Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCT6A Gene

Aliases for CCT6A Gene

  • Chaperonin Containing TCP1 Subunit 6A 2 3 5
  • Chaperonin Containing TCP1, Subunit 6A (Zeta 1) 2 3
  • CCT-Zeta-1 3 4
  • TCP-1-Zeta 3 4
  • CCT6 3 4
  • HTR3 3 4
  • Acute Morphine Dependence Related Protein 2 3
  • Acute Morphine Dependence-Related Protein 2 4
  • Amino Acid Transport Defect-Complementing 3
  • Chaperonin Containing T-Complex Subunit 6 3
  • T-Complex Protein 1, Zeta Subunit 3
  • T-Complex Protein 1 Subunit Zeta 3
  • Histidine Transport Regulator 3 3
  • CCT-Zeta 3
  • MoDP-2 3
  • TTCP20 3
  • TCP20 3
  • Tcp20 4
  • Cctz 3
  • TCPZ 3
  • CCTZ 4

External Ids for CCT6A Gene

Previous HGNC Symbols for CCT6A Gene

  • CCT6

Previous GeneCards Identifiers for CCT6A Gene

  • GC07P055583
  • GC07P055827
  • GC07P055861
  • GC07P055893
  • GC07P056086

Summaries for CCT6A Gene

Entrez Gene Summary for CCT6A Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

GeneCards Summary for CCT6A Gene

CCT6A (Chaperonin Containing TCP1 Subunit 6A) is a Protein Coding gene. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Cell cycle_Role of APC in cell cycle regulation. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is CCT6B.

UniProtKB/Swiss-Prot for CCT6A Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT6A Gene

Additional gene information for CCT6A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT6A Gene

Genomics for CCT6A Gene

GeneHancer (GH) Regulatory Elements for CCT6A Gene

Promoters and enhancers for CCT6A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J056049 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 397 4.3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF207 PSPH CCT6A CHCHD2 SUMF2 LOC154937 NIPSNAP2 PSPHP1 PIR60303 GC07P056054
GH07J056104 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 13.4 +54.9 54909 3.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 CHCHD2 SUMF2 LOC154937 CCT6A NIPSNAP2 PSPHP1 ZNF713 PHKG1
GH07J056004 Enhancer 1.2 Ensembl ENCODE 12.4 -43.9 -43924 6.8 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 ETS1 TCF12 SLC30A9 NIPSNAP2 SUMF2 CCT6A PHKG1 LOC154937 MRPS17 PSPHP1 ZNF713 NUPR2 PIR39528
GH07J056059 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.4 +11.1 11054 6.2 HDGF SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 FOS SUMF2 NIPSNAP2 CHCHD2 PHKG1 PSPHP1 MRPS17 PSPH SNORA15 GC07P056082 CCT6A
GH07J055962 Enhancer 0.5 FANTOM5 1.6 -89.4 -89394 0.4 SRF STAT1 STAT2 MRPS17 NIPSNAP2 CCT6A PIR39528
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCT6A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCT6A gene promoter:
  • deltaCREB
  • CREB
  • GR-alpha
  • GR
  • p53
  • SEF-1 (1)
  • IRF-2
  • FOXO1a
  • FOXO1
  • AML1a

Genomic Locations for CCT6A Gene

Genomic Locations for CCT6A Gene
chr7:56,051,630-56,063,989
(GRCh38/hg38)
Size:
12,360 bases
Orientation:
Plus strand
chr7:56,119,323-56,131,682
(GRCh37/hg19)
Size:
12,360 bases
Orientation:
Plus strand

Genomic View for CCT6A Gene

Genes around CCT6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT6A Gene

Proteins for CCT6A Gene

  • Protein details for CCT6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40227-TCPZ_HUMAN
    Recommended name:
    T-complex protein 1 subunit zeta
    Protein Accession:
    P40227
    Secondary Accessions:
    • A6NCD2
    • Q3KP28
    • Q75LP4
    • Q96S46

    Protein attributes for CCT6A Gene

    Size:
    531 amino acids
    Molecular mass:
    58024 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.
    SequenceCaution:
    • Sequence=AAA58676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BU540578; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCT6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT6A Gene

Post-translational modifications for CCT6A Gene

  • Ubiquitination at posLast=530530, Lys399, posLast=381381, Lys377, Lys307, posLast=295295, posLast=280280, posLast=251251, posLast=138138, Lys129, Lys127, posLast=5858, and Lys10
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCT6A Gene

Domains & Families for CCT6A Gene

Gene Families for CCT6A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CCT6A Gene

Graphical View of Domain Structure for InterPro Entry

P40227

UniProtKB/Swiss-Prot:

TCPZ_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT6A: view

Function for CCT6A Gene

Molecular function for CCT6A Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1),subunit 6A (zeta 1),cytoplasmic,widely expressed,S cerevisiae homolog,TF55/TCP-1 family

Gene Ontology (GO) - Molecular Function for CCT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0044183 protein binding involved in protein folding IBA,IPI --
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with CCT6A: view
genes like me logo Genes that share phenotypes with CCT6A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCT6A

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT6A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT6A Gene

Localization for CCT6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT6A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT6A gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8034610
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex TAS 25467444
GO:0005874 microtubule IDA 21525035
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CCT6A: view

