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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cycli... See more...
Aliases for CCNT2 Gene
Aliases for CCNT2 Gene
External Ids for CCNT2 Gene
- HGNC: 1600
- NCBI Entrez Gene: 905
- Ensembl: ENSG00000082258
- OMIM®: 603862
- UniProtKB/Swiss-Prot: O60583
Previous GeneCards Identifiers for CCNT2 Gene
- GC02P133321
- GC02P133964
- GC02P135698
- GC02P135887
- GC02P135509
- GC02P135392
- GC02P127668
Summaries for CCNT2 Gene
-
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
GeneCards Summary for CCNT2 Gene
CCNT2 (Cyclin T2) is a Protein Coding gene. Diseases associated with CCNT2 include Human Immunodeficiency Virus Type 1. Among its related pathways are Signaling by GPCR and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNT1.
UniProtKB/Swiss-Prot Summary for CCNT2 Gene
-
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).
-
(Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters.
Additional gene information for CCNT2 Gene
- HGNC (1600)
- NCBI Entrez Gene (905)
- Ensembl (ENSG00000082258)
- OMIM® (603862)
- UniProtKB/Swiss-Prot (O60583)
- Open Targets Platform(ENSG00000082258)
- Search for CCNT2 at DataMed
- Search for CCNT2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNT2 Gene
Genomics for CCNT2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCNT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCNT2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNT2
- Top Transcription factor binding sites by QIAGEN in the CCNT2 gene promoter:
-
- AML1a
- E47
- FOXF2
- NF-kappaB1
- NRSF form 1
- Pax-4a
- POU2F1
- POU2F1a
- Sp1
Genomic Locations for CCNT2 Gene
Latest Assembly
- chr2:134,918,235-134,959,342
- (GRCh38/hg38)
- Size:
- 41,108 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:135,676,392-135,716,912
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 40,521 bases
- Orientation:
- Plus strand
- chr2:135,675,805-135,716,912
- (GRCh37/hg19 by Ensembl)
- Size:
- 41,108 bases
- Orientation:
- Plus strand
Genomic View for CCNT2 Gene
Genes around CCNT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q21.3 by HGNC
- 2q21.3 by Entrez Gene
- 2q21.3 by Ensembl
CCNT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCNT2 Gene
Proteins for CCNT2 Gene
-
Protein details for CCNT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60583-CCNT2_HUMAN
- Recommended name:
- Cyclin-T2
- Protein Accession:
- O60583
- A8KA48
- D3DP73
- D3DP74
- O60582
- Q29R66
- Q53SR4
- Q5I1Y0
Protein attributes for CCNT2 Gene
- Size:
- 730 amino acids
- Molecular mass:
- 81029 Da
- Quaternary structure:
-
- Interacts with CDK9 to form P-TEFb (PubMed:9499409, PubMed:16331689). Interacts with POLR2A (via the C-terminal domain (CTD)); mediates transcriptional activity (PubMed:15563843). Interacts with HEXIM1; mediates formation of a tripartite complex with KPNA2. Interacts with HEXIM2 (PubMed:19883659). Interacts with PKN1; enhances MYOD1-dependent transcription (PubMed:16331689). P-TEFB complex interacts with RB1; promotes phosphorylation of RB1 (PubMed:12037672). P-TEFB complex interacts with MYOD1; promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation (By similarity). Interacts with MDFI and MDFIC (PubMed:17289077). Interacts with MON1B; downregulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection (PubMed:21509660).
- (Microbial infection) Interacts with HIV-2 and SIV Tat. Does not bind efficiently to the transactivation domain of the HIV-1 Tat (PubMed:10364329).
Protein Expression for CCNT2 Gene
Post-translational modifications for CCNT2 Gene
Other Protein References for CCNT2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ CCNT2 Polyclonal Antibody and Immunotag™ CCNT2 Antibody
- Novus Biologicals Antibodies for CCNT2
-
Abcam antibodies for CCNT2
- Invitrogen Antibodies for CCNT2 (AFLGC-CCNT2)
-
Biorbyt antibodies for CCNT2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCNT2
Protein products for research
-
OriGene Purified Proteins for CCNT2
- Search Origene for MassSpec and Protein Over-expression Lysates for CCNT2
- Origene Custom Protein Services for CCNT2
- antibodies-online: Show 4 available Cyclin T2 Proteins ranked by validation data
- Compare Top Cyclin T2 Proteins
-
Quality Products:
-
Abcam proteins for CCNT2
Assay products for research
No data available for DME Specific Peptides for CCNT2 Gene
Domains & Families for CCNT2 Gene
Gene Families for CCNT2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CCNT2 Gene
- InterPro:
- Blocks:
-
- Cyclin
- ProtoNet:
Suggested Antigen Peptide Sequences for CCNT2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58505, highly similar to Cyclin-T2 (B4DH21_HUMAN)
- Cyclin-T2 (CCNT2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60583- Family:
-
- Belongs to the cyclin family. Cyclin C subfamily.
