Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD... See more...
Aliases for CD1D Gene
Aliases for CD1D Gene
External Ids for CD1D Gene
- HGNC: 1637
- Entrez Gene: 912
- Ensembl: ENSG00000158473
- OMIM: 188410
- UniProtKB: P15813
Previous GeneCards Identifiers for CD1D Gene
- GC01P155941
- GC01P153882
- GC01P154927
- GC01P155366
- GC01P154962
- GC01P156416
- GC01P158149
- GC01P129508
Summaries for CD1D Gene
-
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
GeneCards Summary for CD1D Gene
CD1D (CD1d Molecule) is a Protein Coding gene. Diseases associated with CD1D include Mycobacterium Malmoense and Glottis Neoplasm. Among its related pathways are Hematopoietic cell lineage and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding. An important paralog of this gene is CD1E.
UniProtKB/Swiss-Prot Summary for CD1D Gene
-
Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
Additional gene information for CD1D Gene
- HGNC(1637)
- Entrez Gene(912)
- Ensembl(ENSG00000158473)
- OMIM(188410)
- UniProtKB(P15813)
- Open Targets Platform(ENSG00000158473)
- Search for CD1D at DataMed
- Search for CD1D at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD1D Gene
Genomics for CD1D Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CD1D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD1D on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD1D
- Top Transcription factor binding sites by QIAGEN in the CD1D gene promoter:
-
- AML1a
- AREB6
- E47
- FOXD3
- HOXA5
- POU2F1
- POU2F1a
- PPAR-gamma1
- STAT3
Genomic Locations for CD1D Gene
Genomic Locations for CD1D Gene
- chr1:158,178,030-158,186,427
- (GRCh38/hg38)
- Size:
- 8,398 bases
- Orientation:
- Plus strand
- chr1:158,149,737-158,156,217
- (GRCh37/hg19)
- Size:
- 6,481 bases
- Orientation:
- Plus strand
Genomic View for CD1D Gene
Genes around CD1D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.1 by HGNC
- 1q23.1 by Entrez Gene
- 1q23.1 by Ensembl
CD1D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD1D Gene
Proteins for CD1D Gene
-
Protein details for CD1D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15813-CD1D_HUMAN
- Recommended name:
- Antigen-presenting glycoprotein CD1d
- Protein Accession:
- P15813
- D3DVD5
- Q5W0J3
- Q9UMM3
- Q9Y5M4
Protein attributes for CD1D Gene
- Size:
- 335 amino acids
- Molecular mass:
- 37717 Da
- Quaternary structure:
-
- Heterodimer with B2M (beta-2-microglobulin). Interacts with MHC II.
- Miscellaneous:
-
- During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.
Protein Expression for CD1D Gene
Post-translational modifications for CD1D Gene
Other Protein References for CD1D Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CD1D Antibody and Immunotag™ CD1D Polyclonal Antibody
- NSJ Bioreagents CD1d Antibody
-
BioLegend
- CD1d Antibody (350306)
- CD1d Antibody (350302)
- CD1d Antibody (350308)
- CD1d Antibody (350305)
- CD1d Antibody (350307)
- PerCP/Cyanine5.5 CD1d Antibody (350311)
- CD1d Antibody (350310)
- CD1d Antibody (350309)
- PerCP/Cyanine5.5 CD1d Antibody (350312)
- CD1d Antibody (350314)
- CD1d Antibody (350316)
- CD1d Antibody (350315)
- TotalSeq(TM)-A0164 CD1d Antibody
-
Custom Antibody ServicesOriGene Antibodies for CD1D
- Novus Biologicals Antibodies for CD1D
-
Abcam antibodies for CD1D
- Invitrogen Antibodies for CD1D (AFLGC-CD1D)
- antibodies-online: Show 55 available CD1d Antibodies ranked by validation data
- Compare Top CD1d Antibodies
-
Recommended
- 75 WB Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 11 IHC (fro) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 46 FACS Antibodies (anti-mouse)
- 25 WB Antibodies (anti-mouse)
- 16 IHC Antibodies (anti-mouse)
- 10 IP Antibodies (anti-mouse)
- 4 IF Antibodies (anti-mouse)
- 4 ICFC Antibodies (anti-mouse)
- 26 WB Antibodies (anti-rat)
- 10 FACS Antibodies (anti-rat)
- 1 ICFC Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD1D
- Sino Biological Antibodies for CD1D
Protein Products
-
OriGene Purified Proteins for CD1D
- Search Origene for MassSpec and Protein Over-expression Lysates for CD1D
- Origene Custom Protein Services for CD1D
- Sino Biological Recombinant Proteins for CD1D
- Sino Biological Cell Lysates for CD1D
- ProSpec Recombinant Proteins for CD1D
-
Abcam proteins for CD1D
Assay Products
- antibodies-online: Show 3 available CD1d Elisa Kits ranked by validation data
- Compare Top CD1d Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CD1D Gene
Domains & Families for CD1D Gene
Gene Families for CD1D Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Predicted membrane proteins
Protein Domains for CD1D Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-type
- ProtoNet:
Suggested Antigen Peptide Sequences for CD1D Gene
- GenScript: Design optimal peptide antigens:
-
- R3G1 (CD1D_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD1D Gene
Function for CD1D Gene
Molecular function for CD1D Gene
- UniProtKB/Swiss-Prot Function:
- Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
- GENATLAS Biochemistry:
- cell differentiation antigen CD1D,49kDa,cell surface molecule,B2M associated,identified by monoclonal antibody NOR3.2 expressed on a cortical thymocyte cell line (see CD1@)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 30126976 |
| GO:0030881 | beta-2-microglobulin binding | TAS | 14500461 |
| GO:0030882 | lipid antigen binding | IDA | 19124746 |
| GO:0030883 | endogenous lipid antigen binding | IBA | 21873635 |
| GO:0030884 | exogenous lipid antigen binding | IDA | 10523605 |
Phenotypes for CD1D Gene
- MGI mutant phenotypes for CD1D:
-
inferred from 6 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for CD1D:
Animal Models for CD1D Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD1D - Select products 50% OFF >
- * CD1D CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD1D
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD1D
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD1D
miRNA for CD1D Gene
- miRTarBase miRNAs that target CD1D
-
- hsa-miR-335-5p (MIRT019031)
- hsa-miR-8081 (MIRT445986)
- hsa-miR-627-5p (MIRT445987)
- hsa-miR-937-5p (MIRT445988)
- hsa-miR-5702 (MIRT445989)
- hsa-miR-5582-3p (MIRT445990)
- hsa-miR-548x-3p (MIRT445991)
- hsa-miR-548j-3p (MIRT445992)
- hsa-miR-548aq-3p (MIRT445993)
- hsa-miR-548am-3p (MIRT445994)
- hsa-miR-548aj-3p (MIRT445995)
- hsa-miR-548ah-3p (MIRT445996)
- hsa-miR-548ae-3p (MIRT445997)
- hsa-miR-548z (MIRT445998)
- hsa-miR-548h-3p (MIRT445999)
- hsa-miR-548d-3p (MIRT446000)
- hsa-miR-548ac (MIRT446001)
- hsa-miR-548bb-3p (MIRT446002)
- hsa-miR-3674 (MIRT528761)
- hsa-miR-744-3p (MIRT528762)
- hsa-miR-4423-5p (MIRT528763)
- hsa-miR-6501-5p (MIRT528764)
- hsa-miR-4732-5p (MIRT528765)
- hsa-miR-6832-5p (MIRT528766)
- hsa-miR-4524a-3p (MIRT528767)
- hsa-miR-1304-3p (MIRT528768)
- hsa-miR-4781-3p (MIRT528769)
- hsa-miR-1182 (MIRT528770)
- hsa-miR-4478 (MIRT528771)
- hsa-miR-4419b (MIRT528772)
- hsa-miR-3929 (MIRT528773)
- hsa-miR-4524b-3p (MIRT528774)
- hsa-miR-7856-5p (MIRT646051)
- hsa-miR-4477b (MIRT646052)
- hsa-miR-506-3p (MIRT646053)
- hsa-miR-124-3p (MIRT646054)
- hsa-miR-3120-3p (MIRT646055)
- hsa-miR-3910 (MIRT646056)
- hsa-miR-3714 (MIRT646057)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD1D
- Browse OriGene Inhibitory RNA Products For CD1D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD1D
Clone Products
- Applied Biological Materials (abm): Clones for CD1D - Select products 50% OFF >
- * CD1D as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CD1D
- Addgene plasmids for CD1D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD1D
Cell Line Products
-
Horizon Cell Lines for CD1D
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD1D Gene
Localization for CD1D Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD1D Gene
