Aliases for CCNO Gene
External Ids for CCNO Gene
Previous HGNC Symbols for CCNO Gene
Previous GeneCards Identifiers for CCNO Gene
This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]
GeneCards Summary for CCNO Gene
CCNO (Cyclin O) is a Protein Coding gene. Diseases associated with CCNO include Ciliary Dyskinesia, Primary, 29 and Primary Ciliary Dyskinesia. Gene Ontology (GO) annotations related to this gene include protein kinase binding and uracil DNA N-glycosylase activity. An important paralog of this gene is CCNB1.
UniProtKB/Swiss-Prot for CCNO Gene
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.