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Aliases for CCNE2 Gene

Aliases for CCNE2 Gene

  • Cyclin E2 2 3 5
  • G1/S-Specific Cyclin-E2 3
  • CYCE2 3

External Ids for CCNE2 Gene

Previous GeneCards Identifiers for CCNE2 Gene

  • GC08M095864
  • GC08M095561
  • GC08M095849
  • GC08M095961
  • GC08M095892
  • GC08M091101

Summaries for CCNE2 Gene

Entrez Gene Summary for CCNE2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNE2 Gene

CCNE2 (Cyclin E2) is a Protein Coding gene. Among its related pathways are Gene Expression and Parkinsons Disease Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot for CCNE2 Gene

  • Essential for the control of the cell cycle at the late G1 and early S phase.

Additional gene information for CCNE2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE2 Gene

Genomics for CCNE2 Gene

GeneHancer (GH) Regulatory Elements for CCNE2 Gene

Promoters and enhancers for CCNE2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J094894 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.8 809 3.6 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZBTB7B E2F8 ZNF143 FOS NDUFAF6 CCNE2 INTS8 VIRMA MIR3150BHG TP53INP1
GH08J094822 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 +73.0 73001 2.6 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B INTS8 TP53INP1 CCNE2 ENSG00000254307 ENSG00000253878 ESRP1 NDUFAF6 ENSG00000272509
GH08J095024 Promoter/Enhancer 1.6 Ensembl ENCODE 11.6 -128.5 -128504 2.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 VIRMA INTS8 TP53INP1 MIR3150BHG ENSG00000253878 CCNE2 RNU6-1209P ENSG00000254307 GC08P094978 NDUFAF6
GH08J095223 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.3 -328.6 -328625 4.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 FOS SP5 MXD4 ZNF592 ENSG00000254248 PLEKHF2 CCNE2 C8orf37 LINC01298 C8orf37-AS1 TRS-AGA2-5
GH08J094990 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.7 -94.3 -94285 1.1 PKNOX1 CLOCK FOXA2 NFIB RCOR1 CREM MIXL1 GATAD2B ELF1 PPARG ENSG00000253878 TP53INP1 CCNE2 RNU6-1209P GC08P094978 NDUFAF6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCNE2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNE2 gene promoter:
  • CUTL1
  • AREB6
  • PPAR-gamma1
  • PPAR-gamma2
  • ATF6

Genomic Locations for CCNE2 Gene

Genomic Locations for CCNE2 Gene
16,909 bases
Minus strand
16,909 bases
Minus strand

Genomic View for CCNE2 Gene

Genes around CCNE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE2 Gene

Proteins for CCNE2 Gene

  • Protein details for CCNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G1/S-specific cyclin-E2
    Protein Accession:
    Secondary Accessions:
    • O95439

    Protein attributes for CCNE2 Gene

    404 amino acids
    Molecular mass:
    46757 Da
    Quaternary structure:
    • Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

    Alternative splice isoforms for CCNE2 Gene


neXtProt entry for CCNE2 Gene

Post-translational modifications for CCNE2 Gene

  • Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNE2 Gene

Domains & Families for CCNE2 Gene

Gene Families for CCNE2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CCNE2 Gene

Suggested Antigen Peptide Sequences for CCNE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin E subfamily.
  • Belongs to the cyclin family. Cyclin E subfamily.
genes like me logo Genes that share domains with CCNE2: view

Function for CCNE2 Gene

Molecular function for CCNE2 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the late G1 and early S phase.
UniProtKB/Swiss-Prot Induction:
Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.

Phenotypes From GWAS Catalog for CCNE2 Gene

Gene Ontology (GO) - Molecular Function for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9840943
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNE2: view
genes like me logo Genes that share phenotypes with CCNE2: view

Animal Models for CCNE2 Gene

MGI Knock Outs for CCNE2:

Animal Model Products

Clone Products

  • Addgene plasmids for CCNE2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNE2 Gene

Localization for CCNE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNE2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0097135 cyclin E2-CDK2 complex IEA --
genes like me logo Genes that share ontologies with CCNE2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCNE2 Gene

Pathways & Interactions for CCNE2 Gene

genes like me logo Genes that share pathways with CCNE2: view

Gene Ontology (GO) - Biological Process for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9840943
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000723 telomere maintenance IEA --
GO:0006270 DNA replication initiation IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CCNE2: view

No data available for SIGNOR curated interactions for CCNE2 Gene

Drugs & Compounds for CCNE2 Gene

(1) Drugs for CCNE2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCNE2: view

Transcripts for CCNE2 Gene

Unigene Clusters for CCNE2 Gene

Cyclin E2:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCNE2

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE2 Gene

No ASD Table

Relevant External Links for CCNE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1).

Protein differential expression in normal tissues from HIPED for CCNE2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCNE2 Gene

Protein tissue co-expression partners for CCNE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNE2 Gene:


SOURCE GeneReport for Unigene cluster for CCNE2 Gene:


mRNA Expression by UniProt/SwissProt for CCNE2 Gene:

Tissue specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.

Evidence on tissue expression from TISSUES for CCNE2 Gene

  • Lung(4.3)
  • Skin(4.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with CCNE2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNE2 Gene

Orthologs for CCNE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCNE2 34 33
  • 99.01 (n)
(Bos Taurus)
Mammalia CCNE2 34 33
  • 94.55 (n)
(Canis familiaris)
Mammalia CCNE2 34 33
  • 92.93 (n)
(Mus musculus)
Mammalia Ccne2 16 34 33
  • 89.66 (n)
(Rattus norvegicus)
Mammalia Ccne2 33
  • 89.5 (n)
(Ornithorhynchus anatinus)
Mammalia CCNE2 34
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
-- 34
  • 76 (a)
-- 34
  • 69 (a)
(Gallus gallus)
Aves CCNE2 34 33
  • 74.64 (n)
(Anolis carolinensis)
Reptilia CCNE2 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccne2 33
  • 66.5 (n)
Str.20470 33
African clawed frog
(Xenopus laevis)
Amphibia ccne2-prov 33
(Danio rerio)
Actinopterygii ccne2 34 33
  • 62.27 (n)
Dr.18081 33
fruit fly
(Drosophila melanogaster)
Insecta CycE 34 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea cye-1 34 35
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB6 34
  • 18 (a)
CLB1 34
  • 17 (a)
CLB3 34
  • 17 (a)
CLB5 34
  • 16 (a)
CLB2 34
  • 16 (a)
CLB4 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for CCNE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNE2 Gene

Gene Tree for CCNE2 (if available)
Gene Tree for CCNE2 (if available)
Evolutionary constrained regions (ECRs) for CCNE2: view image

Paralogs for CCNE2 Gene

Paralogs for CCNE2 Gene

(4) SIMAP similar genes for CCNE2 Gene using alignment to 7 proteins:

  • E5RK20_HUMAN
  • I6L961_HUMAN
genes like me logo Genes that share paralogs with CCNE2: view

Variants for CCNE2 Gene

Sequence variations from dbSNP and Humsavar for CCNE2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000142631 -- 94,892,140(-) AAAAAAAA/AAAAAAAAA intron_variant
rs1000355678 -- 94,891,054(-) C/T intron_variant
rs1000370794 -- 94,897,888(-) A/G upstream_transcript_variant
rs1000636233 -- 94,884,416(-) G/A intron_variant
rs1000989360 -- 94,896,365(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNE2 Gene

Variant ID Type Subtype PubMed ID
nsv6314 CNV insertion 18451855
nsv971685 CNV duplication 23825009

Variation tolerance for CCNE2 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE2 Gene

Disorders for CCNE2 Gene

Additional Disease Information for CCNE2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCNE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNE2 Gene

Publications for CCNE2 Gene

  1. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. (PMID: 9840927) Lauper N … Amati B (Oncogene 1998) 2 3 4 22 58
  2. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PMID: 9840943) Zariwala M … Xiong Y (Oncogene 1998) 2 3 4 22 58
  3. Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. (PMID: 9858585) Gudas JM … Coats S (Molecular and cellular biology 1999) 3 4 22 58
  4. SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis. (PMID: 19084516) Klotz K … Spruck C (Experimental cell research 2009) 3 22 58
  5. Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc. (PMID: 19564413) Caldon CE … Musgrove EA (Molecular and cellular biology 2009) 3 22 58

Products for CCNE2 Gene

Sources for CCNE2 Gene

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