Aliases for CCNF Gene
Aliases for CCNF Gene
External Ids for CCNF Gene
- HGNC: 1591
- Entrez Gene: 899
- Ensembl: ENSG00000162063
- OMIM: 600227
- UniProtKB: P41002
Previous GeneCards Identifiers for CCNF Gene
- GC16P002273
- GC16P002504
- GC16P002419
- GC16P002405
- GC16P002479
Summaries for CCNF Gene
-
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNF Gene
CCNF (Cyclin F) is a Protein Coding gene. Diseases associated with CCNF include Amyotrophic Lateral Sclerosis 1 and Necrotizing Fasciitis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
UniProtKB/Swiss-Prot for CCNF Gene
-
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Additional gene information for CCNF Gene
- Monarch Initiative
- Search for CCNF at DataMed
- Search for CCNF at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNF Gene
Genomics for CCNF Gene
GeneHancer (GH) Regulatory Elements for CCNF Gene
Promoters and enhancers for CCNF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CCNF on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CCNF Gene
Genomic Locations for CCNF Gene
- chr16:2,429,394-2,458,858
- (GRCh38/hg38)
- Size:
- 29,465 bases
- Orientation:
- Plus strand
- chr16:2,479,395-2,508,859
- (GRCh37/hg19)
Genomic View for CCNF Gene
Genes around CCNF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by Ensembl
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC
CCNF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCNF Gene
Proteins for CCNF Gene
-
Protein details for CCNF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P41002-CCNF_HUMAN
- Recommended name:
- Cyclin-F
- Protein Accession:
- P41002
- B2R8H3
- Q96EG9
Protein attributes for CCNF Gene
- Size:
- 786 amino acids
- Molecular mass:
- 87640 Da
- Quaternary structure:
-
- Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway.
- Miscellaneous:
-
- Founding member of the F-box domain protein family, which obtained its name from cyclin-F.
Protein Expression for CCNF Gene
Post-translational modifications for CCNF Gene
- Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence.
- Phosphorylated just before cells enter into mitosis.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CCNF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCNF
- Novus Biologicals Antibodies for CCNF
-
Abcam antibodies for CCNF
- Invitrogen Antibodies for CCNF
- GeneTex CCNF antibody for CCNF
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCNF
Protein Products
-
OriGene Purified Proteins for CCNF
- Search Origene for MassSpec and Protein Over-expression Lysates for CCNF
- Origene Custom Protein Services for CCNF
- antibodies-online: Search results for 4 available Cyclin F Proteins ranked by validation data
- Compare Top Cyclin F Proteins
-
Quality Products:
- Search GeneTex for Proteins for CCNF
-
Abcam proteins for CCNF
Assay Products
- antibodies-online: Search results for 1 available Cyclin F Elisa Kits ranked by validation data
- Compare Top Cyclin F Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CCNF Gene
Domains & Families for CCNF Gene
Gene Families for CCNF Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CCNF Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCNF Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P41002UniProtKB/Swiss-Prot:
CCNF_HUMAN :- The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.
- Belongs to the cyclin family. Cyclin AB subfamily.
- Domain:
-
- The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.
- Family:
-
- Belongs to the cyclin family. Cyclin AB subfamily.
Function for CCNF Gene
Molecular function for CCNF Gene
- GENATLAS Biochemistry:
- cyclin F,involved in the regulation of cell cycle
- UniProtKB/Swiss-Prot Function:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 20596027 |
Phenotypes for CCNF Gene
- MGI mutant phenotypes for CCNF:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CCNF:
Animal Models for CCNF Gene
- MGI Knock Outs for CCNF:
-
- Ccnf tm1.1Sje
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCNF
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCNF gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNF gene
- Search ViGene Biosciences for CCNF
CRISPR Products
-
OriGene CRISPR knockouts for CCNF
- genomics-online: gRNA clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
- Applied Biological Materials CRISPR for CCNF
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNF
- GenScript: Design CRISPR guide RNA sequences for CCNF
miRNA for CCNF Gene
- miRTarBase miRNAs that target CCNF
-
- hsa-mir-503-5p (MIRT000643)
- hsa-mir-424-5p (MIRT000653)
- hsa-let-7b-5p (MIRT005061)
- hsa-mir-98-5p (MIRT027780)
- hsa-mir-423-5p (MIRT038126)
- hsa-mir-615-3p (MIRT040085)
- hsa-mir-324-3p (MIRT042895)
- hsa-let-7c-5p (MIRT051739)
- hsa-mir-762 (MIRT074451)
- hsa-mir-4492 (MIRT074457)
- hsa-mir-4498 (MIRT074458)
- hsa-mir-5001-5p (MIRT074460)
- hsa-mir-30a-5p (MIRT283400)
- hsa-mir-30c-5p (MIRT283401)
- hsa-mir-30d-5p (MIRT283402)
- hsa-mir-30b-5p (MIRT283403)
- hsa-mir-30e-5p (MIRT283404)
- hsa-mir-432-3p (MIRT283405)
- hsa-mir-3681-5p (MIRT283406)
- hsa-mir-3691-5p (MIRT283407)
- hsa-mir-4795-5p (MIRT283408)
- hsa-mir-6849-5p (MIRT283409)
- hsa-mir-218-5p (MIRT440982)
- hsa-mir-4459 (MIRT479709)
- hsa-mir-4497 (MIRT479710)
- hsa-mir-582-5p (MIRT479711)
- hsa-mir-101-3p (MIRT479712)
- hsa-mir-3713 (MIRT479713)
- hsa-mir-25-5p (MIRT479714)
- hsa-mir-658 (MIRT479715)
- hsa-mir-571 (MIRT479716)
- hsa-mir-219a-1-3p (MIRT479717)
- hsa-mir-655-5p (MIRT479718)
- hsa-mir-6087 (MIRT479719)
- hsa-mir-4693-3p (MIRT479720)
- hsa-mir-3174 (MIRT479721)
- hsa-mir-5694 (MIRT479722)
- hsa-mir-8073 (MIRT479723)
- hsa-mir-6516-5p (MIRT479724)
- hsa-mir-3678-3p (MIRT479725)
- hsa-mir-1273h-3p (MIRT479726)
- hsa-mir-885-3p (MIRT479727)
- hsa-mir-1193 (MIRT479728)
- hsa-mir-2467-3p (MIRT479729)
- hsa-mir-3620-5p (MIRT487257)
- hsa-mir-1587 (MIRT487258)
- hsa-mir-2355-5p (MIRT487259)
- hsa-mir-4417 (MIRT487260)
- hsa-mir-4741 (MIRT487261)
- hsa-mir-4675 (MIRT487262)
- hsa-mir-6829-5p (MIRT487263)
- hsa-mir-4656 (MIRT487264)
- hsa-mir-6762-3p (MIRT487265)
- hsa-mir-6853-5p (MIRT487266)
- hsa-mir-484 (MIRT487267)
- hsa-mir-3155b (MIRT487268)
- hsa-mir-3155a (MIRT487269)
- hsa-mir-4692 (MIRT487270)
- hsa-mir-4514 (MIRT487271)
- hsa-mir-6893-5p (MIRT487272)
- hsa-mir-940 (MIRT487273)
- hsa-mir-6808-5p (MIRT487274)
- hsa-mir-4668-5p (MIRT615353)
- hsa-mir-4665-5p (MIRT615354)
- hsa-mir-1275 (MIRT615355)
- hsa-mir-5010-5p (MIRT615356)
- hsa-mir-4525 (MIRT615357)
- hsa-mir-7111-5p (MIRT615358)
- hsa-mir-6870-5p (MIRT615359)
- hsa-mir-5698 (MIRT615360)
- hsa-mir-4723-5p (MIRT615361)
- hsa-mir-625-5p (MIRT615362)
- hsa-mir-7155-5p (MIRT615363)
- hsa-mir-637 (MIRT615364)
- hsa-mir-8089 (MIRT615365)
- hsa-mir-4700-5p (MIRT615366)
- hsa-mir-4667-5p (MIRT615367)
- hsa-mir-3613-3p (MIRT615368)
- hsa-mir-1298-3p (MIRT615369)
- hsa-mir-4422 (MIRT615370)
- hsa-mir-548e-5p (MIRT615371)
- hsa-mir-519d-5p (MIRT628339)
- hsa-mir-6513-5p (MIRT669169)
- hsa-mir-887-5p (MIRT669170)
- hsa-mir-3913-5p (MIRT669171)
- hsa-mir-3122 (MIRT669172)
- hsa-mir-450a-1-3p (MIRT669173)
- hsa-mir-6780a-5p (MIRT669174)
- hsa-mir-6779-5p (MIRT669175)
- hsa-mir-3689c (MIRT669176)
- hsa-mir-3689b-3p (MIRT669177)
- hsa-mir-3689a-3p (MIRT669178)
- hsa-mir-30b-3p (MIRT669179)
- hsa-mir-1273h-5p (MIRT669180)
- hsa-mir-6788-5p (MIRT669181)
- hsa-mir-30c-2-3p (MIRT669182)
- hsa-mir-30c-1-3p (MIRT669183)
- hsa-mir-7977 (MIRT669184)
- hsa-mir-8085 (MIRT669185)
- hsa-mir-6731-5p (MIRT669186)
- hsa-mir-6878-5p (MIRT669187)
- hsa-mir-383-3p (MIRT669188)
miRNA Products
- Search ViGene Biosciences for CCNF
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CCNF
- Browse OriGene Inhibitory RNA Products For CCNF
- genomics-online: shRNA clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNF gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CCNF
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCNF
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CCNF
- Applied Biological Materials Clones for CCNF
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CCNF gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCNF gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNF gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for CCNF Gene
Localization for CCNF Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCNF Gene
- Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
- Centrosome (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 20596027 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | -- |
| GO:0005814 | centriole | IEA,IDA | 20596027 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for CCNF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | DNA Damage | ||
| 3 | GADD45 Pathway | ||
| 4 | GPCR Pathway | ||
| 5 | Innate Immune System |
.61
|
|
Pathways by source for CCNF Gene
1 GeneTex pathway for CCNF Gene
2 Qiagen pathways for CCNF Gene
1 Cell Signaling Technology pathway for CCNF Gene
Interacting Proteins for CCNF Gene
Selected Interacting proteins:
ENSP00000380256
P41002-CCNF_HUMAN
for CCNF Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0000320 | re-entry into mitotic cell cycle | IEA | -- |
| GO:0001890 | placenta development | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0010826 | negative regulation of centrosome duplication | IEA,IDA | 20596027 |
No data available for SIGNOR curated interactions for CCNF Gene
Transcripts for CCNF Gene
mRNA/cDNA for CCNF Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (95) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CCNF
- genomics-online: gRNA clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
- Applied Biological Materials CRISPR for CCNF
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNF
- GenScript: Design CRISPR guide RNA sequences for CCNF
miRNA Products
- Search ViGene Biosciences for CCNF
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CCNF
- Browse OriGene Inhibitory RNA Products For CCNF
- genomics-online: shRNA clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNF gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CCNF
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCNF
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CCNF
- Applied Biological Materials Clones for CCNF
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for CCNF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNF Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CCNF Gene:
CCNFSOURCE GeneReport for Unigene cluster for CCNF Gene:
Hs.1973mRNA Expression by UniProt/SwissProt for CCNF Gene:
P41002-CCNF_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for CCNF Gene
- Eye(4)
Primer Products
-
OriGene qPCR primer pairs for CCNF
-
OriGene qPCR primer pairs and template standards for CCNF
- genomics-online: primer clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNF Gene
Orthologs for CCNF Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCNF 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CCNF 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CCNF 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ccnf 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccnf 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCNF 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCNF 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCNF 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccnf 33 |
|
||
| Str.10283 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC69175 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ccnf 34 33 |
|
OneToOne |
- Species where no ortholog for CCNF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CCNF Gene
No data available for Paralogs for CCNF Gene
Variants for CCNF Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000052798 | -- | 2,448,270(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000058777 | -- | 2,448,622(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000066615 | -- | 2,440,213(+) | C/T | intron_variant | |
| rs1000158835 | -- | 2,425,548(+) | C/T | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
| rs1000165188 | -- | 2,439,569(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422427 | CNV | duplication | 17116639 |
| nsv1052260 | CNV | gain | 25217958 |
| nsv1069901 | CNV | deletion | 25765185 |
| nsv1141940 | OTHER | inversion | 24896259 |
| nsv827513 | CNV | gain | 20364138 |
| nsv833121 | CNV | loss | 17160897 |
| nsv952903 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.54;
44.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCNF Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNF Gene
Disorders for CCNF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amyotrophic lateral sclerosis 1 |
|
|
| necrotizing fasciitis |
|
|
| frontotemporal dementia |
|
|
Search CCNF in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CCNF
No data available for UniProtKB/Swiss-Prot and Genatlas for CCNF Gene
Publications for CCNF Gene
- A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). (PMID: 7896286) Kraus B … Frischauf AM (Genomics 1994) 2 3 4 22 58
- Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. (PMID: 12122006) Fung TK … Poon RY (The Journal of biological chemistry 2002) 3 4 22 58
- SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. (PMID: 8706131) Bai C … Elledge SJ (Cell 1996) 3 4 22 58
- Human cyclin F. (PMID: 7813445) Bai C … Elledge SJ (The EMBO journal 1994) 3 4 22 58
- Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. (PMID: 22441691) Li J … Dynlacht BD (EMBO reports 2012) 3 4 58
Products for CCNF Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for CCNF
- Browse OriGene ELISA Kits
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- OriGene Purified Proteins for CCNF
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCNF
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCNF
- GenScript: Next-day shipping of latest version cDNA ORF clones for CCNF in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CCNF
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- GenScript Custom overexpressing Cell Line Services for CCNF
- GenScript: Design CRISPR guide RNA sequences for CCNF
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- Novus Biologicals Antibodies for CCNF
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCNF
- VectorBuilder custom plasmid, inducible vectors for CCNF
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCNF
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CCNF
- antibodies-online: Search results for 64 available Cyclin F Antibodies ranked by validation data
- Compare Top Cyclin F Antibodies
- antibodies-online: Search results for 1 available Cyclin F Elisa Kits ranked by validation data
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- antibodies-online: Search results for 4 available Cyclin F Proteins ranked by validation data
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- GeneTex CCNF antibody for CCNF
- Search GeneTex for Proteins for CCNF
- ViGene Biosciences adenoviral particle packaged cDNA for CCNF gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCNF gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCNF gene
- Search ViGene Biosciences for CCNF
- Santa Cruz Biotechnology (SCBT) Antibodies for CCNF
- Search Santa Cruz Biotechnology (SCBT) for CCNF siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCNF
- genomics-online: cdna clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
- orf clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
- genomics-online: gRNA clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
- genomics-online: primer clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
- genomics-online: shRNA clones - Search results for 102 available Cyclin F gene related products
- Overview of 102 available Cyclin F gene related products
Sources for CCNF Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems