Free for academic non-profit institutions. Other users need a Commercial license
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19214191 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IEA,IDA | 16672701 |
GO:0009897 | external side of plasma membrane | IEA,IDA | 17213291 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | GAB1 signalosome |
.89
|
|
3 | B cell receptor signaling pathway (KEGG) | ||
4 | HIV Life Cycle |
.45
|
|
5 | Downstream signaling events of B Cell Receptor (BCR) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001923 | B-1 B cell differentiation | IEA | -- |
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002322 | B cell proliferation involved in immune response | IMP | 16672701 |
GO:0002376 | immune system process | IEA | -- |
GO:0016064 | immunoglobulin mediated immune response | IMP | 16672701 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1533,1533 | ||
Tyrosine | Approved, Investigational | Nutra | 1044 | |||
Axicabtagene ciloleucel | Approved | Pharma | Target, antibody | 0 | ||
Blinatumomab | Approved, Investigational | Pharma | Target, activator | 64 | ||
Inebilizumab | Approved, Investigational | Pharma | Target, binder | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD19 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD19 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD19 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cd19 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd19 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | CD19 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
638466 | Uncertain Significance: Common variable immunodeficiency 3 | 28,936,558(+) | T/C | MISSENSE_VARIANT | |
714703 | Likely Benign: not provided | 28,937,498(+) | T/C | SYNONYMOUS_VARIANT | |
715310 | Likely Benign: not provided | 28,938,677(+) | G/T | SYNONYMOUS_VARIANT | |
721238 | Likely Benign: not provided | 28,932,515(+) | C/T | SYNONYMOUS_VARIANT | |
723603 | Conflicting Interpretations: Common variable immunodeficiency 3; not provided | 28,932,404(+) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2830n100 | CNV | gain | 25217958 |
dgv2831n100 | CNV | gain | 25217958 |
dgv4987n54 | CNV | gain | 21841781 |
esv2758640 | CNV | gain+loss | 17122850 |
esv3570454 | CNV | gain | 25503493 |
esv3892826 | CNV | gain+loss | 25118596 |
nsv1059555 | CNV | gain | 25217958 |
nsv518648 | CNV | loss | 19592680 |
nsv519100 | CNV | gain | 19592680 |
nsv571805 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency, common variable, 3 |
|
|
common variable immunodeficiency |
|
|
immunodeficiency, common variable, 2 |
|
|
transient hypogammaglobulinemia |
|
|
transient hypogammaglobulinemia of infancy |
|
|