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Aliases for CCT7 Gene

Aliases for CCT7 Gene

  • Chaperonin Containing TCP1 Subunit 7 2 3 5
  • TCP-1-Eta 3 4
  • CCT-Eta 3 4
  • NIP7-1 3 4
  • CCTH 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Eta Subunit 3
  • Chaperonin Containing TCP1, Subunit 7 (Eta) 2
  • T-Complex Protein 1 Subunit Eta 3
  • HIV-1 Nef Interacting Protein 3
  • HIV-1 Nef-Interacting Protein 4
  • TCP1ETA 3
  • CCTETA 3

External Ids for CCT7 Gene

Previous GeneCards Identifiers for CCT7 Gene

  • GC02P073470
  • GC02P073672
  • GC02P073419
  • GC02P073435
  • GC02P073373
  • GC02P073314
  • GC02P073460
  • GC02P073197

Summaries for CCT7 Gene

Entrez Gene Summary for CCT7 Gene

  • This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

GeneCards Summary for CCT7 Gene

CCT7 (Chaperonin Containing TCP1 Subunit 7) is a Protein Coding gene. Diseases associated with CCT7 include Myocardial Infarction and Babesiosis. Among its related pathways are Chaperonin-mediated protein folding and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include identical protein binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CCT7 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Wiki entry for CCT7 Gene

Additional gene information for CCT7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT7 Gene

Genomics for CCT7 Gene

GeneHancer (GH) Regulatory Elements for CCT7 Gene

Promoters and enhancers for CCT7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I073232 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 579.5 +0.9 913 3.9 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 NFYC CCT7 PRADC1 DUSP11 ENSG00000273245 MOB1A FBXO41 TPRKB ALMS1 DGUOK-AS1 PIR47890
GH02I073239 Promoter 0.5 EPDnew 550.4 +6.2 6232 0.1 PIR47890 CCT7 NOTO
GH02I073069 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 25.6 -162.5 -162481 3.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 SFXN5 DUSP11 CCT7 ENSG00000273245 ALMS1 TPRKB SMYD5 DGUOK-AS1 RAB11FIP5 PIR43769
GH02I074196 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.9 +965.3 965327 3.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MTHFD2 ENSG00000279070 PCGF1 DUSP11 INO80B ENSG00000273245 WBP1 AUP1 TTC31 MOB1A
GH02I073736 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 +503.8 503796 2.2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 CBX5 TPRKB PCGF1 DUSP11 CCT7 ENSG00000273245 ALMS1 TTC31 NAT8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCT7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCT7 gene promoter:

Genomic Locations for CCT7 Gene

Genomic Locations for CCT7 Gene
19,603 bases
Plus strand

Genomic View for CCT7 Gene

Genes around CCT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT7 Gene

Proteins for CCT7 Gene

  • Protein details for CCT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-complex protein 1 subunit eta
    Protein Accession:
    Secondary Accessions:
    • A8K7E6
    • A8MWI8
    • B7WNW9
    • B7Z4T9
    • B7Z4Z7
    • O14871
    • Q6FI26

    Protein attributes for CCT7 Gene

    543 amino acids
    Molecular mass:
    59367 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.

    Alternative splice isoforms for CCT7 Gene


neXtProt entry for CCT7 Gene

Post-translational modifications for CCT7 Gene

  • Ubiquitination at posLast=4747, Lys55, Lys77, Lys84, Lys109, posLast=135135, Lys166, Lys172, Lys218, posLast=277277, Lys368, posLast=418418, Lys430, posLast=440440, and posLast=521521
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCT7 Gene

Domains & Families for CCT7 Gene

Gene Families for CCT7 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCP-1 chaperonin family.
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT7: view

Function for CCT7 Gene

Molecular function for CCT7 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Phenotypes From GWAS Catalog for CCT7 Gene

Gene Ontology (GO) - Molecular Function for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0042802 identical protein binding IEA --
GO:0044183 protein binding involved in protein folding IBA --
GO:0051082 unfolded protein binding IBA,IEA --
genes like me logo Genes that share ontologies with CCT7: view
genes like me logo Genes that share phenotypes with CCT7: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT7 Gene

Localization for CCT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT7 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005737 cytoplasm TAS 9819444
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex TAS 25467444
genes like me logo Genes that share ontologies with CCT7: view

