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The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative ... See more...
Aliases for CD163 Gene
Aliases for CD163 Gene
External Ids for CD163 Gene
- HGNC: 1631
- Entrez Gene: 9332
- Ensembl: ENSG00000177575
- OMIM: 605545
- UniProtKB: Q86VB7
Previous GeneCards Identifiers for CD163 Gene
- GC12U990123
- GC12M007759
- GC12M007523
- GC12M007516
- GC12M007517
- GC12M007518
- GC12M007623
Summaries for CD163 Gene
-
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD163 Gene
CD163 (CD163 Molecule) is a Protein Coding gene. Diseases associated with CD163 include Rosai-Dorfman Disease and Non-Langerhans-Cell Histiocytosis. Among its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is CD163L1.
UniProtKB/Swiss-Prot Summary for CD163 Gene
-
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
-
After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Additional gene information for CD163 Gene
- HGNC(1631)
- Entrez Gene(9332)
- Ensembl(ENSG00000177575)
- OMIM(605545)
- UniProtKB(Q86VB7)
- Open Targets Platform(ENSG00000177575)
- Monarch Initiative
- Search for CD163 at DataMed
- Search for CD163 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD163 Gene
Genomics for CD163 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CD163 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J007500 | Promoter | 1 | EPDnew Ensembl | 600.7 | +1.6 | 1592 | 3.4 | CTCF PRDM1 ZNF600 NFE2 SPI1 MAFK | CD163 ATN1 lnc-APOBEC1-2 CD163L1 NONHSAG010376.2 | |
| GH12J007570 | Enhancer | 0.5 | Ensembl | 6.7 | -68.8 | -68808 | 5.4 | SCRT2 MAFF ZNF146 MAFK MAX SP1 | CD163 LRRC23 GAPDHP31 piR-54764-102 APOBEC1 | |
| GH12J007555 | Enhancer | 0.8 | FANTOM5 ENCODE | 4 | -52.5 | -52461 | 1.6 | LEF1 GABPA MEF2D CEBPG ATF3 ZNF660 ATF1 GABPB1 NFE2L2 | CD163L1 CD163 PEX5 SLC2A3 MN309174-098 piR-45932-021 lnc-DPPA3-2 APOBEC1 | |
| GH12J007581 | Enhancer | 0.3 | Ensembl | 5.7 | -77.9 | -77908 | 0.8 | HNF4A | CD163 LRRC23 piR-54764-102 GAPDHP31 APOBEC1 | |
| GH12J007512 | Enhancer | 0.9 | FANTOM5 ENCODE | 1.7 | -8.9 | -8915 | 0.3 | REST JUND SP1 CEBPA CEBPB ZBTB26 NFE2 ATF3 FOS YY1 | PEX5 SLC2A3 CD163 lnc-ACSM4-4 piR-59297-108 APOBEC1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CD163 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD163
- Top Transcription factor binding sites by QIAGEN in the CD163 gene promoter:
-
- CBF(2)
- CBF-A
- CBF-B
- CBF-C
- CP1A
- CP1C
- NF-kappaB
- NF-kappaB1
- NF-Y
- NF-YA
Genomic Locations for CD163 Gene
Genomic Locations for CD163 Gene
- chr12:7,470,811-7,503,893
- (GRCh38/hg38)
- Size:
- 33,083 bases
- Orientation:
- Minus strand
- chr12:7,623,409-7,656,489
- (GRCh37/hg19)
- Size:
- 33,081 bases
- Orientation:
- Minus strand
Genomic View for CD163 Gene
Genes around CD163 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by HGNC
- 12p13.31 by Entrez Gene
- 12p13.31 by Ensembl
CD163 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD163 Gene
Proteins for CD163 Gene
-
Protein details for CD163 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86VB7-C163A_HUMAN
- Recommended name:
- Scavenger receptor cysteine-rich type 1 protein M130
- Protein Accession:
- Q86VB7
- C9JIG2
- Q07898
- Q07899
- Q07900
- Q07901
- Q2VLH7
Protein attributes for CD163 Gene
- Size:
- 1156 amino acids
- Molecular mass:
- 125451 Da
- Quaternary structure:
-
- Interacts with CSNK2B.
- SequenceCaution:
-
- Sequence=CAA80541.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA80542.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA80543.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA80544.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAB45233.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- Intravenous lipopolysaccharide (LPS) produces a rapid rise of sCD163 in plasma of patient as it induces metalloproteinase-mediated shedding from monocytes surface. Long-term LPS infusion finally increases expression of the membrane-bound form on circulating monocytes.
- The soluble form (sCD163) in plasma is a novel parameter in diseases affecting macrophage function and monocyte/macrophage load in the body. The concentration of sCD163 is probably reflecting the number of macrophages of the 'alternative macrophage activation' phenotype with a high CD163 expression playing a major role in dampening the inflammatory response and scavenging components of damaged cells. This has initiated a number of clinical studies for evaluation of sCD163 as a disease marker in inflammatory conditions e.g. infection, autoimmune disease, transplantation, atherosclerosis and cancer.
Protein Expression for CD163 Gene
Post-translational modifications for CD163 Gene
- A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.
- Phosphorylated.
-
Glycosylation at Asn105, Asn123, Asn140, Asn445, Asn767, Asn1001, and Asn1027
- NX_Q86VB7 (NX_Q86VB7-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- C163A_HUMAN (1723)
Other Protein References for CD163 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CD163 Monoclonal Antibody (LS-B5967) and CD163 Monoclonal Antibody (LS-B10966)
- G Biosciences Immunotag™ CD163 (AS1A1) monoclonal antibody and Immunotag™ CD163 Antibody
- NSJ Bioreagents CD163 Antibody
- Creative Diagnostics Anti-CD163 monoclonal antibody, clone FE3 [Biotin]
-
BioLegend
- CD163 Antibody (326505)
- CD163 Antibody (326508)
- CD163 Antibody (326506)
- CD163 Antibody (326507)
- CD163 Antibody (333602)
- CD163 Antibody (333603)
- PerCP/Cyanine5.5 CD163 Antibody (333608)
- PerCP/Cyanine5.5 CD163 Antibody (333607)
- CD163 Antibody (333604)
- CD163 Antibody (333605)
- CD163 Antibody (333606)
- CD163 Antibody (333610)
- CD163 Antibody (333609)
- CD163 Antibody (326502)
- CD163 Antibody (333611)
- CD163 Antibody (333613)
- CD163 Antibody (333614)
- CD163 Antibody (333612)
- CD163 Antibody (333615)
- CD163 Antibody (333618)
- CD163 Antibody (333617)
- CD163 Antibody (333619)
- CD163 Antibody (333620)
- APC/Cyanine7 CD163 Antibody (333621)
- APC/Cyanine7 CD163 Antibody (333622)
- CD163 Antibody (333623)
- PerCP/Cyanine5.5 CD163 Antibody (326511)
- PerCP/Cyanine5.5 CD163 Antibody (326512)
- CD163 Antibody (333624)
- CD163 Antibody (326513)
- CD163 Antibody (326514)
- CD163 Antibody (326509)
- CD163 Antibody (326510)
- CD163 Antibody (333616)
- CD163 Antibody (333626)
- CD163 Antibody (333625)
- CD163 Antibody (333629)
- CD163 Antibody (333628)
- CD163 Antibody (333630)
- CD163 Antibody (333627)
- CD163 Antibody (333631)
- CD163 Antibody (333632)
- APC/Fire(TM) 750 CD163 Antibody (333634)
- APC/Fire(TM) 750 CD163 Antibody (333633)
- TotalSeq(TM)-A0358 CD163 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CD163
- AM05884FC-N
- AM05884PU-S
- AM10058SU-N
- AM10062SU-N
- AM26138AC-N
- AM26138PU-N
- AM26138RP-N
- AP26434PU-N
- BM4001
- BM4001F
- BM4021
- BM4041
- BM4041B
- BM4041F
- BM4041PE
- BM4041X
- CF506380
- CF506381
- CF506382
- CF506383
- CF506384
- CF506386
- CF506387
- CF506388
- CF506389
- CF506390
- CF506391
- CF506392
- CF506393
- SM2160P
- TA320238
- TA327621
- TA350807
- TA353026L
- TA506380
- TA506380S
- TA506381
- TA506381S
- TA506382
- TA506382S
- TA506383
- TA506383S
- TA506384
- TA506384S
- TA506386
- TA506386S
- TA506387
- TA506387S
- TA506388
- TA506388S
- TA506389
- TA506389S
- TA506390
- TA506390S
- TA506391
- TA506391S
- TA506392
- TA506392S
- TA506393
- TA506393S
- Novus Biologicals Antibodies for CD163
-
Abcam antibodies for CD163
- Invitrogen Antibodies for CD163 (AFLGC-CD163)
-
Boster Bio Antibodies for CD163
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD163
- Sino Biological Antibodies for CD163
Protein Products
-
OriGene Purified Proteins for CD163
- Search Origene for MassSpec and Protein Over-expression Lysates for CD163
- Origene Custom Protein Services for CD163
- ProSpec Recombinant Proteins for CD163
-
Signalway Proteins for CD163
-
ProSci Proteins for CD163
-
Abcam proteins for CD163
Assay Products
- RayBiotech Human CD163 ELISA
- Creative Diagnostics Human CD163 ELISA Kit (DEIA7851) and Human CD163 ELISA Kit (DEIA3000)
- Novus Biologicals ELISA Kits for CD163
No data available for DME Specific Peptides for CD163 Gene
Domains & Families for CD163 Gene
Gene Families for CD163 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CD163 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD163 Gene
- GenScript: Design optimal peptide antigens:
-
- Hemoglobin scavenger receptor (C163A_HUMAN)
- CD163 antigen, isoform CRA_a (D3DUU0_HUMAN)
- CD163 antigen, isoform CRA_b (D3DUU2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86VB7UniProtKB/Swiss-Prot:
C163A_HUMAN :- The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.
- Domain:
-
- The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.
Function for CD163 Gene
Molecular function for CD163 Gene
- UniProtKB/Swiss-Prot Function:
- Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
- UniProtKB/Swiss-Prot Function:
- After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
- UniProtKB/Swiss-Prot Induction:
- Induced by anti-inflammatory mediators such as glucocorticoids, interleukin-6/IL6 and interleukin-10/IL10; suppressed by proinflammatory mediators like bacterial lipopolysaccharides (LPS), IFNG/IFN-gamma and TNF.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=2.0 nM for hemoglobin/haptoglobin of HP*1S phenotype {ECO:0000269|PubMed:11196644}; KM=0.2 nM for hemoglobin/haptoglobin of HP*1F phenotype {ECO:0000269|PubMed:11196644};
- GENATLAS Biochemistry:
- macrophage associated antigen,involved in myeloid specific gene expression,including several alternatively spliced isoforms,SRCR superfamily
Phenotypes From GWAS Catalog for CD163 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005044 | scavenger receptor activity | TAS,NAS | 8370408 |
| GO:0005515 | protein binding | IPI | 15479433 |
Phenotypes for CD163 Gene
- MGI mutant phenotypes for CD163:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD163:
-
- Increased vaccinia virus (VACV) infection
- Large nuclei
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella proliferation
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- No cells
Animal Models for CD163 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD163 - Select products 50% OFF >
- * CD163 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD163
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD163
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD163
miRNA for CD163 Gene
- miRTarBase miRNAs that target CD163
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD163
- Browse OriGene Inhibitory RNA Products For CD163
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD163
Clone Products
- Applied Biological Materials (abm): Clones for CD163 - Select products 50% OFF >
- * CD163 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG216798
- MG219212
- MR216798
- MR216798L3
- MR216798L4
- MR219212
- MR219212L3
- MR219212L4
- RC208557
- RC208557L1
- RC208557L2
- RC208557L3
- RC208557L4
- RC212754
- RG208557
- RG212754
- RR206586
- RR206586L3
- RR206586L4
- MR216798L3V
- MR216798L4V
- MR219212L3V
- MR219212L4V
- RC208557L1V
- RC208557L2V
- RC208557L3V
- RC208557L4V
- RR206586L3V
- RR206586L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD163
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD163
Cell Line Products
-
Horizon Cell Lines for CD163
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD163 Gene
Localization for CD163 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD163 Gene
- [Soluble CD163]: Secreted.
- Cell membrane. Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8370408 |
| GO:0009897 | external side of plasma membrane | IDA | 24942581 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for CD163 Gene
Pathways by source for CD163 Gene
3 Reactome pathways for CD163 Gene
2 R&D Systems pathways for CD163 Gene
Interacting Proteins for CD163 Gene
Selected Interacting proteins:
Q86VB7-C163A_HUMAN
ENSP00000352071
for CD163 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CD163
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IEA | -- |
| GO:0006898 | receptor-mediated endocytosis | TAS | -- |
| GO:0006953 | acute-phase response | IEA | -- |
| GO:0006954 | inflammatory response | IEA | -- |
Drugs & Compounds for CD163 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CD163 Gene
mRNA/cDNA for CD163 Gene
- 4 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000359156 4268 nts (view in UCSC)
- ENST00000537044 5312 nts (view in UCSC)
- ENST00000542705 496 nts (view in UCSC)
- ENST00000534848 318 nts (view in UCSC)
- ENST00000542280 606 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CD163 - Select products 50% OFF >
- * CD163 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CD163
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD163
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD163
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD163
- Browse OriGene Inhibitory RNA Products For CD163
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD163
Clone Products
- Applied Biological Materials (abm): Clones for CD163 - Select products 50% OFF >
- * CD163 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG216798
- MG219212
- MR216798
- MR216798L3
- MR216798L4
- MR219212
- MR219212L3
- MR219212L4
- RC208557
- RC208557L1
- RC208557L2
- RC208557L3
- RC208557L4
- RC212754
- RG208557
- RG212754
- RR206586
- RR206586L3
- RR206586L4
- MR216798L3V
- MR216798L4V
- MR219212L3V
- MR219212L4V
- RC208557L1V
- RC208557L2V
- RC208557L3V
- RC208557L4V
- RR206586L3V
- RR206586L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD163
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD163
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||
| SP4: | - |
Relevant External Links for CD163 Gene
- GeneLoc Exon Structure for
- CD163
Expression for CD163 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
-
Placenta (Extraembryonic Tissues)
- Hofbauer Cells Chorionic Villus
-
Chorion (Extraembryonic Tissues)
- Hofbauer Cells Chorionic Villus
-
Liver (Hepatobiliary System)
- Mature Mesothelial Cells Liver Lobule
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Bone (Muscoskeletal System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Dermis (Integumentary System)
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for CD163 Gene
This gene is overexpressed in Whole Blood (x7.6), Adipose - Visceral (Omentum) (x4.5), and Spleen (x4.5).
This gene is overexpressed in Serum (18.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD163 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD163
SOURCE GeneReport for Unigene cluster for CD163 Gene:
Hs.504641mRNA Expression by UniProt/SwissProt for CD163 Gene:
Q86VB7-C163A_HUMAN
Tissue specificity:
Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
Evidence on tissue expression from TISSUES for CD163 Gene
- Spleen(4.8)
- Liver(4.8)
- Bone marrow(4.6)
- Heart(3.9)
- Lung(3.8)
- Blood(3.7)
- Lymph node(3.6)
- Intestine(3.4)
- Kidney(3.4)
- Muscle(3.4)
- Nervous system(3.2)
- Skin(2.7)
- Adrenal gland(2.5)
- Pancreas(2.5)
- Eye(2.3)
- Stomach(2.3)
- Gall bladder(2.2)
- Bone(2.2)
Primer Products
-
OriGene qPCR primer pairs for CD163
-
OriGene qPCR primer pairs and template standards for CD163
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD163 Gene
Orthologs for CD163 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CD163 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CD163 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CD163 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cd163 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cd163 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-21h14.14 31 |
|
ManyToMany | |
| si:dkey-21h14.10 31 |
|
ManyToMany | |||
| si:dkey-21h14.9 31 |
|
ManyToMany | |||
| si:dkey-21h14.11 31 |
|
ManyToMany | |||
| si:dkey-21h14.8 31 |
|
ManyToMany | |||
| si:ch211-161n3.5 31 |
|
ManyToMany | |||
| si:ch211-161n3.4 31 |
|
ManyToMany |
- Species where no ortholog for CD163 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CD163 Gene
- ENSEMBL:
- Gene Tree for CD163 (if available)
- TreeFam:
- Gene Tree for CD163 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CD163: view image
Paralogs for CD163 Gene
Paralogs for CD163 Gene
(6) SIMAP similar genes for CD163 Gene using alignment to 7 proteins:
- C163A_HUMAN
- C9JHR8_HUMAN
- D3DUU0_HUMAN
- D3DUU2_HUMAN
- F5GZZ9_HUMAN
- H0YFM0_HUMAN
- H0YGZ7_HUMAN
Pseudogenes.org Pseudogenes for CD163 Gene
Variants for CD163 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD163 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711920 | Likely Benign: not provided | 7,479,969(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
| 728962 | Benign: not provided | 7,485,112(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 750324 | Likely Benign: not provided | 7,487,822(-) | G/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 775305 | Benign: not provided | 7,501,130(-) | A/T | INTRON_VARIANT | |
| 776691 | Benign: not provided | 7,485,276(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1350n100 | CNV | loss | 25217958 |
| esv3303553 | CNV | mobile element insertion | 20981092 |
| esv3399549 | CNV | insertion | 20981092 |
| esv3402244 | CNV | insertion | 20981092 |
| nsv525458 | CNV | loss | 19592680 |
| nsv557269 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.97;
74.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD163 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD163 Gene
Disorders for CD163 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rosai-dorfman disease |
|
|
| non-langerhans-cell histiocytosis |
|
|
| necrobiosis lipoidica |
|
|
| adult xanthogranuloma |
|
|
| fibrous histiocytoma |
|
Search CD163 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD163
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CD163 Gene
Publications for CD163 Gene
- Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily. (PMID: 10403791) Ritter M … Schmitz G (Biochemical and biophysical research communications 1999) 2 3 4 23
- Cross-linking of FcgammaR triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163. (PMID: 15075364) Sulahian TH … Guyre PM (Journal of leukocyte biology 2004) 3 4 23
- CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. (PMID: 15478309) Moestrup SK … Møller HJ (Annals of medicine 2004) 3 4 23
- Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163. (PMID: 12377940) Hintz KA … Guyre PM (Journal of leukocyte biology 2002) 3 4 23
- Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3. (PMID: 12296867) Matsushita N … Matsuyama T (Clinical and experimental immunology 2002) 3 4 23
ExternalLinks
Products for CD163 Gene
- View all 30 R&D Systems CD163 (CD163) Products
- View all R&D Systems CD163 (CD163) Proteins and Enzymes
- View all 23 R&D Systems CD163 (CD163) Primary Antibodies
- View all 3 R&D Systems CD163 (CD163) ELISAs
- View all R&D Systems CD163 (CD163) Simple Plex Assays
- View all R&D Systems CD163 (CD163) Luminex Assays
- View all R&D Systems CD163 (CD163) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom CD163 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CD163
- AM05884FC-N
- AM05884PU-S
- AM10058SU-N
- AM10062SU-N
- AM26138AC-N
- AM26138PU-N
- AM26138RP-N
- AP26434PU-N
- BM4001
- BM4001F
- BM4021
- BM4041
- BM4041B
- BM4041F
- BM4041PE
- BM4041X
- CF506380
- CF506381
- CF506382
- CF506383
- CF506384
- CF506386
- CF506387
- CF506388
- CF506389
- CF506390
- CF506391
- CF506392
- CF506393
- SM2160P
- TA320238
- TA327621
- TA350807
- TA353026L
- TA506380
- TA506380S
- TA506381
- TA506381S
- TA506382
- TA506382S
- TA506383
- TA506383S
- TA506384
- TA506384S
- TA506386
- TA506386S
- TA506387
- TA506387S
- TA506388
- TA506388S
- TA506389
- TA506389S
- TA506390
- TA506390S
- TA506391
- TA506391S
- TA506392
- TA506392S
- TA506393
- TA506393S
- Custom Assay Services
- OriGene Purified Proteins for CD163
- Search Origene for MassSpec and Protein Over-expression Lysates for CD163
- Origene Custom Protein Services for CD163
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD163
- Browse OriGene Inhibitory RNA Products For CD163
- OriGene qPCR primer pairs for CD163
- OriGene qPCR primer pairs and template standards for CD163
- OriGene CRISPR knockouts for CD163
- MG216798
- MG219212
- MR216798
- MR216798L3
- MR216798L4
- MR219212
- MR219212L3
- MR219212L4
- RC208557
- RC208557L1
- RC208557L2
- RC208557L3
- RC208557L4
- RC212754
- RG208557
- RG212754
- RR206586
- RR206586L3
- RR206586L4
- MR216798L3V
- MR216798L4V
- MR219212L3V
- MR219212L4V
- RC208557L1V
- RC208557L2V
- RC208557L3V
- RC208557L4V
- RR206586L3V
- RR206586L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD163
- Sino Biological Human cDNA Clone for CD163
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CD163
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CD163
- Novus Biologicals proteins and lysates for CD163
- Novus Biologicals ELISA Kits for CD163
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CD163
- Abcam proteins for CD163
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for CD163 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CD163 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CD163 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CD163 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CD163
- antibodies-online: Show 120 available CD163 Antibodies ranked by validation data
- Compare Top CD163 Antibodies
- antibodies-online: Show 73 available CD163 Elisa Kits ranked by validation data
- Compare Top CD163 Elisa Kits
- antibodies-online: Show 15 available CD163 Proteins ranked by validation data
- Compare Top CD163 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CD163
- Search Santa Cruz Biotechnology (SCBT) for CD163 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD163
- Horizon Cell Lines for CD163
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CD163
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CD163
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CD163
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD163
Sources for CD163 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB