Aliases for CD109 Gene
External Ids for CD109 Gene
Previous GeneCards Identifiers for CD109 Gene
This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
GeneCards Summary for CD109 Gene
CD109 (CD109 Molecule) is a Protein Coding gene. Diseases associated with CD109 include Fetal And Neonatal Alloimmune Thrombocytopenia and Gallbladder Squamous Cell Carcinoma. Among its related pathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and transforming growth factor beta binding. An important paralog of this gene is A2M.
UniProtKB/Swiss-Prot Summary for CD109 Gene
Modulates negatively TGFB1 signaling in keratinocytes.