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The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT inc... See more...
Aliases for CCT4 Gene
Aliases for CCT4 Gene
External Ids for CCT4 Gene
- HGNC: 1617
- Entrez Gene: 10575
- Ensembl: ENSG00000115484
- OMIM: 605142
- UniProtKB: P50991
Previous GeneCards Identifiers for CCT4 Gene
- GC02M062223
- GC02M062281
- GC02M062052
- GC02M062070
- GC02M062069
- GC02M062006
- GC02M062095
- GC02M061835
Summaries for CCT4 Gene
-
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CCT4 Gene
CCT4 (Chaperonin Containing TCP1 Subunit 4) is a Protein Coding gene. Diseases associated with CCT4 include Sensory Peripheral Neuropathy and Hereditary Sensory Neuropathy. Among its related pathways are Chaperonin-mediated protein folding and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is CCT5.
UniProtKB/Swiss-Prot Summary for CCT4 Gene
-
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCT4 Gene
Genomics for CCT4 Gene
GeneHancer (GH) Regulatory Elements for CCT4 Gene
Promoters and enhancers for CCT4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCT4 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCT4
- Top Transcription factor binding sites by QIAGEN in the CCT4 gene promoter:
-
- AP-1
- C/EBPbeta
- GATA-1
- PPAR-gamma1
- PPAR-gamma2
- STAT1beta
- TBP
- TFIID
Genomic Locations for CCT4 Gene
Genomic Locations for CCT4 Gene
- chr2:61,868,085-61,888,671
- (GRCh38/hg38)
- Size:
- 20,587 bases
- Orientation:
- Minus strand
- chr2:62,095,224-62,115,939
- (GRCh37/hg19)
- Size:
- 20,716 bases
- Orientation:
- Minus strand
Genomic View for CCT4 Gene
Genes around CCT4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p15 by HGNC
- 2p15 by Entrez Gene
- 2p15 by Ensembl
CCT4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCT4 Gene
Proteins for CCT4 Gene
-
Protein details for CCT4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50991-TCPD_HUMAN
- Recommended name:
- T-complex protein 1 subunit delta
- Protein Accession:
- P50991
- B2R6I3
- B7Z8B1
- F5H5W3
- O14870
- Q53QP9
- Q96C51
Protein attributes for CCT4 Gene
- Size:
- 539 amino acids
- Molecular mass:
- 57924 Da
- Quaternary structure:
-
- Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with DNAAF4 (By similarity).
Three dimensional structures from OCA and Proteopedia for CCT4 Gene
Protein Expression for CCT4 Gene
Post-translational modifications for CCT4 Gene
Other Protein References for CCT4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents TCP1 delta Antibody / CCT4
- Creative Diagnostics Anti-CCT4 monoclonal antibody, clone FQS9506(C)
- Creative Biolabs Hi-Affi™ Recombinant Rabbit Anti-CCT4 Monoclonal Antibody (DS529AB)
- Novus Biologicals Antibodies for CCT4
-
Abcam antibodies for CCT4
- Invitrogen Antibodies for CCT4 (AFLGC-CCT4)
-
Boster Bio Antibodies for CCT4
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCT4
Protein Products
- Creative Biomart Recombinant Human CCT4, His-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for CCT4
- Origene Custom Protein Services for CCT4
No data available for DME Specific Peptides for CCT4 Gene
Domains & Families for CCT4 Gene
Gene Families for CCT4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CCT4 Gene
- Blocks:
-
- Chaperonin TCP-1
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCT4 Gene
- GenScript: Design optimal peptide antigens:
-
- T-complex protein 1 subunit delta (B7Z2F4_HUMAN)
- T-complex protein 1 subunit delta (B7Z9L0_HUMAN)
- T-complex protein 1 subunit delta (F5H5W3_HUMAN)
- Stimulator of TAR RNA-binding (TCPD_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P50991- Family:
-
- Belongs to the TCP-1 chaperonin family.
Function for CCT4 Gene
Molecular function for CCT4 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
- GENATLAS Biochemistry:
- chaperonin containing TCP1 (T complex protein 1) subunit 4 (delta),cytosolic,TF55/TCP-1 family,required for the maturation of cyclin E
Phenotypes From GWAS Catalog for CCT4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 16085932 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0051082 | unfolded protein binding | TAS,IEA | -- |
Phenotypes for CCT4 Gene
- GenomeRNAi human phenotypes for CCT4:
-
- G0/1 arrest
- Increased G2M DNA content, increased 8N DNA content
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased Nanog expression
- Decreased viability
- no effect
- Increased gamma-H2AX phosphorylation
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased viability with paclitaxel
- Increased viability
- Increased replication of vaccinia virus (VACV)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCT4 - Select products 50% OFF >
- * CCT4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCT4
- genomics-online: gRNA clones - Search results for available CCT4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCT4
miRNA for CCT4 Gene
- miRTarBase miRNAs that target CCT4
-
- hsa-mir-1227-3p (MIRT036402)
- hsa-mir-193b-3p (MIRT041331)
- hsa-mir-186-5p (MIRT045238)
- hsa-mir-149-5p (MIRT045425)
- hsa-mir-29a-3p (MIRT049979)
- hsa-mir-190a-3p (MIRT515509)
- hsa-mir-4789-5p (MIRT515510)
- hsa-mir-3941 (MIRT515511)
- hsa-mir-5011-5p (MIRT515512)
- hsa-mir-4789-3p (MIRT515513)
- hsa-mir-603 (MIRT515514)
- hsa-mir-362-3p (MIRT515515)
- hsa-mir-329-3p (MIRT515516)
- hsa-mir-8485 (MIRT515517)
- hsa-mir-1277-5p (MIRT515518)
- hsa-mir-195-3p (MIRT539953)
- hsa-mir-16-2-3p (MIRT539954)
- hsa-mir-34c-3p (MIRT539955)
- hsa-mir-548c-3p (MIRT539956)
- hsa-mir-6736-5p (MIRT628617)
- hsa-mir-4701-3p (MIRT628618)
- hsa-mir-1262 (MIRT628619)
- hsa-mir-7703 (MIRT628620)
- hsa-mir-6720-5p (MIRT628621)
- hsa-mir-6512-3p (MIRT628622)
- hsa-mir-661 (MIRT628623)
- hsa-mir-4252 (MIRT628624)
- hsa-mir-27b-5p (MIRT628625)
- hsa-mir-6776-5p (MIRT628626)
- hsa-mir-4793-3p (MIRT628627)
- hsa-mir-766-3p (MIRT628628)
- hsa-mir-6742-3p (MIRT628629)
- hsa-mir-6849-3p (MIRT628630)
- hsa-mir-1273g-3p (MIRT628631)
- hsa-mir-556-5p (MIRT628632)
- hsa-mir-208b-5p (MIRT628633)
- hsa-mir-208a-5p (MIRT628634)
- hsa-mir-508-5p (MIRT628635)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCT4
- Browse OriGene Inhibitory RNA Products For CCT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT4
- genomics-online: shRNA clones - Search results for available CCT4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CCT4 - Select products 50% OFF >
- * CCT4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCT4
- genomics-online: cdna clones - Search results for available CCT4 gene related products
- orf clones - Search results for available CCT4 gene related products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT4 Gene
Localization for CCT4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCT4 Gene
- Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269 PubMed:17081065}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002199 | zona pellucida receptor complex | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 20080638 |
| GO:0005815 | microtubule organizing center | IEA | -- |
Pathways & Interactions for CCT4 Gene
Pathways by source for CCT4 Gene
1 GeneGo (Thomson Reuters) pathway for CCT4 Gene
- Cell cycle_Role of APC in cell cycle regulation
Interacting Proteins for CCT4 Gene
Selected Interacting proteins:
P50991-TCPD_HUMAN
ENSP00000377958
for CCT4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CCT4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | TAS | -- |
| GO:0007339 | binding of sperm to zona pellucida | IEA | -- |
| GO:0032212 | positive regulation of telomere maintenance via telomerase | IMP | 25467444 |
| GO:0050821 | protein stabilization | IMP | 25467444 |
| GO:0051973 | positive regulation of telomerase activity | IMP | 25467444 |
No data available for SIGNOR curated interactions for CCT4 Gene
Drugs & Compounds for CCT4 Gene
No Compound Related Data Available
Drug Products
- Creative Biomart Recombinant Human CCT4, His-tagged
Transcripts for CCT4 Gene
mRNA/cDNA for CCT4 Gene
- 2 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000394440 2376 bps (ENST00000394440.8)
- ENST00000461370 388 bps (ENST00000461370.1)
- ENST00000461540 638 bps (ENST00000461540.2)
- ENST00000544079 2261 bps (ENST00000544079.2)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCT4 - Select products 50% OFF >
- * CCT4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCT4
- genomics-online: gRNA clones - Search results for available CCT4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCT4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCT4
- Browse OriGene Inhibitory RNA Products For CCT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT4
- genomics-online: shRNA clones - Search results for available CCT4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CCT4 - Select products 50% OFF >
- * CCT4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCT4
- genomics-online: cdna clones - Search results for available CCT4 gene related products
- orf clones - Search results for available CCT4 gene related products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for CCT4 Gene
- GeneLoc Exon Structure for
- CCT4
Expression for CCT4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCT4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCT4
SOURCE GeneReport for Unigene cluster for CCT4 Gene:
Hs.421509Evidence on tissue expression from TISSUES for CCT4 Gene
- Nervous system(5)
- Liver(4.8)
- Blood(4.4)
- Lung(4.2)
- Intestine(3.4)
- Skin(3.4)
- Eye(3.3)
- Kidney(2.8)
- Heart(2.4)
- Bone(2.2)
Primer Products
-
OriGene qPCR primer pairs for CCT4
-
OriGene qPCR primer pairs and template standards for CCT4
- genomics-online: primer clones - Search results for available CCT4 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT4 Gene
