Aliases for CD177 Gene
Aliases for CD177 Gene
External Ids for CD177 Gene
- HGNC: 30072
- Entrez Gene: 57126
- Ensembl: ENSG00000204936
- OMIM: 162860
- UniProtKB: Q8N6Q3
Previous GeneCards Identifiers for CD177 Gene
- GC19P048550
- GC19P043857
- GC19P040287
Summaries for CD177 Gene
-
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
GeneCards Summary for CD177 Gene
CD177 (CD177 Molecule) is a Protein Coding gene. Diseases associated with CD177 include Polycythemia and Neonatal Alloimmune Neutropenia. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Cell surface interactions at the vascular wall. An important paralog of this gene is TEX101.
UniProtKB/Swiss-Prot for CD177 Gene
-
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD177 Gene
Genomics for CD177 Gene
GeneHancer (GH) Regulatory Elements for CD177 Gene
Promoters and enhancers for CD177 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19J043263 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 650.2 | -86.9 | -86891 | 5.7 | PKNOX1 NFIB ZSCAN4 INSM2 FEZF1 ZEB1 ZNF335 ZNF366 SCRT2 FOS | PSG9 CD177 PSG4 LOC100505715 ZNF428 ZNF575 LOC100379224 MEGF8 ZNF404 ZNF576 | |
| GH19J043354 | Promoter | 0.7 | EPDnew | 650.7 | +0.0 | 8 | 0.1 | GLIS1 ZIC2 | CD177 ENSG00000272396 | |
| GH19J043352 | Enhancer | 0.5 | FANTOM5 | 653 | -1.3 | -1334 | 0.4 | ZSCAN21 GATA3 GLIS1 ZNF112 | CD177 MRPS15P2 ZNF283 ENSG00000267191 ZNF221 LOC101928063 ZNF576 ZNF223 ZNF225 PRG1 | |
| GH19J043325 | Promoter | 0.5 | EPDnew | 650.3 | -27.9 | -27943 | 0.1 | CD177 PSG4 ENSG00000231412 CEACAMP4 | ||
| GH19J043353 | Enhancer | 0.4 | Ensembl | 658.6 | +0.3 | 342 | 0.4 | ZFP69B GLIS1 ZIC2 | CD177 ENSG00000272396 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD177 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CD177 gene promoter:
-
- STAT3
- YY1
- Pax-4a
- ER-alpha
- AREB6
- GATA-3
- C/EBPalpha
- Roaz
Regulatory Element Products
Genomic Locations for CD177 Gene
Genomic Locations for CD177 Gene
- chr19:43,353,659-43,363,172
- (GRCh38/hg38)
- Size:
- 9,514 bases
- Orientation:
- Plus strand
- chr19:43,857,811-43,867,480
- (GRCh37/hg19)
- Size:
- 9,670 bases
- Orientation:
- Plus strand
Genomic View for CD177 Gene
Genes around CD177 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.31 by Entrez Gene
- 19q13.31 by HGNC
- 19q13.31 by Ensembl
CD177 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD177 Gene
Proteins for CD177 Gene
-
Protein details for CD177 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N6Q3-CD177_HUMAN
- Recommended name:
- CD177 antigen
- Protein Accession:
- Q8N6Q3
- Q711Q2
- Q8NCV9
- Q96QH1
- Q9HDA5
Protein attributes for CD177 Gene
- Size:
- 437 amino acids
- Molecular mass:
- 46363 Da
- Quaternary structure:
-
- Found in a complex with integrin ITGAM/CD11b and ITGB2/CD18 (PubMed:28807980, PubMed:21193407). Interacts with PECAM1 (via Ig-like C2-type domain 6); the interaction is Ca(2+)-dependent; the interaction is direct (PubMed:17580308). Interacts with serine protease PRTN3/myeloblastin; the interaction tethers PRTN3 to the cell surface; the interaction is direct (PubMed:17244676, PubMed:28240246).
Protein Expression for CD177 Gene
Post-translational modifications for CD177 Gene
- N-glycosylated.
- A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding).
- Glycosylation at Asn189
- Modification sites at PhosphoSitePlus
Other Protein References for CD177 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD177 (CD177)
- Novus Biologicals Antibodies for CD177
-
Abcam antibodies for CD177
- Invitrogen Antibodies for CD177 (AFLGC-CD177)
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-
Boster Bio Antibodies for CD177
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD177
- Sino Biological Antibodies for CD177
Protein Products
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-
OriGene Purified Proteins for CD177
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- Search GeneTex for Proteins for CD177
-
ProSci Proteins for CD177
-
Abcam proteins for CD177
Assay Products
No data available for DME Specific Peptides for CD177 Gene
Domains & Families for CD177 Gene
Gene Families for CD177 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for CD177 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD177 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD177 Gene
Function for CD177 Gene
Molecular function for CD177 Gene
- UniProtKB/Swiss-Prot Function:
- In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369).