Function for CCNT2 Gene
Molecular function for CCNT2 Gene
- UniProtKB/Swiss-Prot Function:
- Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters.
Phenotypes From GWAS Catalog for CCNT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001223 | transcription coactivator binding | IPI | 12037672 |
| GO:0003682 | chromatin binding | IEA,ISS | -- |
| GO:0005515 | protein binding | IPI | 9499409 |
| GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | IEA,IBA | 21873635 |
| GO:0019901 | protein kinase binding | IPI | -- |
Phenotypes for CCNT2 Gene
- MGI mutant phenotypes for CCNT2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CCNT2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased ionizing radiation sensitivity
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in pancreas lineage
- Increased HPV18 LCR reporter activity
- Decreased shRNA abundance (Z-score < -2)
- Decreased Aire reporter expression
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased G1 length
- Increased G1 length, increased G2 length
Animal Models for CCNT2 Gene
- MGI Knock Outs for CCNT2:
-
- Ccnt2 Ccnt2<tm1b(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCNT2 - Starting at $85 >
- * CCNT2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCNT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCNT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNT2
miRNA for CCNT2 Gene
- miRTarBase miRNAs that target CCNT2
-
- mmu-miR-16-5p (MIRT001689)
- hsa-miR-16-5p (MIRT001801)
- mmu-miR-15a-5p (MIRT006378)
- mmu-miR-7b-5p (MIRT009211)
- mmu-miR-223-3p (MIRT009611)
- mmu-miR-340-5p (MIRT010275)
- mmu-miR-297a-5p (MIRT012975)
- mmu-miR-24-3p (MIRT013739)
- mmu-miR-136-5p (MIRT014880)
- hsa-miR-29c-3p (MIRT020397)
- hsa-miR-196a-5p (MIRT026073)
- hsa-miR-22-3p (MIRT030643)
- hsa-miR-877-5p (MIRT037376)
- hsa-miR-484 (MIRT041987)
- hsa-miR-423-3p (MIRT042585)
- hsa-miR-204-5p (MIRT047016)
- hsa-miR-142-3p (MIRT052995)
- hsa-miR-29a-3p (MIRT052997)
- hsa-miR-15a-5p (MIRT085215)
- hsa-miR-15b-5p (MIRT085216)
- hsa-miR-195-5p (MIRT085217)
- hsa-miR-19a-3p (MIRT085259)
- hsa-miR-19b-3p (MIRT085260)
- hsa-miR-3927-3p (MIRT085286)
- hsa-miR-6831-5p (MIRT085291)
- hsa-miR-95-5p (MIRT085292)
- hsa-miR-29b-3p (MIRT085293)
- hsa-miR-3163 (MIRT085294)
- hsa-miR-4272 (MIRT085295)
- hsa-miR-4699-5p (MIRT085297)
- hsa-miR-5682 (MIRT085299)
- hsa-miR-6884-3p (MIRT085300)
- hsa-miR-19a-5p (MIRT155378)
- hsa-miR-19b-1-5p (MIRT155379)
- hsa-miR-19b-2-5p (MIRT155380)
- hsa-miR-500a-3p (MIRT155386)
- hsa-miR-507 (MIRT155387)
- hsa-miR-557 (MIRT155388)
- hsa-miR-6804-3p (MIRT155407)
- hsa-miR-27a-3p (MIRT155411)
- hsa-miR-27b-3p (MIRT155416)
- hsa-miR-607 (MIRT155432)
- hsa-miR-4282 (MIRT155449)
- hsa-miR-3668 (MIRT155488)
- hsa-miR-6073 (MIRT155502)
- hsa-miR-7852-3p (MIRT155506)
- hsa-miR-155-5p (MIRT155511)
- hsa-miR-1273e (MIRT155517)
- hsa-miR-3674 (MIRT203319)
- hsa-miR-5692a (MIRT203321)
- hsa-miR-302b-5p (MIRT203348)
- hsa-miR-302d-5p (MIRT203349)
- hsa-miR-4280 (MIRT448967)
- hsa-miR-1304-5p (MIRT450895)
- hsa-miR-6765-5p (MIRT450896)
- hsa-miR-3671 (MIRT450897)
- hsa-miR-1827 (MIRT450898)
- hsa-miR-4762-5p (MIRT450899)
- hsa-miR-585-5p (MIRT479692)
- hsa-miR-6871-3p (MIRT479693)
- hsa-miR-3680-3p (MIRT502952)
- hsa-miR-450b-5p (MIRT502953)
- hsa-miR-4677-5p (MIRT502954)
- hsa-miR-22-5p (MIRT502955)
- hsa-miR-2116-5p (MIRT502956)
- hsa-miR-5680 (MIRT502957)
- hsa-miR-4682 (MIRT502958)
- hsa-miR-200b-3p (MIRT502959)
- hsa-miR-429 (MIRT502960)
- hsa-miR-200c-3p (MIRT502961)
- hsa-miR-4650-3p (MIRT548960)
- hsa-miR-6077 (MIRT548961)
- hsa-miR-7-5p (MIRT548962)
- hsa-miR-4790-3p (MIRT548963)
- hsa-miR-548f-3p (MIRT548964)
- hsa-miR-548e-3p (MIRT548965)
- hsa-miR-548az-3p (MIRT548966)
- hsa-miR-548ar-3p (MIRT548967)
- hsa-miR-548a-3p (MIRT548968)
- hsa-miR-4458 (MIRT548969)
- hsa-let-7b-5p (MIRT548970)
- hsa-let-7c-5p (MIRT548971)
- hsa-let-7d-5p (MIRT548972)
- hsa-let-7g-5p (MIRT548973)
- hsa-miR-98-5p (MIRT548974)
- hsa-let-7i-5p (MIRT548975)
- hsa-miR-4500 (MIRT548976)
- hsa-let-7a-5p (MIRT548977)
- hsa-let-7e-5p (MIRT548978)
- hsa-let-7f-5p (MIRT548979)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCNT2
- Browse OriGene Inhibitory RNA Products For CCNT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNT2
