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Aliases for CCR10 Gene

Aliases for CCR10 Gene

  • C-C Motif Chemokine Receptor 10 2 3 5
  • Chemokine (C-C Motif) Receptor 10 2 3
  • G-Protein Coupled Receptor 2 3 4
  • C-C CKR-10 3 4
  • CC-CKR-10 3 4
  • CCR-10 3 4
  • GPR2 3 4
  • C-C Chemokine Receptor Type 10 3
  • G Protein-Coupled Receptor 2 2
  • CC Chemokine Receptor 10 3

External Ids for CCR10 Gene

Previous HGNC Symbols for CCR10 Gene

  • GPR2

Previous GeneCards Identifiers for CCR10 Gene

  • GC17M038086
  • GC17M040830
  • GC17M036600

Summaries for CCR10 Gene

Entrez Gene Summary for CCR10 Gene

  • Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CCR10 Gene

CCR10 (C-C Motif Chemokine Receptor 10) is a Protein Coding gene. Diseases associated with CCR10 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CXCR3.

UniProtKB/Swiss-Prot for CCR10 Gene

  • Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Gene Wiki entry for CCR10 Gene

Additional gene information for CCR10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR10 Gene

Genomics for CCR10 Gene

GeneHancer (GH) Regulatory Elements for CCR10 Gene

Promoters and enhancers for CCR10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J042672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 664.5 +5.2 5219 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 DHX8 TUBG2 HMGN1P29 ENSG00000267758 ENSG00000267002 ENSG00000266962
GH17J042684 Enhancer 0.2 ENCODE 650.7 -0.6 -592 0.1 CNTNAP1 CCR10 GC17M042684 PSMC3IP HMGN2P15 RAMP2 RAMP2-AS1 VPS25 ENSG00000267765
GH17J043322 Enhancer 1.5 Ensembl ENCODE dbSUPER 71.2 -639.2 -639246 1.6 CLOCK MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 UBTF ASB16-AS1 ENSG00000267340 DHX8 ENSG00000267002 HMGN1P29 TMUB2 NBR2 LINC00910 PLEKHH3
GH17J041687 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 21.6 +993.5 993518 6.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 EIF1 GC17P041692 GC17P041691 ENSG00000267758 ENSG00000259623 KLHL10 CNTNAP1 HSD17B1 NT5C3B KAT2A
GH17J043024 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.2 -341.1 -341122 2 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 VAT1 RND2 NBR2 HMGN1P29 CCR10 ENSG00000267758 ENSG00000267002 LINC00910 DHX8 HSD17B1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCR10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCR10 gene promoter:
  • ATF-2
  • c-Jun
  • AML1a
  • AP-1
  • ITF-2
  • Tal-1beta

Genomic Locations for CCR10 Gene

Genomic Locations for CCR10 Gene
chr17:42,678,889-42,683,917
(GRCh38/hg38)
Size:
5,029 bases
Orientation:
Minus strand
chr17:40,830,907-40,835,935
(GRCh37/hg19)
Size:
5,029 bases
Orientation:
Minus strand

Genomic View for CCR10 Gene

Genes around CCR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR10 Gene

Proteins for CCR10 Gene

  • Protein details for CCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46092-CCR10_HUMAN
    Recommended name:
    C-C chemokine receptor type 10
    Protein Accession:
    P46092
    Secondary Accessions:
    • Q4V749
    • Q6T7X2
    • Q9NZG2

    Protein attributes for CCR10 Gene

    Size:
    362 amino acids
    Molecular mass:
    38416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR10 Gene

Post-translational modifications for CCR10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCR10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCR10 Gene

Domains & Families for CCR10 Gene

Gene Families for CCR10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CCR10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46092

UniProtKB/Swiss-Prot:

CCR10_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR10: view

Function for CCR10 Gene

Molecular function for CCR10 Gene

UniProtKB/Swiss-Prot Function:
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Phenotypes From GWAS Catalog for CCR10 Gene

Gene Ontology (GO) - Molecular Function for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS 7851889
GO:0004950 chemokine receptor activity IEA --
GO:0005515 protein binding IPI 26941067
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR10: view
genes like me logo Genes that share phenotypes with CCR10: view

