The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequ... See more...

Aliases for CCNG2 Gene

Aliases for CCNG2 Gene

  • Cyclin G2 2 3 5
  • Cyclin-G2 3 4

External Ids for CCNG2 Gene

Previous GeneCards Identifiers for CCNG2 Gene

  • GC04P077988
  • GC04P078268
  • GC04P078471
  • GC04P078536
  • GC04P078435
  • GC04P078078
  • GC04P073832

Summaries for CCNG2 Gene

Entrez Gene Summary for CCNG2 Gene

  • The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNG2 Gene

CCNG2 (Cyclin G2) is a Protein Coding gene. Diseases associated with CCNG2 include Thyroid Lymphoma. Among its related pathways are DNA Damage Response and Mitotic G1-G1/S phases. An important paralog of this gene is CCNG1.

UniProtKB/Swiss-Prot Summary for CCNG2 Gene

  • May play a role in growth regulation and in negative regulation of cell cycle progression.

Gene Wiki entry for CCNG2 Gene

Additional gene information for CCNG2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNG2 Gene

Genomics for CCNG2 Gene

GeneHancer (GH) Regulatory Elements for CCNG2 Gene

Promoters and enhancers for CCNG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J077151 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 508.1 -0.9 -911 9 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 SIN3A TCF12 NRF1 MYC POLR2G CCNG2 LOC101928864 lnc-CCNI-1 CNOT6L RPL7P17 NONHSAG038271.2 RF00026-798 RNU6-1187P lnc-CCNI-3
GH04J077095 Enhancer 1.1 FANTOM5 Ensembl ENCODE 13.3 -61.7 -61703 1 CTCF TEAD4 REST RAD21 TRIM22 SMC3 ZNF316 YY1 ARNT SMARCA5 CCNG2 HSALNG0035347 LOC339966
GH04J077092 Enhancer 1 FANTOM5 Ensembl ENCODE 14 -63.8 -63781 2.4 ZBTB5 RUNX1 WT1 GABPA CEBPG FOS IRF1 SPI1 VEZF1 POLR2A HSALNG0035347 CCNG2 SEPTIN11 SOWAHB LOC339966
GH04J077201 Enhancer 0.8 Ensembl ENCODE 11.8 +45.3 45319 3 CTCF REST RAD21 TRIM22 SMC3 MXI1 FOS SRF YY1 NFE2 CCNG2 lnc-CXCL13-1 FTLP9
GH04J077122 Enhancer 0.7 Ensembl ENCODE 12.6 -31.5 -31504 7.4 SPI1 ZNF146 FEZF1 TBX21 POLR2A FOXA1 RUNX3 CCNG2 CCNI SOWAHB ENSG00000271676 RF00026-798 RNU6-1187P lnc-CCNI-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNG2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNG2

Top Transcription factor binding sites by QIAGEN in the CCNG2 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • GATA-1
  • GATA-2
  • GATA-3
  • HEN1
  • HOXA9
  • HOXA9B
  • Meis-1
  • STAT5A

Genomic Locations for CCNG2 Gene

Genomic Locations for CCNG2 Gene
chr4:77,157,204-77,433,388
(GRCh38/hg38)
Size:
276,185 bases
Orientation:
Plus strand
chr4:78,078,304-78,354,542
(GRCh37/hg19)
Size:
276,239 bases
Orientation:
Plus strand

Genomic View for CCNG2 Gene

Genes around CCNG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNG2 Gene

Proteins for CCNG2 Gene

  • Protein details for CCNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16589-CCNG2_HUMAN
    Recommended name:
    Cyclin-G2
    Protein Accession:
    Q16589
    Secondary Accessions:
    • B4DF25
    • Q6FGA7
    • Q6FGC6

    Protein attributes for CCNG2 Gene

    Size:
    344 amino acids
    Molecular mass:
    38866 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNG2 Gene

Post-translational modifications for CCNG2 Gene

  • Ubiquitination at Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNG2 Gene

No data available for DME Specific Peptides for CCNG2 Gene

Domains & Families for CCNG2 Gene

Gene Families for CCNG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CCNG2 Gene

Blocks:
  • Cyclin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNG2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56533, highly similar to Cyclin-G2 (B4DF25_HUMAN)
  • Cyclin-G2 (CCNG2_HUMAN)
  • CCNG2 protein (Q6FGA7_HUMAN)
  • cDNA FLJ76918, highly similar to Homo sapiens cyclin G2 (CCNG2), mRNA (Q6FGC6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16589

UniProtKB/Swiss-Prot:

CCNG2_HUMAN :
  • Belongs to the cyclin family. Cyclin G subfamily.
Family:
  • Belongs to the cyclin family. Cyclin G subfamily.
genes like me logo Genes that share domains with CCNG2: view

Function for CCNG2 Gene

Molecular function for CCNG2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in growth regulation and in negative regulation of cell cycle progression.
UniProtKB/Swiss-Prot Induction:
Activated by actinomycin-D induced DNA damage.

