This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiqu... See more...

Aliases for CCNF Gene

Aliases for CCNF Gene

  • Cyclin F 2 3 5
  • FBXO1 2 3 4
  • FBX1 2 3 4
  • F-Box Only Protein 1 3 4
  • Cyclin-F 3 4
  • G2/Mitotic-Specific Cyclin-F 3
  • CCNF 5

External Ids for CCNF Gene

Previous GeneCards Identifiers for CCNF Gene

  • GC16P002273
  • GC16P002504
  • GC16P002419
  • GC16P002405
  • GC16P002479

Summaries for CCNF Gene

Entrez Gene Summary for CCNF Gene

  • This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNF Gene

CCNF (Cyclin F) is a Protein Coding gene. Diseases associated with CCNF include Amyotrophic Lateral Sclerosis 1 and Deafness, Autosomal Recessive 86. Among its related pathways are GADD45 Pathway and Innate Immune System. An important paralog of this gene is CCNB1.

UniProtKB/Swiss-Prot Summary for CCNF Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.

Gene Wiki entry for CCNF Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNF Gene

Genomics for CCNF Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNF on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNF

Top Transcription factor binding sites by QIAGEN in the CCNF gene promoter:
  • AhR
  • C/EBPalpha
  • E47
  • Egr-2
  • FOXO1
  • LCR-F1
  • p300
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for CCNF Gene

Genomic Locations for CCNF Gene
chr16:2,429,394-2,458,854
(GRCh38/hg38)
Size:
29,461 bases
Orientation:
Plus strand
chr16:2,479,395-2,508,859
(GRCh37/hg19)
Size:
29,465 bases
Orientation:
Plus strand

Genomic View for CCNF Gene

Genes around CCNF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNF Gene

Proteins for CCNF Gene

  • Protein details for CCNF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41002-CCNF_HUMAN
    Recommended name:
    Cyclin-F
    Protein Accession:
    P41002
    Secondary Accessions:
    • B2R8H3
    • Q96EG9

    Protein attributes for CCNF Gene

    Size:
    786 amino acids
    Molecular mass:
    87640 Da
    Quaternary structure:
    • Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway.
    Miscellaneous:
    • Founding member of the F-box domain protein family, which obtained its name from cyclin-F.

neXtProt entry for CCNF Gene

Post-translational modifications for CCNF Gene

  • Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence.
  • Phosphorylated just before cells enter into mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNF Gene

No data available for DME Specific Peptides for CCNF Gene

Domains & Families for CCNF Gene

Gene Families for CCNF Gene

Suggested Antigen Peptide Sequences for CCNF Gene

GenScript: Design optimal peptide antigens:
  • F-box only protein 1 (CCNF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41002

UniProtKB/Swiss-Prot:

CCNF_HUMAN :
  • The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.
  • Belongs to the cyclin family. Cyclin AB subfamily.
Domain:
  • The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNF: view

Function for CCNF Gene

Molecular function for CCNF Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
GENATLAS Biochemistry:
cyclin F,involved in the regulation of cell cycle

Phenotypes From GWAS Catalog for CCNF Gene

Gene Ontology (GO) - Molecular Function for CCNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0005515 protein binding IPI 20596027
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with CCNF: view
genes like me logo Genes that share phenotypes with CCNF: view

Human Phenotype Ontology for CCNF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CCNF Gene

MGI Knock Outs for CCNF:
  • Ccnf Ccnf<tm1.1Sje>

Animal Model Products

CRISPR Products

miRNA for CCNF Gene

miRTarBase miRNAs that target CCNF

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNF

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCNF Gene

Localization for CCNF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNF Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNF gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA,IDA 20596027
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IBA,IDA --
GO:0005814 centriole IEA,IDA 20596027
genes like me logo Genes that share ontologies with CCNF: view

Pathways & Interactions for CCNF Gene

genes like me logo Genes that share pathways with CCNF: view

Pathways by source for CCNF Gene

2 Qiagen pathways for CCNF Gene
  • GADD45 Pathway
  • Pancreatic Adenocarcinoma
1 Cell Signaling Technology pathway for CCNF Gene
1 GeneTex pathway for CCNF Gene

Gene Ontology (GO) - Biological Process for CCNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000209 protein polyubiquitination TAS --
GO:0000320 re-entry into mitotic cell cycle IEA --
GO:0001890 placenta development IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with CCNF: view

No data available for SIGNOR curated interactions for CCNF Gene

Drugs & Compounds for CCNF Gene

No Compound Related Data Available

Transcripts for CCNF Gene

mRNA/cDNA for CCNF Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNF

Alternative Splicing Database (ASD) splice patterns (SP) for CCNF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5:

Relevant External Links for CCNF Gene

GeneLoc Exon Structure for
CCNF

Expression for CCNF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCNF Gene



Protein tissue co-expression partners for CCNF Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNF

SOURCE GeneReport for Unigene cluster for CCNF Gene:

Hs.1973

mRNA Expression by UniProt/SwissProt for CCNF Gene:

P41002-CCNF_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for CCNF Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with CCNF: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNF Gene

Orthologs for CCNF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCNF Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCNF 30 31
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCNF 30 31
  • 86.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCNF 30 31
  • 84.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccnf 30
  • 84.06 (n)
Mouse
(Mus musculus)
Mammalia Ccnf 30 17 31
  • 83.42 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CCNF 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCNF 31
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCNF 30 31
  • 70.14 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccnf 30
  • 64.23 (n)
Str.10283 30
African clawed frog
(Xenopus laevis)
Amphibia MGC69175 30
Zebrafish
(Danio rerio)
Actinopterygii ccnf 30 31
  • 62.41 (n)
OneToOne
Species where no ortholog for CCNF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCNF Gene

ENSEMBL:
Gene Tree for CCNF (if available)
TreeFam:
Gene Tree for CCNF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNF: view image

Paralogs for CCNF Gene

genes like me logo Genes that share paralogs with CCNF: view

Variants for CCNF Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNF Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
714682 Benign: not provided 2,449,455(+) C/T SYNONYMOUS_VARIANT
715829 Benign: not provided 2,455,530(+) C/T SYNONYMOUS_VARIANT
717033 Benign: not provided 2,455,452(+) G/A SYNONYMOUS_VARIANT
722268 Likely Benign: not provided 2,456,731(+) G/A MISSENSE_VARIANT
722753 Likely Benign: not provided 2,445,453(+) C/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CCNF Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNF Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv1069901 CNV deletion 25765185
nsv1141940 OTHER inversion 24896259
nsv827513 CNV gain 20364138
nsv833121 CNV loss 17160897
nsv952903 CNV deletion 24416366

Variation tolerance for CCNF Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNF Gene

Human Gene Mutation Database (HGMD)
CCNF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNF Gene

Disorders for CCNF Gene

MalaCards: The human disease database

(11) MalaCards diseases for CCNF Gene - From: Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CCNF in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CCNF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNF Gene

Publications for CCNF Gene

  1. A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). (PMID: 7896286) Kraus B … Frischauf AM (Genomics 1994) 2 3 4 23
  2. Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. (PMID: 12122006) Fung TK … Poon RY (The Journal of biological chemistry 2002) 3 4 23
  3. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. (PMID: 8706131) Bai C … Elledge SJ (Cell 1996) 3 4 23
  4. Human cyclin F. (PMID: 7813445) Bai C … Elledge SJ (The EMBO journal 1994) 3 4 23
  5. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. (PMID: 22441691) Li J … Dynlacht BD (EMBO reports 2012) 3 4

Products for CCNF Gene

  • Signalway Proteins for CCNF

Sources for CCNF Gene