The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex... See more...

Aliases for CCT3 Gene

Aliases for CCT3 Gene

  • Chaperonin Containing TCP1 Subunit 3 2 3 5
  • Chaperonin Containing TCP1, Subunit 3 (Gamma) 2 3
  • T-Complex Protein 1 Subunit Gamma 3 4
  • TCP-1-Gamma 3 4
  • CCT-Gamma 3 4
  • HTRiC5 3 4
  • TRIC5 3 4
  • CCTG 3 4
  • TCP1 (T-Complex-1) Ring Complex, Polypeptide 5 3
  • T-Complex Protein 1, Gamma Subunit 3
  • PIG48 3
  • CCT3 5
  • Cctg 2

External Ids for CCT3 Gene

Previous HGNC Symbols for CCT3 Gene

  • TRIC5

Previous GeneCards Identifiers for CCT3 Gene

  • GC01M154147
  • GC01M152043
  • GC01M153056
  • GC01M153495
  • GC01M153091
  • GC01M154545
  • GC01M156278
  • GC01M127638

Summaries for CCT3 Gene

Entrez Gene Summary for CCT3 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

GeneCards Summary for CCT3 Gene

CCT3 (Chaperonin Containing TCP1 Subunit 3) is a Protein Coding gene. Diseases associated with CCT3 include Contractural Arachnodactyly, Congenital and Distal Arthrogryposis. Among its related pathways are Chaperonin-mediated protein folding and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is CCT4.

UniProtKB/Swiss-Prot Summary for CCT3 Gene

  • Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).

Gene Wiki entry for CCT3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCT3 Gene

Genomics for CCT3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCT3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCT3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCT3

Top Transcription factor binding sites by QIAGEN in the CCT3 gene promoter:
  • aMEF-2
  • AML1a
  • ARP-1
  • CBF(2)
  • CBF-A
  • CBF-B
  • Egr-1
  • MEF-2A
  • Nkx5-1

Genomic Locations for CCT3 Gene

Latest Assembly
chr1:156,308,968-156,367,873
(GRCh38/hg38)
Size:
58,906 bases
Orientation:
Minus strand

Previous Assembly
chr1:156,278,759-156,308,083
(GRCh37/hg19 by Entrez Gene)
Size:
29,325 bases
Orientation:
Minus strand

chr1:156,278,759-156,337,664
(GRCh37/hg19 by Ensembl)
Size:
58,906 bases
Orientation:
Minus strand

Genomic View for CCT3 Gene

Genes around CCT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT3 Gene

Proteins for CCT3 Gene

  • Protein details for CCT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49368-TCPG_HUMAN
    Recommended name:
    T-complex protein 1 subunit gamma
    Protein Accession:
    P49368
    Secondary Accessions:
    • A6NE14
    • Q5SZY1
    • Q9BR64

    Protein attributes for CCT3 Gene

    Size:
    545 amino acids
    Molecular mass:
    60534 Da
    Quaternary structure:
    • Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with DNAAF4 (By similarity).
    SequenceCaution:
    • Sequence=AAH08019.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCT3 Gene

    Alternative splice isoforms for CCT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT3 Gene

Post-translational modifications for CCT3 Gene

  • Ubiquitination at Lys21, Lys31, Lys44, Lys48, Lys78, Lys248, Lys249, Lys354, Lys381, Lys427, Lys502, and Lys507
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCT3 Gene

Domains & Families for CCT3 Gene

Gene Families for CCT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CCT3 Gene

Suggested Antigen Peptide Sequences for CCT3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57904, highly similar to T-complex protein 1 subunit gamma (A6NE14_HUMAN)
  • cDNA, FLJ79286, highly similar to T-complex protein 1 subunit gamma (B4DUR8_HUMAN)
  • Chaperonin containing TCP1, subunit 3 (Gamma) (Q5SZX8_HUMAN)
  • Chaperonin containing TCP1, subunit 3 (Gamma) (Q5SZY0_HUMAN)
  • hTRiC5 (TCPG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49368

UniProtKB/Swiss-Prot:

TCPG_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT3: view

Function for CCT3 Gene

Molecular function for CCT3 Gene

UniProtKB/Swiss-Prot Function:
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1) subunit 3 (gamma),cytosolic,widely expressed in fetal and adult tissues,TF55/TCP-1 family

Phenotypes From GWAS Catalog for CCT3 Gene

Gene Ontology (GO) - Molecular Function for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 12620389
GO:0005524 ATP binding IEA --
GO:0044183 protein binding involved in protein folding IDA 30955883
genes like me logo Genes that share ontologies with CCT3: view
genes like me logo Genes that share phenotypes with CCT3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT3 Gene

Localization for CCT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
extracellular 4
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex TAS 25467444
GO:0005856 cytoskeleton TAS 8001976
genes like me logo Genes that share ontologies with CCT3: view

Pathways & Interactions for CCT3 Gene

genes like me logo Genes that share pathways with CCT3: view

Pathways by source for CCT3 Gene

1 GeneGo (Thomson Reuters) pathway for CCT3 Gene
  • Cell cycle_Role of APC in cell cycle regulation

Gene Ontology (GO) - Biological Process for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA,TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0046931 pore complex assembly IEA --
GO:0050821 protein stabilization IMP 25467444
genes like me logo Genes that share ontologies with CCT3: view