Animal Models for CCR10 Gene

MGI Knock Outs for CCR10:

Animal Model Products

Clone Products

  • Addgene plasmids for CCR10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCR10 Gene

Localization for CCR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR10 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7851889
GO:0009986 cell surface IDA 18308860
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCR10: view

Pathways & Interactions for CCR10 Gene

genes like me logo Genes that share pathways with CCR10: view

Gene Ontology (GO) - Biological Process for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with CCR10: view

No data available for SIGNOR curated interactions for CCR10 Gene

Drugs & Compounds for CCR10 Gene

(3) Drugs for CCR10 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
CCL27 Pharma Full agonist, Agonist 0
CCL28 Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with CCR10: view

Transcripts for CCR10 Gene

mRNA/cDNA for CCR10 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCR10 Gene

Chemokine (C-C motif) receptor 10:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCR10

Alternative Splicing Database (ASD) splice patterns (SP) for CCR10 Gene

No ASD Table

Relevant External Links for CCR10 Gene

GeneLoc Exon Structure for
CCR10
ECgene alternative splicing isoforms for
CCR10

Expression for CCR10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCR10 Gene

mRNA differential expression in normal tissues according to GTEx for CCR10 Gene

This gene is overexpressed in Pituitary (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of CCR10 Gene:

CCR10

SOURCE GeneReport for Unigene cluster for CCR10 Gene:

Hs.744542

mRNA Expression by UniProt/SwissProt for CCR10 Gene:

P46092-CCR10_HUMAN
Tissue specificity: Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.
genes like me logo Genes that share expression patterns with CCR10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR10 Gene

Orthologs for CCR10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR10 34 33
  • 99.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCR10 34 33
  • 88.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCR10 34 33
  • 88.27 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr10 16 34 33
  • 84.99 (n)
rat
(Rattus norvegicus)
Mammalia Ccr10 33
  • 84.9 (n)
oppossum
(Monodelphis domestica)
Mammalia CCR10 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCR10 34 33
  • 61.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCR10 34
  • 41 (a)
OneToOne
Species where no ortholog for CCR10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR10 Gene

ENSEMBL:
Gene Tree for CCR10 (if available)
TreeFam:
Gene Tree for CCR10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCR10: view image

Paralogs for CCR10 Gene

(23) SIMAP similar genes for CCR10 Gene using alignment to 3 proteins:

  • CCR10_HUMAN
  • K7EPC9_HUMAN
  • K7ER70_HUMAN
genes like me logo Genes that share paralogs with CCR10: view

Variants for CCR10 Gene

Sequence variations from dbSNP and Humsavar for CCR10 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001097202 -- 42,680,678(-) G/A intron_variant
rs1001277959 -- 42,680,357(-) C/G coding_sequence_variant, synonymous_variant
rs1002087060 -- 42,679,337(-) G/T downstream_transcript_variant
rs1002695110 -- 42,681,018(-) T/A intron_variant
rs1003292726 -- 42,682,605(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCR10 Gene

Variant ID Type Subtype PubMed ID
esv1007587 CNV deletion 20482838
esv33998 OTHER inversion 15654335
nsv1118758 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv833450 CNV loss 17160897
nsv953899 CNV deletion 24416366

Variation tolerance for CCR10 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCR10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR10 Gene

Disorders for CCR10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCR10 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
mycosis fungoides
  • mf
sezary's disease
  • sezary disease
- elite association - COSMIC cancer census association via MalaCards
Search CCR10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCR10

genes like me logo Genes that share disorders with CCR10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR10 Gene

Publications for CCR10 Gene

  1. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PMID: 10975800) Pan J … Soler D (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
  2. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). (PMID: 10725697) Homey B … Zlotnik A (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
  3. Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. (PMID: 10725696) Jarmin DI … Gerard C (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
  4. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A … O'Dowd BF (Genomics 1994) 2 3 4 58
  5. CCR4 and CCR10 are expressed on epidermal keratinocytes and are involved in cutaneous immune reaction. (PMID: 18782672) Fujimoto S … Tamaki K (Cytokine 2008) 3 22 58

Products for CCR10 Gene

Sources for CCR10 Gene

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