The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cycli... See more...

Aliases for CCNI Gene

Aliases for CCNI Gene

  • Cyclin I 2 3 5
  • Cyclin-I 3 4
  • CCNI1 2 3
  • Cyclin ITI 3
  • CYC1 3
  • CCNI 5
  • CYI 3

External Ids for CCNI Gene

Previous GeneCards Identifiers for CCNI Gene

  • GC04M077878
  • GC04M078159
  • GC04M078361
  • GC04M078427
  • GC04M078326
  • GC04M077968
  • GC04M073720

Summaries for CCNI Gene

Entrez Gene Summary for CCNI Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]

GeneCards Summary for CCNI Gene

CCNI (Cyclin I) is a Protein Coding gene. Diseases associated with CCNI include Epilepsy, Familial Temporal Lobe, 3 and 3-Methylglutaconic Aciduria, Type I. An important paralog of this gene is CCNI2.

Gene Wiki entry for CCNI Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNI Gene

Genomics for CCNI Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNI Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J077072 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.2 1164 6 CEBPG SP1 CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST ZNF512 LEF1 CCNI lnc-SEPT11-2 lnc-SOWAHB-7 NUP54 CNOT6L RPL7P17 lnc-SOWAHB-6 SEPTIN11
GH04J077052 Enhancer 1 Ensembl ENCODE dbSUPER 12.9 +23.4 23439 0.9 CTCF PKNOX1 REST RAD21 SCRT2 HMBOX1 CEBPB ZNF444 SMC3 SMARCA5 lnc-SOWAHB-6 CCNI SEPTIN11 lnc-SOWAHB-7
GH04J077175 Enhancer 1 Ensembl ENCODE CraniofacialAtlas dbSUPER 12 -100.7 -100688 5.3 TEAD4 POLR2A EZH2 USF1 ZBTB17 SMARCA4 NANOG SP1 CCNI CCNG2 LOC107986292 lnc-CCNI-3 CXCL13
GH04J077171 Enhancer 0.8 Ensembl ENCODE dbSUPER 12 -96.2 -96211 2.4 CEBPB FOS BHLHE40 NFE2L2 CCNI CCNG2 lnc-CCNI-3 LOC107986292 CXCL13
GH04J077196 Enhancer 0.7 Ensembl ENCODE 12.7 -121.4 -121412 2.4 EED RUNX3 JUNB EBF1 ATF7 SPI1 IKZF1 CCNI CCNG2 lnc-CXCL13-1 lnc-CCNI-4 FTLP9 CXCL13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNI on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNI

Top Transcription factor binding sites by QIAGEN in the CCNI gene promoter:
  • C/EBPalpha
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • NCX
  • Nkx2-5
  • STAT3
  • STAT5B

Genomic Locations for CCNI Gene

Genomic Locations for CCNI Gene
chr4:77,047,155-77,075,989
(GRCh38/hg38)
Size:
28,835 bases
Orientation:
Minus strand
chr4:77,968,311-77,997,158
(GRCh37/hg19)
Size:
28,848 bases
Orientation:
Minus strand

Genomic View for CCNI Gene

Genes around CCNI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNI Gene

Proteins for CCNI Gene

  • Protein details for CCNI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14094-CCNI_HUMAN
    Recommended name:
    Cyclin-I
    Protein Accession:
    Q14094
    Secondary Accessions:
    • B2R6M0
    • B7Z6X4

    Protein attributes for CCNI Gene

    Size:
    377 amino acids
    Molecular mass:
    42557 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNI Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNI Gene

Post-translational modifications for CCNI Gene

  • Ubiquitination at Lys2 and Lys18
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCNI Gene

Domains & Families for CCNI Gene

Gene Families for CCNI Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNI Gene

InterPro:
Blocks:
  • Cyclin
ProtoNet:

Suggested Antigen Peptide Sequences for CCNI Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50245, highly similar to Cyclin-I (B7Z6X4_HUMAN)
  • Cyclin-I (CCNI_HUMAN)
  • CCNI protein (Q6FHH0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14094

UniProtKB/Swiss-Prot:

CCNI_HUMAN :
  • Belongs to the cyclin family.
Family:
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNI: view

Function for CCNI Gene

Phenotypes From GWAS Catalog for CCNI Gene

Gene Ontology (GO) - Molecular Function for CCNI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0005515 protein binding IPI 25852190
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with CCNI: view
genes like me logo Genes that share phenotypes with CCNI: view

Animal Models for CCNI Gene

MGI Knock Outs for CCNI:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNI

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNI Gene

Localization for CCNI Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNI Gene

Nucleus membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNI gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CCNI: view

Pathways & Interactions for CCNI Gene

PathCards logo

SuperPathways for CCNI Gene

No Data Available

Pathways by source for CCNI Gene

1 GeneTex pathway for CCNI Gene

Gene Ontology (GO) - Biological Process for CCNI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0007283 spermatogenesis NAS 9705831
GO:0044772 mitotic cell cycle phase transition IBA 21873635
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CCNI: view

No data available for SIGNOR curated interactions for CCNI Gene

Drugs & Compounds for CCNI Gene

No Compound Related Data Available

Transcripts for CCNI Gene

mRNA/cDNA for CCNI Gene

10 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNI

Alternative Splicing Database (ASD) splice patterns (SP) for CCNI Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: - - - -
SP3: -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7:
SP8: -
SP9: - - - -

Relevant External Links for CCNI Gene

GeneLoc Exon Structure for
CCNI

Expression for CCNI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNI Gene

This gene is overexpressed in Bone (56.5) and Pancreas (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCNI Gene



Protein tissue co-expression partners for CCNI Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNI

SOURCE GeneReport for Unigene cluster for CCNI Gene:

Hs.518827

mRNA Expression by UniProt/SwissProt for CCNI Gene:

Q14094-CCNI_HUMAN
Tissue specificity: Highest levels in adult heart, brain and skeletal muscle. Lower levels in adult placenta, lung, kidney and pancreas. Also high levels in fetal brain and lower levels in fetal lung, liver and kidney. Also abundant in testis and thyroid.

Evidence on tissue expression from TISSUES for CCNI Gene

  • Nervous system(5)
  • Kidney(4.7)
  • Muscle(4.6)
  • Spleen(4.4)
  • Eye(4.2)
  • Lung(4)
  • Pancreas(3.4)
  • Skin(3.4)
  • Intestine(3)
  • Blood(2.9)
  • Heart(2.8)
  • Liver(2.5)
  • Thyroid gland(2.5)
  • Lymph node(2.4)
  • Stomach(2.4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with CCNI: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNI Gene

Orthologs for CCNI Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNI Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCNI 30 31
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCNI 30 31
  • 94.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCNI 30 31
  • 93.72 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccni 30 17 31
  • 92.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccni 30
  • 92.57 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 83 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia CCNI 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCNI 30 31
  • 79.49 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCNI 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccni 30
  • 71.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68660 30
Zebrafish
(Danio rerio)
Actinopterygii ccni 30 31
  • 63.19 (n)
OneToOne
Dr.10085 30
Fruit Fly
(Drosophila melanogaster)
Insecta CycG 31
  • 12 (a)
OneToMany
Species where no ortholog for CCNI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCNI Gene

ENSEMBL:
Gene Tree for CCNI (if available)
TreeFam:
Gene Tree for CCNI (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNI: view image

Paralogs for CCNI Gene

(3) SIMAP similar genes for CCNI Gene using alignment to 8 proteins:

  • CCNI_HUMAN
  • B7Z6X4_HUMAN
  • D6RDK3_HUMAN
  • D6REZ3_HUMAN
  • D6RG12_HUMAN
  • D6RH01_HUMAN
  • H0YA27_HUMAN
  • Q6FHH0_HUMAN
genes like me logo Genes that share paralogs with CCNI: view

Variants for CCNI Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNI Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs4252903 - p.Val207Ile

Additional dbSNP identifiers (rs#s) for CCNI Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNI Gene

Variant ID Type Subtype PubMed ID
nsv1073775 CNV deletion 25765185
nsv7363 OTHER inversion 18451855

Variation tolerance for CCNI Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNI

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNI Gene

Disorders for CCNI Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCNI Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CCNI in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNI

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CCNI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNI Gene

Publications for CCNI Gene

  1. Cyclin I: a new cyclin encoded by a gene isolated from human brain. (PMID: 7493655) Nakamura T … Mori N (Experimental cell research 1995) 2 3 4 23
  2. Expression of a novel isoform of cyclin I in human testis. (PMID: 9705831) Zhu X … Naz RK (Biochemical and biophysical research communications 1998) 3 4 23
  3. Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. (PMID: 17507299) Sun ZL … Miao Y (Biochimica et biophysica acta 2007) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for CCNI Gene

  • Signalway Proteins for CCNI

Sources for CCNI Gene