The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010] See more...

Aliases for CD14 Gene

Aliases for CD14 Gene

  • CD14 Molecule 2 3 5
  • Myeloid Cell-Specific Leucine-Rich Glycoprotein 3 4
  • Monocyte Differentiation Antigen CD14 3 4
  • CD14 Antigen 2 4

External Ids for CD14 Gene

Previous GeneCards Identifiers for CD14 Gene

  • GC05M139827
  • GC05M140594
  • GC05M139994
  • GC05M140039
  • GC05M139991
  • GC05M135156

Summaries for CD14 Gene

Entrez Gene Summary for CD14 Gene

  • The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

GeneCards Summary for CD14 Gene

CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Mycobacterium Chelonae and Mycobacterium Kansasii. Among its related pathways are Phagosome and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.

UniProtKB/Swiss-Prot Summary for CD14 Gene

  • Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).

Gene Wiki entry for CD14 Gene

Additional gene information for CD14 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD14 Gene

Genomics for CD14 Gene

GeneHancer (GH) Regulatory Elements for CD14 Gene

Promoters and enhancers for CD14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J140630 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 763.7 +1.5 1537 3.7 NR2F6 HLF RAD21 ELF3 SP1 CEBPG ZNF687 SP5 FOSL2 CEBPA CD14 SRA1 TMCO6 APBB3 piR-38423-056
GH05J140635 Enhancer 0.7 ENCODE 750.6 -1.6 -1645 0.5 CTCF NR2F6 CC2D1A L3MBTL2 RAD21 SP5 ZNF644 IKZF1 RXRA REST CD14 piR-51819-021 TMCO6
GH05J140634 Promoter 0.6 Ensembl 750.6 -0.6 -600 0.2 MIXL1 SP1 DRAP1 FOXP1 CD14 SRA1 piR-51819-021 TMCO6
GH05J140611 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 37.6 +21.9 21870 1.5 ZBTB40 SMARCE1 CC2D1A MAX TEAD4 ZKSCAN8 ZNF148 GTF2F1 SP1 MLLT1 CD14 APBB3 PCDHA10 TMCO6 PCDHA6 PCDHA2 PCDHA7 PCDHB17P SLC35A4 IK
GH05J140601 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 26.1 +31.1 31141 1.9 MLX HLF L3MBTL2 SP1 CEBPG ZNF384 CREB1 CEBPA RXRA GATAD2A APBB3 CD14 SRA1 TMCO6 SLC35A4 IK NDUFA2 EIF4EBP3 HBEGF ANKHD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD14 gene promoter:
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for CD14 Gene

Genomic Locations for CD14 Gene
chr5:140,631,728-140,633,701
(GRCh38/hg38)
Size:
1,974 bases
Orientation:
Minus strand
chr5:140,011,313-140,013,286
(GRCh37/hg19)
Size:
1,974 bases
Orientation:
Minus strand

Genomic View for CD14 Gene

Genes around CD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD14 Gene

Proteins for CD14 Gene

  • Protein details for CD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08571-CD14_HUMAN
    Recommended name:
    Monocyte differentiation antigen CD14
    Protein Accession:
    P08571
    Secondary Accessions:
    • Q53XT5
    • Q96FR6
    • Q96L99
    • Q9UNS3

    Protein attributes for CD14 Gene

    Size:
    375 amino acids
    Molecular mass:
    40076 Da
    Quaternary structure:
    • Interacts with LPS-bound LPB (PubMed:1698311, PubMed:23264655). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Interacts with LPAR1 (By similarity). Interacts with the TLR2:TLR6 or TLR2:TLR1 heterodimers; upon interaction with ligands such as diacylated lipopeptides and triacylated lipopeptides, respectively (PubMed:16880211). Interacts with MYO18A (PubMed:25965346).

    Three dimensional structures from OCA and Proteopedia for CD14 Gene

neXtProt entry for CD14 Gene

Post-translational modifications for CD14 Gene

  • N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Asn37, Asn151, Asn282, Asn323, and Thr336
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CD14_HUMAN (774)

Antibody Products

  • Abcam antibodies for CD14

No data available for DME Specific Peptides for CD14 Gene

Domains & Families for CD14 Gene

Gene Families for CD14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CD14 Gene

Suggested Antigen Peptide Sequences for CD14 Gene

GenScript: Design optimal peptide antigens:
  • Myeloid cell-specific leucine-rich glycoprotein (CD14_HUMAN)
  • Myeloid cell-specific leucine-rich glycoprotein (F1C4A7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08571

UniProtKB/Swiss-Prot:

CD14_HUMAN :
  • The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.
Domain:
  • The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.
genes like me logo Genes that share domains with CD14: view

Function for CD14 Gene

Molecular function for CD14 Gene

UniProtKB/Swiss-Prot Function:
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
UniProtKB/Swiss-Prot Induction:
The expression in monocytes is highly induced by 27-hydroxycholesterol, priming monocytes/macrophages such that LPS-mediated inflammatory reaction is accelerated. Secretion of soluble CD14 is also enhanced.
GENATLAS Biochemistry:
cell differentiation antigen CD14,55kDa,expressed on macrophages and monocytes,involved in the clearance of apoptotic cells,also receptor for bacterial liposaccharides and recruiting LPS to TLR proteins and inducing a liposaccharide signaling pathway,regulator of IgE levels,identified by monoclonal antibodies My4,Mo2,UCHM1,VIM13,MoP15,risk factor for myocardial infarction