Clone products for research
- Applied Biological Materials (abm): Clones for CCNT2 - Starting at $45 >
- * CCNT2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCNT2
- Addgene plasmids for CCNT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCNT2
Cell Lines for research
-
Horizon Cell Lines for CCNT2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNT2 Gene
Localization for CCNT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCNT2 Gene
- Cytoplasm, perinuclear region. Nucleus. Note=Nucleus in differentiating cells. {ECO:0000250 UniProtKB:Q7TQK0}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 4 |
| cytosol | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
- Cytosol (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 16109376 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for CCNT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Formation of HIV-1 elongation complex containing HIV-1 Tat | ||
| 2 | HIV Life Cycle |
.91
.64
|
.45
|
| 3 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 4 | GPCR Pathway |
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
|
| 5 | Gene Expression |
.48
|
|
Pathways by source for CCNT2 Gene
22 Reactome pathways for CCNT2 Gene
1 KEGG pathway for CCNT2 Gene
2 Qiagen pathways for CCNT2 Gene
- Breast Cancer Regulation by Stathmin1
- Pancreatic Adenocarcinoma
1 GeneTex pathway for CCNT2 Gene
Interacting Proteins for CCNT2 Gene
Selected Interacting proteins:
O60583-CCNT2_HUMAN
ENSP00000264157
for CCNT2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CCNT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | IEA,TAS | 9499409 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
| GO:0006366 | transcription by RNA polymerase II | TAS | -- |
| GO:0006368 | transcription elongation from RNA polymerase II promoter | TAS | -- |
No data available for SIGNOR curated interactions for CCNT2 Gene
Transcripts for CCNT2 Gene
mRNA/cDNA for CCNT2 Gene
- 4 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264157 6920 nts (view in UCSC)
- ENST00000295238 4491 nts (view in UCSC)
- ENST00000417175 811 nts (view in UCSC)
- ENST00000419781 5414 nts (view in UCSC)
- ENST00000438691 632 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CCNT2 - Starting at $85 >
- * CCNT2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CCNT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCNT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNT2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCNT2
- Browse OriGene Inhibitory RNA Products For CCNT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNT2
Clone products for research
- Applied Biological Materials (abm): Clones for CCNT2 - Starting at $45 >
- * CCNT2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CCNT2
- Addgene plasmids for CCNT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCNT2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11a | · | 11b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | - | ||||||||
| SP12: | |||||||||
| SP13: |
Relevant External Links for CCNT2 Gene
- GeneLoc Exon Structure for
- CCNT2
Expression for CCNT2 Gene
This gene is overexpressed in Pancreatic juice (48.4) and Pancreas (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNT2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNT2
SOURCE GeneReport for Unigene cluster for CCNT2 Gene:
Hs.744115mRNA Expression by UniProt/SwissProt for CCNT2 Gene:
O60583-CCNT2_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for CCNT2 Gene
- Nervous system(4.7)
- Liver(4.3)
Primer products for research
-
OriGene qPCR primer pairs for CCNT2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNT2 Gene
Orthologs for CCNT2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CCNT2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CCNT2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CCNT2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CCNT2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ccnt2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ccnt2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CCNT2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CCNT2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CCNT2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ccnt2 30 |
