Aliases for CCT3 Gene
External Ids for CCT3 Gene
Previous HGNC Symbols for CCT3 Gene
Previous GeneCards Identifiers for CCT3 Gene
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
GeneCards Summary for CCT3 Gene
CCT3 (Chaperonin Containing TCP1 Subunit 3) is a Protein Coding gene. Diseases associated with CCT3 include Contractural Arachnodactyly, Congenital and Distal Arthrogryposis. Among its related pathways are Chaperonin-mediated protein folding and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is CCT4.
UniProtKB/Swiss-Prot Summary for CCT3 Gene
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).