Aliases for CD180 Gene
External Ids for CD180 Gene
Previous HGNC Symbols for CD180 Gene
Previous GeneCards Identifiers for CD180 Gene
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD180 Gene
CD180 (CD180 Molecule) is a Protein Coding gene. Diseases associated with CD180 include Retinitis Pigmentosa 14. Among its related pathways are Activated TLR4 signalling and IL-2 Pathway. An important paralog of this gene is TLR8.
UniProtKB/Swiss-Prot Summary for CD180 Gene
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).