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The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT inc... See more...
Aliases for CCT4 Gene
Aliases for CCT4 Gene
External Ids for CCT4 Gene
- HGNC: 1617
- NCBI Entrez Gene: 10575
- Ensembl: ENSG00000115484
- OMIM®: 605142
- UniProtKB/Swiss-Prot: P50991
Previous GeneCards Identifiers for CCT4 Gene
- GC02M062223
- GC02M062281
- GC02M062052
- GC02M062070
- GC02M062069
- GC02M062006
- GC02M062095
- GC02M061835
Summaries for CCT4 Gene
-
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CCT4 Gene
CCT4 (Chaperonin Containing TCP1 Subunit 4) is a Protein Coding gene. Diseases associated with CCT4 include Sensory Peripheral Neuropathy and Hereditary Sensory Neuropathy. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is CCT5.
UniProtKB/Swiss-Prot Summary for CCT4 Gene
-
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Additional gene information for CCT4 Gene
- HGNC (1617)
- NCBI Entrez Gene (10575)
- Ensembl (ENSG00000115484)
- OMIM® (605142)
- UniProtKB/Swiss-Prot (P50991)
- Open Targets Platform(ENSG00000115484)
- Search for CCT4 at DataMed
- Search for CCT4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCT4 Gene
Genomics for CCT4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCT4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCT4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCT4
- Top Transcription factor binding sites by QIAGEN in the CCT4 gene promoter:
-
- AP-1
- C/EBPbeta
- GATA-1
- PPAR-gamma1
- PPAR-gamma2
- STAT1beta
- TBP
- TFIID
Genomic Locations for CCT4 Gene
Latest Assembly
- chr2:61,868,085-61,888,671
- (GRCh38/hg38)
- Size:
- 20,587 bases
- Orientation:
- Minus strand
Previous Assembly
- chr2:62,095,220-62,115,806
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 20,587 bases
- Orientation:
- Minus strand
- chr2:62,095,224-62,115,939
- (GRCh37/hg19 by Ensembl)
- Size:
- 20,716 bases
- Orientation:
- Minus strand
Genomic View for CCT4 Gene
Genes around CCT4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p15 by HGNC
- 2p15 by Entrez Gene
- 2p15 by Ensembl
CCT4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCT4 Gene
Proteins for CCT4 Gene
-
Protein details for CCT4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50991-TCPD_HUMAN
- Recommended name:
- T-complex protein 1 subunit delta
- Protein Accession:
- P50991
- B2R6I3
- B7Z8B1
- F5H5W3
- O14870
- Q53QP9
- Q96C51
Protein attributes for CCT4 Gene
- Size:
- 539 amino acids
- Molecular mass:
- 57924 Da
- Quaternary structure:
-
- Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with DNAAF4 (By similarity).
Three dimensional structures from OCA and Proteopedia for CCT4 Gene
Protein Expression for CCT4 Gene
Post-translational modifications for CCT4 Gene
Other Protein References for CCT4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- NSJ Bioreagents TCP1 delta Antibody / CCT4
- Novus Biologicals Antibodies for CCT4
-
Abcam antibodies for CCT4
- Invitrogen Antibodies for CCT4 (AFLGC-Cct4)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCT4
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CCT4
- Origene Custom Protein Services for CCT4
Assay products for research
- antibodies-online: Search results for available CCT4 related products ranked by validation data
No data available for DME Specific Peptides for CCT4 Gene
Domains & Families for CCT4 Gene
Gene Families for CCT4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CCT4 Gene
- InterPro:
- Blocks:
-
- Chaperonin TCP-1
- ProtoNet:
Suggested Antigen Peptide Sequences for CCT4 Gene
- GenScript: Design optimal peptide antigens:
-
- T-complex protein 1 subunit delta (B7Z2F4_HUMAN)
- T-complex protein 1 subunit delta (B7Z9L0_HUMAN)
- T-complex protein 1 subunit delta (F5H5W3_HUMAN)
- Stimulator of TAR RNA-binding (TCPD_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P50991- Family:
-
- Belongs to the TCP-1 chaperonin family.
Function for CCT4 Gene
Molecular function for CCT4 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
- GENATLAS Biochemistry:
- chaperonin containing TCP1 (T complex protein 1) subunit 4 (delta),cytosolic,TF55/TCP-1 family,required for the maturation of cyclin E
Phenotypes From GWAS Catalog for CCT4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 16085932 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0044183 | protein binding involved in protein folding | IDA | 30955883 |
Phenotypes for CCT4 Gene
- GenomeRNAi human phenotypes for CCT4:
-
- Increased gamma-H2AX phosphorylation
- no effect
- Decreased viability
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased Nanog expression
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Cell division defect
- Decreased viability with paclitaxel
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased G2M DNA content
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCT4 - Starting at $85 >
- * CCT4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCT4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCT4
miRNA for CCT4 Gene
- miRTarBase miRNAs that target CCT4
-
- hsa-miR-1227-3p (MIRT036402)
- hsa-miR-193b-3p (MIRT041331)
- hsa-miR-186-5p (MIRT045238)
- hsa-miR-149-5p (MIRT045425)
- hsa-miR-29a-3p (MIRT049979)
- hsa-miR-190a-3p (MIRT515509)
- hsa-miR-4789-5p (MIRT515510)
- hsa-miR-3941 (MIRT515511)
- hsa-miR-5011-5p (MIRT515512)
- hsa-miR-4789-3p (MIRT515513)
- hsa-miR-603 (MIRT515514)
- hsa-miR-362-3p (MIRT515515)
- hsa-miR-329-3p (MIRT515516)
- hsa-miR-8485 (MIRT515517)
- hsa-miR-1277-5p (MIRT515518)
- hsa-miR-195-3p (MIRT539953)
- hsa-miR-16-2-3p (MIRT539954)
- hsa-miR-34c-3p (MIRT539955)
- hsa-miR-548c-3p (MIRT539956)
- hsa-miR-6736-5p (MIRT628617)
- hsa-miR-4701-3p (MIRT628618)
- hsa-miR-1262 (MIRT628619)
- hsa-miR-7703 (MIRT628620)
- hsa-miR-6720-5p (MIRT628621)
- hsa-miR-6512-3p (MIRT628622)
- hsa-miR-661 (MIRT628623)
- hsa-miR-4252 (MIRT628624)
- hsa-miR-27b-5p (MIRT628625)
- hsa-miR-6776-5p (MIRT628626)
- hsa-miR-4793-3p (MIRT628627)
- hsa-miR-766-3p (MIRT628628)
- hsa-miR-6742-3p (MIRT628629)
- hsa-miR-6849-3p (MIRT628630)
- hsa-miR-1273g-3p (MIRT628631)
- hsa-miR-556-5p (MIRT628632)
- hsa-miR-208b-5p (MIRT628633)
- hsa-miR-208a-5p (MIRT628634)
- hsa-miR-508-5p (MIRT628635)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCT4
- Browse OriGene Inhibitory RNA Products For CCT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT4
Clone products for research
- Applied Biological Materials (abm): Clones for CCT4 - Starting at $45 >
- * CCT4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCT4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT4 Gene
Localization for CCT4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCT4 Gene
- Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269 PubMed:17081065}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002199 | zona pellucida receptor complex | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 20080638 |
| GO:0005815 | microtubule organizing center | IEA | -- |
Pathways & Interactions for CCT4 Gene
Pathways by source for CCT4 Gene
1 GeneGo (Thomson Reuters) pathway for CCT4 Gene
- Cell cycle_Role of APC in cell cycle regulation
Interacting Proteins for CCT4 Gene
Selected Interacting proteins:
P50991-TCPD_HUMAN
ENSP00000377958
for CCT4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CCT4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | IDA,TAS | -- |
| GO:0007339 | binding of sperm to zona pellucida | IEA | -- |
| GO:0032212 | positive regulation of telomere maintenance via telomerase | IMP | 25467444 |
| GO:0050821 | protein stabilization | IMP | 25467444 |
| GO:0051973 | positive regulation of telomerase activity | IMP | 25467444 |
No data available for SIGNOR curated interactions for CCT4 Gene
Transcripts for CCT4 Gene
mRNA/cDNA for CCT4 Gene
- 2 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000394440 2376 nts (view in UCSC)
- ENST00000461370 388 nts (view in UCSC)
- ENST00000461540 638 nts (view in UCSC)
- ENST00000544079 2261 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCT4 - Starting at $85 >
- * CCT4 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCT4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCT4
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCT4
- Browse OriGene Inhibitory RNA Products For CCT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT4
Clone products for research
- Applied Biological Materials (abm): Clones for CCT4 - Starting at $45 >
- * CCT4 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCT4
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for CCT4 Gene
- GeneLoc Exon Structure for
- CCT4
Expression for CCT4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCT4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCT4
SOURCE GeneReport for Unigene cluster for CCT4 Gene:
Hs.421509Evidence on tissue expression from TISSUES for CCT4 Gene
- Nervous system(5)
- Liver(4.9)
- Blood(4.5)
- Lung(4.3)
- Skin(3.8)
- Intestine(3.7)
- Eye(3.6)
- Kidney(3.3)
- Heart(3)
- Bone(2.6)
- Lymph node(2.4)
- Muscle(2.4)
- Pancreas(2.4)
- Adrenal gland(2.2)
- Spleen(2.1)
- Bone marrow(2.1)
Primer products for research
-
OriGene qPCR primer pairs for CCT4
-
OriGene qPCR primer pairs and template standards for CCT4
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT4 Gene
Orthologs for CCT4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chimpanzee (Pan troglodytes) |
Mammalia | CCT4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CCT4 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CCT4 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CCT4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cct4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cct4 30 |
|
||
| Chicken (Gallus gallus) |
Aves | CCT4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CCT4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cct4 30 |
|
||
| Str.2717 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398959 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cct4 30 31 |
|
OneToOne | |
| zgc65789 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1747 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG5525 30 31 32 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009505 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | cct-4 30 31 32 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CCT4 30 31 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F05005g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR083W 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G18190 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10395 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.5713 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0332200 30 |
|
||
| Os.9114 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.2601 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.1648 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.6601 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.45 31 |
|
OneToOne | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cct4 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU02839 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.12186 30 |
|
- Species where no ortholog for CCT4 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for CCT4 Gene
- ENSEMBL:
- Gene Tree for CCT4 (if available)
- TreeFam:
- Gene Tree for CCT4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCT4: view image
Paralogs for CCT4 Gene
Paralogs for CCT4 Gene
(8) SIMAP similar genes for CCT4 Gene using alignment to 3 proteins:
- TCPD_HUMAN
- B7Z2F4_HUMAN
- B7Z9L0_HUMAN
Pseudogenes.org Pseudogenes for CCT4 Gene
Variants for CCT4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCT4 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2272428 | - |
p.Ile112Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2657259 | CNV | deletion | 23128226 |
| esv2720131 | CNV | deletion | 23290073 |
| esv34000 | CNV | loss | 18971310 |
| esv3591026 | CNV | loss | 21293372 |
| nsv1009446 | CNV | gain | 25217958 |
| nsv458074 | CNV | gain | 19166990 |
| nsv470467 | CNV | gain | 18288195 |
| nsv582118 | CNV | gain | 21841781 |
| nsv582122 | CNV | gain | 21841781 |
| nsv582123 | CNV | gain | 21841781 |
| nsv7313 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.31;
26.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCT4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCT4
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT4 Gene
Disorders for CCT4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sensory peripheral neuropathy |
|
|
| hereditary sensory neuropathy |
|
|
| peroxisome biogenesis disorder 11a |
|
|
| dystonia, dopa-responsive, due to sepiapterin reductase deficiency |
|
|
Search CCT4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCT4
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CCT4 Gene
Publications for CCT4 Gene
- Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won KA … Reed SI (Molecular and cellular biology 1998) 2 3 4
- Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. (PMID: 8626763) Wu-Baer F … Gaynor RB (The Journal of biological chemistry 1996) 3 4 23
- Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. (PMID: 25467444) Freund A … Artandi SE (Cell 2014) 3 4
- BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. (PMID: 20080638) Seo S … Sheffield VC (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4
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Products for CCT4 Gene
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- antibodies-online: Show 18 available CCT4 Antibodies ranked by validation data
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Sources for CCT4 Gene
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