This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myelo... See more...

Aliases for CCR1 Gene

Aliases for CCR1 Gene

  • C-C Motif Chemokine Receptor 1 2 3 5
  • Macrophage Inflammatory Protein 1-Alpha Receptor 3 4
  • Chemokine (C-C Motif) Receptor 1 2 3
  • C-C Chemokine Receptor Type 1 3 4
  • LD78 Receptor 3 4
  • MIP-1alpha-R 3 4
  • C-C CKR-1 3 4
  • CC-CKR-1 3 4
  • RANTES-R 3 4
  • CMKBR1 3 4
  • MIP1aR 2 3
  • SCYAR1 3 4
  • CD191 2 3
  • CKR-1 2 3
  • HM145 3 4
  • CCR-1 3 4
  • RANTES Receptor 3
  • CD191 Antigen 4
  • CMKR1 4
  • CKR1 3
  • CCR1 5

External Ids for CCR1 Gene

Previous HGNC Symbols for CCR1 Gene

  • SCYAR1
  • CMKBR1

Previous GeneCards Identifiers for CCR1 Gene

  • GC03M045484
  • GC03M046062
  • GC03M046204

Summaries for CCR1 Gene

Entrez Gene Summary for CCR1 Gene

  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR1 Gene

CCR1 (C-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CCR1 include Behcet Syndrome and Immune-Complex Glomerulonephritis. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR3.

UniProtKB/Swiss-Prot Summary for CCR1 Gene

  • Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

Tocris Summary for CCR1 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Gene Wiki entry for CCR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCR1 Gene

Genomics for CCR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J046205 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 291.5 +1.0 984 4 BCLAF1 BCL11A CTCF REST TARDBP TRIM22 ELF1 MAFF RAD21 IRF4 CCR1 CCRL2 CCR5 MK280407 CCR3
GH03J046209 Enhancer 0.5 FANTOM5 dbSUPER 280.1 -1.6 -1579 0.2 SPI1 CCR1 CCRL2 CCR5 CCR2 NONHSAG034948.2 CCR3
GH03J046367 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 45.7 -162.0 -161955 4.7 BCLAF1 ZNF654 BCL11A REST TRIM22 CTCF RAD21 IRF4 SMC3 TEAD3 CCR5 MK280408 CCRL2 CCR1 CCR5AS LRRC2 TDGF1 CCR2
GH03J046094 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 52 +111.2 111181 5.2 BCLAF1 SP1 POLR2A BCL11A CTCF CEBPB TRIM22 IRF4 EBF1 CBFB lnc-CCR3-2 lnc-XCR1-3 CCR1 CCRL2 CXCR6 FYCO1 CCR5AS CCR2 CCR5 CCDC12
GH03J046106 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 47.2 +96.7 96668 9.6 BCLAF1 SP1 ZNF207 POLR2A CEBPA JUND NFIC CTCF CEBPB DEK CCR1 CCRL2 CXCR6 FYCO1 CCR2 CCR5 CCDC12 LIMD1 XCR1 CCR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCR1

Top Transcription factor binding sites by QIAGEN in the CCR1 gene promoter:
  • AP-1
  • ATF-2
  • c-Ets-1
  • c-Jun
  • C/EBPalpha
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for CCR1 Gene

Latest Assembly
chr3:46,201,711-46,208,313
(GRCh38/hg38)
Size:
6,603 bases
Orientation:
Minus strand

Previous Assembly
chr3:46,243,202-46,249,804
(GRCh37/hg19 by Entrez Gene)
Size:
6,603 bases
Orientation:
Minus strand

chr3:46,243,200-46,249,887
(GRCh37/hg19 by Ensembl)
Size:
6,688 bases
Orientation:
Minus strand

Genomic View for CCR1 Gene

Genes around CCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR1 Gene

Proteins for CCR1 Gene

  • Protein details for CCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32246-CCR1_HUMAN
    Recommended name:
    C-C chemokine receptor type 1
    Protein Accession:
    P32246
    Secondary Accessions:
    • Q86VA9

    Protein attributes for CCR1 Gene

    Size:
    355 amino acids
    Molecular mass:
    41173 Da
    Quaternary structure:
    • Interacts with CREB3.

