The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex... See more...

Aliases for CCT2 Gene

Aliases for CCT2 Gene

  • Chaperonin Containing TCP1 Subunit 2 2 3 5
  • Chaperonin Containing TCP1, Subunit 2 (Beta) 2 3
  • T-Complex Protein 1 Subunit Beta 3 4
  • TCP-1-Beta 3 4
  • CCT-Beta 3 4
  • 99D8.1 3 4
  • CCTB 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Beta Subunit 3
  • Chaperonin Containing T-Complex Polypeptide 1, Subunit 2 3
  • Epididymis Secretory Sperm Binding Protein Li 100n 3
  • T-Complex Protein 1, Beta Subunit 3
  • HEL-S-100n 3
  • PRO1633 3
  • CCT2 5
  • Cctb 2

External Ids for CCT2 Gene

Previous GeneCards Identifiers for CCT2 Gene

  • GC12P069837
  • GC12P069695
  • GC12P068265
  • GC12P069979
  • GC12P067028

Summaries for CCT2 Gene

Entrez Gene Summary for CCT2 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CCT2 Gene

CCT2 (Chaperonin Containing TCP1 Subunit 2) is a Protein Coding gene. Diseases associated with CCT2 include Bardet-Biedl Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and unfolded protein binding. An important paralog of this gene is TCP1.

UniProtKB/Swiss-Prot Summary for CCT2 Gene

  • Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).

Gene Wiki entry for CCT2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCT2 Gene

Genomics for CCT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCT2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCT2

Top Transcription factor binding sites by QIAGEN in the CCT2 gene promoter:
  • FOXO4
  • GATA-2
  • LCR-F1
  • Nkx2-5
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU3F2

Genomic Locations for CCT2 Gene

Genomic Locations for CCT2 Gene
chr12:69,585,426-69,601,570
(GRCh38/hg38)
Size:
16,145 bases
Orientation:
Plus strand
chr12:69,979,114-69,995,357
(GRCh37/hg19)
Size:
16,244 bases
Orientation:
Plus strand

Genomic View for CCT2 Gene

Genes around CCT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT2 Gene

Proteins for CCT2 Gene

  • Protein details for CCT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78371-TCPB_HUMAN
    Recommended name:
    T-complex protein 1 subunit beta
    Protein Accession:
    P78371
    Secondary Accessions:
    • A8K402
    • B5BTY7
    • B7Z243
    • B7Z7K4
    • B7ZAT2
    • Q14D36
    • Q6IAT3

    Protein attributes for CCT2 Gene

    Size:
    535 amino acids
    Molecular mass:
    57488 Da
    Quaternary structure:
    • Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with FLCN (PubMed:27353360).

    Three dimensional structures from OCA and Proteopedia for CCT2 Gene

    Alternative splice isoforms for CCT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT2 Gene

Post-translational modifications for CCT2 Gene

  • Ubiquitination at Lys13, Lys72, Lys82, Lys40, Lys46, Lys120, Lys154, Lys191, Lys204, Lys236, Lys248, Lys250, Lys284, Lys342, Lys402, Lys441, and Lys522
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT2 Gene

No data available for DME Specific Peptides for CCT2 Gene

Domains & Families for CCT2 Gene

Gene Families for CCT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CCT2 Gene

Suggested Antigen Peptide Sequences for CCT2 Gene

GenScript: Design optimal peptide antigens:
  • T-complex protein 1 subunit beta (B5BTY7_HUMAN)
  • cDNA, FLJ79307, highly similar to T-complex protein 1 subunit beta (B7ZAT2_HUMAN)
  • CCT-beta (TCPB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78371

UniProtKB/Swiss-Prot:

TCPB_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT2: view

Function for CCT2 Gene

Molecular function for CCT2 Gene

UniProtKB/Swiss-Prot Function:
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
GENATLAS Biochemistry:
chaperonin containing TCP1,subunit 2 (beta),cytosolic,TF55/TCP-1 family

Phenotypes From GWAS Catalog for CCT2 Gene

Gene Ontology (GO) - Molecular Function for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 21753002
GO:0044183 protein binding involved in protein folding IDA 25467444
genes like me logo Genes that share ontologies with CCT2: view
genes like me logo Genes that share phenotypes with CCT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT2 Gene

Localization for CCT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 4
lysosome 4
mitochondrion 2
nucleus 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex IDA 23011926
genes like me logo Genes that share ontologies with CCT2: view

Pathways & Interactions for CCT2 Gene

genes like me logo Genes that share pathways with CCT2: view

Pathways by source for CCT2 Gene

1 GeneGo (Thomson Reuters) pathway for CCT2 Gene
  • Cell cycle_Role of APC in cell cycle regulation

SIGNOR curated interactions for CCT2 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS,TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0043312 neutrophil degranulation TAS --
GO:0050821 protein stabilization IMP 25467444
genes like me logo Genes that share ontologies with CCT2: view

Drugs & Compounds for CCT2 Gene

No Compound Related Data Available

Transcripts for CCT2 Gene

mRNA/cDNA for CCT2 Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCT2

Alternative Splicing Database (ASD) splice patterns (SP) for CCT2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: - -

Relevant External Links for CCT2 Gene

GeneLoc Exon Structure for
CCT2

Expression for CCT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCT2 Gene

Protein differential expression in normal tissues from HIPED for CCT2 Gene

This gene is overexpressed in Lymph node (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCT2 Gene



Protein tissue co-expression partners for CCT2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCT2

SOURCE GeneReport for Unigene cluster for CCT2 Gene:

Hs.189772

Evidence on tissue expression from TISSUES for CCT2 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Blood(4.6)
  • Skin(3.9)
  • Lung(3.4)
  • Intestine(3.4)
  • Eye(3.3)
  • Kidney(3.2)
  • Heart(2.8)
  • Bone(2.4)
  • Pancreas(2.4)
  • Stomach(2.4)
  • Muscle(2.4)
  • Lymph node(2.2)
  • Adrenal gland(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with CCT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT2 Gene

Orthologs for CCT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCT2 30 31
  • 99.88 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCT2 31
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCT2 31
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CCT2 30 31
  • 93.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCT2 30 31
  • 92.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cct2 30
  • 90.16 (n)
Mouse
(Mus musculus)
Mammalia Cct2 30 17 31
  • 89.1 (n)
OneToOne
Chicken
(Gallus gallus)
Aves LRRC10 31
  • 93 (a)
OneToOne
CCT2 30
  • 81.81 (n)
Lizard
(Anolis carolinensis)
Reptilia CCT2 31
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cct2 30
  • 77.94 (n)
Str.1354 30
African clawed frog
(Xenopus laevis)
Amphibia cct2-prov 30
Zebrafish
(Danio rerio)
Actinopterygii cct2 30 31
  • 72.21 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8395 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG7033 30 31 32
  • 62.78 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009694 30
  • 62.22 (n)
Worm
(Caenorhabditis elegans)
Secernentea cct-2 30 31
  • 61.92 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11451g 30
  • 63.96 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER415W 30
  • 62.15 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT2 30 31 33
  • 61.89 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G20890 30
  • 64.81 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2222 30
Soybean
(Glycine max)
eudicotyledons Gma.4039 30
Rice
(Oryza sativa)
Liliopsida Os05g0556700 30
  • 66.46 (n)
Os.8383 30
Barley
(Hordeum vulgare)
Liliopsida Hv.6194 30
Wheat
(Triticum aestivum)
Liliopsida Ta.394 30
Corn
(Zea mays)
Liliopsida Zm.6590 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6937 31
  • 75 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct2 30
  • 63.3 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02207 30
  • 62.01 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2654 30
Species where no ortholog for CCT2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT2 Gene

ENSEMBL:
Gene Tree for CCT2 (if available)
TreeFam:
Gene Tree for CCT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCT2: view image

Paralogs for CCT2 Gene

Paralogs for CCT2 Gene

(8) SIMAP similar genes for CCT2 Gene using alignment to 3 proteins:

  • TCPB_HUMAN
  • F5GWF6_HUMAN
  • F8VQ14_HUMAN

Pseudogenes.org Pseudogenes for CCT2 Gene

genes like me logo Genes that share paralogs with CCT2: view

Variants for CCT2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCT2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
835634 Uncertain Significance: not provided 69,587,933(+) T/C MISSENSE_VARIANT
839650 Uncertain Significance: not provided 69,599,890(+) T/C MISSENSE_VARIANT
840493 Uncertain Significance: not provided 69,598,359(+) G/A MISSENSE_VARIANT
841930 Uncertain Significance: not provided 69,589,570(+) C/T MISSENSE_VARIANT
842316 Uncertain Significance: not provided 69,587,938(+) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CCT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCT2 Gene

Variant ID Type Subtype PubMed ID
dgv1523n100 CNV gain 25217958
nsv1113492 CNV deletion 24896259

Variation tolerance for CCT2 Gene

Residual Variation Intolerance Score: 11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCT2 Gene

Human Gene Mutation Database (HGMD)
CCT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT2 Gene

Disorders for CCT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • biedl-bardet syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CCT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CCT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT2 Gene

Publications for CCT2 Gene

  1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won KA … Reed SI (Molecular and cellular biology 1998) 2 3 4
  2. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford MR … Mollapour M (Nature communications 2016) 3 4
  3. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. (PMID: 25467444) Freund A … Artandi SE (Cell 2014) 3 4
  4. BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. (PMID: 20080638) Seo S … Sheffield VC (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41

Products for CCT2 Gene

Sources for CCT2 Gene