This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013] See more...

Aliases for CCT8 Gene

Aliases for CCT8 Gene

  • Chaperonin Containing TCP1 Subunit 8 2 3 5
  • Chaperonin Containing T-Complex Polypeptide 1 Subunit 8 3 4
  • Chaperonin Containing TCP1, Subunit 8 (Theta) 2 3
  • T-Complex Protein 1 Subunit Theta 3 4
  • Renal Carcinoma Antigen NY-REN-15 3 4
  • TCP-1-Theta 3 4
  • C21orf112 3 4
  • CCT-Theta 3 4
  • Chromosome 21 Open Reading Frame 112 2
  • KIAA0002 4
  • D21S246 3
  • PRED71 3
  • Cctq 3
  • CCTQ 4

External Ids for CCT8 Gene

Previous HGNC Symbols for CCT8 Gene

  • C21orf112

Previous GeneCards Identifiers for CCT8 Gene

  • GC21M027007
  • GC21M029350
  • GC21M029349
  • GC21M030428
  • GC21M015834

Summaries for CCT8 Gene

Entrez Gene Summary for CCT8 Gene

  • This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

GeneCards Summary for CCT8 Gene

CCT8 (Chaperonin Containing TCP1 Subunit 8) is a Protein Coding gene. Diseases associated with CCT8 include Otomycosis. Among its related pathways are Innate Immune System and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is CCT8L2.

UniProtKB/Swiss-Prot Summary for CCT8 Gene

  • Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).

Gene Wiki entry for CCT8 Gene

Additional gene information for CCT8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCT8 Gene

Genomics for CCT8 Gene

GeneHancer (GH) Regulatory Elements for CCT8 Gene

Promoters and enhancers for CCT8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCT8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCT8

Top Transcription factor binding sites by QIAGEN in the CCT8 gene promoter:
  • AhR
  • AP-2gamma
  • Arnt
  • FOXJ2
  • LCR-F1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • POU2F1
  • POU2F1a

Genomic Locations for CCT8 Gene

Genomic Locations for CCT8 Gene
chr21:29,055,805-29,073,797
(GRCh38/hg38)
Size:
17,993 bases
Orientation:
Minus strand
chr21:30,428,126-30,446,118
(GRCh37/hg19)
Size:
17,993 bases
Orientation:
Minus strand

Genomic View for CCT8 Gene

Genes around CCT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT8 Gene

Proteins for CCT8 Gene

  • Protein details for CCT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50990-TCPQ_HUMAN
    Recommended name:
    T-complex protein 1 subunit theta
    Protein Accession:
    P50990
    Secondary Accessions:
    • A6NN54
    • B4DEM7
    • B4DQH4
    • Q4VBP8

    Protein attributes for CCT8 Gene

    Size:
    548 amino acids
    Molecular mass:
    59621 Da
    Quaternary structure:
    • Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with DNAAF4 (By similarity).
    SequenceCaution:
    • Sequence=BAA02792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCT8 Gene

    Alternative splice isoforms for CCT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT8 Gene

Post-translational modifications for CCT8 Gene

  • Ubiquitination at Lys7, Lys16, Lys37, Lys20, Lys54, Lys62, Lys152, Lys171, Lys235, Lys254, Lys260, Lys270, Lys326, Lys400, Lys421, Lys440, Lys459, Lys466, Lys528, and Lys540
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCT8 Gene

Domains & Families for CCT8 Gene

Gene Families for CCT8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CCT8 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53379, highly similar to T-complex protein 1 subunit theta (B4DEM7_HUMAN)
  • cDNA FLJ59382, highly similar to T-complex protein 1 subunit theta (B4DQH4_HUMAN)
  • Chaperonin containing TCP1, subunit 8 (Theta), isoform CRA_c (Q7Z759_HUMAN)
  • Renal carcinoma antigen NY-REN-15 (TCPQ_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50990

UniProtKB/Swiss-Prot:

TCPQ_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT8: view

Function for CCT8 Gene

Molecular function for CCT8 Gene

UniProtKB/Swiss-Prot Function:
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).

