Aliases for CCNI Gene
External Ids for CCNI Gene
- HGNC: 1595
- Entrez Gene: 10983
- Ensembl: ENSG00000118816
- UniProtKB: Q14094
Previous GeneCards Identifiers for CCNI Gene
- GC04M077878
- GC04M078159
- GC04M078361
- GC04M078427
- GC04M078326
- GC04M077968
- GC04M073720
Summaries for CCNI Gene
-
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]
GeneCards Summary for CCNI Gene
CCNI (Cyclin I) is a Protein Coding gene. Diseases associated with CCNI include Epilepsy, Familial Temporal Lobe, 3. An important paralog of this gene is CCNI2.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNI Gene
Genomics for CCNI Gene
GeneHancer (GH) Regulatory Elements for CCNI Gene
Promoters and enhancers for CCNI Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04I077072 | Promoter/Enhancer | 2.4 | EPDnew Ensembl ENCODE dbSUPER | 550.8 | +1.3 | 1274 | 5.8 | MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 | CCNI GC04P077075 NUP54 CNOT6L RPL7P17 GC04M077051 | |
| GH04I077052 | Enhancer | 0.9 | ENCODE dbSUPER | 12.9 | +23.6 | 23550 | 0.7 | MEIS2 CTCF PKNOX1 CEBPG RAD21 CC2D1A ARID2 SCRT2 ZNF143 ZNF444 | GC04M077051 CCNI SEPT11 GC04P077075 | |
| GH04I077174 | Enhancer | 0.7 | ENCODE dbSUPER | 12 | -99.2 | -99205 | 1.2 | SP1 USF1 POLR2A MAX EZH2 | CCNI CCNG2 FTLP9 | |
| GH04I077176 | Enhancer | 0.7 | ENCODE dbSUPER | 12 | -101.8 | -101832 | 3 | SP1 POLR2A EZH2 ZBTB17 | CCNI CCNG2 FTLP9 | |
| GH04I077053 | Enhancer | 0.5 | FANTOM5 dbSUPER | 14 | +22.5 | 22457 | 0.4 | GC04M077051 CCNI SEPT11 GC04P077075 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CCNI on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CCNI gene promoter:
Regulatory Element Products
Genomic Locations for CCNI Gene
Genomic Locations for CCNI Gene
- chr4:77,047,155-77,076,013
- (GRCh38/hg38)
- Size:
- 28,859 bases
- Orientation:
- Minus strand
- chr4:77,968,311-77,997,158
- (GRCh37/hg19)
Genomic View for CCNI Gene
Genes around CCNI on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q21.1 by Ensembl
- 4q21.1 by Entrez Gene
- 4q21.1 by HGNC
CCNI Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCNI Gene
Proteins for CCNI Gene
-
Protein details for CCNI Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14094-CCNI_HUMAN
- Recommended name:
- Cyclin-I
- Protein Accession:
- Q14094
- B2R6M0
- B7Z6X4
Protein attributes for CCNI Gene
- Size:
- 377 amino acids
- Molecular mass:
- 42557 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCNI Gene
Post-translational modifications for CCNI Gene
Other Protein References for CCNI Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCNI
- Novus Biologicals Antibodies for CCNI
-
Abcam antibodies for CCNI
- Invitrogen Antibodies for CCNI
- antibodies-online: Search results for 51 available Cyclin I Antibodies ranked by validation data
- Compare Top Cyclin I Antibodies
-
Recommended
- GeneTex CCNI antibody for CCNI
Protein Products
-
OriGene Purified Proteins for CCNI
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-
Abcam proteins for CCNI
Assay Products
No data available for DME Specific Peptides for CCNI Gene
Domains & Families for CCNI Gene
Gene Families for CCNI Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CCNI Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCNI Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14094- Family:
-
- Belongs to the cyclin family.