- UniProtKB/Swiss-Prot Induction:
- By CSF3/G-CSF in resting granulocytes (PubMed:10753836). Induced during CSF3/G-CSF-mediated neutrophil differentiation (PubMed:17244676, PubMed:18462208). Induced during pregnancy (PubMed:12675722). Induced in patients with polycythemia vera (PV) and with essential thrombocythemia (ET) (PubMed:10753836, PubMed:12377969).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 17244676 |
| GO:0005178 | integrin binding | IPI | 21193407 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0048306 | calcium-dependent protein binding | IPI | 17580308 |
Phenotypes for CD177 Gene
- MGI mutant phenotypes for CD177:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CD177:
Animal Models for CD177 Gene
- MGI Knock Outs for CD177:
-
- Cd177 Cd177<tm1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD177
-
CRISPR Products
-
OriGene CRISPR knockouts for CD177
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- Overview of 90 available CD177 gene related products
- Applied Biological Materials CRISPR for CD177
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD177
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miRNA for CD177 Gene
- miRTarBase miRNAs that target CD177
miRNA Products
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- Overview of 90 available CD177 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD177
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- Applied Biological Materials Clones for CD177
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CD177
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD177 Gene
Localization for CD177 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD177 Gene
- Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-like-anchor. Secreted. Cytoplasmic granule membrane. Cell projection, lamellipodium. Note=Cell surface expression on neutrophils is increased upon TNF-alpha, fMLP or CXCL8/IL8-mediated stimulation (PubMed:17244676, PubMed:17580308). In neutrophils, stored predominantly in secondary and tertiary granules (PubMed:18462208). Can also be shedded from the cell membrane (PubMed:12239154, PubMed:18462208). Localizes to lamellar protrusions in spreading neutrophils (PubMed:28807980). {ECO:0000269 PubMed:12239154, ECO:0000269 PubMed:17244676, ECO:0000269 PubMed:17580308, ECO:0000269 PubMed:18462208, ECO:0000269 PubMed:28807980}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030027 | lamellipodium | IEA | -- |
| GO:0030667 | secretory granule membrane | IDA | 18462208 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD177 Gene
Pathways & Interactions for CD177 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Formation of Fibrin Clot (Clotting Cascade) | ||
| 3 | Cell surface interactions at the vascular wall | ||
| 4 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for CD177 Gene
7 Reactome pathways for CD177 Gene
Interacting Proteins for CD177 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0007155 | cell adhesion | IMP | 28807980 |
| GO:0007159 | leukocyte cell-cell adhesion | IMP | 17580308 |
| GO:0007596 | blood coagulation | TAS | -- |
| GO:0030100 | regulation of endocytosis | IDA | 28807980 |
No data available for SIGNOR curated interactions for CD177 Gene
Transcripts for CD177 Gene
mRNA/cDNA for CD177 Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (66) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000618265 2222 bps (uc032hyu.2)
- ENST00000607855 536 bps (uc021uvf.2)
- ENST00000378012 1512 bps (uc060zla.1)
CRISPR Products
-
OriGene CRISPR knockouts for CD177
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD177
- genomics-online: gRNA clones - Search results for 90 available CD177 gene related products
- Overview of 90 available CD177 gene related products
- Applied Biological Materials CRISPR for CD177
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD177
- GenScript: Design CRISPR guide RNA sequences for CD177
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD177
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD177
- genomics-online: shRNA clones - Search results for 90 available CD177 gene related products
- Overview of 90 available CD177 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CD177
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD177
- Applied Biological Materials Clones for CD177
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CD177 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CD177 Gene
This gene is overexpressed in Whole Blood (x47.7).
This gene is overexpressed in Nasal epithelium (45.5), Cervix (6.9), and Saliva (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD177 Gene
NURSA nuclear receptor signaling pathways regulating expression of CD177 Gene:
CD177SOURCE GeneReport for Unigene cluster for CD177 Gene:
Hs.232165mRNA Expression by UniProt/SwissProt for CD177 Gene:
Q8N6Q3-CD177_HUMAN
Tissue specificity:
Highly expressed in normal bone marrow and weakly expressed in fetal liver (PubMed:10753836). During neutrophil differentiation, expression begins at the metamyelocyte stage and continues throughout the subsequent stages (at protein level) (PubMed:17244676, PubMed:18462208, PubMed:24926686). Expressed by a subset of mature neutrophils (at protein level) (PubMed:10753836, PubMed:28240246, PubMed:12377969, PubMed:18462208, PubMed:12675722, PubMed:17244676, PubMed:17580308, PubMed:21193407, PubMed:24926686, PubMed:28807980, PubMed:27227454). The percentage of neutrophils expressing CD177 varies across the population (PubMed:17244676, PubMed:27227454). Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET) (PubMed:10753836, PubMed:12377969).
Evidence on tissue expression from TISSUES for CD177 Gene
- Intestine(4.8)
- Bone marrow(2.4)
- Blood(2.3)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for CD177
-
OriGene qPCR primer pairs and template standards for CD177
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- Overview of 90 available CD177 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD177 Gene
Orthologs for CD177 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD177 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC612424 33 |
|
||
| CD177 34 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Cd177 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd177 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | CD177 34 |
|
OneToOne |
- Species where no ortholog for CD177 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CD177 Gene
- ENSEMBL:
- Gene Tree for CD177 (if available)
- TreeFam:
- Gene Tree for CD177 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD177: view image
Paralogs for CD177 Gene
Variants for CD177 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CD177 Gene
- CD177_HUMAN-Q8N6Q3
- There is a significant association between the variants Ala-3, Leu-251 and Thr-348 and a low expression of CD177 on neutrophils (PubMed:12623849, PubMed:14692971). Expression of CD177 on neutrophils is a trait determined by ratio of CD177/CD177P1 alleles (PubMed:27227454). The phenotype of CD177 null neutrophils is due to recombination between exon 7 of CD177 and the pseudogene CD177P1 through gene conversion, changing Lys-263 codon into stop codon (PubMed:27227454). The lack of CD177 expression affects 1-10 percent of the population placing them at risk for formation of anti-neutrophil antibodies that can cause transfusion-related acute lung injury and neonatal alloimmune neutropenia.
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000207945 | -- | 43,354,142(+) | G/A | intron_variant | |
| rs1000336340 | -- | 43,352,947(+) | C/T | upstream_transcript_variant | |
| rs1000383035 | -- | 43,361,832(+) | G/C | intron_variant | |
| rs1000678785 | -- | 43,353,164(+) | A/C | upstream_transcript_variant | |
| rs1001220105 | -- | 43,362,242(+) | C/A/T | coding_sequence_variant, intron_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3591n100 | CNV | loss | 25217958 |
| dgv3603n100 | CNV | gain | 25217958 |
| dgv6502n54 | CNV | loss | 21841781 |
| esv2751795 | CNV | loss | 17911159 |
| esv2758763 | CNV | gain+loss | 17122850 |
| esv3644464 | CNV | loss | 21293372 |
| esv5616 | OTHER | inversion | 19470904 |
| esv8862 | OTHER | inversion | 19470904 |
| nsv1057657 | CNV | gain | 25217958 |
| nsv1057682 | CNV | loss | 25217958 |
| nsv1060280 | CNV | gain | 25217958 |
| nsv469666 | CNV | loss | 16826518 |
| nsv469787 | CNV | loss | 16826518 |
| nsv516973 | CNV | gain+loss | 19592680 |
| nsv526966 | CNV | loss | 19592680 |
| nsv828560 | CNV | gain | 20364138 |
| nsv828561 | CNV | loss | 20364138 |
| nsv963057 | CNV | duplication | 23825009 |
| nsv978908 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
50.6% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD177 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for CD177 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| polycythemia |
|
|
| neonatal alloimmune neutropenia |
|
|
| polycythemia vera |
|
|
| essential thrombocythemia |
|
|
| deep leiomyoma |
|
|
Search CD177 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD177
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CD177 Gene
Publications for CD177 Gene
- Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms. (PMID: 12623849) Wolff J … Bux J (Blood 2003) 3 4 22 44 58
- Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. (PMID: 10753836) Temerinac S … Pahl HL (Blood 2000) 2 3 4 22 58
- Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing. (PMID: 18462208) von Vietinghoff S … Kettritz R (Clinical and experimental immunology 2008) 3 4 22 58
- CD177 polymorphisms: correlation between high-frequency single nucleotide polymorphisms and neutrophil surface protein expression. (PMID: 14692971) Caruccio L … Stroncek D (Transfusion 2004) 3 4 22 58
- Expression of human neutrophil antigen-2a (NB1) is increased in pregnancy. (PMID: 12675722) Caruccio L … Stroncek D (Transfusion 2003) 3 4 22 58
Products for CD177 Gene
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CD177 (AFLGC-CD177)
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD177
- antibodies-online: Search results for available CD177 related products ranked by validation data
- antibodies-online: Search results for available CD177 related products ranked by validation data
- antibodies-online: Search results for available CD177 related products ranked by validation data
- GeneTex CD177 Antibody for CD177
- Search GeneTex for Proteins for CD177
- Santa Cruz Biotechnology (SCBT) Antibodies for CD177
- Search Santa Cruz Biotechnology (SCBT) for CD177 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD177
- Search for CD177 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CD177
- Horizon Cell Lines for CD177
- genomics-online: cdna clones - Search results for 90 available CD177 gene related products
- Overview of 90 available CD177 gene related products
- orf clones - Search results for 90 available CD177 gene related products
- Overview of 90 available CD177 gene related products
- genomics-online: gRNA clones - Search results for 90 available CD177 gene related products
- Overview of 90 available CD177 gene related products
- genomics-online: primer clones - Search results for 90 available CD177 gene related products
- Overview of 90 available CD177 gene related products
- genomics-online: shRNA clones - Search results for 90 available CD177 gene related products
- Overview of 90 available CD177 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD177
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD177
- GeneCopoeia miRNA 3'UTR Target clone products for CD177
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD177
- Boster Bio Antibodies for CD177
- Browse Boster Bio ELISA Kits
Sources for CD177 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt