External Ids for CCNE2 Gene
Previous GeneCards Identifiers for CCNE2 Gene
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNE2 Gene
CCNE2 (Cyclin E2) is a Protein Coding gene. Diseases associated with CCNE2 include Systemic Epstein-Barr Virus-Positive T-Cell Lymphoma Of Childhood and Retinoblastoma. Among its related pathways are E2F transcription factor network and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CCNE1.
UniProtKB/Swiss-Prot Summary for CCNE2 Gene
Essential for the control of the cell cycle at the late G1 and early S phase.