Aliases for CCNP Gene

Aliases for CCNP Gene

  • Cyclin P 2 3
  • Cyclin N-Terminal Domain Containing 2 2 3 5
  • CNTD2 3 4 5
  • Cyclin N-Terminal Domain-Containing Protein 2 3 4
  • FLJ13265 2
  • Cyclin-P 4

External Ids for CCNP Gene

Previous HGNC Symbols for CCNP Gene

  • CNTD2

Previous GeneCards Identifiers for CCNP Gene

  • GC02U900005

Summaries for CCNP Gene

GeneCards Summary for CCNP Gene

CCNP (Cyclin P) is a Protein Coding gene. An important paralog of this gene is CCNA1.

UniProtKB/Swiss-Prot Summary for CCNP Gene

  • Seems to be involved in the regulation of proliferation and migration.

Additional gene information for CCNP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNP Gene

Genomics for CCNP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J040225 Promoter/Enhancer 1.2 Ensembl ENCODE 600.7 +0.8 840 1.1 GATAD2A NFKBIZ KDM1A ZNF692 RCOR2 ZIC2 RBFOX2 RXRB SP1 ZNF561 CCNP C19orf47 lnc-TTC9B-1 TTC9B
GH19J040226 Enhancer 0.9 ENCODE 600.7 +0.2 162 0.2 CREB1 GATAD2A NFKBIZ RCOR2 RXRB SP1 CEBPA KMT2B CEBPB ZKSCAN1 CCNP lnc-TTC9B-1 TTC9B
GH19J040228 Enhancer 0.2 Ensembl 600.7 -1.3 -1290 0.4 CCNP ENSG00000206925 PLD3 C19orf47 HIPK4 piR-45328 AKT2
GH19J040190 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.2 +35.6 35610 3 HNRNPL PRDM10 ZNF629 SIX5 IKZF1 CTCF ZNF692 POLR2A ZNF174 BACH1 MAP3K10 lnc-TTC9B-2 ZNF780B NUMBL CYP2G1P SUPT5H EID2B PAF1 TTC9B CCNP
GH19J040089 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +136.8 136811 3 CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 LEF1 SOX13 IKZF1 ZNF692 ZNF780A ENSG00000269749 SNRPA ENSG00000269843 FBL PLEKHG2 AKT2 ITPKC SUPT5H COQ8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNP

Genomic Locations for CCNP Gene

Genomic Locations for CCNP Gene
chr19:40,222,208-40,227,111
(GRCh38/hg38)
Size:
4,904 bases
Orientation:
Minus strand
chr19:40,728,115-40,732,597
(GRCh37/hg19)
Size:
4,483 bases
Orientation:
Minus strand

Genomic View for CCNP Gene

Genes around CCNP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNP Gene

Proteins for CCNP Gene

  • Protein details for CCNP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8S5-CCNP_HUMAN
    Recommended name:
    Cyclin-P
    Protein Accession:
    Q9H8S5
    Secondary Accessions:
    • B4DX65

    Protein attributes for CCNP Gene

    Size:
    307 amino acids
    Molecular mass:
    33574 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for CCNP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNP Gene

Post-translational modifications for CCNP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNP Gene

No data available for DME Specific Peptides for CCNP Gene

Domains & Families for CCNP Gene

Gene Families for CCNP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNP Gene

Suggested Antigen Peptide Sequences for CCNP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50906, weakly similar to G2/mitotic-specific cyclin-B2 (B4DX65_HUMAN)
  • Cyclin N-terminal domain-containing protein 2 (CNTD2_HUMAN)
genes like me logo Genes that share domains with CCNP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCNP Gene

Function for CCNP Gene

Molecular function for CCNP Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in the regulation of proliferation and migration.

Phenotypes From GWAS Catalog for CCNP Gene

Gene Ontology (GO) - Molecular Function for CCNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with CCNP: view
genes like me logo Genes that share phenotypes with CCNP: view

Animal Model Products

CRISPR Products

miRNA for CCNP Gene

miRTarBase miRNAs that target CCNP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNP Gene

Localization for CCNP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
mitochondrion 2
plasma membrane 1
extracellular 1
endosome 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for CCNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA,IDA 28860486
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IBA --
GO:0097124 cyclin A2-CDK2 complex IBA 21873635
genes like me logo Genes that share ontologies with CCNP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCNP Gene

Pathways & Interactions for CCNP Gene

PathCards logo

SuperPathways for CCNP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0044772 mitotic cell cycle phase transition IBA 21873635
genes like me logo Genes that share ontologies with CCNP: view

No data available for Pathways by source and SIGNOR curated interactions for CCNP Gene

Drugs & Compounds for CCNP Gene

No Compound Related Data Available

Transcripts for CCNP Gene

mRNA/cDNA for CCNP Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNP

Alternative Splicing Database (ASD) splice patterns (SP) for CCNP Gene

No ASD Table

Relevant External Links for CCNP Gene

GeneLoc Exon Structure for
CCNP

Expression for CCNP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNP

SOURCE GeneReport for Unigene cluster for CCNP Gene:

Hs.631603

mRNA Expression by UniProt/SwissProt for CCNP Gene:

Q9H8S5-CCNP_HUMAN
Tissue specificity: Expression is induced in lung and colon cancer cells.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNP Gene

Orthologs for CCNP Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCNP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CNTD2 30 31
  • 98.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CNTD2 30 31
  • 82.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CNTD2 30 31
  • 78.94 (n)
OneToOne
Species where no ortholog for CCNP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCNP Gene

ENSEMBL:
Gene Tree for CCNP (if available)
TreeFam:
Gene Tree for CCNP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNP: view image

Paralogs for CCNP Gene

genes like me logo Genes that share paralogs with CCNP: view

Variants for CCNP Gene

Additional dbSNP identifiers (rs#s) for CCNP Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNP Gene

Variant ID Type Subtype PubMed ID
esv2758761 CNV gain 17122850
esv3644344 CNV gain 21293372
esv3644345 CNV gain 21293372

Variation tolerance for CCNP Gene

Gene Damage Index Score: 1.33; 26.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNP Gene

Disorders for CCNP Gene

No disorders were found for CCNP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNP Gene

Publications for CCNP Gene

  1. The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration. (PMID: 30087414) Sánchez-Botet A … Clotet J (Scientific reports 2018) 2 3 4
  2. A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer. (PMID: 28860486) Gasa L … Clotet J (Scientific reports 2017) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Can sequencing shed light on cell cycling? (PMID: 11237006) Murray AW … Marks D (Nature 2001) 2 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for CCNP Gene

Sources for CCNP Gene