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CD101 (CD101 Molecule) is a Protein Coding gene. Diseases associated with CD101 include Langerhans Cell Histiocytosis and Histiocytosis. Among its related pathways are Innate Immune System and Translocation of ZAP-70 to Immunological synapse. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is IGSF3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | 7722300 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | TAS,IBA | 21873635 |
GO:0070062 | extracellular exosome | HDA | 20458337 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Lymphoid Cell Differentiation Pathways | ||
2 | Class I MHC mediated antigen processing and presentation | ||
3 | Translocation of ZAP-70 to Immunological synapse | ||
4 | Innate Immune System |
.61
|
|
5 | TCR signaling (REACTOME) |
.83
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002763 | positive regulation of myeloid leukocyte differentiation | IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | TAS | 7722300 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6876 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||
SP2: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CD101 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CD101 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CD101 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cd101 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cd101 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CD101 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CD101 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CD101 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CD101 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | zgc:91849 31 |
|
ManyToMany | |
CABZ01067072.1 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs116063197 | Benign: not provided | 117,018,408(+) |
G/A NM_001256106.2(CD101):c.1865G>A (p.Arg622His) |
MISSENSE | |
rs12093834 | Benign: not provided. - | 117,025,878(+) |
G/Ap.Arg933Gln NM_001256106.2(CD101):c.2798G>A (p.Arg933Gln) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
rs138020050 | Benign: not provided | 117,025,888(+) |
C/A NM_001256106.2(CD101):c.2808C>A (p.Leu936=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
rs141474998 | Likely Benign: not provided | 117,021,666(+) |
A/G NM_001256106.2(CD101):c.2111A>G (p.Asn704Ser) |
MISSENSE | |
rs147095176 | Likely Benign: not provided | 117,013,503(+) |
A/G NM_001256106.2(CD101):c.939A>G (p.Pro313=) |
SYNONYMOUS |
Disorder | Aliases | PubMed IDs |
---|---|---|
langerhans cell histiocytosis |
|
|
histiocytosis |
|
|