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CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
CD180 (CD180 Molecule) is a Protein Coding gene. Diseases associated with CD180 include Retinitis Pigmentosa 14. Among its related pathways are Activated TLR4 signalling and IL-2 Pathway. An important paralog of this gene is TLR8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 21857663 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0031012 | extracellular matrix | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Activated TLR4 signalling | ||
3 | IL-2 Pathway |
PI3K Signaling in B-Lymphocyte
.35
|
|
4 | Toll-like Receptor Signaling Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002322 | B cell proliferation involved in immune response | IEA,IBA | 21873635 |
GO:0002376 | immune system process | IEA | -- |
GO:0006954 | inflammatory response | IEA | -- |
GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway | IBA,IGI | 10880523 |
GO:0045087 | innate immune response | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD180 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD180 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD180 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd180 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cd180 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CD180 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CD180 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD180 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CD180 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cd180 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC101885327 30 |
|
||
CD180 (2 of 2) 31 |
|
OneToMany | |||
cd180 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709971 | Benign: not provided | 67,183,091(-) | C/T | SYNONYMOUS_VARIANT | |
725876 | Likely Benign: not provided | 67,183,037(-) | C/T | SYNONYMOUS_VARIANT | |
725877 | Benign: not provided | 67,184,177(-) | C/T | SYNONYMOUS_VARIANT | |
757510 | Likely Benign: not provided | 67,184,177(-) | C/G | SYNONYMOUS_VARIANT | |
782700 | Benign: not provided | 67,183,649(-) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759347 | CNV | gain | 17122850 |
Disorder | Aliases | PubMed IDs |
---|---|---|
retinitis pigmentosa 14 |
|
|