Phenotypes From GWAS Catalog for CD14 Gene

Gene Ontology (GO) - Molecular Function for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 12594207
GO:0001847 opsonin receptor activity TAS 2402637
GO:0005515 protein binding IPI 16880211
GO:0016019 peptidoglycan receptor activity TAS 8798531
GO:0070891 lipoteichoic acid binding IDA 12594207
genes like me logo Genes that share ontologies with CD14: view
genes like me logo Genes that share phenotypes with CD14: view

Animal Models for CD14 Gene

MGI Knock Outs for CD14:

Animal Model Products

CRISPR Products

miRNA for CD14 Gene

miRTarBase miRNAs that target CD14

Clone Products

  • Addgene plasmids for CD14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD14 Gene

Localization for CD14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD14 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269 PubMed:2462937, ECO:0000269 PubMed:2779588, ECO:0000269 PubMed:3385210}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD14 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
endosome 4
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,HDA 16502470
GO:0005794 Golgi apparatus IEA,IDA 16880211
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA,IEA 21873635
genes like me logo Genes that share ontologies with CD14: view

Pathways & Interactions for CD14 Gene

PathCards logo

SuperPathways for CD14 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Diseases associated with the TLR signaling cascade
3 Toll-like Receptor Signaling Pathway
4 Toll Comparative Pathway
.61
.34
5 Innate Immune System
genes like me logo Genes that share pathways with CD14: view

SIGNOR curated interactions for CD14 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002237 response to molecule of bacterial origin IEA --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CD14: view

Drugs & Compounds for CD14 Gene

(48) Drugs for CD14 Gene - From: PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
IC14 Pharma 0

(53) Additional Compounds for CD14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD14: view

Transcripts for CD14 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for CD14

Alternative Splicing Database (ASD) splice patterns (SP) for CD14 Gene

No ASD Table

Relevant External Links for CD14 Gene

GeneLoc Exon Structure for
CD14
ECgene alternative splicing isoforms for
CD14

Expression for CD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD14 Gene

This gene is overexpressed in Whole Blood (x14.7) and Liver (x7.0).

Protein differential expression in normal tissues from HIPED for CD14 Gene

This gene is overexpressed in Milk (24.2), Urine (18.9), and Vitreous humor (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD14 Gene



Protein tissue co-expression partners for CD14 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD14 Gene:

CD14

SOURCE GeneReport for Unigene cluster for CD14 Gene:

Hs.163867

mRNA Expression by UniProt/SwissProt for CD14 Gene:

P08571-CD14_HUMAN
Tissue specificity: Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Evidence on tissue expression from TISSUES for CD14 Gene

  • Liver(4.7)
  • Nervous system(4.7)
  • Blood(4.6)
  • Bone marrow(4.4)
  • Lung(3)
  • Muscle(2.7)
  • Lymph node(2.1)
  • Stomach(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CD14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD14 Gene

Orthologs for CD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD14 33 32
  • 99.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CD14 33 32
  • 79.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CD14 32
  • 77.75 (n)
mouse
(Mus musculus)
Mammalia Cd14 17 33 32
  • 72.99 (n)
rat
(Rattus norvegicus)
Mammalia Cd14 32
  • 72.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CD14 33
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD14 33
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD14 33
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 22 (a)
OneToMany
-- 33
  • 20 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10497 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13785 32
Species where no ortholog for CD14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD14 Gene

ENSEMBL:
Gene Tree for CD14 (if available)
TreeFam:
Gene Tree for CD14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD14: view image

Paralogs for CD14 Gene

No data available for Paralogs for CD14 Gene

Variants for CD14 Gene

Sequence variations from dbSNP and Humsavar for CD14 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1002825640 -- 140,631,601(-) GAGGAGGA/GAGGA downstream_transcript_variant
rs1003752066 -- 140,634,734(-) C/G upstream_transcript_variant
rs1003922204 -- 140,634,314(-) G/A upstream_transcript_variant
rs1006243753 -- 140,631,697(-) T/C downstream_transcript_variant
rs1006335701 -- 140,631,323(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CD14 Gene

Variant ID Type Subtype PubMed ID
esv3606953 CNV loss 21293372

Variation tolerance for CD14 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD14 Gene

Human Gene Mutation Database (HGMD)
CD14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD14 Gene

Disorders for CD14 Gene

MalaCards: The human disease database

(17) MalaCards diseases for CD14 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mycobacterium chelonae
  • m. chelonae
mycobacterium kansasii
  • m. kansasii
croup
  • acute laryngotracheobronchitis
monocytic leukemia
  • schilling's leukemia
paroxysmal nocturnal hemoglobinuria
  • marchiafava-micheli disease
- elite association - COSMIC cancer census association via MalaCards
Search CD14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD14 Gene

Publications for CD14 Gene

  1. CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation? (PMID: 20398919) Munthe-Kaas MC … Lyle R (The Journal of allergy and clinical immunology 2010) 3 23 43 56
  2. Influence of C-159T SNP of the CD14 gene promoter on lung function in smokers. (PMID: 19361972) Zhou H … Peden DB (Respiratory medicine 2009) 3 23 43 56
  3. Influence of CD14 polymorphism on CD14 expression in patients with extensive burns. (PMID: 18951711) Lin J … Sheng ZY (Burns : journal of the International Society for Burn Injuries 2009) 3 23 43 56
  4. Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation. (PMID: 17949800) Levan TD … Martinez FD (The Journal of allergy and clinical immunology 2008) 3 23 43 56
  5. Effects of CD14-159 C/T polymorphism on CD14 expression and the balance between proinflammatory and anti-inflammatory cytokines in whole blood culture. (PMID: 17515856) Lin J … Sheng ZY (Shock (Augusta, Ga.) 2007) 3 23 43 56

Products for CD14 Gene