Aliases for CD14 Gene
Aliases for CD14 Gene
External Ids for CD14 Gene
- HGNC: 1628
- Entrez Gene: 929
- Ensembl: ENSG00000170458
- OMIM: 158120
- UniProtKB: P08571
Previous GeneCards Identifiers for CD14 Gene
- GC05M139827
- GC05M139994
- GC05M140039
- GC05M139991
- GC05M135156
Summaries for CD14 Gene
-
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
GeneCards Summary for CD14 Gene
CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Mycobacterium Chelonae and Croup. Among its related pathways are Bacterial infections in CF airways and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.
UniProtKB/Swiss-Prot for CD14 Gene
-
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
Additional gene information for CD14 Gene
- Monarch Initiative
- Search for CD14 at DataMed
- Search for CD14 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD14 Gene
Genomics for CD14 Gene
GeneHancer (GH) Regulatory Elements for CD14 Gene
Promoters and enhancers for CD14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CD14 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CD14 gene promoter:
Regulatory Element Products
Genomic Locations for CD14 Gene
Genomic Locations for CD14 Gene
- chr5:140,631,728-140,633,701
- (GRCh38/hg38)
- Size:
- 1,974 bases
- Orientation:
- Minus strand
- chr5:140,011,313-140,013,286
- (GRCh37/hg19)
Genomic View for CD14 Gene
Genes around CD14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.3 by Ensembl
- 5q31.3 by Entrez Gene
- 5q31.3 by HGNC
CD14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD14 Gene
Proteins for CD14 Gene
-
Protein details for CD14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08571-CD14_HUMAN
- Recommended name:
- Monocyte differentiation antigen CD14
- Protein Accession:
- P08571
- Q53XT5
- Q96FR6
- Q96L99
- Q9UNS3
Protein attributes for CD14 Gene
- Size:
- 375 amino acids
- Molecular mass:
- 40076 Da
- Quaternary structure:
-
- Interacts with LPS-bound LPB (PubMed:1698311, PubMed:23264655). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Interacts with LPAR1 (By similarity). Interacts with the TLR2:TLR6 or TLR2:TLR1 heterodimers; upon interaction with ligands such as diacylated lipopeptides and triacylated lipopeptides, respectively (PubMed:16880211). Interacts with MYO18A (PubMed:25965346).
Protein Expression for CD14 Gene
Post-translational modifications for CD14 Gene
- N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
- Glycosylation at Asn37, Asn151, Asn282, Asn323, and posLast=336336
Other Protein References for CD14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD14 (CD14)
-
Custom Antibody ServicesOriGene Antibodies for CD14
- TA353656
- TA353024
- TA327620
- TA320236
- TA303082
- TA302272
- TA302271
- SM3163R
- SM3163PP
- SM3163P
- SM3163F
- SM3163B
- SM3163APC
- SM3009R
- SM3009P
- SM3009F
- SM3009B
- SM3009AS
- SM3009APC
- SM1071RT
- SM1071R
- SM1071PT
- SM1071PS
- SM1071P
- SM1071FT
- SM1071F
- SM1071BT
- SM1071B
- SM1071APCT
- SM1071APC
- SM1066RT
- SM1066R
- SM1066PT
- SM1066PS
- SM1066P
- SM1066LE
- SM1066FT
- SM1066F
- BM4106
- BM4034B
- BM4034
- AP22502PU-N
- AM33378PU-S
- AM33378PU-N
- AM31358PU-N
- AM31358AF-N
- AM26196PU-N
- AM20473PU-N
- AM06089PU-N
- AM05857FC-N
- AM05677RC55-N
- AM05176PU-N
- AM05176FC-N
- Novus Biologicals Antibodies for CD14
-
Abcam antibodies for CD14
-
Cloud-Clone Corp. Antibodies for CD14
- Invitrogen Antibodies for CD14
- antibodies-online: Search results for 1119 available CD14 Antibodies ranked by validation data
- Compare Top CD14 Antibodies
-
Recommended
- 55 WB Antibodies (anti-mouse)
- 53 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IF Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 340 FACS Antibodies (anti-human)
- 283 WB Antibodies (anti-human)
- 69 IF Antibodies (anti-human)
- 58 IP Antibodies (anti-human)
- 53 IHC Antibodies (anti-human)
- 36 IHC (fro) Antibodies (anti-human)
- 32 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 ICFC Antibodies (anti-human)
- 6 IF/ICC Antibodies (anti-human)
- 3 ICC Antibodies (anti-human)
- 3 IFA Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 1 FACS Antibody (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 14 WB Antibodies (anti-rat)
- 1 InhA Antibody (anti-human)
- 1 IHC (zinc) Antibody (anti-human)
- 1 Func Antibody (anti-human)
- 2 BCA Antibodies (anti-human)
- GeneTex CD14 antibody for CD14
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD14
- Sino Biological Antibodies for CD14
Protein Products
- R&D Systems Proteins and Enzymes for CD14
- Search Origene for MassSpec and Protein Over-expression Lysates for CD14
- Origene Custom Protein Services for CD14
- Sino Biological Recombinant Proteins for CD14
- Sino Biological Cell Lysates for CD14
- ProSpec Recombinant Proteins for CD14
-
Cloud-Clone Corp. Proteins for CD14
- GeneTex Proteins for CD14
-
ProSci Proteins for CD14
-
Abcam proteins for CD14
Assay Products
- R&D Systems Luminex Assays, ELISAs, Cell Selection and Detection Kits, Proteome Profiler Antibody Arrays, and other biochemical assays for CD14 (CD14)
- Novus Biologicals ELISA Kits for CD14
-
Cloud-Clone Corp. Assay Kits for CD14
-
Abcam assays for CD14
- Sino Biological Assays for CD14
No data available for DME Specific Peptides for CD14 Gene
Domains & Families for CD14 Gene
Gene Families for CD14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CD14 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08571UniProtKB/Swiss-Prot:
CD14_HUMAN :- The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.
- Domain:
-
- The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.
Function for CD14 Gene
Molecular function for CD14 Gene
- GENATLAS Biochemistry:
- cell differentiation antigen CD14,55kDa,expressed on macrophages and monocytes,involved in the clearance of apoptotic cells,also receptor for bacterial liposaccharides and recruiting LPS to TLR proteins and inducing a liposaccharide signaling pathway,regulator of IgE levels,identified by monoclonal antibodies My4,Mo2,UCHM1,VIM13,MoP15,risk factor for myocardial infarction
- UniProtKB/Swiss-Prot Function:
- Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
- UniProtKB/Swiss-Prot Induction:
- The expression in monocytes is highly induced by 27-hydroxycholesterol, priming monocytes/macrophages such that LPS-mediated inflammatory reaction is accelerated. Secretion of soluble CD14 is also enhanced.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | IDA | 12594207 |
| GO:0001847 | opsonin receptor activity | TAS | 2402637 |
| GO:0005515 | protein binding | IPI | 16880211 |
| GO:0016019 | peptidoglycan receptor activity | TAS | 8798531 |
| GO:0070891 | lipoteichoic acid binding | IDA | 12594207 |
Phenotypes for CD14 Gene
- MGI mutant phenotypes for CD14:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CD14:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD14
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CD14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD14 gene
- Search ViGene Biosciences for CD14
CRISPR Products
-
OriGene CRISPR knockouts for CD14
- genomics-online: gRNA clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
- Applied Biological Materials CRISPR for CD14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD14
- GenScript: Design CRISPR guide RNA sequences for CD14
miRNA for CD14 Gene
- miRTarBase miRNAs that target CD14
miRNA Products
- Search ViGene Biosciences for CD14
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CD14
- Browse OriGene Inhibitory RNA Products For CD14
- genomics-online: shRNA clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CD14 gene
Clone Products
- Sino Biological Human cDNA Clone for CD14
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD14
- Applied Biological Materials Clones for CD14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD14
Cell Line Products
-
Horizon Cell Lines for CD14
-
ViGene Biosciences adenoviral particle packaged cDNA for CD14 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD14 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD14 Gene
Localization for CD14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD14 Gene
- Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269 PubMed:2462937, ECO:0000269 PubMed:2779588, ECO:0000269 PubMed:3385210}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| golgi apparatus | 5 |
| endosome | 4 |
| lysosome | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | HDA,IDA | 16502470 |
| GO:0005794 | Golgi apparatus | IEA,IDA | 16880211 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
Pathways & Interactions for CD14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | Toll Comparative Pathway |
.34
|
|
| 4 | Innate Immune System |
.61
|
|
| 5 | Bacterial infections in CF airways | ||
Pathways by source for CD14 Gene
1 Sino Biological pathway for CD14 Gene
1 GeneTex pathway for CD14 Gene
4 BioSystems pathways for CD14 Gene
37 Reactome pathways for CD14 Gene
14 KEGG pathways for CD14 Gene
9 GeneGo (Thomson Reuters) pathways for CD14 Gene
3 R&D Systems pathways for CD14 Gene
8 Qiagen pathways for CD14 Gene
Interacting Proteins for CD14 Gene
Selected Interacting proteins:
P08571-CD14_HUMAN
ENSP00000304236
for CD14 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002237 | response to molecule of bacterial origin | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | -- |
No data available for SIGNOR curated interactions for CD14 Gene
Transcripts for CD14 Gene
mRNA/cDNA for CD14 Gene
- (4) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (503) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CD14 Gene
- CD14 molecule:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CD14
- genomics-online: gRNA clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
- Applied Biological Materials CRISPR for CD14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD14
