Free for academic non-profit institutions. Other users need a Commercial license
Aliases for CCNYL2 Gene
Aliases for CCNYL2 Gene
External Ids for CCNYL2 Gene
- HGNC: 23495
- NCBI Entrez Gene: 414194
- Ensembl: ENSG00000182632
- UniProtKB/Swiss-Prot: Q5T2Q4
Previous HGNC Symbols for CCNYL2 Gene
- C10orf21
Previous GeneCards Identifiers for CCNYL2 Gene
- GC10M042225
- GC10M042903
- GC10M039430
- GC10M042418
- GC10M042421
- GC10M042446
- GC10M042449
- GC10M042452
- GC10M042463
- GC10M042423
- GC10M042426
- GC10M042429
- GC10M042431
- GC10M042434
- GC10M042437
- GC10M042440
- GC10M042443
Summaries for CCNYL2 Gene
GeneCards Summary for CCNYL2 Gene
CCNYL2 (Cyclin Y Like 2 (Pseudogene)) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include protein kinase binding.
Additional gene information for CCNYL2 Gene
- Monarch Initiative
- Search for CCNYL2 at DataMed
- Search for CCNYL2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNYL2 Gene
Genomics for CCNYL2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCNYL2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J042474 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE | 250.7 | -0.9 | -938 | 2.6 | ZIC2 SP2 CTCF GLIS1 L3MBTL2 RCOR1 ZFX POLR2A ZNF692 PATZ1 | LINC00839 CCNYL2 lnc-ZNF33B-6 ZNF33B LOC441666 piR-54183 | |
| GH10J043042 | Enhancer | 0.7 | Ensembl CraniofacialAtlas | 5 | -568.6 | -568649 | 2.9 | ZIC2 MYC FOXA1 MAX REST CTCF GLIS1 RAD21 ZFX EP300 | LINC00839 CCNYL2 ENSG00000259869 ZNF33B HSALNG0077522 LINC01264 piR-32214-054 RET BMS1 | |
| GH10J042826 | Enhancer | 0.6 | Ensembl ENCODE | 3.9 | -352.1 | -352088 | 1.5 | CTCF KLF1 RAD21 | HE856085 piR-49555-001 LOC441666 CCNYL2 BMS1 RET |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCNYL2 on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the CCNYL2 gene promoter:
-
- AML1a
- AREB6
- E47
- FOXC1
- p53
- Pax-4a
- Tal-1beta
- USF-1:USF-2
- USF1
- USF2
Genomic Locations for CCNYL2 Gene
Latest Assembly
- chr10:42,408,168-42,475,349
- (GRCh38/hg38)
- Size:
- 67,182 bases
- Orientation:
- Minus strand
Previous Assembly
- chr10:42,903,622-42,967,688
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 64,067 bases
- Orientation:
- Minus strand
- chr10:42,903,616-42,967,688
- (GRCh37/hg19 by Ensembl)
- Size:
- 64,073 bases
- Orientation:
- Minus strand
Genomic View for CCNYL2 Gene
Genes around CCNYL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q11.21 by HGNC
- 10q11.21 by Entrez Gene
- 10q11.21 by Ensembl
CCNYL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCNYL2 Gene
Proteins for CCNYL2 Gene
-
Protein details for CCNYL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5T2Q4-CCYL2_HUMAN
- Recommended name:
- Cyclin-Y-like protein 2
- Protein Accession:
- Q5T2Q4
Protein attributes for CCNYL2 Gene
- Size:
- 361 amino acids
- Molecular mass:
- 41278 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCNYL2 Gene
Post-translational modifications for CCNYL2 Gene
Antibodies for research
- Invitrogen Antibodies for CCNYL2 (AFLGC-CCNYL2)
- antibodies-online: Show 7 available CCNYL2 Antibodies ranked by validation data
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CCNYL2
- Origene Custom Protein Services for CCNYL2
Assay products for research
No data available for DME Specific Peptides for CCNYL2 Gene
Domains & Families for CCNYL2 Gene
Gene Families for CCNYL2 Gene
- HGNC:
Protein Domains for CCNYL2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCNYL2 Gene
- GenScript: Design optimal peptide antigens:
-
- Cyclin-Y-like protein 2 (CCYL2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5T2Q4- Family:
-
- Belongs to the cyclin family. Cyclin Y subfamily.
Function for CCNYL2 Gene
Phenotypes From GWAS Catalog for CCNYL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | IBA | 21873635 |
| GO:0019901 | protein kinase binding | IEA | -- |
Phenotypes for CCNYL2 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCNYL2 - Starting at $85 >
- * CCNYL2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Browse CRISPR knockouts for CCNYL2
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for CCNYL2 - Starting at $45 >
- * CCNYL2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCNYL2 Gene
Localization for CCNYL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005886 | plasma membrane | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CCNYL2 Gene
Pathways & Interactions for CCNYL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | IBA | 21873635 |
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for CCNYL2 Gene
Transcripts for CCNYL2 Gene
mRNA/cDNA for CCNYL2 Gene
- 1 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000472090 1440 nts (view in UCSC)
- ENST00000637719 3311 nts (view in UCSC)
- ENST00000638057 730 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCNYL2 - Starting at $85 >
- * CCNYL2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Browse CRISPR knockouts for CCNYL2
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for CCNYL2 - Starting at $45 >
- * CCNYL2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for CCNYL2 Gene
- GeneLoc Exon Structure for
- CCNYL2
Expression for CCNYL2 Gene
mRNA differential expression in normal tissues according to GTEx for CCNYL2 Gene
This gene is overexpressed in Testis (x25.8).
This gene is overexpressed in Pancreas (51.3) and Brain (17.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCNYL2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNYL2
Primer products for research
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNYL2 Gene
Orthologs for CCNYL2 Gene
No data available for Orthologs for CCNYL2 Gene
Paralogs for CCNYL2 Gene
(8) SIMAP similar genes for CCNYL2 Gene using alignment to 1 proteins:
- CCYL2_HUMAN
No data available for Paralogs for CCNYL2 Gene
Variants for CCNYL2 Gene
Additional Variant Information for CCNYL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCNYL2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for CCNYL2 Gene
Disorders for CCNYL2 Gene
Additional Disease Information for CCNYL2
No disorders were found for CCNYL2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNYL2 Gene
Publications for CCNYL2 Gene
- Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. (PMID: 31796584) Zang W … Zheng X (Proceedings of the National Academy of Sciences of the United States of America 2019) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
ExternalLinks
Products for CCNYL2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CCNYL2
- Origene Custom Protein Services for CCNYL2
- Browse OriGene Inhibitory RNA Products For CCNYL2
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for CCNYL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCNYL2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for CCNYL2 (AFLGC-CCNYL2)
- antibodies-online: Show 7 available CCNYL2 Antibodies ranked by validation data
- antibodies-online: Search results for available CCNYL2 related products ranked by validation data
- antibodies-online: Search results for available CCNYL2 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for CCNYL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for CCNYL2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCNYL2
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for CCNYL2
Sources for CCNYL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB