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Aliases for CD160 Gene

Aliases for CD160 Gene

  • CD160 Molecule 2 3 5
  • CD160 Antigen 2 3 4
  • Natural Killer Cell Receptor BY55 3 4
  • BY55 3 4
  • Natural Killer Cell Receptor, Immunoglobulin Superfamily Member 3
  • CD160 Transmembrane Isoform 3
  • CD160-Delta Ig 3
  • NK28 3
  • NK1 3

External Ids for CD160 Gene

Previous GeneCards Identifiers for CD160 Gene

  • GC01M143371
  • GC01M143444
  • GC01M143184
  • GC01M144407
  • GC01M145696
  • GC01M119659

Summaries for CD160 Gene

Entrez Gene Summary for CD160 Gene

  • CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD160 Gene

CD160 (CD160 Molecule) is a Protein Coding gene. Diseases associated with CD160 include Neurotrophic Keratopathy. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Lymphoid Cell Differentiation Pathways. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and MHC class I receptor activity.

UniProtKB/Swiss-Prot for CD160 Gene

  • Receptor showing broad specificity for both classical and non-classical MHC class I molecules.

Gene Wiki entry for CD160 Gene

Additional gene information for CD160 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD160 Gene

Genomics for CD160 Gene

GeneHancer (GH) Regulatory Elements for CD160 Gene

Promoters and enhancers for CD160 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J145720 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 662.3 +1.6 1555 1.6 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 ZNF143 FOS MXD4 CD160 PDZK1 ANKRD35 PIR35710
GH01J145719 Promoter 0.8 EPDnew 650.7 +0.0 47 0.1 CBFB IKZF1 ATF7 IKZF2 BATF RUNX3 CD160 PIR35710
GH01J145717 Enhancer 0.2 ENCODE 650.7 -1.4 -1402 0.2 CD160 PDZK1
GH01J146034 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 10.1 +318.1 318118 5.6 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 HJV TRH-GTG1-1 TRG-TCC2-1 TRE-CTC1-1 TRK-CTT2-1 PIR58458 GC01P146046 POLR3C PIAS3 NBPF20
GH01J145844 Promoter/Enhancer 1.5 Ensembl ENCODE 9.4 +126.4 126424 1.9 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B NUDT17 NBPF20 POLR3C PIAS3 ITGA10 PEX11B GPR89A TXNIP CD160 MIR6736
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD160 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD160 gene promoter:
  • CREB
  • GR-beta
  • GR-alpha
  • GR
  • deltaCREB
  • FOXF2
  • LCR-F1

Genomic Locations for CD160 Gene

Genomic Locations for CD160 Gene
19,856 bases
Plus strand
19,817 bases
Minus strand

Genomic View for CD160 Gene

Genes around CD160 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD160 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD160 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD160 Gene

Proteins for CD160 Gene

  • Protein details for CD160 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD160 antigen
    Protein Accession:

    Protein attributes for CD160 Gene

    181 amino acids
    Molecular mass:
    19810 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked.

neXtProt entry for CD160 Gene

Post-translational modifications for CD160 Gene

  • Glycosylation at Asn137 and posLast=2828
  • Modification sites at PhosphoSitePlus

Other Protein References for CD160 Gene

No data available for DME Specific Peptides for CD160 Gene

Domains & Families for CD160 Gene

Gene Families for CD160 Gene

Protein Domains for CD160 Gene

Suggested Antigen Peptide Sequences for CD160 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD160: view

No data available for UniProtKB/Swiss-Prot for CD160 Gene

Function for CD160 Gene

Molecular function for CD160 Gene

UniProtKB/Swiss-Prot Function:
Receptor showing broad specificity for both classical and non-classical MHC class I molecules.

Phenotypes From GWAS Catalog for CD160 Gene

Gene Ontology (GO) - Molecular Function for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IDA 9973372
GO:0005515 protein binding IPI 25416956
GO:0032393 MHC class I receptor activity IDA 15494480
GO:0038023 signaling receptor activity TAS 9973372
genes like me logo Genes that share ontologies with CD160: view
genes like me logo Genes that share phenotypes with CD160: view

Animal Models for CD160 Gene

MGI Knock Outs for CD160:

Animal Model Products

miRNA for CD160 Gene

miRTarBase miRNAs that target CD160

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD160 Gene

Localization for CD160 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD160 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD160 gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0046658 anchored component of plasma membrane IDA 9973372
genes like me logo Genes that share ontologies with CD160: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD160 Gene

Pathways & Interactions for CD160 Gene

genes like me logo Genes that share pathways with CD160: view

Gene Ontology (GO) - Biological Process for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9743336
GO:0007166 cell surface receptor signaling pathway TAS 9973372
GO:0008283 cell proliferation TAS 9973372
GO:0050776 regulation of immune response TAS --
GO:0050829 defense response to Gram-negative bacterium IEA --
genes like me logo Genes that share ontologies with CD160: view

No data available for SIGNOR curated interactions for CD160 Gene

Drugs & Compounds for CD160 Gene

(11) Drugs for CD160 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CD160 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD160: view

Transcripts for CD160 Gene

mRNA/cDNA for CD160 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD160 Gene

CD160 molecule:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD160 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2: -

Relevant External Links for CD160 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD160 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD160 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD160 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4), Brain - Cerebellum (x5.3), and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for CD160 Gene

This gene is overexpressed in NK cells (35.2) and Urine (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD160 Gene

Protein tissue co-expression partners for CD160 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD160 Gene:


SOURCE GeneReport for Unigene cluster for CD160 Gene:


mRNA Expression by UniProt/SwissProt for CD160 Gene:

Tissue specificity: Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.

Evidence on tissue expression from TISSUES for CD160 Gene

  • Blood(4.4)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with CD160: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD160 Gene

Orthologs for CD160 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD160 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD160 34 33
  • 99.45 (n)
(Canis familiaris)
Mammalia CD160 34 33
  • 82.96 (n)
(Mus musculus)
Mammalia Cd160 16 34 33
  • 79.33 (n)
(Rattus norvegicus)
Mammalia Cd160 33
  • 78.21 (n)
Species where no ortholog for CD160 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD160 Gene

Gene Tree for CD160 (if available)
Gene Tree for CD160 (if available)
Evolutionary constrained regions (ECRs) for CD160: view image

Paralogs for CD160 Gene

No data available for Paralogs for CD160 Gene

Variants for CD160 Gene

Sequence variations from dbSNP and Humsavar for CD160 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000009020 -- 145,721,546(+) A/G intron_variant
rs1000059770 -- 145,721,714(+) A/G intron_variant
rs1000309112 -- 145,728,927(+) T/G intron_variant
rs1000407525 -- 145,735,368(+) T/C intron_variant
rs1000743179 -- 145,733,802(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD160 Gene

Variant ID Type Subtype PubMed ID
dgv331n100 CNV gain 25217958
dgv332n100 CNV gain+loss 25217958
dgv33n27 CNV loss 19166990
dgv531n54 CNV loss 21841781
dgv532n54 CNV gain 21841781
dgv533n54 CNV gain 21841781
dgv95e212 CNV gain 25503493
esv3572342 CNV gain 25503493
esv3587421 CNV loss 21293372
esv3587422 CNV gain 21293372
esv3894089 CNV loss 25118596
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv463494 CNV gain 19166990
nsv469752 CNV loss 16826518
nsv470735 CNV gain 18288195
nsv547665 CNV gain+loss 21841781
nsv547670 CNV loss 21841781
nsv818411 CNV loss 17921354
nsv831392 CNV gain 17160897
nsv998178 CNV loss 25217958

Variation tolerance for CD160 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD160 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD160 Gene

Disorders for CD160 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD160 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neurotrophic keratopathy
  • neurotrophic keratitis
- elite association - COSMIC cancer census association via MalaCards
Search CD160 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD160

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD160: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD160 Gene

Publications for CD160 Gene

  1. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. (PMID: 9743336) Anumanthan A … Freeman GJ (Journal of immunology (Baltimore, Md. : 1950) 1998) 2 3 4 22 58
  2. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. (PMID: 9973372) Agrawal S … Bensussan A (Journal of immunology (Baltimore, Md. : 1950) 1999) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. High levels of CD160 expression up-regulated counts of chronic lymphocytic leukemia cells and were associated with other clinical parameters in Chinese patients with chronic lymphocytic leukemia. (PMID: 24882258) Zhang ZH … Qu JH (Leukemia & lymphoma 2015) 3 58
  5. Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection. (PMID: 25449536) Suviolahti E … Toyoda M (Transplant immunology 2015) 3 58

Products for CD160 Gene

Sources for CD160 Gene

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