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Aliases for CCNL2 Gene

Aliases for CCNL2 Gene

  • Cyclin L2 2 3 5
  • Paneth Cell-Enhanced Expression Protein 3 4
  • Cyclin M 2 3
  • Cyclin S 2 3
  • Cyclin-L2 3
  • HCLA-ISO 3
  • ANIA-6B 3
  • HLA-ISO 3
  • SB138 3
  • CCNS 3
  • PCEE 3
  • CCNM 3

External Ids for CCNL2 Gene

Previous HGNC Symbols for CCNL2 Gene

  • CCNM

Previous GeneCards Identifiers for CCNL2 Gene

  • GC01M001073
  • GC01M001247
  • GC01M001276
  • GC01P9A0164
  • GC01P8D0164
  • GC01M001312
  • GC01M000593
  • GC01M001321

Summaries for CCNL2 Gene

Entrez Gene Summary for CCNL2 Gene

  • The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CCNL2 Gene

CCNL2 (Cyclin L2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNL1.

UniProtKB/Swiss-Prot for CCNL2 Gene

  • Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.

Gene Wiki entry for CCNL2 Gene

Additional gene information for CCNL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNL2 Gene

Genomics for CCNL2 Gene

GeneHancer (GH) Regulatory Elements for CCNL2 Gene

Promoters and enhancers for CCNL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001397 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 709.6 -0.8 -776 5.5 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 CCNL2 LOC148413 INTS11 ATAD3B ENSG00000240731 LOC100288379 ENSG00000230092 SLC35E2A LOC100129381 CDK11A
GH01J001775 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 53.4 -380.2 -380188 8.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 NADK INTS11 CCNL2 CDK11A ATAD3B ENSG00000230092 ENSG00000240731 FAAP20 LOC100288379 LINC00115
GH01J000998 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 42.4 +398.8 398849 3.8 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ISG15 HES4 ATAD3B WASH7P INTS11 ENSG00000230092 ENSG00000240731 CDK11A CCNL2 LOC100288379
GH01J001373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 41 +24.2 24215 3.9 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 AURKAIP1 GC01M001374 ENSG00000230092 CDK11A ATAD3B LOC100288379 ENSG00000237094 CCNL2 SDF4 LOC100288069
GH01J001303 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 34.9 +92.1 92133 6.9 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PUSL1 ACAP3 ATAD3B INTS11 ENSG00000240731 SLC35E2A CCNL2 LINC00115 FAAP20 LOC100288379
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNL2 gene promoter:
  • E47
  • Tal-1beta
  • NCX
  • Lmo2
  • POU2F1a
  • Gfi-1
  • POU2F1
  • MyoD
  • c-Myc

Genomic Locations for CCNL2 Gene

Genomic Locations for CCNL2 Gene
chr1:1,385,711-1,399,338
(GRCh38/hg38)
Size:
13,628 bases
Orientation:
Minus strand
chr1:1,321,091-1,334,718
(GRCh37/hg19)
Size:
13,628 bases
Orientation:
Minus strand

Genomic View for CCNL2 Gene

Genes around CCNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNL2 Gene

Proteins for CCNL2 Gene

  • Protein details for CCNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S94-CCNL2_HUMAN
    Recommended name:
    Cyclin-L2
    Protein Accession:
    Q96S94
    Secondary Accessions:
    • A0A024R072
    • A0A024R077
    • A0A0C4DGC4
    • A8K8A3
    • B1B152
    • F2Z3J5
    • Q5T2N5
    • Q5T2N6
    • Q6IQ12
    • Q7Z4Z8
    • Q8N3C9
    • Q8N3D5
    • Q8NHE3
    • Q8TEL0
    • Q96B00

    Protein attributes for CCNL2 Gene

    Size:
    520 amino acids
    Molecular mass:
    58147 Da
    Quaternary structure:
    • Interacts with CDK11A, CDK11B, CDK12, CDK13 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II (PubMed:14684736, PubMed:18216018). May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:14684736, PubMed:18216018).
    SequenceCaution:
    • Sequence=AAH71622.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB84938.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNL2 Gene

Post-translational modifications for CCNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNL2 Gene

Domains & Families for CCNL2 Gene

Gene Families for CCNL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CCNL2 Gene

Suggested Antigen Peptide Sequences for CCNL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96S94

UniProtKB/Swiss-Prot:

CCNL2_HUMAN :
  • Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).
  • Belongs to the cyclin family. Cyclin L subfamily.
Domain:
  • Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).
Family:
  • Belongs to the cyclin family. Cyclin L subfamily.
genes like me logo Genes that share domains with CCNL2: view

Function for CCNL2 Gene

Molecular function for CCNL2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.

