This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various pro... See more...

Aliases for CCT6B Gene

Aliases for CCT6B Gene

  • Chaperonin Containing TCP1 Subunit 6B 2 3 5
  • Chaperonin Containing TCP1, Subunit 6B (Zeta 2) 2 3
  • T-Complex Protein 1 Subunit Zeta-2 3 4
  • Testis-Specific Protein TSA303 3 4
  • Testis-Specific Tcp20 3 4
  • TCP-1-Zeta-2 3 4
  • CCT-Zeta-2 3 4
  • TSA303 2 3
  • Cctz2 2 3
  • Chaperonin-Containing T-Complex Polypeptide 1, Subunit 6B 3
  • TCP-1-Zeta-Like 4
  • CCT-Zeta-Like 4
  • CCTZ-2 3
  • CCT6B 5

External Ids for CCT6B Gene

Previous GeneCards Identifiers for CCT6B Gene

  • GC17M033024
  • GC17M035290
  • GC17M033400
  • GC17M030279
  • GC17M033254
  • GC17M029439

Summaries for CCT6B Gene

Entrez Gene Summary for CCT6B Gene

  • This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for CCT6B Gene

CCT6B (Chaperonin Containing TCP1 Subunit 6B) is a Protein Coding gene. Diseases associated with CCT6B include Oropouche Fever. Among its related pathways are Chaperonin-mediated protein folding and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and protein transporter activity. An important paralog of this gene is CCT6A.

UniProtKB/Swiss-Prot Summary for CCT6B Gene

  • Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.

Gene Wiki entry for CCT6B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCT6B Gene

Genomics for CCT6B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCT6B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCT6B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCT6B

Top Transcription factor binding sites by QIAGEN in the CCT6B gene promoter:
  • AML1a
  • AP-2gamma
  • ATF-2
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • LyF-1
  • p53
  • XBP-1

Genomic Locations for CCT6B Gene

Latest Assembly
chr17:34,927,859-34,981,222
(GRCh38/hg38)
Size:
53,364 bases
Orientation:
Minus strand

Previous Assembly
chr17:33,254,880-33,288,479
(GRCh37/hg19 by Entrez Gene)
Size:
33,600 bases
Orientation:
Minus strand

chr17:33,254,878-33,308,097
(GRCh37/hg19 by Ensembl)
Size:
53,220 bases
Orientation:
Minus strand

Genomic View for CCT6B Gene

Genes around CCT6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT6B Gene

Proteins for CCT6B Gene

  • Protein details for CCT6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92526-TCPW_HUMAN
    Recommended name:
    T-complex protein 1 subunit zeta-2
    Protein Accession:
    Q92526
    Secondary Accessions:
    • B4DX20
    • B4DYB0
    • Q8TC34

    Protein attributes for CCT6B Gene

    Size:
    530 amino acids
    Molecular mass:
    57821 Da
    Quaternary structure:
    • Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

    Alternative splice isoforms for CCT6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT6B Gene

Post-translational modifications for CCT6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Boster Bio Antibodies for CCT6B

No data available for DME Specific Peptides for CCT6B Gene

Domains & Families for CCT6B Gene

Gene Families for CCT6B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCT6B Gene

Suggested Antigen Peptide Sequences for CCT6B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60932, highly similar to T-complex protein 1 subunit zeta-2 (B4DX20_HUMAN)
  • cDNA FLJ51396, highly similar to T-complex protein 1 subunit zeta-2 (B4DYB0_HUMAN)
  • Testis-specific protein TSA303 (TCPW_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92526

UniProtKB/Swiss-Prot:

TCPW_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT6B: view

Function for CCT6B Gene

Molecular function for CCT6B Gene

UniProtKB/Swiss-Prot Function:
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.
GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1),subunit 6B (zeta 2),testis specific,cytoplasmic,S cerevisiae TCP20 homolog,TF55/TCP-1 family

Phenotypes From GWAS Catalog for CCT6B Gene

Gene Ontology (GO) - Molecular Function for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding IEA --
GO:0044183 protein binding involved in protein folding IDA 30955883
GO:0051082 unfolded protein binding IBA 21873635
genes like me logo Genes that share ontologies with CCT6B: view
genes like me logo Genes that share phenotypes with CCT6B: view

Animal Models for research

  • Taconic Biosciences Mouse Models for CCT6B

miRNA for CCT6B Gene

miRTarBase miRNAs that target CCT6B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT6B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT6B Gene

