The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010] See more...

Aliases for CD14 Gene

Aliases for CD14 Gene

  • CD14 Molecule 2 3 5
  • Myeloid Cell-Specific Leucine-Rich Glycoprotein 3 4
  • Monocyte Differentiation Antigen CD14 3 4
  • CD14 Antigen 2 4
  • CD14 5

External Ids for CD14 Gene

Previous GeneCards Identifiers for CD14 Gene

  • GC05M139827
  • GC05M140594
  • GC05M139994
  • GC05M140039
  • GC05M139991
  • GC05M135156

Summaries for CD14 Gene

Entrez Gene Summary for CD14 Gene

  • The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

GeneCards Summary for CD14 Gene

CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Mycobacterium Chelonae and Mycobacterium Kansasii. Among its related pathways are Antigen processing-Cross presentation and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.

UniProtKB/Swiss-Prot Summary for CD14 Gene

  • Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).

Gene Wiki entry for CD14 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CD14 Gene

Genomics for CD14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CD14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J140630 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 613.7 +1.5 1537 3.7 GATAD2A NFKBIZ RCOR2 RXRB IRF2 SP1 GABPA CEBPA RFX1 RUNX3 CD14 SRA1 TMCO6 APBB3 piR-38423-056
GH05J140635 Enhancer 0.7 ENCODE 600.7 -1.6 -1645 0.5 GATAD2A CTCF IKZF1 REST RAD21 IKZF2 TRIM22 YY1 GATAD2B EED CD14 piR-51819-021 IK TMCO6
GH05J140634 Promoter 0.6 Ensembl 600.7 -0.6 -600 0.2 FOXP1 DRAP1 MIXL1 SP1 CD14 SRA1 piR-51819-021 IK TMCO6
GH05J140611 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 37.6 +21.9 21870 1.5 ZNF512 RFX1 LEF1 IKZF1 ETV6 DDX20 MTA2 PKNOX1 MTA1 ZNF24 CD14 TMCO6 APBB3 ANKHD1 IK WDR55 HARS2 SLC35A4 EIF4EBP3 NDUFA2
GH05J140601 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 26.1 +31.1 31141 1.9 CREB1 GATAD2A SP1 CEBPA MGA CEBPB NFE2 FOXA2 YY1 ZBTB33 APBB3 CD14 SRA1 TMCO6 SLC35A4 IK NDUFA2 EIF4EBP3 HBEGF ANKHD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CD14

Top Transcription factor binding sites by QIAGEN in the CD14 gene promoter:
  • c-Jun
  • CREB
  • deltaCREB

Genomic Locations for CD14 Gene

Genomic Locations for CD14 Gene
chr5:140,631,728-140,633,701
(GRCh38/hg38)
Size:
1,974 bases
Orientation:
Minus strand
chr5:140,011,313-140,013,286
(GRCh37/hg19)
Size:
1,974 bases
Orientation:
Minus strand

Genomic View for CD14 Gene

Genes around CD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD14 Gene

Proteins for CD14 Gene

  • Protein details for CD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08571-CD14_HUMAN
    Recommended name:
    Monocyte differentiation antigen CD14
    Protein Accession:
    P08571
    Secondary Accessions:
    • Q53XT5
    • Q96FR6
    • Q96L99
    • Q9UNS3

    Protein attributes for CD14 Gene

    Size:
    375 amino acids
    Molecular mass:
    40076 Da
    Quaternary structure:
    • Interacts with LPS-bound LPB (PubMed:1698311, PubMed:23264655). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Interacts with LPAR1 (By similarity). Interacts with the TLR2:TLR6 or TLR2:TLR1 heterodimers; upon interaction with ligands such as diacylated lipopeptides and triacylated lipopeptides, respectively (PubMed:16880211). Interacts with MYO18A (PubMed:25965346).

    Three dimensional structures from OCA and Proteopedia for CD14 Gene

neXtProt entry for CD14 Gene

Post-translational modifications for CD14 Gene

  • N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Asn37, Asn151, Asn282, Asn323, and Thr336
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CD14_HUMAN (774)

Antibody Products

  • Abcam antibodies for CD14

No data available for DME Specific Peptides for CD14 Gene

Domains & Families for CD14 Gene

Gene Families for CD14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CD14 Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for CD14 Gene

GenScript: Design optimal peptide antigens:
  • Myeloid cell-specific leucine-rich glycoprotein (CD14_HUMAN)
  • Myeloid cell-specific leucine-rich glycoprotein (F1C4A7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08571

UniProtKB/Swiss-Prot:

CD14_HUMAN :
  • The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.
Domain:
  • The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.
genes like me logo Genes that share domains with CD14: view

Function for CD14 Gene

Molecular function for CD14 Gene

UniProtKB/Swiss-Prot Function:
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
UniProtKB/Swiss-Prot Induction:
The expression in monocytes is highly induced by 27-hydroxycholesterol, priming monocytes/macrophages such that LPS-mediated inflammatory reaction is accelerated. Secretion of soluble CD14 is also enhanced.
GENATLAS Biochemistry:
cell differentiation antigen CD14,55kDa,expressed on macrophages and monocytes,involved in the clearance of apoptotic cells,also receptor for bacterial liposaccharides and recruiting LPS to TLR proteins and inducing a liposaccharide signaling pathway,regulator of IgE levels,identified by monoclonal antibodies My4,Mo2,UCHM1,VIM13,MoP15,risk factor for myocardial infarction

Phenotypes From GWAS Catalog for CD14 Gene

Gene Ontology (GO) - Molecular Function for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 12594207
GO:0001847 opsonin receptor activity TAS 2402637
GO:0005515 protein binding IPI 16880211
GO:0016019 peptidoglycan receptor activity TAS 8798531
GO:0070891 lipoteichoic acid binding IDA 12594207
genes like me logo Genes that share ontologies with CD14: view
genes like me logo Genes that share phenotypes with CD14: view

Animal Models for CD14 Gene

MGI Knock Outs for CD14:

CRISPR Products

miRNA for CD14 Gene

miRTarBase miRNAs that target CD14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD14

Clone Products

  • Addgene plasmids for CD14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD14 Gene

Localization for CD14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD14 Gene

Cell membrane. Lipid-anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269 PubMed:2462937, ECO:0000269 PubMed:2779588, ECO:0000269 PubMed:3385210}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD14 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
endosome 4
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,HDA 16502470
GO:0005794 Golgi apparatus IEA,IDA 16880211
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA,IBA 21873635
genes like me logo Genes that share ontologies with CD14: view

Pathways & Interactions for CD14 Gene

PathCards logo

SuperPathways for CD14 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Diseases associated with the TLR signaling cascade
3 Toll-like Receptor Signaling Pathway
4 Toll Comparative Pathway
.61
.46
.34
5 Innate Immune System
genes like me logo Genes that share pathways with CD14: view

Pathways by source for CD14 Gene

9 GeneGo (Thomson Reuters) pathways for CD14 Gene
  • Bacterial infections in CF airways
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
  • Immune response Bacterial infections in normal airways
  • Immune response IL-10 signaling pathway
8 Qiagen pathways for CD14 Gene
  • IL-10 Pathway
  • iNOS Signaling
  • LPS Stimulated MAPK Signaling
  • MIF Action Through Endocytic Pathway
  • MIF Mediated Glucocorticoid Regulation
1 GeneTex pathway for CD14 Gene

SIGNOR curated interactions for CD14 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002237 response to molecule of bacterial origin IEA --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CD14: view

Drugs & Compounds for CD14 Gene

(49) Drugs for CD14 Gene - From: PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
IC14 Pharma 0

(52) Additional Compounds for CD14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD14: view

Transcripts for CD14 Gene

mRNA/cDNA for CD14 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CD14

Clone Products

  • Addgene plasmids for CD14

Alternative Splicing Database (ASD) splice patterns (SP) for CD14 Gene

No ASD Table

Relevant External Links for CD14 Gene

GeneLoc Exon Structure for
CD14

Expression for CD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD14 Gene

This gene is overexpressed in Whole Blood (x14.7) and Liver (x7.0).

Protein differential expression in normal tissues from HIPED for CD14 Gene

This gene is overexpressed in Milk (24.2), Urine (18.9), and Vitreous humor (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD14 Gene



Protein tissue co-expression partners for CD14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CD14

SOURCE GeneReport for Unigene cluster for CD14 Gene:

Hs.163867

mRNA Expression by UniProt/SwissProt for CD14 Gene:

P08571-CD14_HUMAN
Tissue specificity: Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Evidence on tissue expression from TISSUES for CD14 Gene

  • Nervous system(4.8)
  • Liver(4.8)
  • Blood(4.7)
  • Bone marrow(4.5)
  • Lung(3.4)
  • Muscle(3.2)
  • Heart(2.9)
  • Lymph node(2.8)
  • Intestine(2.7)
  • Stomach(2.6)
  • Spleen(2.6)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with CD14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD14 Gene

Orthologs for CD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CD14 30 31
  • 99.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CD14 30 31
  • 79.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CD14 30
  • 77.75 (n)
Mouse
(Mus musculus)
Mammalia Cd14 30 17 31
  • 72.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cd14 30
  • 72.32 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CD14 31
  • 50 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CD14 31
  • 43 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CD14 31
  • 23 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 22 (a)
OneToMany
-- 31
  • 20 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.10497 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13785 30
Species where no ortholog for CD14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CD14 Gene

ENSEMBL:
Gene Tree for CD14 (if available)
TreeFam:
Gene Tree for CD14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CD14: view image

Paralogs for CD14 Gene

No data available for Paralogs for CD14 Gene

Variants for CD14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CD14 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
715333 Benign: not provided 140,632,282(-) C/T MISSENSE_VARIANT
779243 Benign: not provided 140,632,546(-) G/A SYNONYMOUS_VARIANT
rs11556179 - p.Glu341Lys
rs2228049 - p.Asn204Asp

Additional dbSNP identifiers (rs#s) for CD14 Gene

Structural Variations from Database of Genomic Variants (DGV) for CD14 Gene

Variant ID Type Subtype PubMed ID
esv3606953 CNV loss 21293372

Variation tolerance for CD14 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD14 Gene

Human Gene Mutation Database (HGMD)
CD14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD14 Gene

Disorders for CD14 Gene

MalaCards: The human disease database

(27) MalaCards diseases for CD14 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mycobacterium chelonae
  • m. chelonae
mycobacterium kansasii
  • m. kansasii
monocytic leukemia
  • monocytic leukaemia
croup
  • acute laryngotracheobronchitis
paroxysmal nocturnal hemoglobinuria
  • marchiafava-micheli disease
- elite association - COSMIC cancer census association via MalaCards
Search CD14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CD14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD14 Gene

Publications for CD14 Gene

  1. CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation? (PMID: 20398919) Munthe-Kaas MC … Lyle R (The Journal of allergy and clinical immunology 2010) 3 23 41
  2. Host-microbial interactions in childhood atopy: toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli. (PMID: 20109750) Penders J … Postma DS (The Journal of allergy and clinical immunology 2010) 3 23 41
  3. Influence of CD14 polymorphism on CD14 expression in patients with extensive burns. (PMID: 18951711) Lin J … Sheng ZY (Burns : journal of the International Society for Burn Injuries 2009) 3 23 41
  4. Influence of C-159T SNP of the CD14 gene promoter on lung function in smokers. (PMID: 19361972) Zhou H … Peden DB (Respiratory medicine 2009) 3 23 41
  5. Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE. (PMID: 19254290) Tewfik MA … Desrosiers M (Allergy 2009) 3 23 41

Products for CD14 Gene

  • Addgene plasmids for CD14

Sources for CD14 Gene