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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
Cyclin E, while currenly not as widely implicated as its cyclin D counterparts, has been implicated in various carcinomas, including breast, gastric, stomach and colorectal. High levels of cyclin E, either by gene amplification or overexpression, have been shown to lead to poorer prognosis in gastic carcinoma, and these measurements are correlated with later stage disease. In lung cancer, neoplastic cells with higher levels of the cyclin E/CDK2 complex are more radiosensitive than their more lowly expressed counterparts.
CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Chronic Endophthalmitis and Facial Dermatosis. Among its related pathways are Cellular Senescence (REACTOME) and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCNE2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003713 | transcription coactivator activity | NAS | 15572661 |
GO:0004672 | contributes_to protein kinase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 8756624 |
GO:0016301 | kinase activity | IEA | -- |
GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IBA | 21873635 |
GO:0005634 | nucleus | IDA,IEA | 16109376 |
GO:0005654 | nucleoplasm | TAS,IDA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005813 | centrosome | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 |
.78
|
|
2 | Cyclins and Cell Cycle Regulation |
Cyclins and Cell Cycle Regulation
.67
G1-S Phase Transition
.67
|
Cell Cycle Control by BTG Proteins
.36
|
3 | Cell cycle Role of SCF complex in cell cycle regulation | ||
4 | DNA Damage Response | ||
5 | Chaperonin-mediated protein folding |
.94
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | IBA | 21873635 |
GO:0000082 | G1/S transition of mitotic cell cycle | TAS,IEA | -- |
GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | -- |
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0000723 | telomere maintenance | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3240 | ||
Gemcitabine | Approved | Pharma | Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs | 2336 | ||
Alisertib | Investigational | Pharma | inhibitor, Biomarker | Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors | 0 | |
Dinaciclib | Investigational | Pharma | inhibitor, Biomarker | CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors | 0 | |
Anti-Infective Agents | Pharma | 26672 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CCNE1 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | CCNE1 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | CCNE1 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Ccne1 32 |
|
||
mouse (Mus musculus) |
Mammalia | Ccne1 17 33 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | CCNE1 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | CCNE1 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | CCNE1 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | CCNE1 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | ccne1 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ccne1 33 32 |
|
OneToOne | |
-- 32 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3561 32 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CycE 33 34 32 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | cye-1 33 34 |
|
OneToMany | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CLB6 33 |
|
ManyToMany | |
CLB1 33 |
|
ManyToMany | |||
CLB2 33 |
|
ManyToMany | |||
CLB3 33 |
|
ManyToMany | |||
CLB5 33 |
|
ManyToMany | |||
CLB4 33 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany | |
Cin.14750 32 |
|
||||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.14750 32 |
|
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000345404 | -- | 29,811,839(+) | G/A | upstream_transcript_variant | |
rs1000514115 | -- | 29,824,675(+) | G/A | downstream_transcript_variant | |
rs1000522945 | -- | 29,818,351(+) | GGGG/GG/GGGGG | intron_variant | |
rs1000533643 | -- | 29,812,899(+) | T/C | intron_variant | |
rs1000621456 | -- | 29,824,626(+) | A/G | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1035e212 | CNV | loss | 25503493 |
esv274862 | CNV | loss | 21479260 |
nsv1072344 | CNV | deletion | 25765185 |
nsv1121975 | CNV | deletion | 24896259 |
nsv1126519 | CNV | deletion | 24896259 |
nsv1133066 | OTHER | inversion | 24896259 |
nsv2456 | CNV | deletion | 18451855 |
nsv828517 | CNV | gain | 20364138 |
nsv828518 | CNV | loss | 20364138 |
nsv833800 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chronic endophthalmitis |
|
|
facial dermatosis |
|
|
bowenoid papulosis |
|
|
clear cell adenocarcinoma of the ovary |
|
|
lung adenoma |
|
|