External Ids for CCNK Gene
Previous GeneCards Identifiers for CCNK Gene
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNK Gene
CCNK (Cyclin K) is a Protein Coding gene. Diseases associated with CCNK include Intellectual Developmental Disorder With Hypertelorism And Distinctive Facies and Hypertelorism. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and RNA polymerase II CTD heptapeptide repeat kinase activity. An important paralog of this gene is CCNT1.
UniProtKB/Swiss-Prot for CCNK Gene
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).