- Cell membrane. Single-pass type I membrane protein. Basolateral cell membrane. Single-pass type I membrane protein. Endosome membrane. Single-pass type I membrane protein. Lysosome membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. {ECO:0000269 PubMed:9973405}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| endoplasmic reticulum | 4 |
| endosome | 4 |
| lysosome | 4 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Endoplasmic reticulum (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005737 | cytoplasm | IDA | 19124746 |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
Pathways & Interactions for CD1D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Amoebiasis | ||
| 2 | Hematopoietic cell lineage | ||
| 3 | Tight junction | ||
| 4 | Dendritic Cells Developmental Lineage Pathway | ||
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for CD1D Gene
3 Reactome pathways for CD1D Gene
3 KEGG pathways for CD1D Gene
1 R&D Systems pathway for CD1D Gene
Interacting Proteins for CD1D Gene
Selected Interacting proteins:
P15813-CD1D_HUMAN
ENSP00000357153
for CD1D Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CD1D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001916 | positive regulation of T cell mediated cytotoxicity | IBA | 21873635 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006955 | immune response | IBA | 21873635 |
| GO:0016045 | detection of bacterium | TAS | 14500461 |
| GO:0034113 | heterotypic cell-cell adhesion | TAS | 19124746 |
No data available for SIGNOR curated interactions for CD1D Gene
Drugs & Compounds for CD1D Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cis-tetracosenoyl sulfatide | Experimental | Pharma | Target | 0 | ||
| Phytosphingosine | Experimental | Pharma | 0 | |||
| Sphingosine | Experimental | Pharma | 0 | |||
| sphinganine | Pharma | 0 | ||||
| Sphingosine-1-phosphate | Pharma | Agonist, Full agonist | endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3-Dehydrosphinganine |
|
16105-69-4 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/12:0) |
|
852100-88-0 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/14:0) |
|
|
||||
| 3-O-Sulfogalactosylceramide (d18:1/16:0) |
|
862509-48-6 |
|
|||
| 3-O-Sulfogalactosylceramide (d18:1/18:0) |
|
244215-65-4 |
|
Transcripts for CD1D Gene
mRNA/cDNA for CD1D Gene
- 5 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368171 3607 nts (view in UCSC)
- ENST00000673723 3784 nts
- ENST00000673623 3219 nts
- ENST00000674023 882 nts
- ENST00000674085 3492 nts
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD1D - Select products 50% OFF >
- * CD1D CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD1D
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD1D
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD1D
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD1D
- Browse OriGene Inhibitory RNA Products For CD1D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD1D
Clone Products
- Applied Biological Materials (abm): Clones for CD1D - Select products 50% OFF >
- * CD1D as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CD1D
- Addgene plasmids for CD1D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD1D
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: | - | - |
Relevant External Links for CD1D Gene
- GeneLoc Exon Structure for
- CD1D
Expression for CD1D Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Double Negative 4 Thymocytes Thymus
- Double Positive Thymocytes Thymus
- Double Negative 3 Thymocytes Thymus
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Thymus (Hematopoietic System)
- Double Negative 4 Thymocytes Thymus
- Double Positive Thymocytes Thymus
- Double Negative 3 Thymocytes Thymus
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
mRNA differential expression in normal tissues according to GTEx for CD1D Gene
This gene is overexpressed in Whole Blood (x9.9), Spleen (x8.6), Small Intestine - Terminal Ileum (x5.5), and Liver (x4.9).
