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The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]
CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Human Immunodeficiency Virus Type 1 and Idiopathic Anterior Uveitis. Among its related pathways are Signaling by GPCR and Defensins. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR5.
Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004950 | chemokine receptor activity | TAS | 10623817 |
GO:0005515 | protein binding | IPI | 23938203 |
GO:0016493 | C-C chemokine receptor activity | IBA | 21873635 |
GO:0019955 | cytokine binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IDA | 15995708 |
GO:0005829 | cytosol | ISS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 8146186 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
.34
|
|
2 | Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions | ||
3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
4 | Defensins |
.81
.81
|
|
5 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001974 | blood vessel remodeling | ISS | -- |
GO:0002407 | dendritic cell chemotaxis | TAS | 16621978 |
GO:0002548 | monocyte chemotaxis | IEA | -- |
GO:0002724 | regulation of T cell cytokine production | IEA,ISS | -- |
GO:0002827 | positive regulation of T-helper 1 type immune response | IEA,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
INCB3284 | Investigational | Pharma | Target, antagonist | 0 | ||
CCX915 | Investigational | Pharma | Target | 0 | ||
Plozalizumab | Investigational | Pharma | Target | 0 | ||
MK-0812 | Investigational | Pharma | antagonist of chemokine receptor CCR-2 | 0 | ||
RS 504393 | Pharma | Antagonist, antagonist, inhibitor | CCR2 chemokine receptor antagonist, Highly selective CCR2 chemokine receptor antagonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[<sup>125</sup>I]CCL2 |
|
Agonist, Full agonist |
|
|
||
vMIP-II |
|
Antagonist |
|
Compound | Action | Cas Number |
---|---|---|
DAPTA | Chemokine receptor 5 (CCR5) antagonist | 106362-34-9 |
J 113863 | Potent CCR1 chemokine receptor antagonist | 353791-85-2 |
RS 102895 hydrochloride | CCR2b chemokine receptor antagonist | 1173022-16-6 |
RS 504393 | Highly selective CCR2 chemokine receptor antagonist | 300816-15-3 |
ZK 756326 | Selective, non-peptide CCR8 agonist | 874911-96-3 |
Compound | Action | Cas Number |
---|---|---|
BMS CCR2 22 | 445479-97-0 | |
INCB 3284 dimesylate | HCCR2 antagonist | 887401-93-6 |
INCB3344 | CCR2 chemokine receptor antagonist | 1262238-11-8 |
INCB8761(PF-4136309) | 1341224-83-6 | |
MK-0812 | antagonist of chemokine receptor CCR-2 | 624733-88-6 |
RS 102895 hydrochloride | 1173022-16-6 | |
RS 504393 | CCR2 chemokine receptor antagonist | 300816-15-3 |
Teijin compound 1 | 1313730-14-1 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CCR2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CCR2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ccr2 30 17 31 |
|
OneToMany | |
Ccr5 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | CCR2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | CCR5 30 31 |
|
ManyToMany | |
CCR2 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100329767 30 |
|
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714233 | Benign: not provided | 46,357,683(+) | G/T | SYNONYMOUS_VARIANT | |
733880 | Likely Benign: not provided | 46,357,905(+) | C/T | SYNONYMOUS_VARIANT | |
759751 | Likely Benign: not provided | 46,357,716(+) | C/T | SYNONYMOUS_VARIANT | |
rs1799864 | Protective: Human immunodeficiency virus type 1, susceptibility to. - | 46,357,717(+) | G/Ap.Val64Ile | MISSENSE_VARIANT | |
rs368150580 | Uncertain Significance: not provided | 46,359,789(+) | G/A | MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
human immunodeficiency virus type 1 |
|
|
idiopathic anterior uveitis |
|
|
secondary progressive multiple sclerosis |
|
|
cytomegalovirus retinitis |
|
|
acquired immunodeficiency syndrome |
|
|