Localization for CCT6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT6B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT6B gene
Compartment Confidence
cytosol 5
mitochondrion 2
plasma membrane 1
cytoskeleton 1
nucleus 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005832 chaperonin-containing T-complex IDA 30955883
genes like me logo Genes that share ontologies with CCT6B: view

Pathways & Interactions for CCT6B Gene

genes like me logo Genes that share pathways with CCT6B: view

Pathways by source for CCT6B Gene

Gene Ontology (GO) - Biological Process for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IDA 30955883
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT6B: view

No data available for SIGNOR curated interactions for CCT6B Gene

Drugs & Compounds for CCT6B Gene

No Compound Related Data Available

Transcripts for CCT6B Gene

mRNA/cDNA for CCT6B Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT6B

Alternative Splicing Database (ASD) splice patterns (SP) for CCT6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2:
SP3: -

Relevant External Links for CCT6B Gene

GeneLoc Exon Structure for
CCT6B

Expression for CCT6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCT6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCT6B Gene

This gene is overexpressed in Testis (x23.5).

Protein differential expression in normal tissues from HIPED for CCT6B Gene

This gene is overexpressed in Testis (27.1) and Ovary (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCT6B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCT6B

SOURCE GeneReport for Unigene cluster for CCT6B Gene:

Hs.73072

mRNA Expression by UniProt/SwissProt for CCT6B Gene:

Q92526-TCPW_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with CCT6B: view

Primer products for research

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT6B Gene

Orthologs for CCT6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCT6B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCT6B 29 30
  • 99.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCT6B 29
  • 91.82 (n)
-- 30
  • 90 (a)
OneToMany
-- 30
  • 87 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia CCT6B 29 30
  • 91.01 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 87 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Cct6b 29
  • 84.47 (n)
Mouse
(Mus musculus)
Mammalia Cct6b 29 16 30
  • 83.96 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCT6B 30
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCT6 30
  • 85 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.6143 29
Zebrafish
(Danio rerio)
Actinopterygii cct6a 30
  • 84 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Tcp-1zeta 30
  • 68 (a)
OneToMany
CG8231 31
  • 65 (a)
Worm
(Caenorhabditis elegans)
Secernentea cct-6 30 31
  • 64 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT6 30
  • 54 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11031 30
  • 71 (a)
OneToMany
Species where no ortholog for CCT6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCT6B Gene

ENSEMBL:
Gene Tree for CCT6B (if available)
TreeFam:
Gene Tree for CCT6B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCT6B: view image
Alliance of Genome Resources:
Additional Orthologs for CCT6B

Paralogs for CCT6B Gene

Paralogs for CCT6B Gene

(7) SIMAP similar genes for CCT6B Gene using alignment to 2 proteins:

  • TCPW_HUMAN
  • J3KRI6_HUMAN

Pseudogenes.org Pseudogenes for CCT6B Gene

genes like me logo Genes that share paralogs with CCT6B: view

Variants for CCT6B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCT6B Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs142360145 Benign: not provided 34,942,908(-) T/C
NM_006584.4(CCT6B):c.615-2A>G
SPLICE_ACCEPTOR_VARIANT,INTRON
rs2230552 -- p.Val48Ala
rs2230553 -- p.Gly247Ala
rs9635769 -- p.Arg17Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCT6B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCT6B Gene

Variant ID Type Subtype PubMed ID
nsv526685 CNV gain 19592680

Variation tolerance for CCT6B Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.28; 97.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCT6B Gene

Human Gene Mutation Database (HGMD)
CCT6B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT6B
Leiden Open Variation Database (LOVD)
CCT6B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT6B Gene

Disorders for CCT6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCT6B Gene - From: COP

Disorder Aliases PubMed IDs
oropouche fever
  • oropouche virus disease
- elite association - COSMIC cancer census association via MalaCards
Search CCT6B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCT6B

genes like me logo Genes that share disorders with CCT6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT6B Gene

Publications for CCT6B Gene

  1. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PMID: 8812458) Ozaki K … Nakamura Y (Genomics 1996) 2 3 4 22
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. (PMID: 9013858) Kubota H … Willison KR (FEBS letters 1997) 2 3
  4. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. (PMID: 30196744) Arbogast F … Gros F (Autophagy 2019) 3

Products for CCT6B Gene

Sources for CCT6B Gene