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Aliases for CCNI2 Gene

Aliases for CCNI2 Gene

  • Cyclin I Family Member 2 2 3 5
  • Cyclin I Family, Member 2 2
  • Cyclin-I2 3

External Ids for CCNI2 Gene

Previous GeneCards Identifiers for CCNI2 Gene

  • GC05P132112
  • GC05P127275

Summaries for CCNI2 Gene

GeneCards Summary for CCNI2 Gene

CCNI2 (Cyclin I Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNI.

Additional gene information for CCNI2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNI2 Gene

Genomics for CCNI2 Gene

GeneHancer (GH) Regulatory Elements for CCNI2 Gene

Promoters and enhancers for CCNI2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I132746 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.4 353 1.7 RAD21 ZNF335 ZNF121 GLIS2 ZNF143 ATF7 BCLAF1 RUNX3 SMARCA5 ZNF654 CCNI2 SEPT8 GC05P132732 GC05M132777 GC05M132776
GH05I132770 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 12.5 +27.1 27092 7.9 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF143 ZNF263 SP3 SEPT8 GC05M132776 GC05M132777 IL4 ENSG00000202533 LOC105379175 CCNI2 KIF3A SOWAHA AFF4
GH05I132812 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 11 +68.2 68192 5.4 BMI1 YY1 ZNF335 GLIS2 KLF13 EGR2 ZNF202 ZNF362 CEBPB ZEB2 SOWAHA IL4 GDF9 RAD50 AFF4 RNU7-15P RNA5SP192 CCNI2 UQCRQ KIF3A
GH05I132818 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.7 +72.4 72392 2.2 HDGF ATF1 FOXA2 ARNT ARID4B ZNF2 IRF4 YY1 ARID2 ZNF143 ENSG00000272203 IL4 GDF9 ENSG00000202533 LOC105379175 RNU7-15P RNA5SP192 AFF4 UQCRQ C5orf56
GH05I132781 Enhancer 0.9 Ensembl dbSUPER 11.9 +34.9 34886 0.6 JUN TEAD4 MAX RELA FOSL1 MTA3 CTBP1 POLR2A ZNF157 VEZF1 KIF3A CCNI2 SOWAHA RNU7-15P RNA5SP192 IL13 TH2LCRR GC05M132776 GC05M132777 SEPT8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCNI2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNI2 gene promoter:

Genomic Locations for CCNI2 Gene

Genomic Locations for CCNI2 Gene
chr5:132,747,411-132,756,255
(GRCh38/hg38)
Size:
8,845 bases
Orientation:
Plus strand
chr5:132,083,137-132,089,856
(GRCh37/hg19)

Genomic View for CCNI2 Gene

Genes around CCNI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNI2 Gene

Proteins for CCNI2 Gene

  • Protein details for CCNI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMN8-CCNI2_HUMAN
    Recommended name:
    Cyclin-I2
    Protein Accession:
    Q6ZMN8
    Secondary Accessions:
    • B2RNE2
    • B7ZMB7
    • B7ZMB8

    Protein attributes for CCNI2 Gene

    Size:
    369 amino acids
    Molecular mass:
    40622 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNI2 Gene

Post-translational modifications for CCNI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNI2 Gene

No data available for DME Specific Peptides for CCNI2 Gene

Domains & Families for CCNI2 Gene

Gene Families for CCNI2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNI2 Gene

Suggested Antigen Peptide Sequences for CCNI2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMN8

UniProtKB/Swiss-Prot:

CCNI2_HUMAN :
  • Belongs to the cyclin family.
Family:
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNI2: view

Function for CCNI2 Gene

Phenotypes From GWAS Catalog for CCNI2 Gene

Phenotypes for CCNI2 Gene

GenomeRNAi human phenotypes for CCNI2:
genes like me logo Genes that share phenotypes with CCNI2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNI2 Gene

Localization for CCNI2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNI2 gene
Compartment Confidence
nucleus 3
peroxisome 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCNI2 Gene

Pathways & Interactions for CCNI2 Gene

SuperPathways for CCNI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNI2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCNI2 Gene

Drugs & Compounds for CCNI2 Gene

No Compound Related Data Available

Transcripts for CCNI2 Gene

mRNA/cDNA for CCNI2 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCNI2 Gene

Cyclin I family, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNI2 Gene

No ASD Table

Relevant External Links for CCNI2 Gene

GeneLoc Exon Structure for
CCNI2
ECgene alternative splicing isoforms for
CCNI2

Expression for CCNI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNI2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNI2 Gene:

CCNI2

SOURCE GeneReport for Unigene cluster for CCNI2 Gene:

Hs.714496

Evidence on tissue expression from TISSUES for CCNI2 Gene

  • Pancreas(4.8)
  • Lung(4.6)
  • Intestine(4.1)
  • Nervous system(4)
  • Bone(3.9)
  • Eye(3.1)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with CCNI2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNI2 Gene

Orthologs for CCNI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNI2 33 34
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia CCNI2 33 34
  • 86.99 (n)
cow
(Bos Taurus)
Mammalia CCNI2 33 34
  • 75.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNI2 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNI2 34
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNI2 34
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccni2 34
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycG 34
  • 11 (a)
OneToMany
Species where no ortholog for CCNI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNI2 Gene

ENSEMBL:
Gene Tree for CCNI2 (if available)
TreeFam:
Gene Tree for CCNI2 (if available)

Paralogs for CCNI2 Gene

Paralogs for CCNI2 Gene

(1) SIMAP similar genes for CCNI2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCNI2: view

Variants for CCNI2 Gene

Sequence variations from dbSNP and Humsavar for CCNI2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000861189 -- 132,750,369(+) G/A intron_variant
rs1000893645 -- 132,750,028(+) G/A intron_variant
rs1001225027 -- 132,751,583(+) A/G intron_variant
rs1001569119 -- 132,747,945(+) G/A intron_variant
rs1002105270 -- 132,747,154(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNI2 Gene

Variant ID Type Subtype PubMed ID
esv3606809 CNV gain 21293372
nsv528687 CNV gain 19592680
nsv529021 CNV loss 19592680

Variation tolerance for CCNI2 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNI2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNI2 Gene

Disorders for CCNI2 Gene

Additional Disease Information for CCNI2

No disorders were found for CCNI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNI2 Gene

Publications for CCNI2 Gene

  1. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. (PMID: 23707792) Taneera J … Groop L (Molecular and cellular endocrinology 2013) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for CCNI2 Gene

Sources for CCNI2 Gene

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