No data available for SIGNOR curated interactions for CCT3 Gene

Drugs & Compounds for CCT3 Gene

(2) Drugs for CCT3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Experimental, Investigational Pharma Target, ligand 123
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
genes like me logo Genes that share compounds with CCT3: view

Transcripts for CCT3 Gene

mRNA/cDNA for CCT3 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT3

Alternative Splicing Database (ASD) splice patterns (SP) for CCT3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:
SP2: - -
SP3: -

Relevant External Links for CCT3 Gene

GeneLoc Exon Structure for
CCT3

Expression for CCT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCT3 Gene



Protein tissue co-expression partners for CCT3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCT3

SOURCE GeneReport for Unigene cluster for CCT3 Gene:

Hs.491494

Evidence on tissue expression from TISSUES for CCT3 Gene

  • Nervous system(5)
  • Lung(5)
  • Kidney(4.9)
  • Liver(4.9)
  • Skin(4.8)
  • Blood(4.7)
  • Intestine(4.7)
  • Eye(4.6)
  • Lymph node(4.4)
  • Muscle(3.9)
  • Pancreas(3.9)
  • Stomach(3.5)
  • Heart(3.2)
  • Thyroid gland(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CCT3: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT3 Gene

Orthologs for CCT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCT3 29 30
  • 99.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCT3 29 30
  • 92.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCT3 29 30
  • 92.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cct3 29
  • 90.09 (n)
Oppossum
(Monodelphis domestica)
Mammalia CCT3 30
  • 90 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cct3 29 16 30
  • 89.72 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCT3 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 30
  • 85 (a)
OneToMany
CCT3 29
  • 75.51 (n)
-- 30
  • 57 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia CCT3 30
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cct3 29
  • 78.05 (n)
MGC76259 29
African clawed frog
(Xenopus laevis)
Amphibia cct3-prov 29
Zebrafish
(Danio rerio)
Actinopterygii cct3 29 30
  • 75.59 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9536 29
Fruit Fly
(Drosophila melanogaster)
Insecta Cctgamma 29 30 31
  • 67.6 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002759 29
  • 67.23 (n)
Worm
(Caenorhabditis elegans)
Secernentea cct-3 29 30
  • 60.56 (n)
OneToOne
F54A3.3 31
  • 50 (a)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22583g 29
  • 59.53 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR314W 29
  • 59.08 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT3 29 30
  • 58.89 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G26360 29
  • 60.27 (n)
Soybean
(Glycine max)
eudicotyledons Gma.6692 29
Rice
(Oryza sativa)
Liliopsida Os02g0247200 29
  • 59.92 (n)
Os.12204 29
Barley
(Hordeum vulgare)
Liliopsida Hv.11063 29
Wheat
(Triticum aestivum)
Liliopsida Ta.2554 29
Corn
(Zea mays)
Liliopsida Zm.16810 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 70 (a)
OneToMany
CSA.2701 30
  • 69 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU01843 29
  • 63.29 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct3 29
  • 59.3 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2484 29
Species where no ortholog for CCT3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT3 Gene

ENSEMBL:
Gene Tree for CCT3 (if available)
TreeFam:
Gene Tree for CCT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCT3: view image
Alliance of Genome Resources:
Additional Orthologs for CCT3

Paralogs for CCT3 Gene

Paralogs for CCT3 Gene

(23) SIMAP similar genes for CCT3 Gene using alignment to 10 proteins:

  • TCPG_HUMAN
  • B4DUR8_HUMAN
  • E9PM09_HUMAN
  • E9PQ35_HUMAN
  • E9PRC8_HUMAN
  • E9PRM9_HUMAN
  • E9PRN0_HUMAN
  • Q5SZW8_HUMAN
  • Q5SZX6_HUMAN
  • Q5SZX9_HUMAN

Pseudogenes.org Pseudogenes for CCT3 Gene

genes like me logo Genes that share paralogs with CCT3: view

Variants for CCT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCT3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
930642 Uncertain Significance: See cases 156,309,285(-) G/A
NM_005998.5(CCT3):c.1552C>T (p.Arg518Ter)
NONSENSE,NON_CODING_TRANSCRIPT
rs74116819 Benign: not provided 156,334,921(-) A/G
NM_005998.5(CCT3):c.94-3T>C
INTRON
rs2230194 -- p.Leu391Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCT3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCT3 Gene

Variant ID Type Subtype PubMed ID
esv1449360 CNV insertion 17803354
esv3587635 CNV gain 21293372
nsv1113185 CNV deletion 24896259
nsv1122409 CNV deletion 24896259

Variation tolerance for CCT3 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT3
Leiden Open Variation Database (LOVD)
CCT3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT3 Gene

Disorders for CCT3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCT3 Gene - From: COP

Disorder Aliases PubMed IDs
contractural arachnodactyly, congenital
  • cca
distal arthrogryposis
  • arthrogryposis multiplex congenita
- elite association - COSMIC cancer census association via MalaCards
Search CCT3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCT3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT3 Gene

Publications for CCT3 Gene

  1. Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. (PMID: 8573069) Walkley NA … Malik AN (The Biochemical journal 1996) 3 4 22
  2. Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization. (PMID: 8001976) Sévigny G … Lemieux N (Genomics 1994) 3 4 22
  3. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. (PMID: 25467444) Freund A … Artandi SE (Cell 2014) 3 4
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 40
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4

Products for CCT3 Gene