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Aliases for CCT8L2 Gene

Aliases for CCT8L2 Gene

  • Chaperonin Containing TCP1 Subunit 8 Like 2 2 3 5
  • Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 2 2 3
  • CESK1 3 4
  • Putative T-Complex Protein 1 Subunit Theta-Like 2 3
  • T-Complex Protein 1 Subunit Theta-Like 2 3

External Ids for CCT8L2 Gene

Previous GeneCards Identifiers for CCT8L2 Gene

  • GC22M015451
  • GC22M017071
  • GC22M000891

Summaries for CCT8L2 Gene

GeneCards Summary for CCT8L2 Gene

CCT8L2 (Chaperonin Containing TCP1 Subunit 8 Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium-activated potassium channel activity and anion channel activity. An important paralog of this gene is CCT8.

UniProtKB/Swiss-Prot for CCT8L2 Gene

  • Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.

Additional gene information for CCT8L2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT8L2 Gene

Genomics for CCT8L2 Gene

GeneHancer (GH) Regulatory Elements for CCT8L2 Gene

Promoters and enhancers for CCT8L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J016586 Enhancer 0.8 ENCODE 0.4 +6.4 6444 0.2 HDAC1 PKNOX1 ATF7 CEBPB ZEB2 ZNF148 ATF4 SMARCA4 IKZF1 MEIS2 KCNMB3P1 CCT8L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCT8L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCT8L2 gene promoter:
  • HTF
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT4
  • HOXA9
  • NF-AT3
  • Meis-1b
  • Meis-1
  • HOXA9B

Genomic Locations for CCT8L2 Gene

Genomic Locations for CCT8L2 Gene
2,060 bases
Minus strand
2,053 bases
Minus strand

Genomic View for CCT8L2 Gene

Genes around CCT8L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT8L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT8L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT8L2 Gene

Proteins for CCT8L2 Gene

  • Protein details for CCT8L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-complex protein 1 subunit theta-like 2
    Protein Accession:
    Secondary Accessions:
    • A4QPH3
    • Q9UJS3

    Protein attributes for CCT8L2 Gene

    557 amino acids
    Molecular mass:
    59388 Da
    Quaternary structure:
    No Data Available
    • Presence of two highly similar CCT8L genes (CCT8L1P and CCT8L2) in the genomes of human and chimp and of a single copy in other mammal genomes, including rhesus monkey, suggests that the duplication of this gene occurred in the ape lineage (Hominoidea) after its divergence from the old-world monkeys (Cercopithecidae).
    • Expression of CCT8L2 is confirmed by many ESTs mostly identified from the testis.
    • Sequence=AAI39843.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

neXtProt entry for CCT8L2 Gene

Post-translational modifications for CCT8L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCT8L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCT8L2 Gene

Domains & Families for CCT8L2 Gene

Gene Families for CCT8L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CCT8L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCP-1 chaperonin family.
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT8L2: view

Function for CCT8L2 Gene

Molecular function for CCT8L2 Gene

UniProtKB/Swiss-Prot Function:
Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.

Gene Ontology (GO) - Molecular Function for CCT8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005253 anion channel activity TAS 10585773
GO:0005524 ATP binding IEA --
GO:0015269 calcium-activated potassium channel activity TAS 10585773
GO:0044183 protein binding involved in protein folding IBA --
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with CCT8L2: view

Phenotypes for CCT8L2 Gene

genes like me logo Genes that share phenotypes with CCT8L2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCT8L2 Gene

Localization for CCT8L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT8L2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT8L2 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCT8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005832 chaperonin-containing T-complex IBA --
genes like me logo Genes that share ontologies with CCT8L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCT8L2 Gene

Pathways & Interactions for CCT8L2 Gene

SuperPathways for CCT8L2 Gene

No Data Available

Interacting Proteins for CCT8L2 Gene

Gene Ontology (GO) - Biological Process for CCT8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006458 de novo protein folding IBA --
GO:0015698 inorganic anion transport IEA --
GO:0061077 chaperone-mediated protein folding IBA --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with CCT8L2: view

No data available for Pathways by source and SIGNOR curated interactions for CCT8L2 Gene

Drugs & Compounds for CCT8L2 Gene

No Compound Related Data Available

Transcripts for CCT8L2 Gene

mRNA/cDNA for CCT8L2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCT8L2 Gene

Chaperonin containing TCP1, subunit 8 (theta)-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT8L2 Gene

No ASD Table

Relevant External Links for CCT8L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCT8L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCT8L2 Gene

mRNA differential expression in normal tissues according to GTEx for CCT8L2 Gene

This gene is overexpressed in Testis (x51.3).

