Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects ... See more...

Aliases for CCR10 Gene

Aliases for CCR10 Gene

  • C-C Motif Chemokine Receptor 10 2 3 5
  • Chemokine (C-C Motif) Receptor 10 2 3
  • C-C Chemokine Receptor Type 10 3 4
  • G-Protein Coupled Receptor 2 3 4
  • C-C CKR-10 3 4
  • CC-CKR-10 3 4
  • CCR-10 3 4
  • GPR2 3 4
  • G Protein-Coupled Receptor 2 2
  • CC Chemokine Receptor 10 3
  • CCR10 5

External Ids for CCR10 Gene

Previous HGNC Symbols for CCR10 Gene

  • GPR2

Previous GeneCards Identifiers for CCR10 Gene

  • GC17M038086
  • GC17M040830
  • GC17M036600

Summaries for CCR10 Gene

Entrez Gene Summary for CCR10 Gene

  • Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CCR10 Gene

CCR10 (C-C Motif Chemokine Receptor 10) is a Protein Coding gene. Diseases associated with CCR10 include Mycosis Fungoides and Cutaneous T Cell Lymphoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot Summary for CCR10 Gene

  • Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Gene Wiki entry for CCR10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCR10 Gene

Genomics for CCR10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCR10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCR10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCR10

Top Transcription factor binding sites by QIAGEN in the CCR10 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • ITF-2
  • Tal-1beta

Genomic Locations for CCR10 Gene

Latest Assembly
chr17:42,678,889-42,683,917
(GRCh38/hg38)
Size:
5,029 bases
Orientation:
Minus strand

Previous Assembly
chr17:40,830,907-40,833,861
(GRCh37/hg19 by Entrez Gene)
Size:
2,955 bases
Orientation:
Minus strand

chr17:40,830,907-40,835,935
(GRCh37/hg19 by Ensembl)
Size:
5,029 bases
Orientation:
Minus strand

Genomic View for CCR10 Gene

Genes around CCR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR10 Gene

Proteins for CCR10 Gene

  • Protein details for CCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46092-CCR10_HUMAN
    Recommended name:
    C-C chemokine receptor type 10
    Protein Accession:
    P46092
    Secondary Accessions:
    • Q4V749
    • Q6T7X2
    • Q9NZG2

    Protein attributes for CCR10 Gene

    Size:
    362 amino acids
    Molecular mass:
    38416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR10 Gene

Post-translational modifications for CCR10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCR10 Gene

No data available for DME Specific Peptides for CCR10 Gene

Domains & Families for CCR10 Gene

Gene Families for CCR10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for CCR10 Gene

InterPro:
Blocks:
  • Chemokine receptor signature
  • C-C chemokine receptor type 10 signature

Suggested Antigen Peptide Sequences for CCR10 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 2 (CCR10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46092

UniProtKB/Swiss-Prot:

CCR10_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR10: view

Function for CCR10 Gene

Molecular function for CCR10 Gene

UniProtKB/Swiss-Prot Function:
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Phenotypes From GWAS Catalog for CCR10 Gene

Gene Ontology (GO) - Molecular Function for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,TAS 7851889
GO:0004950 chemokine receptor activity IEA --
GO:0005515 protein binding IPI 26941067
GO:0016493 C-C chemokine receptor activity IEA,IBA 21873635
GO:0019957 C-C chemokine binding IBA 21873635
genes like me logo Genes that share ontologies with CCR10: view
genes like me logo Genes that share phenotypes with CCR10: view

Animal Models for CCR10 Gene

MGI Knock Outs for CCR10:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCR10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCR10 Gene

Localization for CCR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR10 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR10 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 3
nucleus 2
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7851889
GO:0009897 external side of plasma membrane IBA 21873635
GO:0009986 cell surface IDA 18308860
genes like me logo Genes that share ontologies with CCR10: view

Pathways & Interactions for CCR10 Gene

genes like me logo Genes that share pathways with CCR10: view

Pathways by source for CCR10 Gene

Gene Ontology (GO) - Biological Process for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006955 immune response IEA,IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA,IBA 21873635
genes like me logo Genes that share ontologies with CCR10: view