    Three dimensional structures from OCA and Proteopedia for CCR1 Gene

neXtProt entry for CCR1 Gene

Post-translational modifications for CCR1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for CCR1

No data available for DME Specific Peptides for CCR1 Gene

Domains & Families for CCR1 Gene

Gene Families for CCR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for CCR1 Gene

InterPro:
Blocks:
  • Chemokine receptor signature
  • C-C chemokine receptor type 1 signature

Suggested Antigen Peptide Sequences for CCR1 Gene

GenScript: Design optimal peptide antigens:
  • RANTES-R (CCR1_HUMAN)
  • Chemokine (C-C motif) receptor 1, isoform CRA_a (Q5U003_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32246

UniProtKB/Swiss-Prot:

CCR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR1: view

Function for CCR1 Gene

Molecular function for CCR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by CREB3.
GENATLAS Biochemistry:
chemokine CC, beta,receptor 1,with high affinity binding for monocyte chemoattractant protein 3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for CCR1 Gene

Gene Ontology (GO) - Molecular Function for CCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IDA 10734056
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004950 chemokine receptor activity IDA 10660125
GO:0005515 protein binding IPI 8699119
GO:0016493 C-C chemokine receptor activity IDA 10734056
genes like me logo Genes that share ontologies with CCR1: view
genes like me logo Genes that share phenotypes with CCR1: view

Human Phenotype Ontology for CCR1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CCR1 Gene

MGI Knock Outs for CCR1:

Animal Models for research

miRNA for CCR1 Gene

miRTarBase miRNAs that target CCR1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCR1 Gene

Localization for CCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7505609
GO:0009897 external side of plasma membrane IDA 10706735
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCR1 Gene

Pathways & Interactions for CCR1 Gene

genes like me logo Genes that share pathways with CCR1: view

SIGNOR curated interactions for CCR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006816 calcium ion transport IDA 10734056
GO:0006874 cellular calcium ion homeostasis IDA 10734056
GO:0006887 exocytosis IDA 10734056
GO:0006935 chemotaxis NAS 15474493
genes like me logo Genes that share ontologies with CCR1: view

Drugs & Compounds for CCR1 Gene

(44) Drugs for CCR1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
DAPTA Investigational Pharma Chemokine receptor 5 (CCR5) antagonist 0
BX 471 Pharma Antagonist CCR1 antagonist,potent and selective 0
CCL3 Pharma Agonist, Full agonist 0
CCL4 Pharma Antagonist 0
J 113863 Pharma Potent CCR1 chemokine receptor antagonist 0

(16) Additional Compounds for CCR1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL2
Agonist, Full agonist
2b-1
Antagonist
vMIP-II
Antagonist

(5) Tocris Compounds for CCR1 Gene

Compound Action Cas Number
DAPTA Chemokine receptor 5 (CCR5) antagonist 106362-34-9
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3
ZK 756326 Selective, non-peptide CCR8 agonist 874911-96-3

(5) ApexBio Compounds for CCR1 Gene

Compound Action Cas Number
BX 471 CCR1 antagonist,potent and selective 217645-70-0
BX 513 hydrochloride Selective CCR1 antagonist 1216540-18-9
J 113863 353791-85-2
RS 102895 hydrochloride 1173022-16-6
UCB 35625
genes like me logo Genes that share compounds with CCR1: view

Drug products for research

Transcripts for CCR1 Gene

mRNA/cDNA for CCR1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCR1

Alternative Splicing Database (ASD) splice patterns (SP) for CCR1 Gene

No ASD Table

Relevant External Links for CCR1 Gene

GeneLoc Exon Structure for
CCR1

Expression for CCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCR1 Gene

mRNA differential expression in normal tissues according to GTEx for CCR1 Gene

This gene is overexpressed in Whole Blood (x23.4) and Spleen (x4.8).

