CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homo... See more...

Aliases for CD160 Gene

Aliases for CD160 Gene

  • CD160 Molecule 2 3 5
  • CD160 Antigen 2 3 4
  • BY55 2 3 4
  • Natural Killer Cell Receptor BY55 3 4
  • NK28 2 3
  • NK1 2 3
  • Natural Killer Cell Receptor, Immunoglobulin Superfamily Member 3
  • CD160 Transmembrane Isoform 3
  • CD160-Delta Ig 3
  • CD160 5

External Ids for CD160 Gene

Previous GeneCards Identifiers for CD160 Gene

  • GC01M143371
  • GC01M143444
  • GC01M143184
  • GC01M144407
  • GC01M145696
  • GC01M119659

Summaries for CD160 Gene

Entrez Gene Summary for CD160 Gene

  • CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD160 Gene

CD160 (CD160 Molecule) is a Protein Coding gene. Diseases associated with CD160 include Neurotrophic Keratopathy and Cone-Rod Dystrophy 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and MHC class I receptor activity.

UniProtKB/Swiss-Prot Summary for CD160 Gene

  • [CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).
  • [CD160 antigen, soluble form]: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.

Gene Wiki entry for CD160 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD160 Gene

Genomics for CD160 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD160 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J145720 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 612.2 +1.7 1676 1.6 CREB1 GATAD2A CTCF PRDM10 ZNF692 RCOR2 TARDBP ZNF143 ZIC2 PATZ1 CD160 PDZK1 ANKRD35 piR-56451-006 POLR3C
GH01J145719 Promoter 0.7 EPDnew 600.7 +0.2 168 0.1 IKZF2 RUNX3 CBFB BATF TBX21 ATF7 MTA2 IKZF1 CD160 lnc-PDZK1-2 piR-56451-006 POLR3C
GH01J145844 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 9.4 +126.5 126502 2 GATAD2A CTCF POLR2A BACH1 TARDBP ZHX2 FOXA1 LARP7 STAT3 PRDM1 NUDT17 HSALNG0006718 HSALNG0006720 NBPF20 POLR3C GPR89A PIAS3 ITGA10 PEX11B TXNIP
GH01J145990 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.2 +276.0 276030 10.5 ARHGAP35 SP1 CREB1 GATAD2A ZBTB33 PRDM10 REST ZNF629 TFE3 LEF1 TXNIP lnc-HFE2-2 piR-42110 POLR3C NBPF20 GPR89A PIAS3 LIX1L-AS1 HJV RBM8A
GH01J145713 Enhancer 1 Ensembl ENCODE 10.6 -3.2 -3211 5 GATAD2A REST TFE3 RXRB IRF2 BRD4 SP1 CEBPA SOX13 ZBTB26 PDZK1 CD160 NUDT17 lnc-PDZK1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD160 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD160

Top Transcription factor binding sites by QIAGEN in the CD160 gene promoter:
  • CREB
  • deltaCREB
  • FOXF2
  • GR
  • GR-alpha
  • GR-beta
  • LCR-F1

Genomic Locations for CD160 Gene

Genomic Locations for CD160 Gene
chr1:145,719,312-145,739,288
(GRCh38/hg38)
Size:
19,977 bases
Orientation:
Plus strand
chr1:145,695,798-145,715,614
(GRCh37/hg19)
Size:
19,817 bases
Orientation:
Minus strand

Genomic View for CD160 Gene

Genes around CD160 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD160 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD160 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD160 Gene

Proteins for CD160 Gene

  • Protein details for CD160 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95971-BY55_HUMAN
    Recommended name:
    CD160 antigen
    Protein Accession:
    O95971
    Secondary Accessions:
    • A0A0B4J2A1
    • B8PRF2
    • Q5T2V6

    Protein attributes for CD160 Gene

    Size:
    181 amino acids
    Molecular mass:
    19810 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked (Probable). Interacts with HLA-G (PubMed:16809620). Interacts with HLA-A2-B2M in complex with an HIV-derived peptide (PubMed:9973372). Interacts with TNFRSF14 (via cysteine-rich domain 1); this interaction is direct (PubMed:18193050). Interacts with LCK and CD247/CD3 zeta chain (PubMed:11978774).
    Miscellaneous:
    • [Isoform 3]: Mutagenesis of TYR-225 to Phe abolishes intracellular signaling.

    Three dimensional structures from OCA and Proteopedia for CD160 Gene

    Alternative splice isoforms for CD160 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD160 Gene

Post-translational modifications for CD160 Gene

  • Glycosylation at Asn28 and Asn137
  • Modification sites at PhosphoSitePlus

Other Protein References for CD160 Gene

Antibody Products

  • Abcam antibodies for CD160

No data available for DME Specific Peptides for CD160 Gene

Domains & Families for CD160 Gene

Gene Families for CD160 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins

Protein Domains for CD160 Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for CD160 Gene

GenScript: Design optimal peptide antigens:
  • Natural killer cell receptor BY55 (BY55_HUMAN)
  • CD160 protein (Q6FH89_HUMAN)
genes like me logo Genes that share domains with CD160: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CD160 Gene

Function for CD160 Gene

Molecular function for CD160 Gene

UniProtKB/Swiss-Prot Function:
[CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).
UniProtKB/Swiss-Prot Function:
[CD160 antigen, soluble form]: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.
UniProtKB/Swiss-Prot Induction:
Up-regulated on CD4+ T cells upon stimulation via T cell receptor plus costimulation via CD28 (PubMed:18193050). Up-regulated by IL15 on immunoregulatory NCAM1/CD56-bright NK cells (PubMed:17237375).

Phenotypes From GWAS Catalog for CD160 Gene

Gene Ontology (GO) - Molecular Function for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005102 signaling receptor binding IDA 9973372
GO:0005515 protein binding IPI 11978774
GO:0019900 kinase binding IPI 11978774
GO:0023024 MHC class I protein complex binding IEA --
genes like me logo Genes that share ontologies with CD160: view
genes like me logo Genes that share phenotypes with CD160: view

Animal Models for CD160 Gene

MGI Knock Outs for CD160:

Animal Model Products

CRISPR Products

miRNA for CD160 Gene

miRTarBase miRNAs that target CD160

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD160

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD160 Gene

Localization for CD160 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD160 Gene

[CD160 antigen]: Cell membrane. Lipid-anchor, GPI-anchor.
[CD160 antigen, soluble form]: Secreted. Note=Released from the cell membrane by GPI cleavage. {ECO:0000269 PubMed:17237375, ECO:0000269 PubMed:23761635, ECO:0000269 PubMed:9743336}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD160 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0046658 anchored component of plasma membrane IBA,IDA 9973372
genes like me logo Genes that share ontologies with CD160: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD160 Gene

Pathways & Interactions for CD160 Gene

genes like me logo Genes that share pathways with CD160: view

Pathways by source for CD160 Gene

Gene Ontology (GO) - Biological Process for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002385 mucosal immune response IEA --
GO:0002729 positive regulation of natural killer cell cytokine production IDA 17307798
genes like me logo Genes that share ontologies with CD160: view

No data available for SIGNOR curated interactions for CD160 Gene

Drugs & Compounds for CD160 Gene

(11) Drugs for CD160 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CD160 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD160: view

Transcripts for CD160 Gene

mRNA/cDNA for CD160 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD160

Alternative Splicing Database (ASD) splice patterns (SP) for CD160 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2: -

Relevant External Links for CD160 Gene

GeneLoc Exon Structure for
CD160

Expression for CD160 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD160 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD160 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4), Brain - Cerebellum (x5.3), and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for CD160 Gene

This gene is overexpressed in NK cells (35.2) and Urine (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD160 Gene



Protein tissue co-expression partners for CD160 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD160

SOURCE GeneReport for Unigene cluster for CD160 Gene:

Hs.740780

mRNA Expression by UniProt/SwissProt for CD160 Gene:

O95971-BY55_HUMAN
Tissue specificity: Expression is restricted to functional NK and cytotoxic T lymphocytes. Expressed in viral-specific effector memory and terminally differentiated effector memory CD8+ T cells. Expressed in memory and activated CD4+ T cell subsets (at protein level) (PubMed:9743336, PubMed:18193050, PubMed:11978774, PubMed:25255144). Expressed at high levels in intraepithelial lymphocytes (at protein level) (PubMed:9743336). Expressed in both alpha-beta and gamma-delta CD8+ T cell subsets (at protein level) (PubMed:9743336, PubMed:18193050, PubMed:11978774). Expressed in umbilical vein endothelial cells (at protein level) (PubMed:16809620). Expressed in monocytes and at lower levels in B cells (PubMed:23761635). Isoform 3: Expressed exclusively in activated NK cells (at protein level) (PubMed:19109136).

Evidence on tissue expression from TISSUES for CD160 Gene

  • Blood(4.6)
  • Nervous system(3)
  • Spleen(2.9)
  • Lymph node(2.4)
genes like me logo Genes that share expression patterns with CD160: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD160 Gene

Orthologs for CD160 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD160 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD160 30 31
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD160 30 31
  • 82.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cd160 30 17 31
  • 79.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd160 30
  • 78.21 (n)
Species where no ortholog for CD160 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD160 Gene

ENSEMBL:
Gene Tree for CD160 (if available)
TreeFam:
Gene Tree for CD160 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD160: view image

Paralogs for CD160 Gene

No data available for Paralogs for CD160 Gene

Variants for CD160 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD160 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
718727 Benign: not provided 145,730,920(+) G/A MISSENSE_VARIANT
rs2231373 - p.Ile91Val

Additional dbSNP identifiers (rs#s) for CD160 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD160 Gene

Variant ID Type Subtype PubMed ID
dgv331n100 CNV gain 25217958
dgv332n100 CNV gain+loss 25217958
dgv33n27 CNV loss 19166990
dgv531n54 CNV loss 21841781
dgv532n54 CNV gain 21841781
dgv533n54 CNV gain 21841781
dgv95e212 CNV gain 25503493
esv3572342 CNV gain 25503493
esv3587421 CNV loss 21293372
esv3587422 CNV gain 21293372
esv3894089 CNV loss 25118596
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv463494 CNV gain 19166990
nsv469752 CNV loss 16826518
nsv470735 CNV gain 18288195
nsv547665 CNV gain+loss 21841781
nsv547670 CNV loss 21841781
nsv818411 CNV loss 17921354
nsv831392 CNV gain 17160897
nsv998178 CNV loss 25217958

Variation tolerance for CD160 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD160 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD160

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD160 Gene

Disorders for CD160 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CD160 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neurotrophic keratopathy
  • neurotrophic keratitis
cone-rod dystrophy 1
  • retinitis pigmentosa 1
macular degeneration, age-related, 8
  • armd8
acute necrotizing encephalitis
  • acute necrotizing encephalopathy
cone-rod dystrophy 2
  • cord2
- elite association - COSMIC cancer census association via MalaCards
Search CD160 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD160

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CD160: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD160 Gene

Publications for CD160 Gene

  1. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. (PMID: 9743336) Anumanthan A … Freeman GJ (Journal of immunology (Baltimore, Md. : 1950) 1998) 2 3 4 23
  2. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. (PMID: 9973372) Agrawal S … Bensussan A (Journal of immunology (Baltimore, Md. : 1950) 1999) 2 3 4
  3. CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells. (PMID: 23761635) Šedý JR … Ware CF (Journal of immunology (Baltimore, Md. : 1950) 2013) 3 4
  4. Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation. (PMID: 19109136) Giustiniani J … Marie-Cardine A (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4
  5. CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. (PMID: 18193050) Cai G … Freeman GJ (Nature immunology 2008) 3 4

Products for CD160 Gene

Sources for CD160 Gene