The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cycli... See more...

Aliases for CCNE2 Gene

Aliases for CCNE2 Gene

  • Cyclin E2 2 3 5
  • G1/S-Specific Cyclin-E2 3 4
  • CYCE2 2 3
  • CCNE2 5

External Ids for CCNE2 Gene

Previous GeneCards Identifiers for CCNE2 Gene

  • GC08M094798
  • GC08M095864
  • GC08M095561
  • GC08M095849
  • GC08M095961
  • GC08M095892
  • GC08M091101

Summaries for CCNE2 Gene

Entrez Gene Summary for CCNE2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNE2 Gene

CCNE2 (Cyclin E2) is a Protein Coding gene. Diseases associated with CCNE2 include Systemic Epstein-Barr Virus-Positive T-Cell Lymphoma Of Childhood and Retinoblastoma. Among its related pathways are E2F transcription factor network and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot Summary for CCNE2 Gene

  • Essential for the control of the cell cycle at the late G1 and early S phase.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCNE2 Gene

Genomics for CCNE2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCNE2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNE2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCNE2

Top Transcription factor binding sites by QIAGEN in the CCNE2 gene promoter:
  • AREB6
  • ATF6
  • CUTL1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CCNE2 Gene

Genomic Locations for CCNE2 Gene
chr8:94,879,770-94,896,678
(GRCh38/hg38)
Size:
16,909 bases
Orientation:
Minus strand
chr8:95,891,998-95,908,906
(GRCh37/hg19)
Size:
16,909 bases
Orientation:
Minus strand

Genomic View for CCNE2 Gene

Genes around CCNE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE2 Gene

Proteins for CCNE2 Gene

  • Protein details for CCNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96020-CCNE2_HUMAN
    Recommended name:
    G1/S-specific cyclin-E2
    Protein Accession:
    O96020
    Secondary Accessions:
    • O95439

    Protein attributes for CCNE2 Gene

    Size:
    404 amino acids
    Molecular mass:
    46757 Da
    Quaternary structure:
    • Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

    Alternative splice isoforms for CCNE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNE2 Gene

Post-translational modifications for CCNE2 Gene

  • Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNE2 Gene

Domains & Families for CCNE2 Gene

Gene Families for CCNE2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CCNE2 Gene

Suggested Antigen Peptide Sequences for CCNE2 Gene

GenScript: Design optimal peptide antigens:
  • G1/S-specific cyclin-E2 (CCNE2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O96020

UniProtKB/Swiss-Prot:

CCNE2_HUMAN :
  • Belongs to the cyclin family. Cyclin E subfamily.
Family:
  • Belongs to the cyclin family. Cyclin E subfamily.
genes like me logo Genes that share domains with CCNE2: view

Function for CCNE2 Gene

Molecular function for CCNE2 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the late G1 and early S phase.
UniProtKB/Swiss-Prot Induction:
Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.

Phenotypes From GWAS Catalog for CCNE2 Gene

Gene Ontology (GO) - Molecular Function for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0005515 protein binding IPI 9840943
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA 21873635
GO:0019901 protein kinase binding IBA,IEA --
genes like me logo Genes that share ontologies with CCNE2: view
genes like me logo Genes that share phenotypes with CCNE2: view

Animal Models for CCNE2 Gene

MGI Knock Outs for CCNE2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNE2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNE2 Gene

Localization for CCNE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNE2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IBA 21873635
genes like me logo Genes that share ontologies with CCNE2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCNE2 Gene

Pathways & Interactions for CCNE2 Gene

genes like me logo Genes that share pathways with CCNE2: view

Pathways by source for CCNE2 Gene

12 Qiagen pathways for CCNE2 Gene
  • Breast Cancer Regulation by Stathmin1
  • Cell Cycle Control by BTG Proteins
  • Cyclins and Cell Cycle Regulation
  • DNA Damage Induced 14-3-3Sigma Signaling
  • Estrogen-mediated S-Phase Entry
1 Cell Signaling Technology pathway for CCNE2 Gene
1 GeneTex pathway for CCNE2 Gene

Gene Ontology (GO) - Biological Process for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000082 G1/S transition of mitotic cell cycle IBA,TAS --
GO:0000723 telomere maintenance IEA --
GO:0006270 DNA replication initiation IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with CCNE2: view

No data available for SIGNOR curated interactions for CCNE2 Gene

Drugs & Compounds for CCNE2 Gene

(1) Drugs for CCNE2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCNE2: view

Transcripts for CCNE2 Gene

mRNA/cDNA for CCNE2 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCNE2

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE2 Gene

No ASD Table

Relevant External Links for CCNE2 Gene

GeneLoc Exon Structure for
CCNE2

Expression for CCNE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1).

Protein differential expression in normal tissues from HIPED for CCNE2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCNE2 Gene



Protein tissue co-expression partners for CCNE2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCNE2

SOURCE GeneReport for Unigene cluster for CCNE2 Gene:

Hs.521693

mRNA Expression by UniProt/SwissProt for CCNE2 Gene:

O96020-CCNE2_HUMAN
Tissue specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.

Evidence on tissue expression from TISSUES for CCNE2 Gene

  • Skin(4.4)
  • Lung(4.4)
  • Nervous system(3)
  • Intestine(2.3)
  • Liver(2.2)
  • Bone marrow(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CCNE2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNE2 Gene

Orthologs for CCNE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCNE2 30 31
  • 99.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCNE2 30 31
  • 94.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCNE2 30 31
  • 92.93 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccne2 30 17 31
  • 89.66 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccne2 30
  • 89.5 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CCNE2 31
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 84 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
-- 31
  • 69 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CCNE2 30 31
  • 74.64 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCNE2 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccne2 30
  • 66.5 (n)
Str.20470 30
African clawed frog
(Xenopus laevis)
Amphibia ccne2-prov 30
Zebrafish
(Danio rerio)
Actinopterygii ccne2 30 31
  • 62.27 (n)
OneToOne
Dr.18081 30
Fruit Fly
(Drosophila melanogaster)
Insecta CycE 31 32
  • 22 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cye-1 31 32
  • 20 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB6 31
  • 18 (a)
ManyToMany
CLB1 31
  • 17 (a)
ManyToMany
CLB3 31
  • 17 (a)
ManyToMany
CLB5 31
  • 16 (a)
ManyToMany
CLB2 31
  • 16 (a)
ManyToMany
CLB4 31
  • 13 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToMany
Species where no ortholog for CCNE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CCNE2 Gene

ENSEMBL:
Gene Tree for CCNE2 (if available)
TreeFam:
Gene Tree for CCNE2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCNE2: view image

Paralogs for CCNE2 Gene

(4) SIMAP similar genes for CCNE2 Gene using alignment to 7 proteins:

  • CCNE2_HUMAN
  • E5RHN2_HUMAN
  • E5RK20_HUMAN
  • H0YBQ2_HUMAN
  • I6L961_HUMAN
  • L8EBC7_HUMAN
  • Q8WUE3_HUMAN
genes like me logo Genes that share paralogs with CCNE2: view

Variants for CCNE2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCNE2 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs28399585 - p.Asn387Ser

Additional dbSNP identifiers (rs#s) for CCNE2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNE2 Gene

Variant ID Type Subtype PubMed ID
nsv6314 CNV insertion 18451855
nsv971685 CNV duplication 23825009

Variation tolerance for CCNE2 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNE2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE2 Gene

Disorders for CCNE2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CCNE2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic epstein-barr virus-positive t-cell lymphoma of childhood
  • ebv-positive t-cell lymphoproliferative disorder of childhood
retinoblastoma
  • rb1
breast cancer
  • breast lobular carcinoma
lung cancer
  • adenocarcinoma of lung
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CCNE2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCNE2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CCNE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNE2 Gene

Publications for CCNE2 Gene

  1. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PMID: 9840943) Zariwala M … Xiong Y (Oncogene 1998) 2 3 4 23
  2. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. (PMID: 9840927) Lauper N … Amati B (Oncogene 1998) 2 3 4 23
  3. Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. (PMID: 9858585) Gudas JM … Coats S (Molecular and cellular biology 1999) 3 4 23
  4. Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells. (PMID: 19638577) Masamha CP … Benbrook DM (Cancer research 2009) 3 23
  5. Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc. (PMID: 19564413) Caldon CE … Musgrove EA (Molecular and cellular biology 2009) 3 23

Products for CCNE2 Gene

  • Addgene plasmids for CCNE2

Sources for CCNE2 Gene