Protein differential expression in normal tissues from HIPED for CCR1 Gene

This gene is overexpressed in Monocytes (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCR1 Gene



Protein tissue co-expression partners for CCR1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCR1

SOURCE GeneReport for Unigene cluster for CCR1 Gene:

Hs.301921

mRNA Expression by UniProt/SwissProt for CCR1 Gene:

P32246-CCR1_HUMAN
Tissue specificity: Widely expressed in different hematopoietic cells.

Evidence on tissue expression from TISSUES for CCR1 Gene

  • Blood(4.6)
  • Spleen(3.1)
  • Bone marrow(2.8)
  • Lymph node(2.8)
  • Intestine(2.8)
  • Heart(2.7)
  • Nervous system(2.6)
  • Liver(2.4)
  • Lung(2.4)
  • Kidney(2.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CCR1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR1 Gene

Orthologs for CCR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCR1 29 30
  • 99.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCR1 29 30
  • 86.01 (n)
OneToMany
-- 30
  • 62 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia CCR1 29
  • 81.44 (n)
Rat
(Rattus norvegicus)
Mammalia Ccr1 29
  • 78.5 (n)
Mouse
(Mus musculus)
Mammalia Ccr1 29 16 30
  • 77.75 (n)
OneToMany
Ccr1l1 30
  • 62 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia CCR1 30
  • 60 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCR1 30
  • 57 (a)
OneToOne
Species where no ortholog for CCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCR1 Gene

ENSEMBL:
Gene Tree for CCR1 (if available)
TreeFam:
Gene Tree for CCR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCR1: view image
Alliance of Genome Resources:
Additional Orthologs for CCR1

Paralogs for CCR1 Gene

Variants for CCR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCR1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs141128686 Benign: not provided 46,203,411(-) G/A
NM_001295.3(CCR1):c.903C>T (p.Tyr301=)
SYNONYMOUS
rs143491674 Likely Benign: not provided 46,203,446(-) C/T
NM_001295.3(CCR1):c.868G>A (p.Ala290Thr)
MISSENSE
rs146268408 Likely Benign: not provided 46,203,876(-) G/A
NM_001295.3(CCR1):c.438C>T (p.Thr146=)
SYNONYMOUS
rs150288365 Benign: not provided 46,203,300(-) C/T
NM_001295.3(CCR1):c.1014G>A (p.Arg338=)
SYNONYMOUS
rs202159281 Likely Benign: not provided 46,203,318(-) G/A
NM_001295.3(CCR1):c.996C>T (p.Ser332=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for CCR1 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCR1 Gene

Human Gene Mutation Database (HGMD)
CCR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR1
Leiden Open Variation Database (LOVD)
CCR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCR1 Gene

Disorders for CCR1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for CCR1 Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
behcet syndrome
  • behcet disease; bd
immune-complex glomerulonephritis
  • immune complex glomerulonephritis
human cytomegalovirus infection
  • cytomegalovirus infection
chromoblastomycosis
  • chromomycosis
corneal ulcer
- elite association - COSMIC cancer census association via MalaCards
Search CCR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCR1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR1 Gene

Publications for CCR1 Gene

  1. Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. (PMID: 18587271) Sung HJ … Ko J (Experimental & molecular medicine 2008) 3 4 22
  2. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. (PMID: 17135764) Nakamura H … Eboshida A (International archives of allergy and immunology 2007) 3 22 40
  3. Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. (PMID: 15001559) Ko J … Na DS (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004) 3 4 22
  4. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PMID: 7505609) Nomura H … Matsushima K (International immunology 1993) 3 4 22
  5. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. (PMID: 7679328) Neote K … Schall TJ (Cell 1993) 2 3 4

Products for CCR1 Gene

Sources for CCR1 Gene