Aliases for CCNI2 Gene

Aliases for CCNI2 Gene

  • Cyclin I Family Member 2 2 3 5
  • Cyclin-I2 3 4
  • Cyclin I Family, Member 2 2
  • FLJ16793 2
  • CCNI2 5

External Ids for CCNI2 Gene

Previous GeneCards Identifiers for CCNI2 Gene

  • GC05P132112
  • GC05P127275

Summaries for CCNI2 Gene

GeneCards Summary for CCNI2 Gene

CCNI2 (Cyclin I Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNI.

Additional gene information for CCNI2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNI2 Gene

Genomics for CCNI2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNI2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J132746 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 600.7 +0.3 286 1.8 CTCF TEAD4 KDM1A ZNF692 BACH1 LARP7 ZIC2 PATZ1 TRIM22 EZH2 CCNI2 SEPTIN8 lnc-KIF3A-2
GH05J132770 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.5 +27.1 27077 7.9 GATAD2A TEAD4 PRDM10 SIX5 LEF1 IKZF1 ZNF692 ETV6 LARP7 MTA2 SEPTIN8 IL4 ENSG00000202533 ENSG00000234290 AFF4 CCNI2 KIF3A RAD50 SOWAHA SHROOM1
GH05J132812 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 11 +68.1 68137 5.5 ZNF629 ZNF692 BACH1 PRDM1 ZIC2 POLR2A PATZ1 NR2C1 EZH2 ZNF600 IL4 GDF9 RAD50 AFF4 RNU7-15P RNA5SP192 UQCRQ CCNI2 KIF3A ZCCHC10
GH05J132781 Enhancer 0.8 Ensembl dbSUPER 16.2 +35.3 35274 1.8 JUND SCRT2 MGA MTA3 CTBP1 ZNF157 E2F5 FOS MYC EP400 SEPTIN8 KIF3A CCNI2 SOWAHA RNU7-15P RNA5SP192 TH2LCRR IL13 lnc-SHROOM1-2 lnc-KIF3A-3
GH05J132818 Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 10.7 +72.4 72377 2.2 GATAD2A CTCF ZNF629 REST ZNF692 JUND PRDM1 ZNF143 RXRB ZNF24 ENSG00000272203 IL4 GDF9 ENSG00000202533 ENSG00000234290 RNU7-15P RNA5SP192 AFF4 UQCRQ IRF1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNI2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNI2

Top Transcription factor binding sites by QIAGEN in the CCNI2 gene promoter:
  • AhR
  • aMEF-2
  • AREB6
  • COMP1
  • HEN1
  • MEF-2A
  • Sox5
  • SRF
  • SRF (504 AA)
  • TBP

Genomic Locations for CCNI2 Gene

Genomic Locations for CCNI2 Gene
chr5:132,747,426-132,754,403
(GRCh38/hg38)
Size:
6,978 bases
Orientation:
Plus strand
chr5:132,083,137-132,089,856
(GRCh37/hg19)
Size:
6,720 bases
Orientation:
Plus strand

Genomic View for CCNI2 Gene

Genes around CCNI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNI2 Gene

Proteins for CCNI2 Gene

  • Protein details for CCNI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMN8-CCNI2_HUMAN
    Recommended name:
    Cyclin-I2
    Protein Accession:
    Q6ZMN8
    Secondary Accessions:
    • B2RNE2
    • B7ZMB7
    • B7ZMB8

    Protein attributes for CCNI2 Gene

    Size:
    369 amino acids
    Molecular mass:
    40622 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNI2 Gene

Post-translational modifications for CCNI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNI2 Gene

No data available for DME Specific Peptides for CCNI2 Gene

Domains & Families for CCNI2 Gene

Gene Families for CCNI2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNI2 Gene

Suggested Antigen Peptide Sequences for CCNI2 Gene

GenScript: Design optimal peptide antigens:
  • CCNI2 protein (B7ZMB7_HUMAN)
  • CCNI2 protein (B7ZMB8_HUMAN)
  • Cyclin-I2 (CCNI2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZMN8

UniProtKB/Swiss-Prot:

CCNI2_HUMAN :
  • Belongs to the cyclin family.
Family:
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNI2: view

Function for CCNI2 Gene

Phenotypes From GWAS Catalog for CCNI2 Gene

Gene Ontology (GO) - Molecular Function for CCNI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with CCNI2: view

Phenotypes for CCNI2 Gene

genes like me logo Genes that share phenotypes with CCNI2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNI2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNI2 Gene

Localization for CCNI2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNI2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CCNI2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNI2 Gene

Pathways & Interactions for CCNI2 Gene

PathCards logo

SuperPathways for CCNI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0044772 mitotic cell cycle phase transition IBA 21873635
genes like me logo Genes that share ontologies with CCNI2: view

No data available for Pathways by source and SIGNOR curated interactions for CCNI2 Gene

Drugs & Compounds for CCNI2 Gene

No Compound Related Data Available

Transcripts for CCNI2 Gene

mRNA/cDNA for CCNI2 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNI2

Alternative Splicing Database (ASD) splice patterns (SP) for CCNI2 Gene

No ASD Table

Relevant External Links for CCNI2 Gene

GeneLoc Exon Structure for
CCNI2

Expression for CCNI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNI2

SOURCE GeneReport for Unigene cluster for CCNI2 Gene:

Hs.714496

Evidence on tissue expression from TISSUES for CCNI2 Gene

  • Pancreas(4.8)
  • Nervous system(4.8)
  • Lung(4.6)
  • Intestine(4.1)
  • Bone(3.9)
  • Eye(3.1)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with CCNI2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNI2 Gene

Orthologs for CCNI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNI2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCNI2 30 31
  • 99.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCNI2 30 31
  • 86.99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCNI2 30 31
  • 75.14 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCNI2 31
  • 36 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCNI2 31
  • 37 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCNI2 31
  • 38 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ccni2 31
  • 37 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CycG 31
  • 11 (a)
OneToMany
Species where no ortholog for CCNI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCNI2 Gene

ENSEMBL:
Gene Tree for CCNI2 (if available)
TreeFam:
Gene Tree for CCNI2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNI2: view image

Paralogs for CCNI2 Gene

(1) SIMAP similar genes for CCNI2 Gene using alignment to 3 proteins:

  • CCNI2_HUMAN
  • B7ZMB7_HUMAN
  • B7ZMB8_HUMAN
genes like me logo Genes that share paralogs with CCNI2: view

Variants for CCNI2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNI2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs803056 - p.Ala91Pro

Additional dbSNP identifiers (rs#s) for CCNI2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNI2 Gene

Variant ID Type Subtype PubMed ID
esv3606809 CNV gain 21293372
nsv528687 CNV gain 19592680
nsv529021 CNV loss 19592680

Variation tolerance for CCNI2 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNI2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNI2 Gene

Disorders for CCNI2 Gene

No disorders were found for CCNI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNI2 Gene

Publications for CCNI2 Gene

  1. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. (PMID: 23707792) Taneera J … Groop L (Molecular and cellular endocrinology 2013) 2 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation. (PMID: 28112194) Liu C … Xu Z (Scientific reports 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for CCNI2 Gene

Sources for CCNI2 Gene