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This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiqu... See more...
Aliases for CCNF Gene
Aliases for CCNF Gene
External Ids for CCNF Gene
- HGNC: 1591
- Entrez Gene: 899
- Ensembl: ENSG00000162063
- OMIM: 600227
- UniProtKB: P41002
Previous GeneCards Identifiers for CCNF Gene
- GC16P002273
- GC16P002504
- GC16P002419
- GC16P002405
- GC16P002479
Summaries for CCNF Gene
-
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNF Gene
CCNF (Cyclin F) is a Protein Coding gene. Diseases associated with CCNF include Amyotrophic Lateral Sclerosis 1 and Deafness, Autosomal Recessive 86. Among its related pathways are GADD45 Pathway and Innate Immune System. An important paralog of this gene is CCNB1.
UniProtKB/Swiss-Prot Summary for CCNF Gene
-
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Additional gene information for CCNF Gene
- HGNC(1591)
- Entrez Gene(899)
- Ensembl(ENSG00000162063)
- OMIM(600227)
- UniProtKB(P41002)
- Open Targets Platform(ENSG00000162063)
- Monarch Initiative
- Search for CCNF at DataMed
- Search for CCNF at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNF Gene
Genomics for CCNF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CCNF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCNF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNF
- Top Transcription factor binding sites by QIAGEN in the CCNF gene promoter:
-
- AhR
- C/EBPalpha
- E47
- Egr-2
- FOXO1
- LCR-F1
- p300
- Pax-4a
- POU2F1
- POU2F1a
Genomic Locations for CCNF Gene
Genomic Locations for CCNF Gene
- chr16:2,429,394-2,458,854
- (GRCh38/hg38)
- Size:
- 29,461 bases
- Orientation:
- Plus strand
- chr16:2,479,395-2,508,859
- (GRCh37/hg19)
- Size:
- 29,465 bases
- Orientation:
- Plus strand
Genomic View for CCNF Gene
Genes around CCNF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by HGNC
- 16p13.3 by Entrez Gene
- 16p13.3 by Ensembl
CCNF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCNF Gene
Proteins for CCNF Gene
-
Protein details for CCNF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P41002-CCNF_HUMAN
- Recommended name:
- Cyclin-F
- Protein Accession:
- P41002
- B2R8H3
- Q96EG9
Protein attributes for CCNF Gene
- Size:
- 786 amino acids
- Molecular mass:
- 87640 Da
- Quaternary structure:
-
- Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway.
- Miscellaneous:
-
- Founding member of the F-box domain protein family, which obtained its name from cyclin-F.
Protein Expression for CCNF Gene
Post-translational modifications for CCNF Gene
- Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence.
- Phosphorylated just before cells enter into mitosis.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CCNF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Cyclin F Antibody
- Creative Diagnostics Rabbit anti-Human Cyclin F polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for CCNF
- Novus Biologicals Antibodies for CCNF
-
Abcam antibodies for CCNF
- Invitrogen Antibodies for CCNF (AFLGC-CCNF)
-
Boster Bio Antibodies for CCNF
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCNF
- Sino Biological Antibodies for CCNF
Protein Products
-
OriGene Purified Proteins for CCNF
- Search Origene for MassSpec and Protein Over-expression Lysates for CCNF
- Origene Custom Protein Services for CCNF
- antibodies-online: Show 4 available Cyclin F Proteins ranked by validation data
- Compare Top Cyclin F Proteins
-
Quality Products:
-
Signalway Proteins for CCNF
-
Abcam proteins for CCNF
No data available for DME Specific Peptides for CCNF Gene
Domains & Families for CCNF Gene
Gene Families for CCNF Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CCNF Gene
- InterPro:
- Blocks:
-
- Cyclin
- ProtoNet:
Suggested Antigen Peptide Sequences for CCNF Gene
- GenScript: Design optimal peptide antigens:
-
- F-box only protein 1 (CCNF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P41002UniProtKB/Swiss-Prot:
CCNF_HUMAN :- The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.
- Belongs to the cyclin family. Cyclin AB subfamily.
- Domain:
-
- The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.
- Family:
-
- Belongs to the cyclin family. Cyclin AB subfamily.
Function for CCNF Gene
Molecular function for CCNF Gene
- UniProtKB/Swiss-Prot Function:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
- GENATLAS Biochemistry:
- cyclin F,involved in the regulation of cell cycle
Phenotypes From GWAS Catalog for CCNF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 20596027 |
| GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | IBA | 21873635 |
| GO:0019901 | protein kinase binding | IBA | -- |
Phenotypes for CCNF Gene
- MGI mutant phenotypes for CCNF:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CCNF:
Animal Models for CCNF Gene
- MGI Knock Outs for CCNF:
-
- Ccnf Ccnf<tm1.1Sje>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCNF - Select products 50% OFF >
- * CCNF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCNF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCNF
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNF
miRNA for CCNF Gene
- miRTarBase miRNAs that target CCNF
-
- hsa-miR-503-5p (MIRT000643)
- hsa-miR-424-5p (MIRT000653)
- hsa-let-7b-5p (MIRT005061)
- mmu-miR-541-5p (MIRT008296)
- mmu-miR-9-5p (MIRT015528)
- hsa-miR-98-5p (MIRT027780)
- hsa-miR-423-5p (MIRT038126)
- hsa-miR-615-3p (MIRT040085)
- hsa-miR-324-3p (MIRT042895)
- hsa-let-7c-5p (MIRT051739)
- hsa-miR-762 (MIRT074451)
- hsa-miR-4492 (MIRT074457)
- hsa-miR-4498 (MIRT074458)
- hsa-miR-5001-5p (MIRT074460)
- hsa-miR-30a-5p (MIRT283400)
- hsa-miR-30c-5p (MIRT283401)
- hsa-miR-30d-5p (MIRT283402)
- hsa-miR-30b-5p (MIRT283403)
- hsa-miR-30e-5p (MIRT283404)
- hsa-miR-432-3p (MIRT283405)
- hsa-miR-3681-5p (MIRT283406)
- hsa-miR-3691-5p (MIRT283407)
- hsa-miR-4795-5p (MIRT283408)
- hsa-miR-6849-5p (MIRT283409)
- hsa-miR-218-5p (MIRT440982)
- hsa-miR-4459 (MIRT479709)
- hsa-miR-4497 (MIRT479710)
- hsa-miR-582-5p (MIRT479711)
- hsa-miR-101-3p (MIRT479712)
- hsa-miR-3713 (MIRT479713)
- hsa-miR-25-5p (MIRT479714)
- hsa-miR-658 (MIRT479715)
- hsa-miR-571 (MIRT479716)
- hsa-miR-219a-1-3p (MIRT479717)
- hsa-miR-655-5p (MIRT479718)
- hsa-miR-6087 (MIRT479719)
- hsa-miR-4693-3p (MIRT479720)
- hsa-miR-3174 (MIRT479721)
- hsa-miR-5694 (MIRT479722)
- hsa-miR-8073 (MIRT479723)
- hsa-miR-6516-5p (MIRT479724)
- hsa-miR-3678-3p (MIRT479725)
- hsa-miR-1273h-3p (MIRT479726)
- hsa-miR-885-3p (MIRT479727)
- hsa-miR-1193 (MIRT479728)
- hsa-miR-2467-3p (MIRT479729)
- hsa-miR-3620-5p (MIRT487257)
- hsa-miR-1587 (MIRT487258)
- hsa-miR-2355-5p (MIRT487259)
- hsa-miR-4417 (MIRT487260)
- hsa-miR-4741 (MIRT487261)
- hsa-miR-4675 (MIRT487262)
- hsa-miR-6829-5p (MIRT487263)
- hsa-miR-4656 (MIRT487264)
- hsa-miR-6762-3p (MIRT487265)
- hsa-miR-6853-5p (MIRT487266)
- hsa-miR-484 (MIRT487267)
- hsa-miR-3155b (MIRT487268)
- hsa-miR-3155a (MIRT487269)
- hsa-miR-4692 (MIRT487270)
- hsa-miR-4514 (MIRT487271)
- hsa-miR-6893-5p (MIRT487272)
- hsa-miR-940 (MIRT487273)
- hsa-miR-6808-5p (MIRT487274)
- hsa-miR-4668-5p (MIRT615353)
- hsa-miR-4665-5p (MIRT615354)
- hsa-miR-1275 (MIRT615355)
- hsa-miR-5010-5p (MIRT615356)
- hsa-miR-4525 (MIRT615357)
- hsa-miR-7111-5p (MIRT615358)
- hsa-miR-6870-5p (MIRT615359)
- hsa-miR-5698 (MIRT615360)
- hsa-miR-4723-5p (MIRT615361)
- hsa-miR-625-5p (MIRT615362)
- hsa-miR-7155-5p (MIRT615363)
- hsa-miR-637 (MIRT615364)
- hsa-miR-8089 (MIRT615365)
- hsa-miR-4700-5p (MIRT615366)
- hsa-miR-4667-5p (MIRT615367)
- hsa-miR-3613-3p (MIRT615368)
- hsa-miR-1298-3p (MIRT615369)
- hsa-miR-4422 (MIRT615370)
- hsa-miR-548e-5p (MIRT615371)
- hsa-miR-519d-5p (MIRT628339)
- hsa-miR-6513-5p (MIRT669169)
- hsa-miR-887-5p (MIRT669170)
- hsa-miR-3913-5p (MIRT669171)
- hsa-miR-3122 (MIRT669172)
- hsa-miR-450a-1-3p (MIRT669173)
- hsa-miR-6780a-5p (MIRT669174)
- hsa-miR-6779-5p (MIRT669175)
- hsa-miR-3689c (MIRT669176)
- hsa-miR-3689b-3p (MIRT669177)
- hsa-miR-3689a-3p (MIRT669178)
- hsa-miR-30b-3p (MIRT669179)
- hsa-miR-1273h-5p (MIRT669180)
- hsa-miR-6788-5p (MIRT669181)
- hsa-miR-30c-2-3p (MIRT669182)
- hsa-miR-30c-1-3p (MIRT669183)
- hsa-miR-7977 (MIRT669184)
- hsa-miR-8085 (MIRT669185)
- hsa-miR-6731-5p (MIRT669186)
- hsa-miR-6878-5p (MIRT669187)
- hsa-miR-383-3p (MIRT669188)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCNF
- Browse OriGene Inhibitory RNA Products For CCNF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNF
Clone Products
- Applied Biological Materials (abm): Clones for CCNF - Select products 50% OFF >
- * CCNF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCNF
- Addgene plasmids for CCNF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCNF
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCNF Gene
Localization for CCNF Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCNF Gene
- Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Centrosome (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IBA | 21873635 |
| GO:0005634 | nucleus | IBA,IDA | 20596027 |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005813 | centrosome | IBA,IDA | -- |
| GO:0005814 | centriole | IEA,IDA | 20596027 |
Pathways & Interactions for CCNF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | DNA Damage | ||
| 3 | GADD45 Pathway |
GADD45 Pathway
-
|
|
| 4 | GPCR Pathway |
Pancreatic Adenocarcinoma
.59
|
|
| 5 | Innate Immune System |
.61
|
|
Pathways by source for CCNF Gene
4 Reactome pathways for CCNF Gene
2 Qiagen pathways for CCNF Gene
- GADD45 Pathway
- Pancreatic Adenocarcinoma
1 Cell Signaling Technology pathway for CCNF Gene
1 GeneTex pathway for CCNF Gene
Interacting Proteins for CCNF Gene
Selected Interacting proteins:
P41002-CCNF_HUMAN
ENSP00000380256
for CCNF Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CCNF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | IBA | 21873635 |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0000320 | re-entry into mitotic cell cycle | IEA | -- |
| GO:0001890 | placenta development | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for CCNF Gene
Transcripts for CCNF Gene
mRNA/cDNA for CCNF Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000293968 4173 nts (view in UCSC)
- ENST00000397066 4230 nts (view in UCSC)
- ENST00000569093 857 nts (view in UCSC)
- ENST00000564333 1937 nts (view in UCSC)
- ENST00000564236 789 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CCNF - Select products 50% OFF >
- * CCNF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CCNF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCNF
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCNF
- Browse OriGene Inhibitory RNA Products For CCNF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNF
Clone Products
- Applied Biological Materials (abm): Clones for CCNF - Select products 50% OFF >
- * CCNF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CCNF
- Addgene plasmids for CCNF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCNF
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for CCNF Gene
- GeneLoc Exon Structure for
- CCNF
Expression for CCNF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCNF Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNF
SOURCE GeneReport for Unigene cluster for CCNF Gene:
Hs.1973mRNA Expression by UniProt/SwissProt for CCNF Gene:
P41002-CCNF_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for CCNF Gene
- Eye(4.1)
Primer Products
-
OriGene qPCR primer pairs for CCNF
-
OriGene qPCR primer pairs and template standards for CCNF
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNF Gene
Orthologs for CCNF Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CCNF 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CCNF 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CCNF 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ccnf 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ccnf 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CCNF 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CCNF 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CCNF 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ccnf 30 |
|
||
| Str.10283 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC69175 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ccnf 30 31 |
|
OneToOne |
- Species where no ortholog for CCNF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CCNF Gene
- ENSEMBL:
- Gene Tree for CCNF (if available)
- TreeFam:
- Gene Tree for CCNF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCNF: view image
Paralogs for CCNF Gene
Variants for CCNF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNF Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 714682 | Benign: not provided | 2,449,455(+) | C/T | SYNONYMOUS_VARIANT | |
| 715829 | Benign: not provided | 2,455,530(+) | C/T | SYNONYMOUS_VARIANT | |
| 717033 | Benign: not provided | 2,455,452(+) | G/A | SYNONYMOUS_VARIANT | |
| 722268 | Likely Benign: not provided | 2,456,731(+) | G/A | MISSENSE_VARIANT | |
| 722753 | Likely Benign: not provided | 2,445,453(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422427 | CNV | duplication | 17116639 |
| nsv1052260 | CNV | gain | 25217958 |
| nsv1069901 | CNV | deletion | 25765185 |
| nsv1141940 | OTHER | inversion | 24896259 |
| nsv827513 | CNV | gain | 20364138 |
| nsv833121 | CNV | loss | 17160897 |
| nsv952903 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.54;
44.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCNF Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNF Gene
Disorders for CCNF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amyotrophic lateral sclerosis 1 |
|
|
| deafness, autosomal recessive 86 |
|
|
| deafness, autosomal dominant 65 |
|
|
| myoclonic epilepsy, familial infantile |
|
|
| ludwig's angina |
|
|
Search CCNF in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCNF
No data available for UniProtKB/Swiss-Prot and Genatlas for CCNF Gene
Publications for CCNF Gene
- A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). (PMID: 7896286) Kraus B … Frischauf AM (Genomics 1994) 2 3 4 23
- Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. (PMID: 12122006) Fung TK … Poon RY (The Journal of biological chemistry 2002) 3 4 23
- SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. (PMID: 8706131) Bai C … Elledge SJ (Cell 1996) 3 4 23
- Human cyclin F. (PMID: 7813445) Bai C … Elledge SJ (The EMBO journal 1994) 3 4 23
- Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. (PMID: 22441691) Li J … Dynlacht BD (EMBO reports 2012) 3 4
ExternalLinks
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Sources for CCNF Gene
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