Aliases for CCNJ Gene

Aliases for CCNJ Gene

  • Cyclin J 2 3 5
  • Cyclin-J 3 4
  • BA690P14.1 3

External Ids for CCNJ Gene

Previous GeneCards Identifiers for CCNJ Gene

  • GC10P097468
  • GC10P097793
  • GC10P091430

Summaries for CCNJ Gene

GeneCards Summary for CCNJ Gene

CCNJ (Cyclin J) is a Protein Coding gene. An important paralog of this gene is CCNJL.

Additional gene information for CCNJ Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNJ Gene

Genomics for CCNJ Gene

GeneHancer (GH) Regulatory Elements for CCNJ Gene

Promoters and enhancers for CCNJ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J096042 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +2.6 2627 3.6 ZBTB40 SP1 ZBTB6 POLR2A CTBP1 FOS ZNF362 MYC NFYC ELF1 CCNJ ZNF518A piR-38351-057 ENTPD1-AS1
GH10J096040 Enhancer 0.2 ENCODE 750.6 -0.6 -599 1.2 CCNJ ZNF518A ENTPD1-AS1 RPL21P90
GH10J096088 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 37.5 +48.1 48110 2.2 ZNF785 SIN3A SP1 ZBTB40 ZBTB6 RBPJ POLR2A ATF1 CREB1 HCFC1 ENTPD1-AS1 ZNF518A CCNJ NPM1P26 TCTN3 RPL13AP5 LCOR RNU6-271P TM9SF3 CC2D2B
GH10J096128 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 30.8 +88.8 88822 3.6 ZNF785 SIN3A SP1 ZBTB40 ZBTB6 LCORL RBPJ POLR2A ATF1 CREB1 ZNF518A ENSG00000287009 lnc-CCNJ-1 lnc-BLNK-4 CCNJ NPM1P26 RPL13AP5 TCTN3 LCOR ENTPD1-AS1
GH10J095286 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.1 -749.6 -749560 11.8 SP1 ZBTB40 SMARCE1 POLR2A CTBP1 ZNF362 ETV6 RELA L3MBTL2 CEBPB PDLIM1 lnc-ACSM6-1 TCTN3 ENSG00000273450 NOC3L CCNJ ZNF518A TBC1D12 CYP2C8 ENTPD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNJ on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNJ gene promoter:
  • AhR
  • ATF6
  • c-Myb
  • Chx10
  • ITF-2
  • MyoD
  • RORalpha2
  • STAT3
  • Tal-1beta

Genomic Locations for CCNJ Gene

Genomic Locations for CCNJ Gene
chr10:96,041,774-96,060,870
(GRCh38/hg38)
Size:
19,097 bases
Orientation:
Plus strand
chr10:97,803,151-97,820,627
(GRCh37/hg19)
Size:
17,477 bases
Orientation:
Plus strand

Genomic View for CCNJ Gene

Genes around CCNJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNJ Gene

Proteins for CCNJ Gene

  • Protein details for CCNJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T5M9-CCNJ_HUMAN
    Recommended name:
    Cyclin-J
    Protein Accession:
    Q5T5M9
    Secondary Accessions:
    • B7Z4E7
    • Q86XL1
    • Q9NV69

    Protein attributes for CCNJ Gene

    Size:
    372 amino acids
    Molecular mass:
    42581 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91887.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNJ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNJ Gene

Post-translational modifications for CCNJ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNJ Gene

Domains & Families for CCNJ Gene

Gene Families for CCNJ Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNJ Gene

Suggested Antigen Peptide Sequences for CCNJ Gene

GenScript: Design optimal peptide antigens:
  • Cyclin-J (CCNJ_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T5M9

UniProtKB/Swiss-Prot:

CCNJ_HUMAN :
  • Belongs to the cyclin family.
Family:
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNJ: view

Function for CCNJ Gene

Phenotypes From GWAS Catalog for CCNJ Gene

Gene Ontology (GO) - Molecular Function for CCNJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 contributes_to protein kinase activity IBA 21873635
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with CCNJ: view
genes like me logo Genes that share phenotypes with CCNJ: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNJ Gene

Localization for CCNJ Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNJ gene
Compartment Confidence
nucleus 4
extracellular 1
peroxisome 1
cytosol 1
golgi apparatus 1
plasma membrane 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CCNJ: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNJ Gene

Pathways & Interactions for CCNJ Gene

PathCards logo

SuperPathways for CCNJ Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0044772 mitotic cell cycle phase transition IBA 21873635
genes like me logo Genes that share ontologies with CCNJ: view

No data available for Pathways by source and SIGNOR curated interactions for CCNJ Gene

Drugs & Compounds for CCNJ Gene

No Compound Related Data Available

Transcripts for CCNJ Gene

mRNA/cDNA for CCNJ Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNJ Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3:
SP4:
SP5: - -

Relevant External Links for CCNJ Gene

GeneLoc Exon Structure for
CCNJ
ECgene alternative splicing isoforms for
CCNJ

Expression for CCNJ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNJ Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNJ Gene:

CCNJ

SOURCE GeneReport for Unigene cluster for CCNJ Gene:

Hs.596479

Evidence on tissue expression from TISSUES for CCNJ Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CCNJ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNJ Gene

Orthologs for CCNJ Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNJ 33 32
  • 99.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCNJ 33 32
  • 93.56 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNJ 33
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNJ 33 32
  • 92.08 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNJ 33
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnj 32
  • 87.77 (n)
mouse
(Mus musculus)
Mammalia Ccnj 17 33 32
  • 87.25 (n)
chicken
(Gallus gallus)
Aves CCNJ 33 32
  • 78.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNJ 33
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnj 32
  • 71.03 (n)
Str.1408 32
zebrafish
(Danio rerio)
Actinopterygii LOC557593 32
  • 66.48 (n)
CCNJ 33
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycJ 33
  • 22 (a)
OneToMany
Species where no ortholog for CCNJ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNJ Gene

ENSEMBL:
Gene Tree for CCNJ (if available)
TreeFam:
Gene Tree for CCNJ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNJ: view image

Paralogs for CCNJ Gene

(1) SIMAP similar genes for CCNJ Gene using alignment to 2 proteins:

  • CCNJ_HUMAN
  • L8EA46_HUMAN

Pseudogenes.org Pseudogenes for CCNJ Gene

genes like me logo Genes that share paralogs with CCNJ: view

Variants for CCNJ Gene

Sequence variations from dbSNP and Humsavar for CCNJ Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000079410 -- 96,042,949(+) G/A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000187916 -- 96,051,560(+) T/C intron_variant
rs1000237337 -- 96,060,271(+) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000296120 -- 96,042,755(+) C/T upstream_transcript_variant
rs1000391610 -- 96,042,390(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNJ Gene

Variant ID Type Subtype PubMed ID
esv3579077 CNV loss 25503493
nsv1110852 OTHER inversion 24896259
nsv825529 CNV loss 20364138

Variation tolerance for CCNJ Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNJ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNJ

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNJ Gene

Disorders for CCNJ Gene

Additional Disease Information for CCNJ

No disorders were found for CCNJ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNJ Gene

Publications for CCNJ Gene

  1. CCNJ detected by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma. (PMID: 25672416) Takano N … Nomoto S (International journal of oncology 2015) 2 3 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J. (PMID: 28202053) Shi L … Ke B (BMC cancer 2017) 3 56
  5. MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. (PMID: 27157613) Venturutti L … Elizalde PV (Oncogene 2016) 3 56

Products for CCNJ Gene

Sources for CCNJ Gene