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Aliases for CCT6B Gene

Aliases for CCT6B Gene

  • Chaperonin Containing TCP1 Subunit 6B 2 3 5
  • Chaperonin Containing TCP1, Subunit 6B (Zeta 2) 2 3
  • Testis-Specific Protein TSA303 3 4
  • Testis-Specific Tcp20 3 4
  • TCP-1-Zeta-2 3 4
  • CCT-Zeta-2 3 4
  • Chaperonin-Containing T-Complex Polypeptide 1, Subunit 6B 3
  • T-Complex Protein 1 Subunit Zeta-2 3
  • TCP-1-Zeta-Like 4
  • CCT-Zeta-Like 4
  • CCTZ-2 3
  • TSA303 3
  • Cctz2 3

External Ids for CCT6B Gene

Previous GeneCards Identifiers for CCT6B Gene

  • GC17M033024
  • GC17M035290
  • GC17M033400
  • GC17M030279
  • GC17M033254
  • GC17M029439

Summaries for CCT6B Gene

Entrez Gene Summary for CCT6B Gene

  • This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for CCT6B Gene

CCT6B (Chaperonin Containing TCP1 Subunit 6B) is a Protein Coding gene. Diseases associated with CCT6B include Pelvic Varices. Among its related pathways are Chaperonin-mediated protein folding and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and protein transporter activity. An important paralog of this gene is CCT6A.

UniProtKB/Swiss-Prot for CCT6B Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Wiki entry for CCT6B Gene

Additional gene information for CCT6B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT6B Gene

Genomics for CCT6B Gene

GeneHancer (GH) Regulatory Elements for CCT6B Gene

Promoters and enhancers for CCT6B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I034979 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.2 +0.1 94 3.5 MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 SSRP1 ZNF610 GLIS1 LIG3 CCT6B GC17P034979 ZNF830 PEX12 LINC02001 TLK2P1
GH17I034960 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.4 +19.4 19394 2.2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B E2F8 ZNF830 CCT6B LIG3 TLK2P1 CCL13 C17orf50 GC17P034979
GH17I035083 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -106.1 -106085 6.6 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 IRF4 YY1 LIG3 RFFL SLFN5 ZNF830 CCT6B NLE1 RPL37P22 ENSG00000267618 RAD51L3-RFFL
GH17I035140 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -160.8 -160847 2 HDGF SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B GC17P035142 NLE1 GC17M035139 LIG3 ZNF830 LINC02001 CCT6B RFFL
GH17I035062 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.2 -83.1 -83149 3.9 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 RFFL LIG3 RNU6-840P CCT6B GC17M035056 ENSG00000267457 GC17P035052 RAD51L3-RFFL ENSG00000267618
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCT6B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCT6B gene promoter:

Genomic Locations for CCT6B Gene

Genomic Locations for CCT6B Gene
53,220 bases
Minus strand

Genomic View for CCT6B Gene

Genes around CCT6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT6B Gene

Proteins for CCT6B Gene

  • Protein details for CCT6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-complex protein 1 subunit zeta-2
    Protein Accession:
    Secondary Accessions:
    • B4DX20
    • B4DYB0
    • Q8TC34

    Protein attributes for CCT6B Gene

    530 amino acids
    Molecular mass:
    57821 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

    Alternative splice isoforms for CCT6B Gene


neXtProt entry for CCT6B Gene

Post-translational modifications for CCT6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCT6B Gene

Domains & Families for CCT6B Gene

Gene Families for CCT6B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCP-1 chaperonin family.
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT6B: view

Function for CCT6B Gene

Molecular function for CCT6B Gene

GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1),subunit 6B (zeta 2),testis specific,cytoplasmic,S cerevisiae TCP20 homolog,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Phenotypes From GWAS Catalog for CCT6B Gene

Gene Ontology (GO) - Molecular Function for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008565 protein transporter activity TAS 8812458
GO:0044183 protein binding involved in protein folding IBA --
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with CCT6B: view
genes like me logo Genes that share phenotypes with CCT6B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCT6B

