This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is ... See more...

Aliases for CCRL2 Gene

Aliases for CCRL2 Gene

  • C-C Motif Chemokine Receptor Like 2 2 3 5
  • CKRX 2 3 4
  • HCR 2 3 4
  • Chemokine (C-C Motif) Receptor-Like 2 2 3
  • Putative MCP-1 Chemokine Receptor 3 4
  • Atypical Chemokine Receptor 5 2 3
  • C-C Chemokine Receptor-Like 2 3 4
  • Chemokine Receptor CCR11 3 4
  • Chemokine Receptor X 3 4
  • CRAM-A 2 3
  • CRAM-B 2 3
  • ACKR5 2 3
  • CRAM 3 4
  • CCRL2 5
  • CCR11 4
  • CCR6 4

External Ids for CCRL2 Gene

Previous GeneCards Identifiers for CCRL2 Gene

  • GC03P045689
  • GC03P046267
  • GC03P046409
  • GC03P9F0095
  • GC03P046448

Summaries for CCRL2 Gene

Entrez Gene Summary for CCRL2 Gene

  • This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCRL2 Gene

CCRL2 (C-C Motif Chemokine Receptor Like 2) is a Protein Coding gene. Diseases associated with CCRL2 include Inflammatory Bowel Disease 18 and Rheumatoid Arthritis. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor binding. An important paralog of this gene is CCR3.

UniProtKB/Swiss-Prot Summary for CCRL2 Gene

  • Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.

Gene Wiki entry for CCRL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCRL2 Gene

Genomics for CCRL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCRL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J046404 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 291.4 -0.6 -568 4.8 MYC IKZF1 NCOR1 ZNF592 NFIC NONO SMAD5 BHLHE40 MBD2 MNT CCRL2 CCR5AS CCR1 CCR2 RTP3 CCR5 LIMD1 LRRC2 TDGF1 PRSS45P
GH03J046367 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 56.2 -36.9 -36898 4.7 BCLAF1 ZNF654 BCL11A REST TRIM22 CTCF RAD21 IRF4 SMC3 TEAD3 CCR5 MK280408 CCRL2 CCR1 CCR5AS LRRC2 TDGF1 CCR2
GH03J046392 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 69.7 -12.6 -12636 4.8 MYC ZNF600 CEBPA ZIC2 REST CEBPB HES1 BHLHE40 MNT MAX piR-48950-118 CCRL2 CCR5 CCR1 CCR2 CCR5AS LRRC2 TDGF1
GH03J046385 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 55.7 -21.0 -20966 6.4 REST PRDM1 NFE2 SKIL JUND SPI1 ETV1 FOXK2 ZEB2 IKZF1 CCRL2 CCR1 CCR5AS CCR2 CCR5 CXCR6 LRRC2 LIMD1 TDGF1 piR-48950-118
GH03J046089 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 50.4 -317.3 -317279 2.1 BCLAF1 SP1 BCL11A CTCF IRF4 EBF1 CBFB SMARCA5 JUND BHLHE40 lnc-CCR3-3 CCRL2 CCR1 CXCR6 FYCO1 CCR5 CCR5AS CCR2 CCR3 LIMD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCRL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCRL2

Top Transcription factor binding sites by QIAGEN in the CCRL2 gene promoter:
  • STAT1
  • STAT5A
  • USF-1
  • USF1

Genomic Locations for CCRL2 Gene

Latest Assembly
chr3:46,407,166-46,412,997
(GRCh38/hg38)
Size:
5,832 bases
Orientation:
Plus strand

Previous Assembly
chr3:46,448,750-46,451,014
(GRCh37/hg19 by Entrez Gene)
Size:
2,265 bases
Orientation:
Plus strand

chr3:46,448,654-46,454,488
(GRCh37/hg19 by Ensembl)
Size:
5,835 bases
Orientation:
Plus strand

Genomic View for CCRL2 Gene

Genes around CCRL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCRL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCRL2 Gene

Proteins for CCRL2 Gene

  • Protein details for CCRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00421-CCRL2_HUMAN
    Recommended name:
    C-C chemokine receptor-like 2
    Protein Accession:
    O00421
    Secondary Accessions:
    • B4DKQ8
    • O75307
    • Q4VBB0
    • Q6IPX0
    • Q7KYQ9
    • Q96KP5
    • Q9UPG0

    Protein attributes for CCRL2 Gene

    Size:
    344 amino acids
    Molecular mass:
    39513 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report. These results are now controversial, and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed:15188357).

    Alternative splice isoforms for CCRL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCRL2 Gene

Post-translational modifications for CCRL2 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCRL2 Gene

Domains & Families for CCRL2 Gene

Gene Families for CCRL2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for CCRL2 Gene

InterPro:
Blocks:
  • Chemokine receptor signature

Suggested Antigen Peptide Sequences for CCRL2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93826, highly similar to Homo sapiens chemokine (C-C motif) receptor-like 2 (CCRL2), mRNA (B2R8C0_HUMAN)
  • Putative MCP-1 chemokine receptor (CCRL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00421

UniProtKB/Swiss-Prot:

CCRL2_HUMAN :
  • Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCRL2: view

Function for CCRL2 Gene

Molecular function for CCRL2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
UniProtKB/Swiss-Prot Induction:
Up-regulated by CCL5 on the pre-B-cell lines NALM-6 and G2.
GENATLAS Biochemistry:
chemokine CC,beta receptor like 3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for CCRL2 Gene

Gene Ontology (GO) - Molecular Function for CCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 9473515
GO:0005515 protein binding IPI --
GO:0016493 C-C chemokine receptor activity IBA 21873635
GO:0019957 C-C chemokine binding IBA 21873635
genes like me logo Genes that share ontologies with CCRL2: view
genes like me logo Genes that share phenotypes with CCRL2: view

Animal Models for CCRL2 Gene

MGI Knock Outs for CCRL2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCRL2

Clone products for research

  • Addgene plasmids for CCRL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCRL2 Gene

Localization for CCRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCRL2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCRL2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IDA 20002784
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCRL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCRL2 Gene

Pathways & Interactions for CCRL2 Gene

genes like me logo Genes that share pathways with CCRL2: view

Pathways by source for CCRL2 Gene

7 Qiagen pathways for CCRL2 Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Molecular Mechanisms of Cancer
  • p38 Signaling

Gene Ontology (GO) - Biological Process for CCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 9473515
GO:0006954 inflammatory response IBA,ISS --
GO:0006955 immune response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with CCRL2: view

No data available for SIGNOR curated interactions for CCRL2 Gene

Drugs & Compounds for CCRL2 Gene

(2) Drugs for CCRL2 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL19 Pharma Agonist, Unknown 0
chemerin C-terminal peptide Pharma Agonist 0
genes like me logo Genes that share compounds with CCRL2: view

Transcripts for CCRL2 Gene

mRNA/cDNA for CCRL2 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCRL2

Clone products for research

  • Addgene plasmids for CCRL2

Alternative Splicing Database (ASD) splice patterns (SP) for CCRL2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -
SP3:

Relevant External Links for CCRL2 Gene

GeneLoc Exon Structure for
CCRL2

Expression for CCRL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCRL2 Gene

This gene is overexpressed in Whole Blood (x8.8), Lung (x4.9), Spleen (x4.1), and Adipose - Visceral (Omentum) (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCRL2

SOURCE GeneReport for Unigene cluster for CCRL2 Gene:

Hs.535713

mRNA Expression by UniProt/SwissProt for CCRL2 Gene:

O00421-CCRL2_HUMAN
Tissue specificity: Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.

Evidence on tissue expression from TISSUES for CCRL2 Gene

  • Blood(4.6)
  • Spleen(4.6)
  • Lung(4.5)
  • Nervous system(4.4)
  • Pancreas(4.4)
  • Lymph node(3)
  • Intestine(2.9)
  • Liver(2.7)
  • Heart(2.6)
  • Bone marrow(2.6)
  • Kidney(2.5)
  • Muscle(2.3)
  • Skin(2.3)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with CCRL2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCRL2 Gene

Orthologs for CCRL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCRL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCRL2 29 30
  • 98.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC515976 29
  • 76.76 (n)
CCRL2 30
  • 64 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC484788 29
  • 76.48 (n)
CCRL2 30
  • 61 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccrl2 29
  • 67.34 (n)
Mouse
(Mus musculus)
Mammalia Ccrl2 29 16 30
  • 67.25 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCRL2 30
  • 45 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCRL2 30
  • 42 (a)
OneToOne
Species where no ortholog for CCRL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCRL2 Gene

ENSEMBL:
Gene Tree for CCRL2 (if available)
TreeFam:
Gene Tree for CCRL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCRL2: view image
Alliance of Genome Resources:
Additional Orthologs for CCRL2

Paralogs for CCRL2 Gene

(15) SIMAP similar genes for CCRL2 Gene using alignment to 3 proteins:

  • CCRL2_HUMAN
  • B2R8C0_HUMAN
  • C9JP23_HUMAN
genes like me logo Genes that share paralogs with CCRL2: view

Variants for CCRL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCRL2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs137877836 Benign: not provided 46,409,113(+) A/C
NM_003965.5(CCRL2):c.1034A>C (p.Ter345Ser)
STOP_LOST
rs11574443 -- p.Tyr4Cys
rs3204849 -- p.Phe167Tyr
rs3204850 -- p.Ile243Val
rs6441977 -- p.Val168Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCRL2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for CCRL2 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.04; 80.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCRL2 Gene

Human Gene Mutation Database (HGMD)
CCRL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCRL2
Leiden Open Variation Database (LOVD)
CCRL2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCRL2 Gene

Disorders for CCRL2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for CCRL2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
inflammatory bowel disease 18
  • ibd18
rheumatoid arthritis
  • ra
arthritis
  • inflammatory disorder of joint
nail disorder, nonsyndromic congenital, 1
  • ndnc1
childhood type dermatomyositis
  • childhood dermatomyositis
- elite association - COSMIC cancer census association via MalaCards
Search CCRL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCRL2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCRL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCRL2 Gene

Publications for CCRL2 Gene

  1. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. (PMID: 20002784) Leick M … Burger M (Immunology 2010) 3 4 22
  2. Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis. (PMID: 15188357) Galligan CL … Yoshimura T (Arthritis and rheumatism 2004) 3 4 22
  3. Cloning and characterization of a novel human chemokine receptor. (PMID: 9473515) Fan P … Li Y (Biochemical and biophysical research communications 1998) 2 3 4
  4. Genome-wide association study implicates PARD3B-based AIDS restriction. (PMID: 21502085) Troyer JL … O'Brien SJ (The Journal of infectious diseases 2011) 3 40
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 40

Products for CCRL2 Gene

Sources for CCRL2 Gene