Aliases for CCT8 Gene
External Ids for CCT8 Gene
Previous HGNC Symbols for CCT8 Gene
Previous GeneCards Identifiers for CCT8 Gene
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
GeneCards Summary for CCT8 Gene
CCT8 (Chaperonin Containing TCP1 Subunit 8) is a Protein Coding gene. Diseases associated with CCT8 include Otomycosis. Among its related pathways are Innate Immune System and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is CCT8L2.
UniProtKB/Swiss-Prot Summary for CCT8 Gene
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).