Phenotypes From GWAS Catalog for CCNL2 Gene

Gene Ontology (GO) - Molecular Function for CCNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA --
genes like me logo Genes that share ontologies with CCNL2: view
genes like me logo Genes that share phenotypes with CCNL2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNL2 Gene

Localization for CCNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNL2 Gene

Nucleus speckle. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNL2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA --
GO:0005634 nucleus IEA,IDA 17494991
GO:0005654 nucleoplasm IEA,IDA --
GO:0016607 nuclear speck IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CCNL2: view

Pathways & Interactions for CCNL2 Gene

SuperPathways for CCNL2 Gene

No Data Available

Pathways by source for CCNL2 Gene

1 GeneTex pathway for CCNL2 Gene

Gene Ontology (GO) - Biological Process for CCNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA --
GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain IBA --
genes like me logo Genes that share ontologies with CCNL2: view

No data available for SIGNOR curated interactions for CCNL2 Gene

Drugs & Compounds for CCNL2 Gene

(1) Drugs for CCNL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCNL2: view

Transcripts for CCNL2 Gene

Unigene Clusters for CCNL2 Gene

Cyclin L2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNL2 Gene

No ASD Table

Relevant External Links for CCNL2 Gene

GeneLoc Exon Structure for
CCNL2
ECgene alternative splicing isoforms for
CCNL2

Expression for CCNL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNL2 Gene

Protein differential expression in normal tissues from HIPED for CCNL2 Gene

This gene is overexpressed in CD8 Tcells (30.4), Blymphocyte (18.8), and NK cells (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCNL2 Gene



Protein tissue co-expression partners for CCNL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNL2 Gene:

CCNL2

SOURCE GeneReport for Unigene cluster for CCNL2 Gene:

Hs.515704

mRNA Expression by UniProt/SwissProt for CCNL2 Gene:

Q96S94-CCNL2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for CCNL2 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Spleen(4.4)
  • Bone marrow(4.3)
  • Bone(4)
  • Lung(3.2)
  • Intestine(2.6)
  • Kidney(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CCNL2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNL2 Gene

Orthologs for CCNL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNL2 34 33
  • 99.36 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnl2 33
  • 88.3 (n)
cow
(Bos Taurus)
Mammalia CCNL2 34 33
  • 88.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCNL2 34 33
  • 87.75 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnl2 16 34 33
  • 85.76 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToMany
-- 34
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCNL2 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNL2 34 33
  • 75.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNL2 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnl2 33
  • 66.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16542 33
fruit fly
(Drosophila melanogaster)
Insecta CG16903 34
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyl-1 34
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN8 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
Species where no ortholog for CCNL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CCNL2 Gene

ENSEMBL:
Gene Tree for CCNL2 (if available)
TreeFam:
Gene Tree for CCNL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNL2: view image

Paralogs for CCNL2 Gene

Paralogs for CCNL2 Gene

(3) SIMAP similar genes for CCNL2 Gene using alignment to 5 proteins:

  • CCNL2_HUMAN
  • C9J148_HUMAN
  • F2Z3J5_HUMAN
  • J3KRL1_HUMAN
  • J3QSH2_HUMAN

Pseudogenes.org Pseudogenes for CCNL2 Gene

genes like me logo Genes that share paralogs with CCNL2: view

Variants for CCNL2 Gene

Sequence variations from dbSNP and Humsavar for CCNL2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000027876 -- 1,395,842(-) T/C intron_variant
rs1000308546 -- 1,392,445(-) G/A/C 3_prime_UTR_variant, 5_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000334281 -- 1,397,605(-) T/C intron_variant
rs1000366882 -- 1,397,805(-) T/C intron_variant
rs1000553473 -- 1,391,478(-) C/T 5_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNL2 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
esv2758913 CNV gain+loss 17122850
esv3584994 CNV gain 21293372
nsv1009541 CNV gain 25217958
nsv1011818 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv482937 CNV loss 15286789
nsv950452 CNV deletion 24416366

Variation tolerance for CCNL2 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNL2 Gene

Disorders for CCNL2 Gene

Additional Disease Information for CCNL2

No disorders were found for CCNL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNL2 Gene

Publications for CCNL2 Gene

  1. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. (PMID: 14684736) Yang L … Cao X (The Journal of biological chemistry 2004) 3 4 22 58
  2. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. (PMID: 18216018) Loyer P … Lahti JM (The Journal of biological chemistry 2008) 3 4 58
  3. Characterization of cyclin L1 as an immobile component of the splicing factor compartment. (PMID: 17494991) Herrmann A … Becker W (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007) 3 22 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. Cyclin S: a new member of the cyclin family plays a role in long-term memory. (PMID: 14725631) Edelheit S … Meiri N (The European journal of neuroscience 2004) 2 3 58

Products for CCNL2 Gene

Sources for CCNL2 Gene

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