This gene is overexpressed in Lung (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD1D Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD1D
SOURCE GeneReport for Unigene cluster for CD1D Gene:
Hs.1799mRNA Expression by UniProt/SwissProt for CD1D Gene:
P15813-CD1D_HUMAN
Tissue specificity:
Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Evidence on tissue expression from TISSUES for CD1D Gene
- Pancreas(4.4)
- Blood(3.8)
- Lymph node(3.8)
- Spleen(3.7)
- Liver(3)
- Bone marrow(3)
- Skin(3)
- Intestine(3)
- Lung(2.8)
- Nervous system(2.8)
- Heart(2.6)
- Kidney(2.4)
- Muscle(2.4)
- Bone(2.2)
Primer Products
-
OriGene qPCR primer pairs for CD1D
-
OriGene qPCR primer pairs and template standards for CD1D
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD1D Gene
Orthologs for CD1D Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CD1D 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LOC788175 30 |
|
||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| CD1D 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Cd1d1 30 17 31 |
|
OneToMany | |
| Cd1d2 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Cd1d1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | CD1D 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CD1A1 31 |
|
ManyToMany | |
| CD1.2 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
- Species where no ortholog for CD1D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CD1D Gene
- ENSEMBL:
- Gene Tree for CD1D (if available)
- TreeFam:
- Gene Tree for CD1D (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD1D: view image
Paralogs for CD1D Gene
Paralogs for CD1D Gene
Variants for CD1D Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD1D Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 724721 | Likely Benign: not provided | 158,181,538(+) | T/C | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 775613 | Benign: not provided | 158,181,583(+) | A/T | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| rs62621276 | - | p.Thr64Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3578208 | CNV | loss | 25503493 |
| nsv999542 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.67;
31.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD1D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD1D
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD1D Gene
Disorders for CD1D Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mycobacterium malmoense |
|
|
| glottis neoplasm |
|
|
| cerebellar vermis medulloblastoma |
|
|
| langerhans cell sarcoma |
|
|
| non-langerhans-cell histiocytosis |
|
|
Search CD1D in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD1D
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CD1D Gene
Publications for CD1D Gene
- CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. (PMID: 17581592) Borg NA … Rossjohn J (Nature 2007) 3 4 23
- Susceptibility to Guillain-Barré syndrome is associated to polymorphisms of CD1 genes. (PMID: 16820217) Caporale CM … Uncini A (Journal of neuroimmunology 2006) 3 23 41
- Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules. (PMID: 11927549) Kang SJ … Cresswell P (The EMBO journal 2002) 3 4 23
- Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule. (PMID: 2463622) Balk SP … Terhorst C (Proceedings of the National Academy of Sciences of the United States of America 1989) 2 3 4
- Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness. (PMID: 19651460) Balreira A … Arosa FA (Immunobiology 2010) 3 23
ExternalLinks
Products for CD1D Gene
- View all 2 R&D Systems CD1D (CD1d) Products
- View all R&D Systems CD1D (CD1d1) Products
- View all R&D Systems CD1D (CD1d) Primary Antibodies
- View all R&D Systems CD1D (CD1d1) Primary Antibodies
- View all R&D Systems CD1D (CD1d) cDNA Clones
- Learn more about R&D Systems custom CD1D antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CD1D
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CD1D
- Search Origene for MassSpec and Protein Over-expression Lysates for CD1D
- Origene Custom Protein Services for CD1D
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD1D
- Browse OriGene Inhibitory RNA Products For CD1D
- OriGene qPCR primer pairs for CD1D
- OriGene qPCR primer pairs and template standards for CD1D
- OriGene CRISPR knockouts for CD1D
- OriGene ORF clones in human for CD1D
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD1D
- Sino Biological Human cDNA Clone for CD1D
- Sino Biological Recombinant Proteins for CD1D
- Sino Biological Cell Lysates for CD1D
- Sino Biological Antibodies for CD1D
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CD1D
- Novus Biologicals proteins and lysates for CD1D
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CD1D
- Abcam proteins for CD1D
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for CD1D (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CD1D (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CD1D (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CD1D CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CD1D
- Addgene plasmids for CD1D
- antibodies-online: Show 55 available CD1d Antibodies ranked by validation data
- Compare Top CD1d Antibodies
- Recommended
- 75 WB Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 11 IHC (fro) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 46 FACS Antibodies (anti-mouse)
- 25 WB Antibodies (anti-mouse)
- 16 IHC Antibodies (anti-mouse)
- 10 IP Antibodies (anti-mouse)
- 4 IF Antibodies (anti-mouse)
- 4 ICFC Antibodies (anti-mouse)
- 26 WB Antibodies (anti-rat)
- 10 FACS Antibodies (anti-rat)
- 1 ICFC Antibody (anti-rat)
- antibodies-online: Show 3 available CD1d Elisa Kits ranked by validation data
- Compare Top CD1d Elisa Kits
- Quality Products:
- antibodies-online: Show 20 available CD1d Proteins ranked by validation data
- Compare Top CD1d Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CD1D
- Search Santa Cruz Biotechnology (SCBT) for CD1D siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD1D
- Horizon Cell Lines for CD1D
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD1D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD1D
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CD1D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD1D
Sources for CD1D Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB