Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCNO Gene

Aliases for CCNO Gene

  • Cyclin O 2 3 5
  • Cyclin U 2 3
  • Cyclin Domain Containing 3
  • Cyclin-O 3
  • CILD29 3
  • UDG2 3
  • CCNU 3

External Ids for CCNO Gene

Previous HGNC Symbols for CCNO Gene

  • CCNU

Previous GeneCards Identifiers for CCNO Gene

  • GC05M054564
  • GC05M054565
  • GC05M054526
  • GC05M051499

Summaries for CCNO Gene

Entrez Gene Summary for CCNO Gene

  • This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

GeneCards Summary for CCNO Gene

CCNO (Cyclin O) is a Protein Coding gene. Diseases associated with CCNO include Ciliary Dyskinesia, Primary, 29 and Ciliary Dyskinesia, Primary, 1. Gene Ontology (GO) annotations related to this gene include protein kinase binding and uracil DNA N-glycosylase activity. An important paralog of this gene is CCNB3.

UniProtKB/Swiss-Prot for CCNO Gene

  • Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.

Gene Wiki entry for CCNO Gene

Additional gene information for CCNO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNO Gene

Genomics for CCNO Gene

GeneHancer (GH) Regulatory Elements for CCNO Gene

Promoters and enhancers for CCNO Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J055232 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 663.4 +0.1 77 3.3 ATF1 SIN3A GLI4 ZNF2 ZNF121 GLIS2 SP3 ZNF610 RFX3 ZSCAN16 LOC105378973 CCNO ENSG00000264281 MCIDAS
GH05J055159 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 19.9 +72.9 72926 2.4 FOXA2 INSM2 MZF1 SIN3A BRCA1 ZNF2 RAD21 YY1 RFX5 ZNF335 GPX8 CCNO LOC105378973 ENSG00000249016 LOC100130990 SNX18 CDC20B MIR449A
GH05J055175 Enhancer 1.4 FANTOM5 Ensembl ENCODE 23 +57.3 57317 1.2 ATF1 SIN3A ZNF2 ZNF48 ZNF766 GLIS2 ZNF213 ZNF143 ATF7 SP3 CCNO ENSG00000240535 LOC105378973 PIR47804 GC05P055180 CDC20B
GH05J055532 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.4 -301.0 -300973 3.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 KLF7 NFKBIZ RNF138P1 PLPP1 CCNO GC05M055517
GH05J055305 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 -73.8 -73799 4.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 MTREX DHX29 SLC38A9 ENSG00000264281 CCNO RNF138P1 GC05P055257
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNO on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNO gene promoter:
  • ZIC2
  • NF-1
  • GATA-1
  • Pax-6
  • Pax-3
  • CUTL1
  • Arnt
  • Tal-1beta
  • CP2
  • ITF-2

Genomic Locations for CCNO Gene

Genomic Locations for CCNO Gene
2,566 bases
Minus strand
2,529 bases
Minus strand

Genomic View for CCNO Gene

Genes around CCNO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNO Gene

Proteins for CCNO Gene

  • Protein details for CCNO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K1W5
    • Q0P6J2
    • Q9H6B0
    • Q9UMD5

    Protein attributes for CCNO Gene

    350 amino acids
    Molecular mass:
    38096 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB05817.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=CAA36728.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNO Gene


neXtProt entry for CCNO Gene

Post-translational modifications for CCNO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNO Gene

Domains & Families for CCNO Gene

Gene Families for CCNO Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CCNO Gene

Suggested Antigen Peptide Sequences for CCNO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family.
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNO: view

Function for CCNO Gene

Molecular function for CCNO Gene

UniProtKB/Swiss-Prot Function:
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.

Gene Ontology (GO) - Molecular Function for CCNO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004844 uracil DNA N-glycosylase activity IDA 12161446
genes like me logo Genes that share ontologies with CCNO: view
genes like me logo Genes that share phenotypes with CCNO: view

Human Phenotype Ontology for CCNO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CCNO Gene

MGI Knock Outs for CCNO:
  • Ccno Ccno<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for CCNO Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNO

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for CCNO Gene

Localization for CCNO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNO Gene

Cytoplasm. Note=Localizes to the apical part of cytoplasm. {ECO:0000269 PubMed:24747639}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNO gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCNO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 12161446
GO:0005737 cytoplasm IDA,IEA 24747639
genes like me logo Genes that share ontologies with CCNO: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCNO Gene

Pathways & Interactions for CCNO Gene

No Data Available

Pathways by source for CCNO Gene

1 GeneTex pathway for CCNO Gene

Gene Ontology (GO) - Biological Process for CCNO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IDA 8419333
GO:0006284 base-excision repair IDA 12161446
GO:0007049 cell cycle IEA --
GO:0030030 cell projection organization IEA --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with CCNO: view

No data available for SIGNOR curated interactions for CCNO Gene

Drugs & Compounds for CCNO Gene

(1) Drugs for CCNO Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCNO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNO: view

Transcripts for CCNO Gene

mRNA/cDNA for CCNO Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(66) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCNO Gene

Cyclin O:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNO

Alternative Splicing Database (ASD) splice patterns (SP) for CCNO Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP3: -

Relevant External Links for CCNO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNO Gene

mRNA differential expression in normal tissues according to GTEx for CCNO Gene

This gene is overexpressed in Pancreas (x5.1) and Testis (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCNO Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNO Gene:


SOURCE GeneReport for Unigene cluster for CCNO Gene:


mRNA Expression by UniProt/SwissProt for CCNO Gene:

Tissue specificity: Present in respiratory cells (at protein level).

Evidence on tissue expression from TISSUES for CCNO Gene

  • Pancreas(4.2)
  • Nervous system(4.1)
  • Blood(4)
  • Kidney(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNO Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeleton
  • urinary
Head and neck:
  • brain
  • cranial nerve
  • ear
  • epiglottis
  • eye
  • head
  • larynx
  • meninges
  • middle ear
  • mouth
  • neck
  • nose
  • olfactory bulb
  • outer ear
  • pharynx
  • sinus
  • skull
  • bronchus
  • lung
  • trachea
  • spleen
  • ovary
  • testicle
  • blood
  • blood vessel
  • peripheral nervous system
  • white blood cell
genes like me logo Genes that share expression patterns with CCNO: view

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for CCNO Gene

Orthologs for CCNO Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNO Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCNO 34 33
  • 99.43 (n)
(Canis familiaris)
Mammalia CCNO 34 33
  • 88.38 (n)
(Bos Taurus)
Mammalia CCNO 34 33
  • 87.84 (n)
(Mus musculus)
Mammalia Ccno 16 34 33
  • 81.52 (n)
(Rattus norvegicus)
Mammalia Ccno 33
  • 80.74 (n)
(Ornithorhynchus anatinus)
Mammalia CCNO 34
  • 68 (a)
(Monodelphis domestica)
Mammalia CCNO 34
  • 67 (a)
(Gallus gallus)
Aves CCNO 34 33
  • 75.03 (n)
(Anolis carolinensis)
Reptilia CCNO 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccno 33
  • 60.73 (n)
Str.1266 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33942 33
(Danio rerio)
Actinopterygii LOC101883490 33
  • 57.89 (n)
ccnd3 34
  • 21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycD 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
Species where no ortholog for CCNO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNO Gene

Gene Tree for CCNO (if available)
Gene Tree for CCNO (if available)
Evolutionary constrained regions (ECRs) for CCNO: view image

Paralogs for CCNO Gene

Paralogs for CCNO Gene

genes like me logo Genes that share paralogs with CCNO: view

Variants for CCNO Gene

Sequence variations from dbSNP and Humsavar for CCNO Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1060503388 pathogenic, Primary ciliary dyskinesia 55,231,653(-) G/A coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs114088695 likely-benign, benign, not provided, Primary ciliary dyskinesia 55,231,488(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs138440180 benign, Primary ciliary dyskinesia 55,231,638(-) C/A/G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs139167004 benign, Primary ciliary dyskinesia 55,231,648(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs139606873 likely-benign, Primary ciliary dyskinesia 55,233,390(-) G/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNO Gene

Variant ID Type Subtype PubMed ID
nsv1027090 CNV gain 25217958
nsv830302 CNV gain 17160897

Variation tolerance for CCNO Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNO Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNO Gene

Disorders for CCNO Gene

MalaCards: The human disease database

(4) MalaCards diseases for CCNO Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ciliary dyskinesia, primary, 29
  • cild29
ciliary dyskinesia, primary, 1
  • cild1
kartagener syndrome
  • kartagener's syndrome
visceral heterotaxy
  • heterotaxia
- elite association - COSMIC cancer census association via MalaCards
Search CCNO in MalaCards View complete list of genes associated with diseases


  • Ciliary dyskinesia, primary, 29 (CILD29) [MIM:615872]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD29 patients do not exhibit situs inversus, a congenital abnormality in which visceral organs are opposite to their normal positions (situs solitus) due to lateral transposition. {ECO:0000269 PubMed:24747639, ECO:0000269 PubMed:26777464}. Note=The disease is caused by mutations affecting the gene represented in this entry. Marked reduction of cilia in multiciliate cells due to defective mother centriole generation and placement. Remaining cilia correctly express axonemal motor proteins, are motile and do not show beating defects. Defects are probably caused by a strong reduction in the number of multiple motile cilia covering the cell surface in respiratory epithelial cells (PubMed:24747639). {ECO:0000269 PubMed:24747639}.

Additional Disease Information for CCNO

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCNO: view

No data available for Genatlas for CCNO Gene

Publications for CCNO Gene

  1. Systematic Analysis of CCNO Variants in a Defined Population: Implications for Clinical Phenotype and Differential Diagnosis. (PMID: 26777464) Amirav I … Israeli PCD Consortium Investigators (Human mutation 2016) 3 4 58
  2. Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia. (PMID: 24747639) Wallmeier J … Omran H (Nature genetics 2014) 3 4 58
  3. The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues. (PMID: 16697536) Hirst R … Miller D (Gene 2006) 4 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58

Products for CCNO Gene

Sources for CCNO Gene

Loading form....