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The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]
CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Mycobacterium Chelonae and Mycobacterium Kansasii. Among its related pathways are Bacterial infections in CF airways and Immune response IL-23 signaling pathway. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001530 | lipopolysaccharide binding | IDA | 12594207 |
GO:0001847 | opsonin receptor activity | TAS | 2402637 |
GO:0005515 | protein binding | IPI | 16880211 |
GO:0016019 | peptidoglycan receptor activity | TAS | 8798531 |
GO:0070891 | lipoteichoic acid binding | IDA | 12594207 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | HDA | 16502470 |
GO:0005794 | Golgi apparatus | IEA,IDA | 16880211 |
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Diseases associated with the TLR signaling cascade | ||
3 | Toll-like Receptor Signaling Pathway | ||
4 | Toll Comparative Pathway |
Toll Comparative Pathway
.61
Immune response MIF in innate immunity response
.46
|
iNOS Signaling
.34
|
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001819 | positive regulation of cytokine production | IBA | -- |
GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
GO:0002237 | response to molecule of bacterial origin | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD14 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD14 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD14 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cd14 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd14 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CD14 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CD14 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD14 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.10497 30 |
|
||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13785 30 |
|
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs144018386 | Benign: not provided | 140,632,546(-) |
G/A NM_000591.4(CD14):c.438C>T (p.Ser146=) |
SYNONYMOUS | |
rs74587733 | Benign: not provided | 140,632,282(-) |
C/T NM_000591.4(CD14):c.702G>A (p.Met234Ile) |
MISSENSE | |
rs11556179 | - |
p.Glu341Lys |
|||
rs2228049 | - |
p.Asn204Asp |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3606953 | CNV | loss | 21293372 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mycobacterium chelonae |
|
|
mycobacterium kansasii |
|
|
croup |
|
|
monocytic leukemia |
|
|
paroxysmal nocturnal hemoglobinuria |
|
|