CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recogni... See more...

Aliases for CD180 Gene

Aliases for CD180 Gene

  • CD180 Molecule 2 3 5
  • CD180 Antigen 2 3 4
  • RP105 2 3 4
  • Radioprotective 105 KDa Protein 3 4
  • Lymphocyte Antigen 64 3 4
  • LY64 3 4
  • Ly78 2 3
  • Lymphocyte Antigen 64 (Mouse) Homolog, Radioprotective, 105kD 2
  • Lymphocyte Antigen-64, Radioprotective, 105kDa 3
  • CD180 5

External Ids for CD180 Gene

Previous HGNC Symbols for CD180 Gene

  • LY64

Previous GeneCards Identifiers for CD180 Gene

  • GC05M066514
  • GC05M063436

Summaries for CD180 Gene

Entrez Gene Summary for CD180 Gene

  • CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD180 Gene

CD180 (CD180 Molecule) is a Protein Coding gene. Diseases associated with CD180 include Retinitis Pigmentosa 14. Among its related pathways are Activated TLR4 signalling and IL-2 Pathway. An important paralog of this gene is TLR8.

UniProtKB/Swiss-Prot Summary for CD180 Gene

  • May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

Gene Wiki entry for CD180 Gene

Additional gene information for CD180 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD180 Gene

Genomics for CD180 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD180 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J067192 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 606.3 +1.9 1875 5 IKZF2 POLR2A RUNX3 SPI1 IKZF1 RAD51 CD180 MAST4-AS1 MAST4 lnc-SGTB-7
GH05J067002 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7.8 +191.3 191298 6.2 GATAD2A PRDM10 ZNF629 REST LEF1 NFKBIZ KDM1A ZNF692 RCOR2 TARDBP MAST4-AS1 MAST4 CD180 piR-59804-019
GH05J067163 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 12.7 +30.7 30682 4.7 CTCF ZBTB33 TEAD4 KDM1A ZNF143 RAD21 POLR2A ZNF24 TRIM22 YY1 CD180 lnc-CD180-8 piR-59804-019 MAST4
GH05J067158 Enhancer 0.8 ENCODE dbSUPER 12.3 +36.2 36242 4.8 FOXA1 SCRT2 SP1 JUND CEBPB FOS JUN PKNOX1 GTF2F1 ZNF217 CD180 lnc-CD180-8 piR-59804-019 MAST4
GH05J067181 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.1 +14.6 14551 1.9 ZNF341 EGR1 NR2C2 ZFHX2 NR2F1 SPI1 ZFP91 NR2F6 NFE2 ZNF398 lnc-CD180-8 CD180 lnc-SGTB-7 MAST4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD180 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD180

Top Transcription factor binding sites by QIAGEN in the CD180 gene promoter:
  • COMP1
  • FOXJ2
  • FOXJ2 (long isoform)
  • IRF-1
  • LCR-F1
  • LUN-1
  • Oct-B1
  • oct-B2
  • POU2F2 (Oct-2.1)
  • RORalpha1

Genomic Locations for CD180 Gene

Genomic Locations for CD180 Gene
chr5:67,179,613-67,196,799
(GRCh38/hg38)
Size:
17,187 bases
Orientation:
Minus strand
chr5:66,478,103-66,492,627
(GRCh37/hg19)
Size:
14,525 bases
Orientation:
Minus strand

Genomic View for CD180 Gene

Genes around CD180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD180 Gene

Proteins for CD180 Gene

  • Protein details for CD180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99467-CD180_HUMAN
    Recommended name:
    CD180 antigen
    Protein Accession:
    Q99467
    Secondary Accessions:
    • B2R7Z7
    • Q32MM5

    Protein attributes for CD180 Gene

    Size:
    661 amino acids
    Molecular mass:
    74179 Da
    Quaternary structure:
    • M-shaped tetramer of two CD180-LY86 heterodimers.

    Three dimensional structures from OCA and Proteopedia for CD180 Gene

neXtProt entry for CD180 Gene

Post-translational modifications for CD180 Gene

  • Glycosylation at Asn34, Asn53, Asn70, Asn78, Asn201, Asn234, Asn244, Asn394, Asn402, Asn451, and Asn573
  • Ubiquitination at Lys176
  • Modification sites at PhosphoSitePlus

Other Protein References for CD180 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD180 Gene

Domains & Families for CD180 Gene

Gene Families for CD180 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for CD180 Gene

InterPro:
Blocks:
  • Cysteine-rich flanking region, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for CD180 Gene

GenScript: Design optimal peptide antigens:
  • Radioprotective 105 kDa protein (CD180_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99467

UniProtKB/Swiss-Prot:

CD180_HUMAN :
  • Belongs to the Toll-like receptor family.
Family:
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with CD180: view

Function for CD180 Gene

Molecular function for CD180 Gene

UniProtKB/Swiss-Prot Function:
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

Phenotypes From GWAS Catalog for CD180 Gene

Gene Ontology (GO) - Molecular Function for CD180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21857663
genes like me logo Genes that share ontologies with CD180: view
genes like me logo Genes that share phenotypes with CD180: view

Animal Models for CD180 Gene

MGI Knock Outs for CD180:

Animal Model Products

CRISPR Products

miRNA for CD180 Gene

miRTarBase miRNAs that target CD180

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD180

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD180 Gene

Localization for CD180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD180 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD180 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CD180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix IBA 21873635
genes like me logo Genes that share ontologies with CD180: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD180 Gene

Pathways & Interactions for CD180 Gene

genes like me logo Genes that share pathways with CD180: view

Pathways by source for CD180 Gene

1 Qiagen pathway for CD180 Gene
  • PI3K Signaling in B-Lymphocyte

Gene Ontology (GO) - Biological Process for CD180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002322 B cell proliferation involved in immune response IEA,IBA 21873635
GO:0002376 immune system process IEA --
GO:0006954 inflammatory response IEA --
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IBA,IGI 10880523
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with CD180: view

No data available for SIGNOR curated interactions for CD180 Gene

Drugs & Compounds for CD180 Gene

(1) Additional Compounds for CD180 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD180: view

Transcripts for CD180 Gene

mRNA/cDNA for CD180 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD180

Alternative Splicing Database (ASD) splice patterns (SP) for CD180 Gene

No ASD Table

Relevant External Links for CD180 Gene

GeneLoc Exon Structure for
CD180

Expression for CD180 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD180 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD180 Gene

This gene is overexpressed in Spleen (x11.4) and Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for CD180 Gene

This gene is overexpressed in Blymphocyte (24.0), Monocytes (19.8), and Lymph node (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD180 Gene



Protein tissue co-expression partners for CD180 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD180

SOURCE GeneReport for Unigene cluster for CD180 Gene:

Hs.87205

mRNA Expression by UniProt/SwissProt for CD180 Gene:

Q99467-CD180_HUMAN
Tissue specificity: Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Evidence on tissue expression from TISSUES for CD180 Gene

  • Lung(4.3)
  • Liver(4.3)
  • Spleen(3)
  • Lymph node(2.8)
  • Blood(2.7)
  • Bone marrow(2.5)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CD180: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD180 Gene

Orthologs for CD180 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD180 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD180 30 31
  • 99.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CD180 30 31
  • 84.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD180 30 31
  • 83.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd180 30
  • 79.73 (n)
Mouse
(Mus musculus)
Mammalia Cd180 30 17 31
  • 78.72 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CD180 31
  • 60 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CD180 31
  • 38 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CD180 30 31
  • 59.95 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CD180 31
  • 47 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cd180 30
  • 50.18 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101885327 30
  • 48.22 (n)
CD180 (2 of 2) 31
  • 39 (a)
OneToMany
cd180 31
  • 38 (a)
OneToMany
Species where no ortholog for CD180 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CD180 Gene

ENSEMBL:
Gene Tree for CD180 (if available)
TreeFam:
Gene Tree for CD180 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD180: view image

Paralogs for CD180 Gene

genes like me logo Genes that share paralogs with CD180: view

Variants for CD180 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD180 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
709971 Benign: not provided 67,183,091(-) C/T SYNONYMOUS_VARIANT
725876 Likely Benign: not provided 67,183,037(-) C/T SYNONYMOUS_VARIANT
725877 Benign: not provided 67,184,177(-) C/T SYNONYMOUS_VARIANT
757510 Likely Benign: not provided 67,184,177(-) C/G SYNONYMOUS_VARIANT
782700 Benign: not provided 67,183,649(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CD180 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD180 Gene

Variant ID Type Subtype PubMed ID
esv2759347 CNV gain 17122850

Variation tolerance for CD180 Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD180 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD180

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD180 Gene

Disorders for CD180 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD180 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 14
  • rp14
- elite association - COSMIC cancer census association via MalaCards
Search CD180 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD180

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CD180: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD180 Gene

Publications for CD180 Gene

  1. RP105 is associated with MD-1 and transmits an activation signal in human B cells. (PMID: 9763566) Miura Y … Kimoto M (Blood 1998) 2 3 4 23
  2. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). (PMID: 8975706) Miura Y … Kimoto M (Genomics 1996) 2 3 4 23
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 41
  4. Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family. (PMID: 21959264) Ohto U … Shimizu T (Journal of molecular biology 2011) 3 4
  5. Potentiation of TLR9 responses for human naïve B-cell growth through RP105 signaling. (PMID: 20133206) Yamazaki K … Agematsu K (Clinical immunology (Orlando, Fla.) 2010) 3 23

Products for CD180 Gene

Sources for CD180 Gene