Orthologs for CCT4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | CCT4 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CCT4 31 30 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CCT4 31 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CCT4 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cct4 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cct4 30 |
|
||
| chicken (Gallus gallus) |
Aves | CCT4 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CCT4 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cct4 30 |
|
||
| Str.2717 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398959 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cct4 31 30 |
|
OneToOne | |
| zgc65789 30 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1747 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5525 31 32 30 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009505 30 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cct-4 31 32 30 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CCT4 31 30 |
|
OneToOne | |
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F05005g 30 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR083W 30 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G18190 30 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.5713 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10395 30 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0332200 30 |
|
||
| Os.9114 30 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.1648 30 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.6601 30 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.2601 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.45 31 |
|
OneToOne | |
| Cin.12186 30 |
|
||||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cct4 30 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU02839 30 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.12186 30 |
|
- Species where no ortholog for CCT4 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for CCT4 Gene
- ENSEMBL:
- Gene Tree for CCT4 (if available)
- TreeFam:
- Gene Tree for CCT4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCT4: view image
Paralogs for CCT4 Gene
Paralogs for CCT4 Gene
(8) SIMAP similar genes for CCT4 Gene using alignment to 3 proteins:
- TCPD_HUMAN
- B7Z2F4_HUMAN
- B7Z9L0_HUMAN
Pseudogenes.org Pseudogenes for CCT4 Gene
Variants for CCT4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCT4 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2272428 | - | p.Ile112Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2657259 | CNV | deletion | 23128226 |
| esv2720131 | CNV | deletion | 23290073 |
| esv34000 | CNV | loss | 18971310 |
| esv3591026 | CNV | loss | 21293372 |
| nsv1009446 | CNV | gain | 25217958 |
| nsv458074 | CNV | gain | 19166990 |
| nsv470467 | CNV | gain | 18288195 |
| nsv582118 | CNV | gain | 21841781 |
| nsv582122 | CNV | gain | 21841781 |
| nsv582123 | CNV | gain | 21841781 |
| nsv7313 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.31;
26.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCT4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCT4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT4 Gene
Disorders for CCT4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sensory peripheral neuropathy |
|
|
| hereditary sensory neuropathy |
|
|
| posterior cerebral artery infarction |
|
|
| peroxisome biogenesis disorder 11a |
|
|
| dystonia, dopa-responsive, due to sepiapterin reductase deficiency |
|
|
Search CCT4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCT4
No data available for UniProtKB/Swiss-Prot and Genatlas for CCT4 Gene
Publications for CCT4 Gene
- Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won KA … Reed SI (Molecular and cellular biology 1998) 2 3 4 54
- Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. (PMID: 8626763) Wu-Baer F … Gaynor RB (The Journal of biological chemistry 1996) 3 4 23 54
- Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. (PMID: 25467444) Freund A … Artandi SE (Cell 2014) 3 4 54
- BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. (PMID: 20080638) Seo S … Sheffield VC (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 54
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4 54
ExternalLinks
Products for CCT4 Gene
- Custom Antibody ServicesOriGene Antibodies for CCT4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CCT4
- Origene Custom Protein Services for CCT4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCT4
- Browse OriGene Inhibitory RNA Products For CCT4
- OriGene qPCR primer pairs for CCT4
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- OriGene CRISPR knockouts for CCT4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCT4
- Sino Biological Human cDNA Clone for CCT4
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Invitrogen Antibodies for CCT4 (AFLGC-CCT4)
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- VectorBuilder CRISPR vectors for CCT4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCT4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCT4
- antibodies-online: Show 18 available CCT4 Antibodies ranked by validation data
- Compare Top CCT4 Antibodies
- antibodies-online: Search results for available CCT4 related products ranked by validation data
- antibodies-online: Show 7 available CCT4 Proteins ranked by validation data
- Compare Top CCT4 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CCT4
- Search Santa Cruz Biotechnology (SCBT) for CCT4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCT4
- genomics-online: cdna clones - Search results for available CCT4 gene related products
- orf clones - Search results for available CCT4 gene related products
- genomics-online: gRNA clones - Search results for available CCT4 gene related products
- genomics-online: primer clones - Search results for available CCT4 gene related products
- genomics-online: shRNA clones - Search results for available CCT4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCT4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT4
- Boster Bio Antibodies for CCT4
- Browse Boster Bio ELISA Kits
Sources for CCT4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontolog