Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
CCNF (Cyclin F) is a Protein Coding gene. Diseases associated with CCNF include Amyotrophic Lateral Sclerosis 1 and Deafness, Autosomal Recessive 86. Among its related pathways are GADD45 Pathway and Innate Immune System. An important paralog of this gene is CCNB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IBA | -- |
GO:0005515 | protein binding | IPI | 20596027 |
GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | IBA | 21873635 |
GO:0019901 | protein kinase binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IBA | 21873635 |
GO:0005634 | nucleus | IBA,IDA | 20596027 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005813 | centrosome | IBA,IDA | -- |
GO:0005814 | centriole | IEA,IDA | 20596027 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | DNA Damage | ||
3 | GADD45 Pathway |
GADD45 Pathway
-
|
|
4 | GPCR Pathway |
Pancreatic Adenocarcinoma
.59
|
|
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | IBA | 21873635 |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0000320 | re-entry into mitotic cell cycle | IEA | -- |
GO:0001890 | placenta development | IEA | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CCNF 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CCNF 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CCNF 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ccnf 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ccnf 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CCNF 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CCNF 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CCNF 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ccnf 30 |
|
||
Str.10283 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC69175 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ccnf 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714682 | Benign: not provided | 2,449,455(+) | C/T | SYNONYMOUS_VARIANT | |
715829 | Benign: not provided | 2,455,530(+) | C/T | SYNONYMOUS_VARIANT | |
717033 | Benign: not provided | 2,455,452(+) | G/A | SYNONYMOUS_VARIANT | |
722268 | Likely Benign: not provided | 2,456,731(+) | G/A | MISSENSE_VARIANT | |
722753 | Likely Benign: not provided | 2,445,453(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2422427 | CNV | duplication | 17116639 |
nsv1052260 | CNV | gain | 25217958 |
nsv1069901 | CNV | deletion | 25765185 |
nsv1141940 | OTHER | inversion | 24896259 |
nsv827513 | CNV | gain | 20364138 |
nsv833121 | CNV | loss | 17160897 |
nsv952903 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
amyotrophic lateral sclerosis 1 |
|
|
deafness, autosomal recessive 86 |
|
|
deafness, autosomal dominant 65 |
|
|
myoclonic epilepsy, familial infantile |
|
|
ludwig's angina |
|
|