Protein differential expression in normal tissues from HIPED for CCT8L2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCT8L2 Gene

Protein tissue co-expression partners for CCT8L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCT8L2 Gene:


SOURCE GeneReport for Unigene cluster for CCT8L2 Gene:


Evidence on tissue expression from TISSUES for CCT8L2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CCT8L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT8L2 Gene

Orthologs for CCT8L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCT8L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCT8L2 34 33
  • 99.1 (n)
(Canis familiaris)
Mammalia CCT8L2 34 33
  • 78.07 (n)
(Bos Taurus)
Mammalia CCT8L2 34 33
  • 74.13 (n)
(Mus musculus)
Mammalia Cct8l1 16 34 33
  • 72.81 (n)
(Rattus norvegicus)
Mammalia LOC102553845 33
  • 70.82 (n)
(Monodelphis domestica)
Mammalia CCT8L2 34
  • 54 (a)
(Anolis carolinensis)
Reptilia CCT8L2 34
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8258 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea cct-8 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT8 34
  • 26 (a)
Species where no ortholog for CCT8L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CCT8L2 Gene

Gene Tree for CCT8L2 (if available)
Gene Tree for CCT8L2 (if available)
Evolutionary constrained regions (ECRs) for CCT8L2: view image

Paralogs for CCT8L2 Gene

Paralogs for CCT8L2 Gene

(2) SIMAP similar genes for CCT8L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCT8L2: view

Variants for CCT8L2 Gene

Sequence variations from dbSNP and Humsavar for CCT8L2 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000946370 -- 16,593,021(-) G/A upstream_transcript_variant
rs1002942513 -- 16,590,686(-) G/A downstream_transcript_variant
rs1003147181 -- 16,590,534(-) T/C downstream_transcript_variant
rs1003382916 -- 16,594,437(-) A/G upstream_transcript_variant
rs1005009023 -- 16,593,110(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCT8L2 Gene

Variant ID Type Subtype PubMed ID
dgv1276e212 CNV gain 25503493
dgv18e196 CNV duplication 17116639
dgv4458n100 CNV gain 25217958
dgv4459n100 CNV gain 25217958
dgv4460n100 CNV gain 25217958
dgv4461n100 CNV loss 25217958
dgv4462n100 CNV gain 25217958
dgv539n27 CNV gain 19166990
dgv540n27 CNV gain 19166990
dgv723n67 CNV gain 20364138
dgv7943n54 CNV gain 21841781
dgv7946n54 CNV gain 21841781
dgv818e214 CNV gain 21293372
dgv819e214 CNV gain 21293372
esv2763696 CNV gain 21179565
esv3575399 CNV gain 25503493
esv3575406 CNV gain 25503493
esv3575407 CNV gain 25503493
esv3584480 CNV gain 24956385
esv3584481 CNV gain 24956385
esv3893423 CNV gain 25118596
nsv1056300 CNV loss 25217958
nsv471178 CNV gain 18288195
nsv517059 CNV gain+loss 19592680
nsv527637 CNV gain 19592680
nsv588062 CNV gain 21841781
nsv588071 CNV gain 21841781
nsv962744 CNV duplication 23825009

Variation tolerance for CCT8L2 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCT8L2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT8L2 Gene

Disorders for CCT8L2 Gene

Additional Disease Information for CCT8L2

No disorders were found for CCT8L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCT8L2 Gene

Publications for CCT8L2 Gene

  1. Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes. (PMID: 20193073) Mukherjee K … Brocchieri L (BMC evolutionary biology 2010) 3 4 58
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  3. Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. (PMID: 10585773) Riazi MA … McDermid HE (Genomics 1999) 3 4 58
  4. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) Östensson M … Torinsson-Naluai Å (PloS one 2013) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for CCT8L2 Gene

Sources for CCT8L2 Gene

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