No data available for SIGNOR curated interactions for CCR10 Gene

Drugs & Compounds for CCR10 Gene

(3) Drugs for CCR10 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL27 Pharma Agonist, Full agonist 0
CCL28 Pharma Agonist, Full agonist 0
Calcium Nutra 6959
genes like me logo Genes that share compounds with CCR10: view

Transcripts for CCR10 Gene

mRNA/cDNA for CCR10 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCR10

Alternative Splicing Database (ASD) splice patterns (SP) for CCR10 Gene

No ASD Table

Relevant External Links for CCR10 Gene

GeneLoc Exon Structure for
CCR10

Expression for CCR10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCR10 Gene

mRNA differential expression in normal tissues according to GTEx for CCR10 Gene

This gene is overexpressed in Pituitary (x5.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCR10

SOURCE GeneReport for Unigene cluster for CCR10 Gene:

Hs.744542

mRNA Expression by UniProt/SwissProt for CCR10 Gene:

P46092-CCR10_HUMAN
Tissue specificity: Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.

Evidence on tissue expression from TISSUES for CCR10 Gene

  • Liver(2.7)
  • Blood(2.6)
  • Spleen(2.2)
  • Bone marrow(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with CCR10: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR10 Gene

Orthologs for CCR10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCR10 29 30
  • 99.36 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCR10 29 30
  • 88.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCR10 29 30
  • 88.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccr10 29 16 30
  • 84.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccr10 29
  • 84.9 (n)
Oppossum
(Monodelphis domestica)
Mammalia CCR10 30
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCR10 29 30
  • 61.9 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCR10 30
  • 41 (a)
OneToOne
Species where no ortholog for CCR10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCR10 Gene

ENSEMBL:
Gene Tree for CCR10 (if available)
TreeFam:
Gene Tree for CCR10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCR10: view image
Alliance of Genome Resources:
Additional Orthologs for CCR10

Paralogs for CCR10 Gene

(23) SIMAP similar genes for CCR10 Gene using alignment to 3 proteins:

  • CCR10_HUMAN
  • K7EPC9_HUMAN
  • K7ER70_HUMAN
genes like me logo Genes that share paralogs with CCR10: view

Variants for CCR10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCR10 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs143090639 Benign: not provided 42,681,816(-) G/A
NM_016602.3(CCR10):c.8C>T (p.Thr3Met)
MISSENSE
rs34866491 Benign: not provided 42,680,177(-) G/C
NM_016602.3(CCR10):c.465C>G (p.Pro155=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCR10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCR10 Gene

Variant ID Type Subtype PubMed ID
esv1007587 CNV deletion 20482838
esv33998 OTHER inversion 15654335
nsv1118758 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv833450 CNV loss 17160897
nsv953899 CNV deletion 24416366

Variation tolerance for CCR10 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCR10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR10
Leiden Open Variation Database (LOVD)
CCR10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR10 Gene

Disorders for CCR10 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CCR10 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
mycosis fungoides
  • mycosis fungoides lymphoma
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
sezary's disease
  • sezary disease
dermatitis
  • eczema
allergic contact dermatitis
  • contact dermatitis, allergic
- elite association - COSMIC cancer census association via MalaCards
Search CCR10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCR10

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCR10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR10 Gene

Publications for CCR10 Gene

  1. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PMID: 10975800) Pan J … Soler D (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22
  2. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). (PMID: 10725697) Homey B … Zlotnik A (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22
  3. Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. (PMID: 10725696) Jarmin DI … Gerard C (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22
  4. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A … O'Dowd BF (Genomics 1994) 2 3 4
  5. CCR4 and CCR10 are expressed on epidermal keratinocytes and are involved in cutaneous immune reaction. (PMID: 18782672) Fujimoto S … Tamaki K (Cytokine 2008) 3 22

Products for CCR10 Gene

Sources for CCR10 Gene