Pathways & Interactions for CCT6A Gene

genes like me logo Genes that share pathways with CCT6A: view

Gene Ontology (GO) - Biological Process for CCT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0006458 de novo protein folding IBA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0050821 protein stabilization IMP 25467444
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with CCT6A: view

No data available for SIGNOR curated interactions for CCT6A Gene

Drugs & Compounds for CCT6A Gene

No Compound Related Data Available

Transcripts for CCT6A Gene

mRNA/cDNA for CCT6A Gene

Unigene Clusters for CCT6A Gene

Chaperonin containing TCP1, subunit 6A (zeta 1):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT6A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT6A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6:
SP7: -
SP8:

Relevant External Links for CCT6A Gene

GeneLoc Exon Structure for
CCT6A
ECgene alternative splicing isoforms for
CCT6A

Expression for CCT6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCT6A Gene

Protein differential expression in normal tissues from HIPED for CCT6A Gene

This gene is overexpressed in Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCT6A Gene



Protein tissue co-expression partners for CCT6A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCT6A Gene:

CCT6A

SOURCE GeneReport for Unigene cluster for CCT6A Gene:

Hs.82916

Evidence on tissue expression from TISSUES for CCT6A Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Blood(4.4)
  • Skin(4.3)
  • Lung(4)
  • Eye(3.9)
  • Kidney(3.3)
  • Pancreas(3.3)
  • Intestine(3.2)
  • Muscle(2.6)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with CCT6A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT6A Gene

Orthologs for CCT6A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT6A 34 33
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCT6A 34 33
  • 92.59 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CCT6A 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT6A 34 33
  • 89.96 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct6a 33
  • 89.01 (n)
mouse
(Mus musculus)
Mammalia Cct6a 16 34 33
  • 88.76 (n)
chicken
(Gallus gallus)
Aves CCT6 34
  • 90 (a)
OneToMany
CCT6A 33
  • 81.54 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cct6a 33
  • 77.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1519 33
zebrafish
(Danio rerio)
Actinopterygii cct6a 34 33 33
  • 74.83 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8765 33
fruit fly
(Drosophila melanogaster)
Insecta CG8231 35
  • 69 (a)
Tcp-1zeta 34 33
  • 63.72 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003477 33
  • 62.02 (n)
worm
(Caenorhabditis elegans)
Secernentea cct-6 34 35 33
  • 60.95 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT6 36 34 33
  • 59.09 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18458g 33
  • 59.03 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL121W 33
  • 57.95 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16070 33
  • 61.98 (n)
soybean
(Glycine max)
eudicotyledons Gma.4814 33
rice
(Oryza sativa)
Liliopsida Os05g0147400 33
  • 62.18 (n)
Os.4990 33
barley
(Hordeum vulgare)
Liliopsida Hv.482 33
corn
(Zea mays)
Liliopsida Zm.6782 33
wheat
(Triticum aestivum)
Liliopsida Ta.6733 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11031 34
  • 73 (a)
OneToMany
Cin.2074 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct6 33
  • 60.66 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09709 33
  • 60.23 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2074 33
Species where no ortholog for CCT6A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT6A Gene

ENSEMBL:
Gene Tree for CCT6A (if available)
TreeFam:
Gene Tree for CCT6A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCT6A: view image

Paralogs for CCT6A Gene

Paralogs for CCT6A Gene

(7) SIMAP similar genes for CCT6A Gene using alignment to 3 proteins:

  • TCPZ_HUMAN
  • A1JUI8_HUMAN
  • B4DPJ8_HUMAN

Pseudogenes.org Pseudogenes for CCT6A Gene

genes like me logo Genes that share paralogs with CCT6A: view

Variants for CCT6A Gene

Sequence variations from dbSNP and Humsavar for CCT6A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs148855313 uncertain-significance, Deficiency of phosphoserine phosphatase 56,051,529(+) C/G upstream_transcript_variant
rs184427284 uncertain-significance, Deficiency of phosphoserine phosphatase 56,051,288(+) T/C upstream_transcript_variant
rs187219685 uncertain-significance, Deficiency of phosphoserine phosphatase 56,051,554(+) G/C/T upstream_transcript_variant
rs190216482 uncertain-significance, Deficiency of phosphoserine phosphatase 56,051,302(+) A/G upstream_transcript_variant
rs190794562 uncertain-significance, Deficiency of phosphoserine phosphatase 56,051,566(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCT6A Gene

Variant ID Type Subtype PubMed ID
dgv1201e199 CNV deletion 23128226
esv2734447 CNV deletion 23290073
esv2734448 CNV deletion 23290073
esv2761334 CNV gain 21179565
esv28230 CNV gain+loss 19812545
esv3576357 CNV gain 25503493
esv3613248 CNV gain 21293372
esv3613258 CNV gain 21293372
esv3613259 CNV gain 21293372
nsv473333 CNV novel sequence insertion 20440878
nsv981474 CNV duplication 23825009

Variation tolerance for CCT6A Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCT6A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT6A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT6A Gene

Disorders for CCT6A Gene

Additional Disease Information for CCT6A

No disorders were found for CCT6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCT6A Gene

Publications for CCT6A Gene

  1. Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast. (PMID: 8034610) Li WZ … Sherman F (The Journal of biological chemistry 1994) 2 3 4 22 58
  2. Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA. (PMID: 1352881) Segel GB … Sherman F (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for CCT6A Gene

Sources for CCT6A Gene

Content
Loading form....