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The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
CCR9 (C-C Motif Chemokine Receptor 9) is a Protein Coding gene. Diseases associated with CCR9 include Ileitis and Celiac Disease 1. Among its related pathways are Signaling by GPCR and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004950 | chemokine receptor activity | TAS | 10229797 |
GO:0016493 | C-C chemokine receptor activity | IBA | 21873635 |
GO:0019956 | chemokine binding | IBA | 21873635 |
GO:0019957 | C-C chemokine binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 10229797 |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
GO:0009986 | cell surface | IDA | 18308860 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
.34
|
|
2 | Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions | ||
3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
4 | Signaling by GPCR | ||
5 | CCR5 Pathway in Macrophages |
Chemokine Signaling
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002305 | CD8-positive, gamma-delta intraepithelial T cell differentiation | IEA | -- |
GO:0006935 | chemotaxis | IBA | 21873635 |
GO:0006955 | immune response | TAS,IBA | 21873635 |
GO:0006968 | cellular defense response | TAS | 10544196 |
GO:0007165 | signal transduction | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[<sup>125</sup>I]CCL25 |
|
Agonist, Full agonist |
|
|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CCR9 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CCR9 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CCR9 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ccr9 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ccr9 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CCR9 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CCR9 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CCR9 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100489281 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100334253 30 |
|
||
ccr9a 31 |
|
OneToMany | |||
ccr9b 31 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
780381 | Benign: not provided | 45,901,194(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs1553617019 | Uncertain Significance: Hirschsprung disease 1 | 45,894,936(+) | G/T | INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
rs12721497 | - | p.Met284Val | |||
rs45530037 | - | p.Ile92Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2462115 | CNV | insertion | 19546169 |
nsv834678 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ileitis |
|
|
celiac disease 1 |
|
|
food allergy |
|
|
precursor t-cell acute lymphoblastic leukemia |
|
|
hirschsprung disease 1 |
|
|