Phenotypes From GWAS Catalog for CCT8 Gene

Gene Ontology (GO) - Molecular Function for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0042623 ATPase activity, coupled TAS 7890169
GO:0045296 cadherin binding HDA 25468996
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with CCT8: view
genes like me logo Genes that share phenotypes with CCT8: view

Animal Model Products

CRISPR Products

miRNA for CCT8 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT8 Gene

Localization for CCT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT8 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT8 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
lysosome 4
plasma membrane 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005576 extracellular region TAS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 25468996
GO:0005813 centrosome IDA 20080638
genes like me logo Genes that share ontologies with CCT8: view

Pathways & Interactions for CCT8 Gene

genes like me logo Genes that share pathways with CCT8: view

Pathways by source for CCT8 Gene

1 GeneGo (Thomson Reuters) pathway for CCT8 Gene
  • Cell cycle_Role of APC in cell cycle regulation

Gene Ontology (GO) - Biological Process for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0043312 neutrophil degranulation TAS --
GO:0046931 pore complex assembly IEA --
genes like me logo Genes that share ontologies with CCT8: view

No data available for SIGNOR curated interactions for CCT8 Gene

Drugs & Compounds for CCT8 Gene

No Compound Related Data Available

Transcripts for CCT8 Gene

mRNA/cDNA for CCT8 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - -
SP6: -
SP7:
SP8: - - -
SP9: -
SP10: - -

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CCT8 Gene

GeneLoc Exon Structure for
CCT8

Expression for CCT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCT8 Gene

This gene is overexpressed in Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCT8 Gene



Protein tissue co-expression partners for CCT8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCT8

SOURCE GeneReport for Unigene cluster for CCT8 Gene:

Hs.125113

Evidence on tissue expression from TISSUES for CCT8 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Bone marrow(4.3)
  • Intestine(4.2)
  • Lung(4)
  • Eye(3.6)
  • Skin(3.4)
  • Kidney(3.2)
  • Blood(2.8)
  • Heart(2.7)
genes like me logo Genes that share expression patterns with CCT8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT8 Gene

Orthologs for CCT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT8 30
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia -- 31
  • 95 (a)
OneToMany
CCT8 31 30
  • 93.73 (n)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CCT8 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT8 31 30
  • 93.13 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct8 30
  • 89.6 (n)
mouse
(Mus musculus)
Mammalia Cct8 17 31 30
  • 88.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCT8 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCT8 31 30
  • 83.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT8 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cct8 30
  • 76.39 (n)
Str.7327 30
African clawed frog
(Xenopus laevis)
Amphibia cct8-prov 30
zebrafish
(Danio rerio)
Actinopterygii cct8 31 30
  • 75.95 (n)
OneToOne
zgc56059 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9154 30
fruit fly
(Drosophila melanogaster)
Insecta CG8258 31 32 30
  • 60.24 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010588 30
  • 57.98 (n)
worm
(Caenorhabditis elegans)
Secernentea cct-8 31 30
  • 59.53 (n)
OneToMany
Y55F3AR.3 32
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT8 33 31 30
  • 53.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09350g 30
  • 53.86 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR045W 30
  • 53.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03960 30
  • 55.96 (n)
rice
(Oryza sativa)
Liliopsida Os03g0804800 30
  • 57.63 (n)
Os.20293 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4432 31
  • 65 (a)
OneToOne
Cin.5094 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct8 30
  • 56.99 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07567 30
  • 53.55 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5094 30
Species where no ortholog for CCT8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCT8 Gene

ENSEMBL:
Gene Tree for CCT8 (if available)
TreeFam:
Gene Tree for CCT8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCT8: view image

Paralogs for CCT8 Gene

Paralogs for CCT8 Gene

(8) SIMAP similar genes for CCT8 Gene using alignment to 6 proteins:

  • TCPQ_HUMAN
  • B4DEM7_HUMAN
  • B4DQH4_HUMAN
  • H7C2U0_HUMAN
  • H7C4C8_HUMAN
  • Q7Z759_HUMAN

Pseudogenes.org Pseudogenes for CCT8 Gene

genes like me logo Genes that share paralogs with CCT8: view

Variants for CCT8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCT8 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
rs16983693 - p.His4Gln
rs8129954 - p.Val409Ile

Additional dbSNP identifiers (rs#s) for CCT8 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCT8 Gene

Variant ID Type Subtype PubMed ID
esv3893402 CNV gain 25118596
nsv1114282 CNV deletion 24896259
nsv3485 CNV deletion 18451855

Variation tolerance for CCT8 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT8 Gene

Disorders for CCT8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCT8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
otomycosis
  • singapore ear
- elite association - COSMIC cancer census association via MalaCards
Search CCT8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCT8

genes like me logo Genes that share disorders with CCT8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT8 Gene

Publications for CCT8 Gene

  1. The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1. (PMID: 7890169) Kubota H … Willison K (Gene 1995) 2 3 4 23 54
  2. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. (PMID: 25467444) Freund A … Artandi SE (Cell 2014) 3 4 54
  3. BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. (PMID: 20080638) Seo S … Sheffield VC (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 54
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for CCT8 Gene

Sources for CCT8 Gene