Aliases for CCR2 Gene
Aliases for CCR2 Gene
External Ids for CCR2 Gene
- HGNC: 1603
- Entrez Gene: 729230
- Ensembl: ENSG00000121807
- OMIM: 601267
- UniProtKB: P41597
Previous HGNC Symbols for CCR2 Gene
- CMKBR2
Previous GeneCards Identifiers for CCR2 Gene
- GC03P045636
- GC03P046214
- GC03P9F0042
- GC03P9K0042
Summaries for CCR2 Gene
-
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]
GeneCards Summary for CCR2 Gene
CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Idiopathic Anterior Uveitis and Human Immunodeficiency Virus Type 1. Among its related pathways are Akt Signaling and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR5.
UniProtKB/Swiss-Prot for CCR2 Gene
-
Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable).
-
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.
-
Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.
Additional gene information for CCR2 Gene
- Monarch Initiative
- Search for CCR2 at DataMed
- Search for CCR2 at HumanCyc
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR2 Gene
Genomics for CCR2 Gene
GeneHancer (GH) Regulatory Elements for CCR2 Gene
Promoters and enhancers for CCR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCR2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CCR2 gene promoter:
-
- GATA-1
- AP-1
- c-Jun
- ATF-2
- ISGF-3
- GATA-3
- SREBP-1a
- SREBP-1b
- SREBP-1c
Regulatory Element Products
Genomic Locations for CCR2 Gene
Genomic Locations for CCR2 Gene
- chr3:46,353,734-46,360,940
- (GRCh38/hg38)
- Size:
- 7,207 bases
- Orientation:
- Plus strand
- chr3:46,395,225-46,402,419
- (GRCh37/hg19)
- Size:
- 7,195 bases
- Orientation:
- Plus strand
Genomic View for CCR2 Gene
Genes around CCR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.31 by Entrez Gene
- 3p21.31 by HGNC
- 3p21.31 by Ensembl
CCR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCR2 Gene
Proteins for CCR2 Gene
-
Protein details for CCR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P41597-CCR2_HUMAN
- Recommended name:
- C-C chemokine receptor type 2
- Protein Accession:
- P41597
- A0AVQ3
- B2RMT0
- O95950
- Q4VBL2
Protein attributes for CCR2 Gene
- Size:
- 374 amino acids
- Molecular mass:
- 41915 Da
- Quaternary structure:
-
- Interacts with ARRB1 (PubMed:9501202). Interacts (via extracellular N-terminal region) with beta-defensin DEFB106A/DEFB106B; this interaction may preferentially require specific tyrosine sulfation on CCR2 (PubMed:23938203). Interacts with NUP85; the interaction is required for CCR2 clusters formation on the cell membrane and CCR2 signaling (PubMed:15995708, PubMed:25283965).
- (Microbial infection) Binds to HIV-1 Tat.
Three dimensional structures from OCA and Proteopedia for CCR2 Gene
Protein Expression for CCR2 Gene
Post-translational modifications for CCR2 Gene
- N-glycosylated.
- Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.
- Glycosylation at Asn14
- Modification sites at PhosphoSitePlus
Other Protein References for CCR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CCR2 (CCR2)
- Novus Biologicals Antibodies for CCR2
- Invitrogen Antibodies for CCR2 (AFLGC-CCR2)
- antibodies-online: Search results for 303 available CCR2 Antibodies ranked by validation data
- Compare Top CCR2 Antibodies
-
Recommended
- 121 WB Antibodies (anti-human)
- 47 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 14 IF Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-mouse)
- 23 WB Antibodies (anti-mouse)
- 16 FACS Antibodies (anti-mouse)
- 12 IF Antibodies (anti-mouse)
- 6 IHC (p) Antibodies (anti-mouse)
- 42 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 13 FACS Antibodies (anti-rat)
- 7 IHC (p) Antibodies (anti-rat)
- GeneTex CCR2 Antibody for CCR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCR2
- Sino Biological Antibodies for CCR2
Protein Products
-
OriGene Purified Proteins for CCR2
- Search Origene for MassSpec and Protein Over-expression Lysates for CCR2
- Origene Custom Protein Services for CCR2
- Search GeneTex for Proteins for CCR2
No data available for DME Specific Peptides for CCR2 Gene
Domains & Families for CCR2 Gene
Gene Families for CCR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for CCR2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P41597- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for CCR2 Gene
Molecular function for CCR2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by CREB3 (PubMed:18587271). In NK cells, induced by IL2 (PubMed:9058802).
- GENATLAS Biochemistry:
- chemokine CC,beta,receptor 2,with high affinity binding for monocyte chemoattractant protein 1 (MCP1),dimerizing in response to MCP1,G protein coupled receptor superfamily,involved in HIV-1 infection and AIDS symptom onset,with a dominant protective effect of the CCR2-64I mutation
Phenotypes From GWAS Catalog for CCR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | obsolete signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0004950 | chemokine receptor activity | TAS | 10623817 |
| GO:0005515 | protein binding | IPI | 23938203 |
| GO:0016493 | C-C chemokine receptor activity | IEA | -- |
Phenotypes for CCR2 Gene
- MGI mutant phenotypes for CCR2:
-
inferred from 10 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- pigmentation phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- mortality/aging
- cellular phenotype
- liver/biliary system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for CCR2:
Animal Models for CCR2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CCR2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCR2
-
CRISPR Products
-
OriGene CRISPR knockouts for CCR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCR2
- genomics-online: gRNA clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
- Applied Biological Materials CRISPR for CCR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCR2
- GenScript: Design CRISPR guide RNA sequences for CCR2
miRNA for CCR2 Gene
- miRTarBase miRNAs that target CCR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCR2
- Browse OriGene Inhibitory RNA Products For CCR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCR2
- genomics-online: shRNA clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
Clone Products
-
OriGene ORF clones in human for CCR2
- RC221234
- RC221234L1
- RC221234L2
- RC221234L3
- RC221234L4
- RC221283
- RC221283L1
- RC221283L2
- RC221283L3
- RC221283L4
- RC225538
- RC225538L1
- RC225538L2
- RC225538L3
- RC225538L4
- RC225572
- RC225572L1
- RC225572L2
- RC225572L3
- RC225572L4
- RC521234
- RC521283
- RG221234
- RG221283
- RG225538
- RG225572
- RC221234L1V
- RC221234L2V
- RC221234L3V
- RC221234L4V
- RC221283L1V
- RC221283L2V
- RC221283L3V
- RC221283L4V
- RC225538L1V
- RC225538L2V
- RC225538L3V
- RC225538L4V
- RC225572L1V
- RC225572L2V
- RC225572L3V
- RC225572L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CCR2
- Addgene plasmids for CCR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCR2
- Applied Biological Materials Clones for CCR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CCR2
Cell Line Products
-
Horizon Cell Lines for CCR2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCR2 Gene
Localization for CCR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCR2 Gene
- Cell membrane; Multi-pass membrane protein. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. {ECO:0000269 PubMed:15995708}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 15995708 |
| GO:0005829 | cytosol | ISS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8146186 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCR2 Gene
Pathways & Interactions for CCR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors |
.34
|
|
| 2 | Akt Signaling |
.60
.60
|
|
| 3 | Defensins |
.82
.82
|
|
| 4 | Signaling by GPCR | ||
| 5 | CCR5 Pathway in Macrophages | ||
Pathways by source for CCR2 Gene
2 Sino Biological pathways for CCR2 Gene
4 BioSystems pathways for CCR2 Gene
16 Reactome pathways for CCR2 Gene
2 KEGG pathways for CCR2 Gene
3 R&D Systems pathways for CCR2 Gene
9 Qiagen pathways for CCR2 Gene
1 Cell Signaling Technology pathway for CCR2 Gene
Interacting Proteins for CCR2 Gene
Selected Interacting proteins:
ENSP00000292301
P41597-CCR2_HUMAN
for CCR2 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for CCR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001974 | blood vessel remodeling | ISS | -- |
| GO:0002407 | dendritic cell chemotaxis | TAS | 16621978 |
| GO:0002548 | monocyte chemotaxis | IEA | -- |
| GO:0002827 | positive regulation of T-helper 1 type immune response | IEA,ISS | -- |
| GO:0002829 | negative regulation of type 2 immune response | IEA,ISS | -- |
No data available for SIGNOR curated interactions for CCR2 Gene
Drugs & Compounds for CCR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 | |||
| INCB3284 | Investigational | Pharma | antagonist, Target | 0 | ||
| CCX915 | Investigational | Pharma | Target | 0 | ||
| Plozalizumab | Investigational | Pharma | Target | 0 | ||
| MK-0812 | Investigational | Pharma | antagonist of chemokine receptor CCR-2 | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [<sup>125</sup>I]CCL2 |
|
Full agonist, Agonist |
|
|
||
| vMIP-II |
|
Antagonist |
|
(5) Tocris Compounds for CCR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| DAPTA | Chemokine receptor 5 (CCR5) antagonist | 106362-34-9 |
| J 113863 | Potent CCR1 chemokine receptor antagonist | 353791-85-2 |
| RS 102895 hydrochloride | CCR2b chemokine receptor antagonist | 1173022-16-6 |
| RS 504393 | Highly selective CCR2 chemokine receptor antagonist | 300816-15-3 |
| ZK 756326 | Selective, non-peptide CCR8 agonist | 874911-96-3 |
Drug Products
Transcripts for CCR2 Gene
mRNA/cDNA for CCR2 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000445132 2386 bps (uc003cpm.5)
- ENST00000465202 886 bps (uc062izo.1)
- ENST00000421659 563 bps (uc062izp.1)
- ENST00000400888 2232 bps (uc062izq.1)
- ENST00000292301 2671 bps (uc003cpn.5)
Unigene Clusters for CCR2 Gene
- Chemokine (C-C motif) receptor 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CCR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCR2
- genomics-online: gRNA clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
- Applied Biological Materials CRISPR for CCR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCR2
- GenScript: Design CRISPR guide RNA sequences for CCR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCR2
- Browse OriGene Inhibitory RNA Products For CCR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCR2
- genomics-online: shRNA clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
Clone Products
-
OriGene ORF clones in human for CCR2
- RC221234
- RC221234L1
- RC221234L2
- RC221234L3
- RC221234L4
- RC221283
- RC221283L1
- RC221283L2
- RC221283L3
- RC221283L4
- RC225538
- RC225538L1
- RC225538L2
- RC225538L3
- RC225538L4
- RC225572
- RC225572L1
- RC225572L2
- RC225572L3
- RC225572L4
- RC521234
- RC521283
- RG221234
- RG221283
- RG225538
- RG225572
- RC221234L1V
- RC221234L2V
- RC221234L3V
- RC221234L4V
- RC221283L1V
- RC221283L2V
- RC221283L3V
- RC221283L4V
- RC225538L1V
- RC225538L2V
- RC225538L3V
- RC225538L4V
- RC225572L1V
- RC225572L2V
- RC225572L3V
- RC225572L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CCR2
- Addgene plasmids for CCR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCR2
- Applied Biological Materials Clones for CCR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CCR2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - |
Expression for CCR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- Hematopoietic Bone Marrow
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for CCR2 Gene
This gene is overexpressed in Whole Blood (x25.7) and Spleen (x7.2).
This gene is overexpressed in Monocytes (35.2) and Peripheral blood mononuclear cells (28.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCR2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CCR2 Gene:
CCR2SOURCE GeneReport for Unigene cluster for CCR2 Gene:
Hs.511794mRNA Expression by UniProt/SwissProt for CCR2 Gene:
P41597-CCR2_HUMAN
Tissue specificity:
Expressed by monocytes and IL2-activated NK cells.
Evidence on tissue expression from TISSUES for CCR2 Gene
- Blood(3.4)
- Spleen(3.1)
- Lymph node(3)
- Bone marrow(2.6)
- Nervous system(2.5)
- Lung(2.4)
- Skin(2.4)
- Intestine(2.3)
- Heart(2)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for CCR2
-
OriGene qPCR primer pairs and template standards for CCR2
- genomics-online: primer clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR2 Gene
Orthologs for CCR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCR2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CCR2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ccr2 16 34 33 |
|
||
| Ccr5 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | CCR2 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CCR5 34 33 |
|
ManyToMany | |
| CCR2 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100329767 33 |
|
- Species where no ortholog for CCR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CCR2 Gene
- ENSEMBL:
- Gene Tree for CCR2 (if available)
- TreeFam:
- Gene Tree for CCR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCR2: view image
Paralogs for CCR2 Gene
Paralogs for CCR2 Gene
(49) SIMAP similar genes for CCR2 Gene using alignment to 6 proteins:
- CCR2_HUMAN
- B4XH68_HUMAN
- B4XH69_HUMAN
- E9PH76_HUMAN
- L7RER4_HUMAN
- L7REX9_HUMAN
Variants for CCR2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CCR2 Gene
- CCR2_HUMAN-P41597
- Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1799864 | protective, Human immunodeficiency virus type 1, susceptibility to | 46,357,717(+) | G/A | coding_sequence_variant, missense_variant | |
| rs1000130725 | -- | 46,359,261(+) | T/C | 3_prime_UTR_variant, intron_variant | |
| rs1000199976 | -- | 46,354,122(+) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000908711 | -- | 46,357,393(+) | T/C | intron_variant | |
| rs1001267279 | -- | 46,355,467(+) | G/C | intron_variant |
Residual Variation Intolerance Score:
18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.77;
73.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCR2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Structural Variations from Database of Genomic Variants (DGV) for CCR2 Gene
Disorders for CCR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| idiopathic anterior uveitis |
|
|
| human immunodeficiency virus type 1 |
|
|
| cd3zeta deficiency |
|
|
| purulent labyrinthitis |
|
|
| cytomegalovirus retinitis |
|
|
Search CCR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CCR2 Gene
Publications for CCR2 Gene
- Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. (PMID: 8146186) Charo IF … Coughlin SR (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 58
- Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. (PMID: 27926736) Zheng Y … Handel TM (Nature 2016) 3 4 58
- Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT. (PMID: 25283965) Esaki K … Terasawa H (The FEBS journal 2014) 3 4 58
- Structural basis for the interaction of human β-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles. (PMID: 23938203) De Paula VS … Valente AP (Journal of molecular biology 2013) 3 4 58
- Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1). (PMID: 23408426) Tan JH … Stone MJ (The Journal of biological chemistry 2013) 3 4 58
Products for CCR2 Gene
- R&D Systems Antibodies for CCR2 (CCR2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CCR2
- Browse Human Proteins and Enzymes
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- Browse Immunoprecipitation Assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CCR2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCR2
- Search Origene for MassSpec and Protein Over-expression Lysates for CCR2
- Origene Custom Protein Services for CCR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCR2
- Browse OriGene Inhibitory RNA Products For CCR2
- OriGene qPCR primer pairs for CCR2
- OriGene qPCR primer pairs and template standards for CCR2
- OriGene CRISPR knockouts for CCR2
- OriGene ORF clones in human for CCR2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for CCR2 in any vector
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- Sino Biological Human cDNA Clone for CCR2
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCR2
- Novus Biologicals proteins and lysates for CCR2
- Novus Biologicals ELISA Kits for CCR2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for CCR2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CCR2 (AFLGC-CCR2)
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCR2
- Addgene plasmids for CCR2
- antibodies-online: Search results for 303 available CCR2 Antibodies ranked by validation data
- Compare Top CCR2 Antibodies
- Recommended
- 121 WB Antibodies (anti-human)
- 47 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 14 IF Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-mouse)
- 23 WB Antibodies (anti-mouse)
- 16 FACS Antibodies (anti-mouse)
- 12 IF Antibodies (anti-mouse)
- 6 IHC (p) Antibodies (anti-mouse)
- 42 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 13 FACS Antibodies (anti-rat)
- 7 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for 15 available CCR2 Elisa Kits ranked by validation data
- Compare Top CCR2 Elisa Kits
- antibodies-online: Search results for 5 available CCR2 Proteins ranked by validation data
- Compare Top CCR2 Proteins
- GeneTex CCR2 Antibody for CCR2
- Search GeneTex for Proteins for CCR2
- Santa Cruz Biotechnology (SCBT) Antibodies for CCR2
- Search Santa Cruz Biotechnology (SCBT) for CCR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCR2
- Horizon Cell Lines for CCR2
- genomics-online: cdna clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
- orf clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
- genomics-online: gRNA clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
- genomics-online: primer clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
- genomics-online: shRNA clones - Search results for 149 available CCR2 gene related products
- Overview of 149 available CCR2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCR2
- GeneCopoeia miRNA 3'UTR Target clone products for CCR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCR2
Sources for CCR2 Gene
- (1) GeneCards
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- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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- (84) Vector BioLabs
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- (92) COMPARTMENTS
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- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
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- (150) Human Protein Atlas
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
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- (164) LncRNADisease
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- (166) miR2Disease
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- (169) Biorbyt