The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells... See more...

Aliases for CCR3 Gene

Aliases for CCR3 Gene

  • C-C Motif Chemokine Receptor 3 2 3 5
  • Chemokine (C-C Motif) Receptor 3 2 3
  • C-C Chemokine Receptor Type 3 3 4
  • Eosinophil Eotaxin Receptor 3 4
  • C-C CKR-3 3 4
  • CC-CKR-3 3 4
  • CMKBR3 3 4
  • CCR-3 3 4
  • CKR3 3 4
  • Eosinophil CC Chemokine Receptor 3 3
  • CC Chemokine Receptor 3 3
  • B-Chemokine Receptor 3
  • CD193 Antigen 4
  • CD193 3

External Ids for CCR3 Gene

Previous HGNC Symbols for CCR3 Gene

  • CMKBR3

Previous GeneCards Identifiers for CCR3 Gene

  • GC03P045547
  • GC03P046024
  • GC03P046244

Summaries for CCR3 Gene

Entrez Gene Summary for CCR3 Gene

  • The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

GeneCards Summary for CCR3 Gene

CCR3 (C-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CCR3 include Folliculotropic Mycosis Fungoides and Aids Dementia Complex. Among its related pathways are CCR5 Pathway in Macrophages and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR1.

UniProtKB/Swiss-Prot Summary for CCR3 Gene

  • Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Tocris Summary for CCR3 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Gene Wiki entry for CCR3 Gene

Additional gene information for CCR3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCR3 Gene

Genomics for CCR3 Gene

GeneHancer (GH) Regulatory Elements for CCR3 Gene

Promoters and enhancers for CCR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J046161 Promoter/Enhancer 1 Ensembl ENCODE 750.6 -0.2 -218 2.8 GATA3 POLR2A FOSL2 CEBPB ZNF316 NFE2 ZFX MAFG DPF2 NFIB CCR3 CCR1 CCRL2 piR-39341-236 LOC105377067
GH03J046242 Promoter 0.8 EPDnew Ensembl 755.8 +79.2 79197 1.2 PKNOX1 CCR3 NONHSAG034948.2 CCR1 CCR2 CCRL2 ENSG00000223552 piR-32559-281
GH03J046233 Enhancer 0.9 FANTOM5 Ensembl 42.4 +71.1 71097 5 MYC L3MBTL2 MAX ZKSCAN8 ZNF639 IKZF1 MNT ZNF766 NR2C2 GABPA CCR3 CCR1 CCR2 RN7SL145P SETD2 CCRL2 ENSG00000223552 SACM1L LIMD1 XCR1
GH03J046106 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 5.5 -52.0 -51959 9.6 SP1 SREBF1 POLR2A CREB1 MIXL1 MYC ETV6 HLF MAX MAFK CCR1 CCRL2 CXCR6 FYCO1 CCR2 CCR5 CCDC12 LIMD1 XCR1 CCR3
GH03J046353 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.6 +191.4 191372 3.3 TEAD4 MEF2D CEBPG TAL1 CBFA2T3 CCR2 CCR1 CCRL2 CCR3 CCR5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCR3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCR3 gene promoter:
  • AML1a
  • AREB6
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • GCNF
  • Ik-1
  • STAT5B

Genomic Locations for CCR3 Gene

Genomic Locations for CCR3 Gene
chr3:46,163,604-46,266,706
(GRCh38/hg38)
Size:
103,103 bases
Orientation:
Plus strand
chr3:46,205,096-46,308,197
(GRCh37/hg19)
Size:
103,102 bases
Orientation:
Plus strand

Genomic View for CCR3 Gene

Genes around CCR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR3 Gene

Proteins for CCR3 Gene

  • Protein details for CCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51677-CCR3_HUMAN
    Recommended name:
    C-C chemokine receptor type 3
    Protein Accession:
    P51677
    Secondary Accessions:
    • B3KVQ1
    • F5GWL6
    • Q15748
    • Q2YDB9
    • Q86WD2
    • Q8TDP6
    • Q9ULY8

    Protein attributes for CCR3 Gene

    Size:
    355 amino acids
    Molecular mass:
    41044 Da
    Quaternary structure:
    • (Microbial infection) Interacts with HIV-1 protein Tat.
    Miscellaneous:
    • Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).

    Alternative splice isoforms for CCR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR3 Gene

Post-translational modifications for CCR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for CCR3
  • Santa Cruz Biotechnology (SCBT) Antibodies for CCR3

No data available for DME Specific Peptides for CCR3 Gene

Domains & Families for CCR3 Gene

Gene Families for CCR3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CCR3 Gene

GenScript: Design optimal peptide antigens:
  • Eosinophil eotaxin receptor (CCR3_HUMAN)
  • CC chemokine receptor 3 (Q8TDP6_HUMAN)
  • CC chemokine receptor 3 (Q8TDP7_HUMAN)
  • CC chemokine receptor 3 (Q8TDP8_HUMAN)
  • CC chemokine receptor 3 (Q96T96_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51677

UniProtKB/Swiss-Prot:

CCR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR3: view

Function for CCR3 Gene

Molecular function for CCR3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
GENATLAS Biochemistry:
chemokine CC,beta,receptor 3,expressed in eosinophil,basophil and T helper 2 cell,G protein coupled receptor superfamily,expressed by the thymocytes for the mobilization of lymphocytes within and from the thymus

Phenotypes From GWAS Catalog for CCR3 Gene

Gene Ontology (GO) - Molecular Function for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 10415069
GO:0005515 protein binding IPI 23597562
GO:0016493 C-C chemokine receptor activity IBA 21873635
GO:0019956 chemokine binding IBA 21873635
genes like me logo Genes that share ontologies with CCR3: view
genes like me logo Genes that share phenotypes with CCR3: view

Animal Models for CCR3 Gene

MGI Knock Outs for CCR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCR3

CRISPR Products

Clone Products

  • Addgene plasmids for CCR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCR3 Gene

Localization for CCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9302298
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCR3 Gene

Pathways & Interactions for CCR3 Gene

genes like me logo Genes that share pathways with CCR3: view

SIGNOR curated interactions for CCR3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0006935 chemotaxis IBA 21873635
GO:0006954 inflammatory response IBA,TAS 21873635
GO:0006955 immune response IBA 21873635
GO:0006968 cellular defense response TAS 10713092
genes like me logo Genes that share ontologies with CCR3: view

Drugs & Compounds for CCR3 Gene

(60) Drugs for CCR3 Gene - From: ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
Orange Approved Pharma 349
[<sup>125</sup>I]CCL11 (human) Pharma Antagonist 0
[<sup>125</sup>I]CCL5 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]CCL7 (human) Pharma Full agonist, Agonist 0

(13) Additional Compounds for CCR3 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Met-Ckbeta7
Antagonist

(5) Tocris Compounds for CCR3 Gene

Compound Action Cas Number
DAPTA Chemokine receptor 5 (CCR5) antagonist 106362-34-9
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3
ZK 756326 Selective, non-peptide CCR8 agonist 874911-96-3

(3) ApexBio Compounds for CCR3 Gene

Compound Action Cas Number
SB 297006 58816-69-6
SB 328437 247580-43-4
UCB 35625
genes like me logo Genes that share compounds with CCR3: view

Transcripts for CCR3 Gene

mRNA/cDNA for CCR3 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for CCR3

Alternative Splicing Database (ASD) splice patterns (SP) for CCR3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for CCR3 Gene

GeneLoc Exon Structure for
CCR3
ECgene alternative splicing isoforms for
CCR3

Expression for CCR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR3 Gene

This gene is overexpressed in Whole Blood (x40.3).

Protein differential expression in normal tissues from HIPED for CCR3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCR3 Gene



Protein tissue co-expression partners for CCR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCR3 Gene:

CCR3

SOURCE GeneReport for Unigene cluster for CCR3 Gene:

Hs.506190

mRNA Expression by UniProt/SwissProt for CCR3 Gene:

P51677-CCR3_HUMAN
Tissue specificity: In eosinophils as well as trace amounts in neutrophils and monocytes.

Evidence on tissue expression from TISSUES for CCR3 Gene

  • Blood(4.6)
  • Skin(2.4)
  • Lung(2.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CCR3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR3 Gene

Orthologs for CCR3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR3 33 32
  • 99.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCR3 33 32
  • 79.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCR3 33 32
  • 77.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr3 17 33 32
  • 77.01 (n)
rat
(Rattus norvegicus)
Mammalia Ccr3 32
  • 76.53 (n)
oppossum
(Monodelphis domestica)
Mammalia CCR3 33
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCR3 33
  • 59 (a)
OneToOne
Species where no ortholog for CCR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR3 Gene

ENSEMBL:
Gene Tree for CCR3 (if available)
TreeFam:
Gene Tree for CCR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCR3: view image

Paralogs for CCR3 Gene

(54) SIMAP similar genes for CCR3 Gene using alignment to 7 proteins:

  • CCR3_HUMAN
  • Q8TDP4_HUMAN
  • Q8TDP5_HUMAN
  • Q8TDP7_HUMAN
  • Q8TDP8_HUMAN
  • Q96T96_HUMAN
  • Q96T97_HUMAN
genes like me logo Genes that share paralogs with CCR3: view

Variants for CCR3 Gene

Sequence variations from dbSNP and Humsavar for CCR3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000071842 -- 46,229,633(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000079016 -- 46,247,544(+) A/G intron_variant
rs1000182626 -- 46,224,332(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000184298 -- 46,244,136(+) A/G intron_variant
rs1000284988 -- 46,231,127(+) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCR3 Gene

Variant ID Type Subtype PubMed ID
nsv1109510 CNV deletion 24896259

Variation tolerance for CCR3 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCR3 Gene

Human Gene Mutation Database (HGMD)
CCR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR3 Gene

Disorders for CCR3 Gene

MalaCards: The human disease database

(22) MalaCards diseases for CCR3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
folliculotropic mycosis fungoides
  • mycosis fungoides-associated follicular mucinosis
aids dementia complex
  • adc
orofacial granulomatosis
  • granulomatosis, orofacial
allergic hypersensitivity disease
  • allergic disease
kimura disease
  • kimura's disease
- elite association - COSMIC cancer census association via MalaCards
Search CCR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR3 Gene

Publications for CCR3 Gene

  1. New variations of human CC-chemokine receptors CCR3 and CCR4. (PMID: 11196669) Kato H … Tokunaga K (Genes and immunity 1999) 3 4 23 43 56
  2. The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan. (PMID: 17845580) Wang TN … Ko YC (Allergy 2007) 3 23 43 56
  3. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. (PMID: 17135764) Nakamura H … Eboshida A (International archives of allergy and immunology 2007) 3 23 43 56
  4. Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients. (PMID: 17983872) Lee JH … Shin HD (The Journal of allergy and clinical immunology 2007) 3 23 43 56
  5. The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. (PMID: 17146638) Yang F … Deng HW (Human genetics 2007) 3 23 43 56

Products for CCR3 Gene

Sources for CCR3 Gene