Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]
CCNI (Cyclin I) is a Protein Coding gene. Diseases associated with CCNI include Epilepsy, Familial Temporal Lobe, 3 and 3-Methylglutaconic Aciduria, Type I. An important paralog of this gene is CCNI2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IBA | -- |
GO:0005515 | protein binding | IPI | 25852190 |
GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | IBA | 21873635 |
GO:0019901 | protein kinase binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IBA | 21873635 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | IBA | 21873635 |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0007283 | spermatogenesis | NAS | 9705831 |
GO:0044772 | mitotic cell cycle phase transition | IBA | 21873635 |
GO:0051726 | regulation of cell cycle | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CCNI 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CCNI 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CCNI 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ccni 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ccni 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | CCNI 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CCNI 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CCNI 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ccni 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68660 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ccni 30 31 |
|
OneToOne | |
Dr.10085 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CycG 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs4252903 | - | p.Val207Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1073775 | CNV | deletion | 25765185 |
nsv7363 | OTHER | inversion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
epilepsy, familial temporal lobe, 3 |
|
|
3-methylglutaconic aciduria, type i |
|
|