Phenotypes From GWAS Catalog for CCNG2 Gene

Gene Ontology (GO) - Molecular Function for CCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 contributes_to protein kinase activity IBA 21873635
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with CCNG2: view
genes like me logo Genes that share phenotypes with CCNG2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNG2 Gene

Localization for CCNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNG2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNG2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CCNG2: view

Pathways & Interactions for CCNG2 Gene

genes like me logo Genes that share pathways with CCNG2: view

Pathways by source for CCNG2 Gene

2 KEGG pathways for CCNG2 Gene
1 GeneTex pathway for CCNG2 Gene

Gene Ontology (GO) - Biological Process for CCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0044772 mitotic cell cycle phase transition IBA 21873635
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CCNG2: view

No data available for SIGNOR curated interactions for CCNG2 Gene

Drugs & Compounds for CCNG2 Gene

(3) Drugs for CCNG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCNG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNG2: view

Transcripts for CCNG2 Gene

mRNA/cDNA for CCNG2 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNG2 Gene

No ASD Table

Relevant External Links for CCNG2 Gene

GeneLoc Exon Structure for
CCNG2

Expression for CCNG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNG2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNG2

SOURCE GeneReport for Unigene cluster for CCNG2 Gene:

Hs.740456

mRNA Expression by UniProt/SwissProt for CCNG2 Gene:

Q16589-CCNG2_HUMAN
Tissue specificity: High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.

Evidence on tissue expression from TISSUES for CCNG2 Gene

  • Nervous system(4.8)
  • Blood(4.4)
  • Spleen(4.3)
  • Lymph node(2.3)
  • Bone marrow(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CCNG2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNG2 Gene

Orthologs for CCNG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNG2 31 30
  • 99.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCNG2 31 30
  • 92.81 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNG2 31
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNG2 31 30
  • 91.67 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccng2 30
  • 85.33 (n)
mouse
(Mus musculus)
Mammalia Ccng2 17 31 30
  • 85.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNG2 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNG2 31 30
  • 78.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNG2 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccng2 30
  • 75.1 (n)
Str.17220 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15316 30
zebrafish
(Danio rerio)
Actinopterygii ccng2 31 30
  • 63.31 (n)
OneToOne
-- 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6763 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001730 30
  • 39.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CycG 31
  • 17 (a)
OneToMany
Species where no ortholog for CCNG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNG2 Gene

ENSEMBL:
Gene Tree for CCNG2 (if available)
TreeFam:
Gene Tree for CCNG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNG2: view image

Paralogs for CCNG2 Gene

(3) SIMAP similar genes for CCNG2 Gene using alignment to 3 proteins:

  • CCNG2_HUMAN
  • D6RHI3_HUMAN
  • Q8N5D4_HUMAN

Pseudogenes.org Pseudogenes for CCNG2 Gene

genes like me logo Genes that share paralogs with CCNG2: view

Variants for CCNG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNG2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
708394 Benign: not provided 77,164,408(+) C/T SYNONYMOUS_VARIANT
708768 Benign: not provided 77,158,615(+) A/G MISSENSE_VARIANT
787030 Benign: not provided 77,158,583(+) T/C SYNONYMOUS_VARIANT
787031 Benign: not provided 77,160,852(+) T/C SYNONYMOUS_VARIANT
rs4150050 - p.Leu4Val

Additional dbSNP identifiers (rs#s) for CCNG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNG2 Gene

Variant ID Type Subtype PubMed ID
nsv290177 CNV deletion 16902084
nsv7363 OTHER inversion 18451855

Variation tolerance for CCNG2 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNG2 Gene

Disorders for CCNG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCNG2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
thyroid lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search CCNG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNG2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCNG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNG2 Gene

Publications for CCNG2 Gene

  1. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. (PMID: 8806701) Bates S … Vousden KH (Oncogene 1996) 2 3 4 23 54
  2. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. (PMID: 8626390) Horne MC … Wahl AF (The Journal of biological chemistry 1996) 3 4 23 54
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41 54
  4. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham JM … Goode EL (British journal of cancer 2009) 3 41 54
  5. Expression levels of cyclin G2, but not cyclin E, correlate with gastric cancer progression. (PMID: 19559447) Choi MG … Kim S (The Journal of surgical research 2009) 3 23 54

Products for CCNG2 Gene

Sources for CCNG2 Gene