards
Search CD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD2 Gene

Publications for CD2 Gene

  1. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. (PMID: 2437578) Seed B … Aruffo A (Proceedings of the National Academy of Sciences of the United States of America 1987) 2 3 4 54
  2. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PMID: 19898481) Raychaudhuri S … Plenge RM (Nature genetics 2009) 3 41 54
  3. Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1. (PMID: 19586919) Clarkson NG … Brown MH (The Journal of biological chemistry 2009) 3 23 54
  4. The expression of CD2 in chronic HBV infection. (PMID: 18318997) Li J … Xie M (Cellular & molecular immunology 2008) 3 23 54
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54

Products for CD2 Gene

Sources for CD2 Gene