Function for CCNI Gene
Phenotypes for CCNI Gene
- MGI mutant phenotypes for CCNI:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CCNI:
-
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Dynamic nuclei (hole, folded or small irregular)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased shRNA abundance (Z-score < -2)
Animal Models for CCNI Gene
- MGI Knock Outs for CCNI:
-
- Ccni tm1Jro
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCNI
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCNI gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNI gene
- Search ViGene Biosciences for CCNI
CRISPR Products
-
OriGene CRISPR knockouts for CCNI
- genomics-online: gRNA clones - Search results for 130 available Cyclin I gene related products
- Overview of 130 available Cyclin I gene related products
- Applied Biological Materials CRISPR for CCNI
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNI
- GenScript: Design CRISPR guide RNA sequences for CCNI
miRNA for CCNI Gene
- miRTarBase miRNAs that target CCNI
-
- hsa-mir-374b-5p (MIRT016039)
- hsa-mir-26b-5p (MIRT028976)
- hsa-mir-423-5p (MIRT038027)
- hsa-mir-320a (MIRT044457)
- hsa-mir-148a-3p (MIRT048043)
- hsa-mir-92a-3p (MIRT049008)
- hsa-mir-129-5p (MIRT641667)
- hsa-mir-133b (MIRT641668)
- hsa-mir-133a-3p (MIRT641669)
- hsa-mir-6848-3p (MIRT641670)
- hsa-mir-6843-3p (MIRT641671)
- hsa-mir-455-5p (MIRT641672)
miRNA Products
- Search ViGene Biosciences for CCNI
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 130 available Cyclin I gene related products
- Overview of 130 available Cyclin I gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNI gene
Clone Products
- Sino Biological Human cDNA Clone for CCNI
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CCNI
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCNI
-
ViGene Biosciences adenoviral particle packaged cDNA for CCNI gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCNI gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNI gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNI Gene
Localization for CCNI Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| golgi apparatus | 3 |
| mitochondrion | 1 |
- Golgi apparatus (3)
- Nuclear bodies (2)
- Nucleoplasm (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCNI Gene
Pathways & Interactions for CCNI Gene
No Data Available
Pathways by source for CCNI Gene
1 GeneTex pathway for CCNI Gene
Interacting Proteins for CCNI Gene
Selected Interacting proteins:
ENSP00000237654
Q14094-CCNI_HUMAN
for CCNI Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007283 | spermatogenesis | NAS | 9705831 |
| GO:0051726 | regulation of cell cycle | IEA | -- |
No data available for SIGNOR curated interactions for CCNI Gene
Transcripts for CCNI Gene
mRNA/cDNA for CCNI Gene
- (11) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (1180) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CCNI
- genomics-online: gRNA clones - Search results for 130 available Cyclin I gene related products
- Overview of 130 available Cyclin I gene related products
- Applied Biological Materials CRISPR for CCNI
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNI
- GenScript: Design CRISPR guide RNA sequences for CCNI
miRNA Products
- Search ViGene Biosciences for CCNI
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CCNI
- Browse OriGene Inhibitory RNA Products For CCNI
- genomics-online: shRNA clones - Search results for 130 available Cyclin I gene related products
- Overview of 130 available Cyclin I gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNI gene
Clone Products
- Sino Biological Human cDNA Clone for CCNI
- VectorBuilder custom plasmid, inducible vectors for CCNI
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCNI
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CCNI
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - |
Expression for CCNI Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Endoderm (Gastrulation Derivatives)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Bone (56.5) and Pancreas (12.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNI Gene
NURSA nuclear receptor signaling pathways regulating expression of CCNI Gene:
CCNISOURCE GeneReport for Unigene cluster for CCNI Gene:
Hs.518827mRNA Expression by UniProt/SwissProt for CCNI Gene:
Q14094-CCNI_HUMAN
Tissue specificity:
Highest levels in adult heart, brain and skeletal muscle. Lower levels in adult placenta, lung, kidney and pancreas. Also high levels in fetal brain and lower levels in fetal lung, liver and kidney. Also abundant in testis and thyroid.
Evidence on tissue expression from TISSUES for CCNI Gene
- Nervous system(4.9)
- Kidney(4.7)
- Muscle(4.5)
- Spleen(4.4)
- Eye(4.1)
- Lung(3.8)
- Pancreas(3)
- Skin(2.8)
- Intestine(2.7)
- Heart(2.5)
- Stomach(2.4)
- Thyroid gland(2.2)
- Liver(2.1)
- Blood(2)
- Gall bladder(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for CCNI
-
OriGene qPCR primer pairs and template standards for CCNI
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNI Gene
Orthologs for CCNI Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCNI 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CCNI 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CCNI 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccni 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccni 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | CCNI 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCNI 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CCNI 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccni 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68660 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ccni 33 34 |
|
||
| Dr.10085 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CycG 34 |
|
OneToMany |
- Species where no ortholog for CCNI was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CCNI Gene
(3) SIMAP similar genes for CCNI Gene using alignment to 8 proteins:
Variants for CCNI Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10000115 | -- | 77,069,590(-) | T/C | intron_variant | |
| rs1000044096 | -- | 77,066,034(-) | G/A | intron_variant | |
| rs1000098133 | -- | 77,050,681(-) | T/G | intron_variant | |
| rs1000136644 | -- | 77,075,572(-) | T/C | 5_prime_UTR_variant | |
| rs1000213747 | -- | 77,069,080(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1073775 | CNV | deletion | 25765185 |
| nsv7363 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.36;
26.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCNI Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCNI
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNI Gene
Disorders for CCNI Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epilepsy, familial temporal lobe, 3 |
|
|
Search CCNI in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCNI
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CCNI Gene
Publications for CCNI Gene
- Cyclin I: a new cyclin encoded by a gene isolated from human brain. (PMID: 7493655) Nakamura T … Mori N (Experimental cell research 1995) 2 3 4 22 58
- Expression of a novel isoform of cyclin I in human testis. (PMID: 9705831) Zhu X … Naz RK (Biochemical and biophysical research communications 1998) 3 4 22 58
- Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. (PMID: 17507299) Sun ZL … Miao Y (Biochimica et biophysica acta 2007) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R … Aloy P (Journal of molecular biology 2015) 3 58
Products for CCNI Gene
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- Custom Antibody ServicesOriGene Antibodies for CCNI
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CCNI
- VectorBuilder custom plasmid, inducible vectors for CCNI
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCNI
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 51 available Cyclin I Antibodies ranked by validation data
- Compare Top Cyclin I Antibodies
- Recommended
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- GeneTex CCNI antibody for CCNI
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- genomics-online: cdna clones - Search results for 130 available Cyclin I gene related products
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- Overview of 130 available Cyclin I gene related products
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Sources for CCNI Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
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