Aliases for CCNYL1 Gene

Aliases for CCNYL1 Gene

  • Cyclin Y Like 1 2 3 5
  • Cyclin-Y-Like Protein 1 3 4
  • Cyclin Y-Like 1 2

External Ids for CCNYL1 Gene

Previous GeneCards Identifiers for CCNYL1 Gene

  • GC02P208285
  • GC02P208576
  • GC02P200418

Summaries for CCNYL1 Gene

GeneCards Summary for CCNYL1 Gene

CCNYL1 (Cyclin Y Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNY.

Additional gene information for CCNYL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNYL1 Gene

Genomics for CCNYL1 Gene

GeneHancer (GH) Regulatory Elements for CCNYL1 Gene

Promoters and enhancers for CCNYL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNYL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNYL1

Top Transcription factor binding sites by QIAGEN in the CCNYL1 gene promoter:
  • c-Myc
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Max
  • USF-1
  • USF1

Genomic Locations for CCNYL1 Gene

Genomic Locations for CCNYL1 Gene
50,300 bases
Plus strand
50,300 bases
Plus strand

Genomic View for CCNYL1 Gene

Genes around CCNYL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNYL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNYL1 Gene

Proteins for CCNYL1 Gene

  • Protein details for CCNYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-Y-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6NX60

    Protein attributes for CCNYL1 Gene

    359 amino acids
    Molecular mass:
    40705 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH67253.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNYL1 Gene


neXtProt entry for CCNYL1 Gene

Post-translational modifications for CCNYL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNYL1 Gene

Domains & Families for CCNYL1 Gene

Gene Families for CCNYL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNYL1 Gene

Suggested Antigen Peptide Sequences for CCNYL1 Gene

GenScript: Design optimal peptide antigens:
  • Cyclin-Y-like protein 1 (CCYL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin Y subfamily.
  • Belongs to the cyclin family. Cyclin Y subfamily.
genes like me logo Genes that share domains with CCNYL1: view

Function for CCNYL1 Gene

Phenotypes From GWAS Catalog for CCNYL1 Gene

Gene Ontology (GO) - Molecular Function for CCNYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22184064
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNYL1: view
genes like me logo Genes that share phenotypes with CCNYL1: view

Animal Models for CCNYL1 Gene

MGI Knock Outs for CCNYL1:
  • Ccnyl1 Ccnyl1<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for CCNYL1 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNYL1 Gene

Localization for CCNYL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNYL1 gene
Compartment Confidence
plasma membrane 4
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with CCNYL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNYL1 Gene

Pathways & Interactions for CCNYL1 Gene

PathCards logo

SuperPathways for CCNYL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
genes like me logo Genes that share ontologies with CCNYL1: view

No data available for Pathways by source and SIGNOR curated interactions for CCNYL1 Gene

Drugs & Compounds for CCNYL1 Gene

No Compound Related Data Available

Transcripts for CCNYL1 Gene

mRNA/cDNA for CCNYL1 Gene

10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNYL1 Gene

No ASD Table

Relevant External Links for CCNYL1 Gene

GeneLoc Exon Structure for

Expression for CCNYL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNYL1 Gene

Protein differential expression in normal tissues from HIPED for CCNYL1 Gene

This gene is overexpressed in Breast (21.9), Heart (18.8), Peripheral blood mononuclear cells (15.2), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNYL1 Gene

Protein tissue co-expression partners for CCNYL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNYL1

SOURCE GeneReport for Unigene cluster for CCNYL1 Gene:


Evidence on tissue expression from TISSUES for CCNYL1 Gene

  • Liver(4.2)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with CCNYL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNYL1 Gene

Orthologs for CCNYL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNYL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCNYL1 31
  • 100 (a)
(Canis familiaris)
Mammalia CCNYL1 31 30
  • 95.73 (n)
(Bos Taurus)
Mammalia CCNYL1 31 30
  • 94.81 (n)
(Mus musculus)
Mammalia Ccnyl1 17 31 30
  • 94.46 (n)
(Rattus norvegicus)
Mammalia Ccnyl1 30
  • 93.7 (n)
(Ornithorhynchus anatinus)
Mammalia CCNYL1 31
  • 69 (a)
(Monodelphis domestica)
Mammalia CCNYL1 31
  • 69 (a)
(Gallus gallus)
Aves CCNYL1 31 30
  • 83.45 (n)
(Anolis carolinensis)
Reptilia CCNYL1 31
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnyl1 30
  • 80.39 (n)
Str.135 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14028 30
(Danio rerio)
Actinopterygii ccnyl1 31 30
  • 74.63 (n)
wufi41h04 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.775 30
fruit fly
(Drosophila melanogaster)
Insecta CycY 31
  • 39 (a)
(Caenorhabditis elegans)
Secernentea cyy-1 31
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5028 31
  • 50 (a)
Cin.6853 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6853 30
Species where no ortholog for CCNYL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNYL1 Gene

Gene Tree for CCNYL1 (if available)
Gene Tree for CCNYL1 (if available)
Evolutionary constrained regions (ECRs) for CCNYL1: view image

Paralogs for CCNYL1 Gene

Paralogs for CCNYL1 Gene

(6) SIMAP similar genes for CCNYL1 Gene using alignment to 4 proteins:

  • H7C0P7_HUMAN
genes like me logo Genes that share paralogs with CCNYL1: view

Variants for CCNYL1 Gene

Additional dbSNP identifiers (rs#s) for CCNYL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNYL1 Gene

Variant ID Type Subtype PubMed ID
nsv3133 CNV insertion 18451855
nsv963769 CNV duplication 23825009

Variation tolerance for CCNYL1 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNYL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNYL1 Gene

Disorders for CCNYL1 Gene

Additional Disease Information for CCNYL1

No disorders were found for CCNYL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNYL1 Gene

Publications for CCNYL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for CCNYL1 Gene

Sources for CCNYL1 Gene