CRISPR Products

miRNA for CCT6B Gene

miRTarBase miRNAs that target CCT6B

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT6B Gene

Localization for CCT6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT6B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT6B gene
Compartment Confidence
cytosol 5
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005832 chaperonin-containing T-complex IBA --
genes like me logo Genes that share ontologies with CCT6B: view

Pathways & Interactions for CCT6B Gene

genes like me logo Genes that share pathways with CCT6B: view

Gene Ontology (GO) - Biological Process for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 8812458
GO:0006458 de novo protein folding IBA --
GO:0007283 spermatogenesis TAS 8812458
GO:0015031 protein transport IEA --
GO:0051131 chaperone-mediated protein complex assembly TAS 8812458
genes like me logo Genes that share ontologies with CCT6B: view

No data available for SIGNOR curated interactions for CCT6B Gene

Drugs & Compounds for CCT6B Gene

No Compound Related Data Available

Transcripts for CCT6B Gene

Unigene Clusters for CCT6B Gene

Chaperonin containing TCP1, subunit 6B (zeta 2):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP3: -

Relevant External Links for CCT6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCT6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCT6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCT6B Gene

This gene is overexpressed in Testis (x23.5).

Protein differential expression in normal tissues from HIPED for CCT6B Gene

This gene is overexpressed in Testis (27.1) and Ovary (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCT6B Gene

NURSA nuclear receptor signaling pathways regulating expression of CCT6B Gene:


SOURCE GeneReport for Unigene cluster for CCT6B Gene:


mRNA Expression by UniProt/SwissProt for CCT6B Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with CCT6B: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT6B Gene

Orthologs for CCT6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCT6B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCT6B 33 34
  • 99.25 (n)
(Canis familiaris)
Mammalia CCT6B 33
  • 91.82 (n)
-- 34
  • 90 (a)
-- 34
  • 87 (a)
(Bos Taurus)
Mammalia CCT6B 33 34
  • 91.01 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Cct6b 33
  • 84.47 (n)
(Mus musculus)
Mammalia Cct6b 33 16 34
  • 83.96 (n)
(Monodelphis domestica)
Mammalia CCT6B 34
  • 57 (a)
(Gallus gallus)
Aves CCT6 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6143 33
(Danio rerio)
Actinopterygii cct6a 34
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tcp-1zeta 34
  • 68 (a)
CG8231 35
  • 65 (a)
(Caenorhabditis elegans)
Secernentea cct-6 35 34
  • 61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT6 34
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11031 34
  • 71 (a)
Species where no ortholog for CCT6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCT6B Gene

Gene Tree for CCT6B (if available)
Gene Tree for CCT6B (if available)

Paralogs for CCT6B Gene

Paralogs for CCT6B Gene

(7) SIMAP similar genes for CCT6B Gene using alignment to 2 proteins: Pseudogenes for CCT6B Gene

genes like me logo Genes that share paralogs with CCT6B: view

Variants for CCT6B Gene

Sequence variations from dbSNP and Humsavar for CCT6B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000049411 -- 34,946,617(-) G/T intron_variant
rs1000096608 -- 34,934,598(-) A/T intron_variant
rs1000108026 -- 34,940,154(-) G/A intron_variant
rs1000125341 -- 34,978,523(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000173473 -- 34,947,631(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCT6B Gene

Variant ID Type Subtype PubMed ID
nsv526685 CNV gain 19592680

Variation tolerance for CCT6B Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.28; 97.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCT6B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT6B Gene

Disorders for CCT6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCT6B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
pelvic varices
- elite association - COSMIC cancer census association via MalaCards
Search CCT6B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCT6B

genes like me logo Genes that share disorders with CCT6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT6B Gene

Publications for CCT6B Gene

  1. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PMID: 8812458) Ozaki K … Nakamura Y (Genomics 1996) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. (PMID: 9013858) Kubota H … Willison KR (FEBS letters 1997) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58

Products for CCT6B Gene

Sources for CCT6B Gene

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