Pathways & Interactions for CCT7 Gene

genes like me logo Genes that share pathways with CCT7: view

Gene Ontology (GO) - Biological Process for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA,TAS --
GO:0006458 de novo protein folding IBA --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0050821 protein stabilization IMP 25467444
genes like me logo Genes that share ontologies with CCT7: view

No data available for SIGNOR curated interactions for CCT7 Gene

Drugs & Compounds for CCT7 Gene

No Compound Related Data Available

Transcripts for CCT7 Gene

Unigene Clusters for CCT7 Gene

Chaperonin containing TCP1, subunit 7 (eta):
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a ·
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: -
SP13: - -

ExUns: 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14
SP14: -

Relevant External Links for CCT7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCT7 Gene

Protein tissue co-expression partners for CCT7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCT7 Gene:


SOURCE GeneReport for Unigene cluster for CCT7 Gene:


Evidence on tissue expression from TISSUES for CCT7 Gene

  • Nervous system(5)
  • Skin(4.9)
  • Liver(4.8)
  • Heart(4.7)
  • Intestine(4.6)
  • Lung(4.6)
  • Pancreas(4.5)
  • Eye(4.4)
  • Muscle(4.1)
  • Kidney(4)
  • Blood(3.6)
  • Stomach(3.4)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with CCT7: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT7 Gene

Orthologs for CCT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCT7 33 34
  • 99.69 (n)
(Bos Taurus)
Mammalia CCT7 33 34
  • 91.22 (n)
(Canis familiaris)
Mammalia CCT7 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Cct7 33
  • 90.43 (n)
(Mus musculus)
Mammalia Cct7 33 16 34
  • 89.87 (n)
(Ornithorhynchus anatinus)
Mammalia CCT7 34
  • 87 (a)
(Monodelphis domestica)
Mammalia CCT7 34
  • 86 (a)
(Gallus gallus)
Aves CCT7 33 34
  • 81.51 (n)
(Anolis carolinensis)
Reptilia CCT7 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cct7 33
  • 79.8 (n)
Str.2286 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6672 33
(Danio rerio)
Actinopterygii cct7 33 34
  • 78.74 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12021 33
fruit fly
(Drosophila melanogaster)
Insecta CG8351 35
  • 76 (a)
Tcp-1eta 33 34
  • 69.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002762 33
  • 69.66 (n)
(Caenorhabditis elegans)
Secernentea cct-7 33 34
  • 62.97 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR067W 33
  • 63.97 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21340g 33
  • 61.54 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT7 33 34 36
  • 61.04 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11830 33
  • 63.56 (n)
(Glycine max)
eudicotyledons Gma.8037 33
(Oryza sativa)
Liliopsida Os06g0687700 33
  • 63.24 (n)
Os.11699 33
(Hordeum vulgare)
Liliopsida Hv.3076 33
(Triticum aestivum)
Liliopsida Ta.14018 33
(Zea mays)
Liliopsida Zm.3176 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5206 34
  • 79 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09700 33
  • 63.1 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct7 33
  • 62.32 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4924 33
Species where no ortholog for CCT7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT7 Gene

Gene Tree for CCT7 (if available)
Gene Tree for CCT7 (if available)

Paralogs for CCT7 Gene

(8) SIMAP similar genes for CCT7 Gene using alignment to 6 proteins: Pseudogenes for CCT7 Gene

genes like me logo Genes that share paralogs with CCT7: view

No data available for Paralogs for CCT7 Gene

Variants for CCT7 Gene

Sequence variations from dbSNP and Humsavar for CCT7 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs587777929 pathogenic, Myocardial infarction 1 73,252,803(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000062074 -- 73,238,093(+) G/A intron_variant
rs1000238228 -- 73,237,548(+) A/T intron_variant
rs1000265149 -- 73,243,433(+) T/G intron_variant
rs1000666126 -- 73,236,521(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCT7 Gene

Variant ID Type Subtype PubMed ID
esv3583864 CNV loss 25503493
nsv2776 CNV deletion 18451855

Variation tolerance for CCT7 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCT7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT7 Gene

Disorders for CCT7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCT7 Gene - From: HGMD, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, susceptibility to
  • babesiasis
dupuytren contracture
  • dupuytren contracture 1
- elite association - COSMIC cancer census association via MalaCards
Search CCT7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCT7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT7 Gene

Publications for CCT7 Gene

  1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won KA … Reed SI (Molecular and cellular biology 1998) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PMID: 14532270) Imai Y … Takahashi R (The Journal of biological chemistry 2003) 3 4 58

Products for CCT7 Gene

Sources for CCT7 Gene

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