|
||
| Str.6760 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | ccnt2a 30 31 |
|
OneToMany | |
| ccnt2b 31 |
|
OneToMany | |||
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CycT 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cit-1.1 31 |
|
ManyToMany | |
| cit-1.2 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for CCNT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CCNT2 Gene
- ENSEMBL:
- Gene Tree for CCNT2 (if available)
- TreeFam:
- Gene Tree for CCNT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCNT2: view image
Paralogs for CCNT2 Gene
(3) SIMAP similar genes for CCNT2 Gene using alignment to 7 proteins:
- CCNT2_HUMAN
- B4DH21_HUMAN
- C9JUL2_HUMAN
- F2Z2C9_HUMAN
- F8WDY7_HUMAN
- H7BZ27_HUMAN
- H7C411_HUMAN
Pseudogenes.org Pseudogenes for CCNT2 Gene
Variants for CCNT2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNT2 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1559101733 | Uncertain Significance: Premature ovarian insufficiency | 134,939,063(+) |
G/C NM_058241.3(CCNT2):c.430+1G>C |
SPLICE_DONOR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.84;
17.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCNT2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCNT2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCNT2 Gene
Disorders for CCNT2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| human immunodeficiency virus type 1 |
|
|
Search CCNT2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCNT2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CCNT2 Gene
Publications for CCNT2 Gene
- Identification of multiple cyclin subunits of human P-TEFb. (PMID: 9499409) Peng J … Price DH (Genes & development 1998) 2 3 4 23
- Pkn is a novel partner of cyclin T2a in muscle differentiation. (PMID: 16331689) Cottone G … De Luca A (Journal of cellular physiology 2006) 3 4 23
- Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb. (PMID: 15563843) Kurosu T … Peterlin BM (Gene 2004) 3 4 23
- The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity. (PMID: 10465067) Napolitano G … Lania L (AIDS (London, England) 1999) 2 3 23
- HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2. (PMID: 21509660) Wu W … Li Q (Science China. Life sciences 2011) 3 4
ExternalLinks
Products for CCNT2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCNT2
- Search Origene for MassSpec and Protein Over-expression Lysates for CCNT2
- Origene Custom Protein Services for CCNT2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCNT2
- Browse OriGene Inhibitory RNA Products For CCNT2
- OriGene qPCR primer pairs for CCNT2
- OriGene CRISPR knockouts for CCNT2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCNT2
- Sino Biological Human cDNA Clone for CCNT2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CCNT2
- Novus Biologicals proteins and lysates for CCNT2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CCNT2
- Abcam proteins for CCNT2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CCNT2 (AFLGC-CCNT2)
- VectorBuilder Custom and pre-made DNA vectors for CCNT2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CCNT2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CCNT2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CCNT2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CCNT2
- Addgene plasmids for CCNT2
- antibodies-online: Show 10 available Cyclin T2 Antibodies ranked by validation data
- Compare Top Cyclin T2 Antibodies
- antibodies-online: Show 12 available Cyclin T2 Elisa Kits ranked by validation data
- Compare Top Cyclin T2 Elisa Kits
- antibodies-online: Show 4 available Cyclin T2 Proteins ranked by validation data
- Compare Top Cyclin T2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for CCNT2
- Search Santa Cruz Biotechnology (SCBT) for CCNT2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCNT2
- Horizon Cell Lines for CCNT2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCNT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCNT2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CCNT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNT2
- Biorbyt antibodies for CCNT2
Sources for CCNT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB