Aliases for CD2 Gene
External Ids for CD2 Gene
Previous HGNC Symbols for CD2 Gene
Previous GeneCards Identifiers for CD2 Gene
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]
GeneCards Summary for CD2 Gene
CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Mastocytosis, Cutaneous and Mastocytosis. Among its related pathways are Hematopoietic cell lineage and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CD84.
UniProtKB/Swiss-Prot Summary for CD2 Gene
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.