This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine... See more...

Aliases for CCR8 Gene

Aliases for CCR8 Gene

  • C-C Motif Chemokine Receptor 8 2 3 5
  • TER1 2 3 4
  • Chemokine (C-C Motif) Receptor 8 2 3
  • C-C Chemokine Receptor Type 8 3 4
  • CC Chemokine Receptor CHEMR1 3 4
  • Chemokine Receptor-Like 1 3 4
  • CC-CKR-8 3 4
  • CMKBRL2 3 4
  • GPR-CY6 2 4
  • CDw198 2 3
  • CMKBR8 3 4
  • GPRCY6 3 4
  • CKR-L1 2 4
  • CCR-8 3 4
  • CKRL1 3 4
  • CY6 2 3
  • Chemokine (C-C) Receptor-Like 2 3
  • CC-Chemokine Receptor Chemr1 3
  • Chemokine (C-C) Receptor 8 3
  • CC Chemokine Receptor 8 3
  • CDw198 Antigen 4
  • C-C CKR-8 4
  • CCR8 5

External Ids for CCR8 Gene

Previous HGNC Symbols for CCR8 Gene

  • CMKBRL2
  • CMKBR8

Previous GeneCards Identifiers for CCR8 Gene

  • GC03P038710
  • GC03P038604
  • GC03P039184
  • GC03P039331
  • GC03P039346
  • GC03P039371

Summaries for CCR8 Gene

Entrez Gene Summary for CCR8 Gene

  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR8 Gene

CCR8 (C-C Motif Chemokine Receptor 8) is a Protein Coding gene. Diseases associated with CCR8 include Kaposi Sarcoma and Molluscum Contagiosum. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR4.

UniProtKB/Swiss-Prot Summary for CCR8 Gene

  • Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.

Tocris Summary for CCR8 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Gene Wiki entry for CCR8 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCR8 Gene

Genomics for CCR8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCR8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J039329 Promoter/Enhancer 0.6 EPDnew dbSUPER 250.7 0.0 0 0.1 SMARCA5 CCR8 ADAD1P1 CX3CR1 ENSG00000287780
GH03J039331 Enhancer 0.4 FANTOM5 252.6 +1.5 1512 0.2 IRF9 ATF4 ZNF512 CCR8 MOBP HNRNPA1P21 SLC25A38 ENSG00000287780
GH03J039361 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 15.5 +32.3 32298 1.6 SP1 BCL11A ZNF316 CBFB MAX BATF STAT5A EGR1 MTA3 ATF2 RPSA HNRNPA1P21 CCR8 SNORA6 CX3CR1 XIRP1 SLC25A38 WDR48 lnc-SLC25A38-3 piR-46256-023
GH03J039358 Enhancer 0.9 FANTOM5 Ensembl ENCODE dbSUPER 14.2 +29.2 29192 2.2 ZNF384 EEF1A1P24 lnc-SLC25A38-3 RPSA HNRNPA1P21 CX3CR1 CCR8 SNORA6 SLC25A38 piR-46256-023 LOC105377644
GH03J039279 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 10.2 -50.2 -50208 4.6 CTCF SPI1 CX3CR1 XIRP1 GORASP1 TTC21A CCR8 HNRNPA1P21 RPSA RNU6-1227P LOC102724104
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCR8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCR8

Top Transcription factor binding sites by QIAGEN in the CCR8 gene promoter:
  • AML1a
  • AREB6
  • ATF6
  • FOXC1
  • GATA-1
  • IRF-2
  • NF-kappaB1
  • Pax-2
  • Pax-2a
  • Pax-2b

Genomic Locations for CCR8 Gene

Latest Assembly
chr3:39,329,709-39,333,680
(GRCh38/hg38)
Size:
3,972 bases
Orientation:
Plus strand

Previous Assembly
chr3:39,371,200-39,375,171
(GRCh37/hg19 by Entrez Gene)
Size:
3,972 bases
Orientation:
Plus strand

chr3:39,371,197-39,375,171
(GRCh37/hg19 by Ensembl)
Size:
3,975 bases
Orientation:
Plus strand

Genomic View for CCR8 Gene

Genes around CCR8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR8 Gene

Proteins for CCR8 Gene

  • Protein details for CCR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51685-CCR8_HUMAN
    Recommended name:
    C-C chemokine receptor type 8
    Protein Accession:
    P51685
    Secondary Accessions:
    • B2RC64
    • Q3KNQ8
    • Q3KNR3
    • Q9BYX5

    Protein attributes for CCR8 Gene

    Size:
    355 amino acids
    Molecular mass:
    40844 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCR8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR8 Gene

Post-translational modifications for CCR8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCR8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCR8 Gene

Domains & Families for CCR8 Gene

Gene Families for CCR8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CCR8 Gene

InterPro:
Blocks:
  • Chemokine receptor signature
  • C-C chemokine receptor type 8 signature

Suggested Antigen Peptide Sequences for CCR8 Gene

GenScript: Design optimal peptide antigens:
  • TER1 (CCR8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51685

UniProtKB/Swiss-Prot:

CCR8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR8: view

Function for CCR8 Gene

Molecular function for CCR8 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
GENATLAS Biochemistry:
chemokine CC,beta receptor 8,expressed in thymus,spleen and NK cells,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for CCR8 Gene

Gene Ontology (GO) - Molecular Function for CCR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 9417093
GO:0015026 coreceptor activity TAS 9417093
GO:0016493 C-C chemokine receptor activity IBA 21873635
GO:0019957 C-C chemokine binding IBA 21873635
genes like me logo Genes that share ontologies with CCR8: view
genes like me logo Genes that share phenotypes with CCR8: view

Animal Models for CCR8 Gene

MGI Knock Outs for CCR8:

Animal Models for research

  • Taconic Biosciences Mouse Models for CCR8

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCR8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCR8 Gene

Localization for CCR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR8 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR8 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8816377
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCR8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCR8 Gene

Pathways & Interactions for CCR8 Gene

genes like me logo Genes that share pathways with CCR8: view

Pathways by source for CCR8 Gene

SIGNOR curated interactions for CCR8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CCR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10910894
GO:0006955 immune response TAS,IBA 21873635
GO:0007155 cell adhesion TAS 10910894
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CCR8: view

Drugs & Compounds for CCR8 Gene

(15) Drugs for CCR8 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
DAPTA Investigational Pharma Chemokine receptor 5 (CCR5) antagonist 0
ZK 756326 Pharma Agonist, Full agonist Selective, non-peptide CCR8 agonist 0
[<sup>125</sup>I]CCL1 (human) Pharma Agonist, Full agonist 0
CCL1 Pharma Agonist, Full agonist 0
vMCC-I Pharma Antagonist 0

(3) Additional Compounds for CCR8 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
vMIP-II
Antagonist

(5) Tocris Compounds for CCR8 Gene

Compound Action Cas Number
DAPTA Chemokine receptor 5 (CCR5) antagonist 106362-34-9
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3
ZK 756326 Selective, non-peptide CCR8 agonist 874911-96-3

(1) ApexBio Compounds for CCR8 Gene

Compound Action Cas Number
ZK 756326 874911-96-3
genes like me logo Genes that share compounds with CCR8: view

Drug products for research

Transcripts for CCR8 Gene

mRNA/cDNA for CCR8 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCR8

Alternative Splicing Database (ASD) splice patterns (SP) for CCR8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for CCR8 Gene

GeneLoc Exon Structure for
CCR8

Expression for CCR8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCR8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCR8 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCR8 Gene



Protein tissue co-expression partners for CCR8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCR8

SOURCE GeneReport for Unigene cluster for CCR8 Gene:

Hs.113222

Evidence on tissue expression from TISSUES for CCR8 Gene

  • Blood(2.3)
  • Lymph node(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CCR8: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR8 Gene

Orthologs for CCR8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCR8 29 30
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCR8 29 30
  • 85.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCR8 29 30
  • 82.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccr8 29
  • 76.11 (n)
Mouse
(Mus musculus)
Mammalia Ccr8 29 16 30
  • 76.02 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 65 (a)
OneToMany
-- 30
  • 62 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CCR8L 29 30
  • 60.34 (n)
OneToMany
CCR8 30
  • 46 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ccr8.1 30 30
  • 34 (a)
ManyToMany
BX537113.1 30 30
  • 33 (a)
ManyToMany
BX511173.1 30
  • 32 (a)
ManyToMany
CABZ01093075.1 30
  • 32 (a)
ManyToMany
Species where no ortholog for CCR8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCR8 Gene

ENSEMBL:
Gene Tree for CCR8 (if available)
TreeFam:
Gene Tree for CCR8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCR8: view image
Alliance of Genome Resources:
Additional Orthologs for CCR8

Paralogs for CCR8 Gene

Variants for CCR8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCR8 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs2853699 -- p.Ala27Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCR8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCR8 Gene

Variant ID Type Subtype PubMed ID
esv29441 CNV loss 19812545
esv3595925 CNV loss 21293372
nsv460509 CNV loss 19166990
nsv518801 CNV loss 19592680
nsv590107 CNV loss 21841781
nsv963309 CNV duplication 23825009

Variation tolerance for CCR8 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCR8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR8
Leiden Open Variation Database (LOVD)
CCR8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR8 Gene

Disorders for CCR8 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CCR8 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
molluscum contagiosum
igg4-related sclerosing cholangitis
ileitis
  • crohn's ileitis
secondary progressive multiple sclerosis
  • secondary-progressive ms
- elite association - COSMIC cancer census association via MalaCards
Search CCR8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCR8

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCR8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR8 Gene

Publications for CCR8 Gene

  1. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. (PMID: 8886020) Zaballos A … Márquez G (Biochemical and biophysical research communications 1996) 2 3 4 22
  2. Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. (PMID: 8816377) Napolitano M … Santoni A (Journal of immunology (Baltimore, Md. : 1950) 1996) 2 3 4 22
  3. Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. (PMID: 12551893) DeVries ME … Kelvin DJ (The Journal of biological chemistry 2003) 3 4 22
  4. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PMID: 10540332) Garlisi CG … Umland SP (European journal of immunology 1999) 3 4 22
  5. Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. (PMID: 9469461) Goya I … Márquez G (Journal of immunology (Baltimore, Md. : 1950) 1998) 3 4 22

Products for CCR8 Gene

Sources for CCR8 Gene