Aliases for CD109 Gene
External Ids for CD109 Gene
Previous GeneCards Identifiers for CD109 Gene
This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
GeneCards Summary for CD109 Gene
CD109 (CD109 Molecule) is a Protein Coding gene. Diseases associated with CD109 include Fetal And Neonatal Alloimmune Thrombocytopenia and Gallbladder Squamous Cell Carcinoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and transforming growth factor beta binding. An important paralog of this gene is CPAMD8.
UniProtKB/Swiss-Prot Summary for CD109 Gene
Modulates negatively TGFB1 signaling in keratinocytes.