- GenScript: Design CRISPR guide RNA sequences for CD14
miRNA Products
- Search ViGene Biosciences for CD14
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CD14
- Browse OriGene Inhibitory RNA Products For CD14
- genomics-online: shRNA clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CD14 gene
Clone Products
- Sino Biological Human cDNA Clone for CD14
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD14
- Applied Biological Materials Clones for CD14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD14
Expression for CD14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Myeloid Dendritic Cells Peripheral Blood
- Macrophages Peripheral Blood
- Hematopoietic Bone Marrow
- Endothelium (Cardiovascular System)
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Duct Cells Pancreatic Ducts
- Limbal epithelial stem cells
- Limbal epithelial stem cells (family)
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Limbal epithelial stem cells
- Limbal epithelial stem cells (family)
- Skeletal Muscle (Muscoskeletal System)
- Bone (Muscoskeletal System)
-
Placenta (Extraembryonic Tissues)
- Hofbauer Cells Chorionic Villus
-
Chorion (Extraembryonic Tissues)
- Hofbauer Cells Chorionic Villus
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Liver (Hepatobiliary System)
- Sinusoidal Endothelial Cells Sinusoids
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
- Mesenchymal Stem Cells
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for CD14 Gene
This gene is overexpressed in Whole Blood (x14.7) and Liver (x7.0).
This gene is overexpressed in Milk (24.2), Urine (18.9), and Vitreous humor (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD14 Gene
NURSA nuclear receptor signaling pathways regulating expression of CD14 Gene:
CD14SOURCE GeneReport for Unigene cluster for CD14 Gene:
Hs.163867mRNA Expression by UniProt/SwissProt for CD14 Gene:
P08571-CD14_HUMAN
Tissue specificity:
Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Evidence on tissue expression from TISSUES for CD14 Gene
- Liver(4.7)
- Nervous system(4.7)
- Blood(4.6)
- Bone marrow(4.4)
- Lung(3)
- Muscle(2.7)
- Lymph node(2.1)
- Stomach(2.1)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for CD14
-
OriGene qPCR primer pairs and template standards for CD14
- genomics-online: primer clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD14 Gene
Orthologs for CD14 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD14 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CD14 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CD14 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd14 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd14 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CD14 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CD14 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CD14 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.10497 33 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13785 33 |
|
- Species where no ortholog for CD14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CD14 Gene
No data available for Paralogs for CD14 Gene
Variants for CD14 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1002825640 | -- | 140,631,601(-) | GAGGAGGA/GAGGA | downstream_transcript_variant | |
| rs1003752066 | -- | 140,634,734(-) | C/G | upstream_transcript_variant | |
| rs1003922204 | -- | 140,634,314(-) | G/A | upstream_transcript_variant | |
| rs1006243753 | -- | 140,631,697(-) | T/C | downstream_transcript_variant | |
| rs1006335701 | -- | 140,631,323(-) | G/A | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3606953 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.12;
38.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD14 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD14 Gene
Disorders for CD14 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mycobacterium chelonae |
|
|
| croup |
|
|
| monocytic leukemia |
|
|
| mycobacterium kansasii |
|
|
| paroxysmal nocturnal hemoglobinuria |
|
Search CD14 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CD14 Gene
Publications for CD14 Gene
- CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation? (PMID: 20398919) Munthe-Kaas MC … Lyle R (The Journal of allergy and clinical immunology 2010) 3 22 44 58
- Influence of CD14 polymorphism on CD14 expression in patients with extensive burns. (PMID: 18951711) Lin J … Sheng ZY (Burns : journal of the International Society for Burn Injuries 2009) 3 22 44 58
- Influence of C-159T SNP of the CD14 gene promoter on lung function in smokers. (PMID: 19361972) Zhou H … Peden DB (Respiratory medicine 2009) 3 22 44 58
- Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation. (PMID: 17949800) Levan TD … Martinez FD (The Journal of allergy and clinical immunology 2008) 3 22 44 58
- CD14 C (-260)T polymorphism, atherosclerosis, elderly: role of cytokines and metallothioneins. (PMID: 17098305) Giacconi R … Mocchegiani E (International journal of cardiology 2007) 3 22 44 58
Products for CD14 Gene
- R&D Systems Antibodies for CD14 (CD14)
- R&D Systems Proteins and Enzymes for CD14
- R&D Systems Cell Selection and Detection Kits, ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CD14 (CD14)
- R&D Systems cDNA Clones for CD14
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for CD14
- AM05176FC-N
- AM05176PU-N
- AM05677RC55-N
- AM05857FC-N
- AM06089PU-N
- AM20473PU-N
- AM26196PU-N
- AM31358AF-N
- AM31358PU-N
- AM33378PU-N
- AM33378PU-S
- AP22502PU-N
- BM4034
- BM4034B
- BM4106
- SM1066F
- SM1066FT
- SM1066LE
- SM1066P
- SM1066PS
- SM1066PT
- SM1066R
- SM1066RT
- SM1071APC
- SM1071APCT
- SM1071B
- SM1071BT
- SM1071F
- SM1071FT
- SM1071P
- SM1071PS
- SM1071PT
- SM1071R
- SM1071RT
- SM3009APC
- SM3009AS
- SM3009B
- SM3009F
- SM3009P
- SM3009R
- SM3163APC
- SM3163B
- SM3163F
- SM3163P
- SM3163PP
- SM3163R
- TA302271
- TA302272
- TA303082
- TA320236
- TA327620
- TA353024
- TA353656
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CD14
- Origene Custom Protein Services for CD14
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD14
- Browse OriGene Inhibitory RNA Products For CD14
- OriGene qPCR primer pairs and template standards for CD14
- OriGene qPCR primer pairs for CD14
- OriGene CRISPR knockouts for CD14
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD14
- GenScript: Next-day shipping of latest version cDNA ORF clones for CD14 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CD14
- GenScript Custom Assay Services for CD14
- GenScript Custom overexpressing Cell Line Services for CD14
- GenScript: Design CRISPR guide RNA sequences for CD14
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD14
- Sino Biological Human cDNA Clone for CD14
- Sino Biological Recombinant Proteins for CD14
- Sino Biological Cell Lysates for CD14
- Sino Biological Antibodies for CD14
- Sino Biological Assays for CD14
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CD14
- Novus Biologicals lysates and proteins for CD14
- Novus Biologicals ELISA Kits for CD14
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CD14
- Abcam proteins for CD14
- Abcam assays for CD14
- Find your target
- Browse Primary Antibodies
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- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CD14
- Cloud-Clone Corp. Antibodies for CD14
- Cloud-Clone Corp. Proteins for CD14
- Cloud-Clone Corp. Assay Kits for CD14
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CD14
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD14
- VectorBuilder custom plasmid, inducible vectors for CD14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD14
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD14
- antibodies-online: Search results for 1119 available CD14 Antibodies ranked by validation data
- Compare Top CD14 Antibodies
- Recommended
- 55 WB Antibodies (anti-mouse)
- 53 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IF Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 340 FACS Antibodies (anti-human)
- 283 WB Antibodies (anti-human)
- 69 IF Antibodies (anti-human)
- 58 IP Antibodies (anti-human)
- 53 IHC Antibodies (anti-human)
- 36 IHC (fro) Antibodies (anti-human)
- 32 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 ICFC Antibodies (anti-human)
- 6 IF/ICC Antibodies (anti-human)
- 3 ICC Antibodies (anti-human)
- 3 IFA Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IHC (zinc) Antibody (anti-human)
- 1 InhA Antibody (anti-human)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- antibodies-online: Search results for 49 available CD14 Elisa Kits ranked by validation data
- Compare Top CD14 Elisa Kits
- antibodies-online: Search results for 56 available CD14 Proteins ranked by validation data
- Compare Top CD14 Proteins
- GeneTex CD14 antibody for CD14
- GeneTex Proteins for CD14
- ViGene Biosciences adenoviral particle packaged cDNA for CD14 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD14 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD14 gene
- Search ViGene Biosciences for CD14
- Santa Cruz Biotechnology (SCBT) Antibodies for CD14
- Search Santa Cruz Biotechnology (SCBT) for CD14 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD14
- Horizon Cell Lines for CD14
- genomics-online: cdna clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
- orf clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
- genomics-online: gRNA clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
- genomics-online: primer clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
- genomics-online: shRNA clones - Search results for 170 available CD14 gene related products
- Overview of 170 available CD14 gene related products
Sources for CD14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew